37418-88-5 Usage
Description
1,3-Isobenzofurandione, 4-hydroxy-, also known as 3-Hydroxyphthalic Anhydride, is an organic compound with the molecular formula C8H4O5. It is a white crystalline solid that is soluble in organic solvents. It is used as a reagent in organic synthesis and has potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
1,3-Isobenzofurandione, 4-hydroxyis used as a reagent in the synthesis of 3-Hydroxyphthalic Anhydride-modified human serum albumin, which has high potency as a microbicide for the prevention of sexual transmission of HIV. This application is significant in the development of new strategies to combat the spread of HIV.
Used in Organic Synthesis:
1,3-Isobenzofurandione, 4-hydroxyis used as a reagent in the organic synthesis of other compounds, including the synthesis of inhibitors of NF-κB derived from thalidomide. NF-κB is a protein complex that controls transcription of DNA, cytokine production, and cell survival, and its inhibition can have therapeutic effects in various diseases.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 5092, 1955 DOI: 10.1021/ja01624a042Synthesis, p. 788, 1985 DOI: 10.1055/s-1985-31350
Check Digit Verification of cas no
The CAS Registry Mumber 37418-88-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,4,1 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 37418-88:
(7*3)+(6*7)+(5*4)+(4*1)+(3*8)+(2*8)+(1*8)=135
135 % 10 = 5
So 37418-88-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H4O4/c9-5-3-1-2-4-6(5)8(11)12-7(4)10/h1-3,9H
37418-88-5Relevant articles and documents
Method for synthesizing herbicide pyriminobac-methyl in paddy field
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Paragraph 0007; 0042; 0043-0047; 0063-0067; 0083-0087; 0103, (2021/02/24)
The invention belongs to the field of fine chemical engineering, and particularly relates to a preparation method of herbicide pyriminobac-methyl for a paddy fields. The preparation method comprises the following steps: synthesizing 3-hydroxy phthalic anhydride by using 3-chlorophthalic anhydride as a new raw material, protecting carbonyl by using diethyl malonate, hydrolyzing to obtain 2-acetyl-6-hydroxy benzoic acid, and esterifying to obtain 2-acetyl-6-hydroxy methyl benzoate; then carrying out imidization reaction with methoxyamine hydrochloride to obtain 2-hydroxy-6-(1-methoxy iminoethyl-methyl)-benzoate, and finally, condensing with 2-tosyl-4, 6-dimethoxypyrimidine to obtain pyriminobac-methyl. In the process of preparing pyriminobac-methyl, high-risk reagents such as n-butyllithiumare avoided, a large amount of wastewater generated by diazotization is avoided, the income is increased, and the environment is protected.
DIMERIC IMMUNO-MODULATORY COMPOUNDS AGAINST CEREBLON-BASED MECHANISMS
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Page/Page column 66, (2020/02/06)
Disclosed are small molecules against cereblon to enhance effector T cell function. Methods of making these molecules and methods of using them to treat various disease states are also disclosed.
OLIGONUCLEOTIDE-BASED PROTEOLYSIS TARGETING CHIMERA
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Paragraph 0427; 0431; 0434, (2020/01/08)
Disclosed herein, inter alia, are oligonucleotide-based proteolysis targeting chimeras and methods of use thereof.