448964-01-0

Basic information

• Product Name: 2-Piperidinecarboxylic acid, 5-hydroxy-, (2R,5R)- (9CI)
• Synonyms: 2-Piperidinecarboxylic acid, 5-hydroxy-, (2R,5R)- (9CI);(2R,5R)-5-Hydroxy-2-piperidinecarboxylic acid;(2R, 5R)-5-Hydroxypiperidine-2-carboxylic acid
• CAS NO: 448964-01-0
• Molecular Formula: C6H11NO3
• Molecular Weight: 145.15644
• Product Categories: CARBOXYLICACID;ALCOHOL
• Mol File: 448964-01-0.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 354.8 °C at 760 mmHg
• Flash Point: 168.4 °C
• Appearance: /
• Density: 1.299
• PKA: 2.31±0.40(Predicted)
• CAS DataBase Reference: 2-Piperidinecarboxylic acid, 5-hydroxy-, (2R,5R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinecarboxylic acid, 5-hydroxy-, (2R,5R)- (9CI)(448964-01-0)
• EPA Substance Registry System: 2-Piperidinecarboxylic acid, 5-hydroxy-, (2R,5R)- (9CI)(448964-01-0)

Safety Data

• Hazardous Substances Data: 448964-01-0(Hazardous Substances Data)

Usage

General Description

2-Piperidinecarboxylic acid, 5-hydroxy-, (2R,5R)- (9CI) is a chemical compound with a piperidine ring and a carboxylic acid group attached to a 5-hydroxy group. It is a stereoisomer with a 2R,5R configuration. 2-Piperidinecarboxylic acid, 5-hydroxy-, (2R,5R)- (9CI) is not commonly found in nature but can be synthesized in the laboratory. It may have potential applications in the pharmaceutical or medical industry due to its unique structure and potential biological activity. Further research and investigation are needed to fully understand the properties and potential uses of this chemical compound.

Upstream product

• 15069-92-8 5-hydroxypicolinic acid 
• 13096-31-6 rac-(2R*,5S*)-5-hydroxypiperidine-2-carboxylic acid 
• 84409-89-2 (2S,5R)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid 
• 3105-95-1 pipecolinic acid 
• 59182-85-3 benzyloxycarbonyl-L-baikiain 
• 504-91-6 2,6-diamino-5-hydroxy-hexanoic acid 
• 2219-28-5 δ-hydroxylysine hydrochloride 
• 917507-80-3 (2S,5S)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid 
• 15366-19-5 methyl (S)-2-benzyloxycarbonylamino-6-diazo-5-oxohexanoate 
• 13907-82-9 N²-benzyloxycarbonyl-L-glutamine methyl ester 
• 5672-83-3 Z-L-GluOMe 
• 117836-15-4 (S)-2-Benzyloxycarbonylamino-5-ethoxycarbonyloxy-5-oxo-pentanoic acid methyl ester 
• 117836-26-7 cis-5(S)-hydroxy-2(S)-N₁-benzyloxycarbonylpipecolic acid methyl ester 
• 117836-13-2 (S)-5-Oxo-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 

Downstream Products

• 1510832-15-1 (1S,4S)-5-((2-nitrophenyl)sulfonyl)-2-oxa-5-azabicyclo[2.2.2]octan-3-one 
• 1510832-19-5 4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester 
• 1510831-80-7 C₃₁H₄₂N₄O₈S₂ 
• 1510832-11-7 C₃₅H₄₂N₆O₁₂S₂ 
• 1174020-63-3 tert-butyl 4-((1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate 
• 1174020-64-4 tert-butyl 4-((2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate hydrate 
• 1174018-99-5 (2S,5R)-sulfuric acid mono{[(4-aminopiperidin-4-yl)carbonyl]-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl}ester 
• 1174020-24-6 tetrabutyl ammonium salt (25,5R)-4-tert-butyl{(6-sulfooxy-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-ylcarbonyl)amino}piperidine-1-carboxylate 
• 1510832-18-4 tert-butyl 4-((2S,5S)-1-((2-nitrophenyl)sulfonyl)-5-(((2-nitrophenyl)sulfonyl)oxy)piperidine-2-carboxamido)piperidine-1-carboxylate 
• 1510832-12-8 C₁₂H₁₄N₂O₇S 
• 1174020-25-7 (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid 
• 1416134-73-0 (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate methyl ester 
• 1383814-58-1 (2S,5R)-6-benzyloxy-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-carboxylic acid methyl ester 
• 1436862-11-1 trans-sulfuric acid mono-[2-hydrazinocarbonyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl]ester 

Relevant articles and documents

Development of a Stereoselective Synthesis of (1 R,4 R)- and (1 S,4 S)-2-Oxa-5-azabicyclo[2.2.2]octane

Despite the prevalence of morpholine derivatives and bridged heterocycles in medicinally relevant compounds, bridged bicyclic morpholines remain scarce because of the challenges associated with their synthesis. MRK A, an IDH1mut inhibitor for the treatment of glioma, derives its potency in part from substitution of a zigzag 2,5-bicyclic morpholine, 2-oxa-5-azabicyclo[2.2.2]octane, at C8. While existing entries suffered from low yields and lack of stereochemical control, we developed concise stereospecific routes toward both enantiomers of the zigzag morpholine antipode. The key common intermediate in the two routes was a chiral bicyclic lactone, which was readily synthesized following our previous synthesis of relebactam from optically pure (2S,5S)-5-hydroxypiperidine-2-carboxylic acid (HPA). The desired (R,R) enantiomer for incorporation into MRK A required inversion of both stereocenters of the bicyclic lactone intermediate, which was accomplished by epimerization via a crystallization-induced diastereomer transformation process followed by a key Ti(OiPr)4-mediated intramolecular SN2 ring closure. By this method, the (R,R)-zigzag morpholine was synthesized in six steps from HPA in 25% overall yield.

METHODS OF USING RAD51 INHIBITORS FOR TREATMENT OF PANCREATIC CANCER

This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat pancreatic cancer.

METHOD FOR PRODUCING 5-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID

A method for producing (2S,5S)/(2R,5R)-5-hydroxypiperidine-2-carboxylic acid represented by formula (10) below: the method including removing the protecting group from the hydroxyl group in a compound represented by formula (7) below: (wherein P represents a protecting group, R3 represents an alkyl group containing 1 to 4 carbon atoms, and A represents an alkyl group containing 1 to 10 carbon atoms, an aryl group containing 6 to 12 carbon atoms, an alkyloxy group containing 1 to 4 carbon atoms, or an aralkyloxy group containing 7 to 20 carbon atoms) to synthesize a compound represented by formula (8) below: (wherein R3 represents an alkyl group containing 1 to 4 carbon atoms, and A represents an alkyl group containing 1 to 10 carbon atoms, an aryl group containing 6 to 12 carbon atoms, an alkyloxy group containing 1 to 4 carbon atoms, or an aralkyloxy group containing 7 to 20 carbon atoms).