56578-38-2

Basic information

• Product Name: 3-Fluorocinnamaldehyde
• Synonyms: 3-FLUOROCINNAMALDEHYDE;2-PROPENAL, 3-(3-FLUOROPHENYL)-,(2E);(E)-3-(3-Fluorophenyl)-2-propenal;(E)-3-(3-fluorophenyl)acrylaldehyde
• CAS NO: 56578-38-2
• Molecular Formula: C₉H₇FO
• Molecular Weight: 150.15
• Mol File: 56578-38-2.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 246 ºC
• Flash Point: 91 ºC
• Appearance: /
• Density: 1.138
• Vapor Pressure: 0.028mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 3-Fluorocinnamaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluorocinnamaldehyde(56578-38-2)
• EPA Substance Registry System: 3-Fluorocinnamaldehyde(56578-38-2)

Safety Data

• Hazardous Substances Data: 56578-38-2(Hazardous Substances Data)

Usage

General Description

3-Fluorocinnamaldehyde is a chemical compound with the molecular formula C9H7FO. It is a pale yellow liquid with a strong, sweet, floral odor. 3-Fluorocinnamaldehyde is an important intermediate in the synthesis of numerous pharmaceuticals and agrochemicals. It is also commonly used in the synthesis of various organic compounds, such as dyes and fragrances. Additionally, 3-Fluorocinnamaldehyde has been studied for its potential pharmacological properties, including its anticancer and anti-inflammatory activities. Due to its versatile applications and unique chemical properties, 3-Fluorocinnamaldehyde is an important compound in the field of organic chemistry.

InChI:InChI=1/C9H7FO/c10-9-5-1-3-8(7-9)4-2-6-11/h1-7H/b4-2+

Upstream product

• 3054-95-3 acrylaldehyde diethyl acetal 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 1073-06-9 3-fluorobromobenzene 
• 125872-67-5 (E)-3-(3-fluorophenyl)prop-2-en-1-ol 
• 20595-30-6 3-Fluorocinnamic acid 
• 351-46-2 3-(3-Fluorophenyl)acrylic acid ethyl ester 
• 245070-85-3 3-(3-fluorophenyl)propanal 
• 1446099-77-9 (E)-3-(dimethyl(phenyl)silyl)-1-(3-fluorophenyl)prop-2-en-1-ol 
• 2136-75-6 (triphenylphosphoranylidene)acetaldehyde 
• 456-48-4 3-Fluorobenzaldehyde 
• 74325-03-4 methyl (E)-m-fluorocinnamate 
• 197239-54-6 3-(3-fluorophenyl)prop-2-yn-1-ol 
• 201230-82-2 carbon monoxide 
• 2561-17-3 1-ethynyl-3-fluoro-benzene 

Downstream Products

• 1000682-29-0 C₁₂H₁₀FN₃O₂ 
• 1065509-93-4 3-(3-fluorophenyl)-4-nitrobutyraldehyde 
• 1015486-71-1 3-(3-fluoro-phenyl)-oxirane-2-carbaldehyde 
• 1073495-61-0 (1R)-9-fluoro-1-[(4-{[(2E)-3-(3-fluorophenyl)-2-propen-1-yl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one 
• 1062144-14-2 C₁₉H₁₈FNO₂ 
• 1221716-69-3 dimethyl-2-(3-fluorophenyl)-3-formyl-4-methylcyclopent-3-ene-1,1-dicarboxylate 
• 1222468-69-0 (S)-3-(3-fluoro-phenyl)-3-(1,1,3,3-tetraoxo-2,3-dihydro-1H-1λ(6),3λ(6)-benzo[1,3]dithiol-2-yl)-propionaldehyde 
• 1320256-66-3 (E)-N-(tert-butyl)-4-(3-fluorophenyl)-2-oxobut-3-enamide 
• 1321200-93-4 (3R,4R)-5-benzoyl-3-(3-fluorobenzyl)-4,6-diphenyl-3,4-dihydro-2H-pyran-2-one 
• 1361214-42-7 C₂₅H₂₉FN₂O₃ 
• 1361214-45-0 (R)-tert-butyl 3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoate 
• 1361214-48-3 (R)-3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid 
• 1361214-50-7 (R)-4-([1,4'-bipiperidin]-1'-yl)-2-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-N-((R)-1-phenylethyl)butanamide 

Relevant articles and documents

Method for preparing olefine aldehyde by catalyzing terminal alkyne or terminal conjugated eneyne and diphosphine ligand used in method

The invention discloses a method for preparing olefine aldehyde by catalyzing terminal alkyne or terminal conjugated eneyne and a diphosphine ligand used in the method. According to the invention, indole-substituted phosphoramidite diphosphine ligand which is stable in air and insensitive to light is synthesized by utilizing a continuous one-pot method, and the indole-substituted phosphoramidite diphosphine ligand and a rhodium catalyst are used for jointly catalyzing to successfully achieve a hydroformylation reaction of aromatic terminal alkyne and terminal conjugated eneyne under the condition of synthesis gas for the first time, so that an olefine aldehyde structure compound can be rapidly and massively prepared, and particularly, a polyolefine aldehyde structure compound which is more difficult to synthesize in the prior art can be easily prepared and synthesized, and a novel method is provided for synthesis and modification of drug molecules, intermediates and chemical products.

Regioselective Silylations of Propargyl and Allyl Pivalates through Ca-Promoted Reductive C(sp3)-O Bond Cleavage

A practical protocol for the regioselective preparation of 3-phenylpropargylsilanes and 3-phenylallylsilanes in yields of 36-77 and 48-86%, respectively, from readily accessible 3-phenylpropargyl and 1-phenylallyl pivalates was developed through reductive C(sp3)-O bond cleavage. This method represents the first example of the direct application of vastly abundant calcium granules to a reductive coupling reaction. A broad range of propargylsilanes and allylsilanes are simply prepared using easy-to-handle pivalates and chlorotrimethylsilane under mild catalyst-free and additive-free conditions.

Highly Regio- A nd Enantioselective Hydrogenation of Conjugated α-Substituted Dienoic Acids

Highly regio- A nd enantioselective hydrogenation of conjugated α-substituted dienoic acids was realized for the first time using Trifer-Rh complex, providing a straightforward method for the synthesis of chiral α-substituted ?,?′-unsaturated acids. DFT calculations revealed N+H-O hydrogen bonding interaction is formed to stabilize the transition state and the coordination of 4,5-double bond to Rh(III) center would facilitate the reductive elimination process. This hydrogenation provided a gram-scale synthesis of the precursor of sacubitril.