(R)-(+)-1-Phenylethanol supplier

Name
(R)-(+)-1-Phenylethanol
EINECS
CAS No. 1517-69-7
Article Data997
CAS DataBase
Density 1.012
Solubility 20 G/L (20 ºC)
Melting Point 9-11 °C(lit.)
Formula C8H10 O
Boiling Point 206.9 °C at 760 mmHg
Molecular Weight 122.167
Flash Point 85 ºC
Transport Information UN 2937
Appearance Colorless to light yellow liquid
Safety 26-39-37/39
Risk Codes R22;R36/37/38
Molecular Structure
Hazard Symbols
Synonyms Benzenemethanol,a-methyl-, (R)-; Benzyl alcohol, a-methyl-, (R)-(+)- (8CI); (+)-1-Phenylethanol;(+)-1-Phenylethyl alcohol; (+)-sec-Phenethyl alcohol; (+)-a-Methylbenzyl alcohol; (+)-a-Phenethyl alcohol; (+)-a-Phenylethanol; (1R)-1-Phenylethanol;(R)-(+)-1-Phenylethanol; (R)-(+)-sec-Phenethyl alcohol; (R)-(+)-a-Hydroxyethylbenzene; (R)-(+)-a-Methylbenzenemethanol; (R)-(+)-a-Methylbenzyl alcohol; (R)-(+)-a-Phenethyl alcohol; (R)-(+)-a-Phenylethanol; (R)-1-Phenylethanol; (R)-1-Phenylethylalcohol; (R)-Phenylethanol; (R)-Phenylmethylcarbinol; (R)-sec-Phenethylalcohol; (R)-sec-Phenylethyl alcohol; (R)-a-Hydroxyethylbenzene; (R)-a-Methylbenzenemethanol; (R)-a-Methylbenzyl alcohol; (R)-a-Phenethyl alcohol; (R)-a-Phenylethanol; (aR)-a-Methylbenzenemethanol;D-(+)-Methylphenylcarbinol; D-(+)-a-Phenylethanol;R(+)-Phenylethanol; R-a-Methylbenzylalcohol; d-1-Phenylethanol; d-a-Phenethyl alcohol
PSA 20.23000
LogP 1.73990

Synthetic route

: 98-86-2
acetophenone

A: 1445-91-6
(S)-1-phenylethanol

B: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With RuBr2[(S,S)-2,4-bis(diphenylphosphino)pentane](2-aminomethyl-3,5-dimethylpyridine); potassium tert-butylate; hydrogen In ethanol at 40℃; under 7600.51 Torr; for 19h; Reagent/catalyst; Inert atmosphere; Autoclave;	A 100% B n/a
With dimethylsulfide borane complex; diphenyl-N-(3-pyridylmethyl)prolinol N-oxide In tetrahydrofuran for 5h; Heating;	A n/a B 99%
With borane-THF; (R)-1-(1'-amino-1'-phenylmethyl)cyclopentanol In tetrahydrofuran at 30℃; for 2h; Title compound not separated from byproducts;	A 98% B n/a

: 98-86-2
acetophenone

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With (S)-2-amino-1,1,3-triphenylpropan-1-ol borane In tetrahydrofuran at 30℃;	100%
With dimethylsulfide borane complex; (S)-chiral amino alcohol; aluminum ethoxide In tetrahydrofuran at 20℃; Reduction;	100%
With (S)-diphenylprolinol; dimethylsulfide borane complex In tetrahydrofuran at 20℃;	100%

: 75-24-1
trimethylaluminum

: 100-52-7
benzaldehyde

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With titanium(IV) isopropylate; (R,S)-2-OH-3,5-Cl2-C6H2-SO2-NH-CH(CH2Ph)-CH(Ph)OH In tetrahydrofuran at 0℃; for 12h;	100%
In tetrahydrofuran; hexane at -20℃; for 3h; Product distribution / selectivity;	60%

: 98-86-2
acetophenone

: 1896-62-4
(E)-benzalacetone

A: 1445-91-6
(S)-1-phenylethanol

B: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With Triethoxysilane; (S,S,S,S)-N,N'-di(α-phenylethyl)cyclohexane-1,2-diamine; diethylzinc In toluene at 20℃; for 18h; Title compound not separated from byproducts.;	A n/a B 100%
With polymethylhydrosiloxane; (S,S,S,S)-N,N'-di(α-phenylethyl)cyclohexane-1,2-diamine; diethylzinc In toluene at 20℃; for 24h; Title compound not separated from byproducts.;	A n/a B 90%

...Expand

: 1445-91-6
(S)-1-phenylethanol

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With Candida albicans CCT 0776 In water at 30℃; for 360h; Time; Enzymatic reaction; enantioselective reaction;	100%
With C48H48N2O4Ru2 In benzene at 30℃; for 20h; Irradiation; Darkness; optical yield given as %ee;	99.9%
Stage #1: (S)-1-phenylethanol With azodicarboxylic acid bis(2-methoxyethyl) ester; 4-diphenylphosphanobenzoic acid In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: With water; sodium hydroxide In tetrahydrofuran at 20℃; stereospecific reaction;	90%

: 98-85-1, 13323-81-4
1-Phenylethanol

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With alcohol dehydrogenase from Thermoanaerobium brockii; NADH-specific (R)-selective-ADH; YcnD-oxidoreductase at 30℃; for 6h; pH=7.5; aq. buffer; Resolution of racemate; Enzymatic reaction; optical yield given as %ee; enantiospecific reaction;	99%
In water at 30℃; for 24h; Geotrichum Candidum IFQ 5767;	96%
With cells of Geotrichum candidum IFO 5767 In water at 30℃; for 24h;	96%

: 38053-75-7
(R)-1-phenyl-1-(trichlorosilyl)ethane

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate In tetrahydrofuran; methanol for 16h;	99%
With potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate In tetrahydrofuran; methanol; water at 20℃; for 12h; enantioselective reaction;	37%
With potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate In tetrahydrofuran; methanol for 10h; Ambient temperature; Yield given;

: 16197-92-5
(R)-1-phenethyl acetate

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With water; potassium carbonate In methanol at 20℃; optical yield given as %ee;	99%
With methanol; sodium hydroxide for 1h;	99%
With methanol; oxo[hexa(trifluoroacetato)]tetrazinc for 18h; Reflux; Inert atmosphere;	98%

: 544-97-8
dimethyl zinc(II)

: 100-52-7
benzaldehyde

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With titanium(IV) isopropylate In hexane at -35℃; for 3h;	99%
Stage #1: dimethyl zinc(II) With (1S,2S,4R)-1,3,3-trimethyl-2-[(R)-2-(6-phenylpyridin-2-yl)phenyl]bicyclo-[2.2.1]heptan-2-ol In toluene at 0 - 20℃; Inert atmosphere; Stage #2: benzaldehyde In toluene at 0℃; for 96h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%
Stage #1: dimethyl zinc(II); benzaldehyde With (2R,3S,3aS,4aR,6R,8aS)-2-isopropyl-6,9,9-trimethyl-3-phenyldecahydro-4aH-pyrrolo[2,1-b][1,3]benzoxazin-3-ol In hexane; toluene at -20 - 20℃; for 30h; Inert atmosphere; Stage #2: With ammonium chloride In hexane; water; toluene Inert atmosphere; optical yield given as %ee; enantioselective reaction;	96%

: 1440524-56-0
(S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-allylmalonate

A: 1517-69-7
(R)-1-phenylethanol

B: 1440524-79-7
(S)-2-((tert-butoxy)carbonyl)-2-methylpent-4-enoic acid

Conditions

Conditions	Yield
With water; potassium hydroxide In methanol at 20℃; for 24h;	A n/a B 98%

: 70-11-1
α-bromoacetophenone

A: 1517-69-7
(R)-1-phenylethanol

B: 2425-28-7, 73908-23-3, 74497-33-9, 76155-80-1
(S)-2-bromo-1-phenylethanol

Conditions

Conditions	Yield
With sodium formate; cetyltrimethylammonim bromide; sodium dodecyl-sulfate; (R,R)-TsDPEN; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer In water at 28℃; for 1h;	A 3 % Spectr. B 97%

: 536-74-3
phenylacetylene

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
Stage #1: phenylacetylene With chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); water In methanol at 110℃; for 6h; Stage #2: With C26H26ClN2O2RhS; water; sodium formate In methanol at 30℃; for 5h;	97%
Stage #1: phenylacetylene With formic acid at 100℃; for 0.5h; Inert atmosphere; Sealed tube; Stage #2: With pentamethylcyclopentadienyl*RhCl[(S,S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine]; water; sodium hydroxide at 20 - 40℃; for 3h; pH=7; enantioselective reaction;	87%
With iron(III) chloride; sodium formate In water at 40℃; for 24h; optical yield given as %ee;	86%

: C8H10O4S*CH5N3

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With water In tetrahydrofuran for 12h; Reagent/catalyst; Reflux;	97%

: 86436-19-3
(R,R)-(-)-1,6-bis(o-chlorophenyl)-1,6-diphenylhexa-2,4-diyne-1,6-diol

: 98-86-2
acetophenone

A: 1445-91-6
(S)-1-phenylethanol

B: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With 1,2-diaminoethane-bisborane In solid Product distribution; enantioselective reduction of var. ketones in optically active host compounds with a BH3-ethylenediamine complex in the solid state;	A n/a B 96%

...Expand

: 18006-13-8
methyltriisopropoxytitanium(IV)

: 100-52-7
benzaldehyde

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With (Sa)-2'-((S)-hydroxy(phenyl)methyl)-[1,1'-binaphthalen]-2-ol In tetrahydrofuran; diethyl ether at 0℃; for 1.5h; Catalytic behavior; Solvent; Temperature; enantioselective reaction;	96%

: 98-85-1, 13323-81-4
1-Phenylethanol

: 876-27-7
4-chlorophenyl acetate

A: 1445-91-6
(S)-1-phenylethanol

B: 1517-69-7
(R)-1-phenylethanol

C: 16197-92-5
(R)-1-phenethyl acetate

Conditions

Conditions	Yield
With Novozym 435; potassium tert-butylate; sodium carbonate; [2,3,4,5-Ph4(η5-C4CNH(i-Pr))]Ru(CO)2Cl In toluene at 25℃; for 42h;	A n/a B n/a C 95%
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; potassium tert-butylate; sodium carbonate In toluene at 60℃; for 48h; Inert atmosphere; Schlenk technique; Enzymatic reaction; Overall yield = 70 %Spectr.; Optical yield = 40 %ee; enantioselective reaction;

...Expand

: (R)-1-phenylethyl diphenylacetate

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; methanol at 0 - 20℃; for 1.5h;	94%

: benzyl (+/-)-cis-(2-aminocyclopentyl)carbamate

: 93-92-5, 50373-55-2
1-phenylethyl acetate

A: 1517-69-7
(R)-1-phenylethanol

B: 1240201-04-0
benzyl (1S,2R)-[(2-acetylamino)cyclopentyl]carbamate

Conditions

Conditions	Yield
With triethylamine In tert-butyl methyl ether at 50℃; for 216h; Inert atmosphere; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;	A n/a B 94%

...Expand

: 100-41-4
ethylbenzene

A: 1517-69-7
(R)-1-phenylethanol

B: 98-86-2
acetophenone

Conditions

Conditions	Yield
With Aspergillus niger MTCC-404 at 35℃; for 24h; aq. phosphate buffer; Microbiological reaction; Closed tube; optical yield given as %ee;	A 93% B n/a
Stage #1: ethylbenzene With 1-(tert-butoxycarbonyl)-L-proline; [(2R,2’R)-1,1’-bis((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)-2,2’-bipyrrolidineMnII(OTf)2]; dihydrogen peroxide at -40℃; Stage #2: In acetonitrile enantioselective reaction;	A 39% B n/a
With calcium sulfite; recombinant peroxygenase from Agrocybe aegerita; sulfite oxidase from Arabidopsis thaliana In aq. phosphate buffer at 30℃; pH=7; Catalytic behavior; Enzymatic reaction; enantioselective reaction;	A 155 mg B 23%

: 120-45-6
1-phenylethyl propanoate

: 123-82-0
2-heptylamine

A: 1517-69-7
(R)-1-phenylethanol

B: (R)-N-(heptan-2-yl)propionamide

C: 107832-32-6
(R)-1-phenylethyl propionate

D: 120-45-6, 107832-32-6, 117405-47-7, 117290-46-7
(S)-1-phenylethyl propionate

Conditions

Conditions	Yield
With hydrogen; lipase B from Candida antarctica In toluene at 70℃; under 750.075 Torr; for 48h; Resolution of racemate; Enzymatic reaction;	A 47% B 93% C n/a D n/a

...Expand

: 120-45-6
1-phenylethyl propanoate

: 123-82-0
2-heptylamine

A: (R)-2-methoxy-N-(octan-2-yl)acetamide

B: 1517-69-7
(R)-1-phenylethanol

C: 107832-32-6
(R)-1-phenylethyl propionate

D: 120-45-6, 107832-32-6, 117405-47-7, 117290-46-7
(S)-1-phenylethyl propionate

Conditions

Conditions	Yield
With hydrogen; lipase B from Candida antarctica In toluene at 70℃; under 750.075 Torr; for 48h; Resolution of racemate; Enzymatic reaction;	A 93% B 47% C n/a D n/a

...Expand

: 120-45-6
1-phenylethyl propanoate

: 31828-71-4
RS-mexiletine

A: 1517-69-7
(R)-1-phenylethanol

B: C14H21NO2

C: 120-45-6, 107832-32-6, 117405-47-7, 117290-46-7
(S)-1-phenylethyl propionate

Conditions

Conditions	Yield
With hydrogen; lipase B from Candida antarctica In toluene at 70℃; under 750.075 Torr; for 48h; Resolution of racemate; Enzymatic reaction;	A 46% B 93% C n/a

...Expand

: 108-22-5
Isopropenyl acetate

: 98-85-1, 13323-81-4
1-Phenylethanol

A: 1445-91-6
(S)-1-phenylethanol

B: 1517-69-7
(R)-1-phenylethanol

C: 16197-92-5
(R)-1-phenethyl acetate

Conditions

Conditions	Yield
With Candida antarctica lipase B; dicarbonyl(chloro)(η5-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate In tetrahydrofuran; toluene at 20℃; for 3h;	A n/a B n/a C 92%
With Pseudomonas cepacia lipase In diethyl ether at 40℃; for 24h; Enzymatic reaction; enantioselective reaction;	A n/a B n/a C 9%
With Novozym 435; potassium tert-butylate; sodium carbonate; [2,3,4,5-Ph4(η5-C4CNH(i-Pr))]Ru(CO)2Cl In toluene at 25℃; for 30h; Product distribution; Further Variations:; Reagents; Solvents; reaction times;

...Expand

: 137203-34-0
bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct

: 100-52-7
benzaldehyde

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
In tetrahydrofuran at 5℃; for 1h; Product distribution / selectivity;	92%

: 98-85-1, 13323-81-4
1-Phenylethanol

A: 1445-91-6
(S)-1-phenylethanol

B: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With (S,S)-2,3-O-isopropylidene-1,1,4,4-tetraphenylthreitol In hexane at 20℃; for 72h;	A n/a B 90%
With Candida antarctica lipase B; 1-(10-carboxydecyl)-3-methylimidazolium hexafluorophosphate; diisopropyl-carbodiimide In acetone at 40℃; for 14h; Catalytic behavior; Reagent/catalyst; Temperature; Concentration; Resolution of racemate; Enzymatic reaction; enantioselective reaction;	A 51% B 32%
Stage #1: 1-Phenylethanol With Novozym 435(R); 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 35℃; under 100 Torr; for 96h; Stage #2: With ethanol at 35℃; for 24h; Further stages.;	A n/a B 22.5%

: 81978-44-1
<2S-(2α(S*),3aα,4α,7α,7aα)>-2,3,3a,4,5,6,7,7a-Octahydro-7,8,8-trimethyl-2-(1-phenylethoxy)-4,7-methanobenzofuran

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; triethylamine In methanol for 1h; Ambient temperature;	90%

: 13735-81-4
1-styrenyloxytrimethylsilane

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
Stage #1: 1-styrenyloxytrimethylsilane With tri-tert-butyl phosphine; C52H54; hydrogen; bis(pentafluorophenyl)borohydride In 1,3,5-trimethyl-benzene; pentane at 50℃; under 30003 Torr; for 24h; Inert atmosphere; Sealed tube; Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran; 1,3,5-trimethyl-benzene; pentane at 20℃; for 1h; Reagent/catalyst; Concentration; Solvent; enantioselective reaction;	90%
Multi-step reaction with 2 steps 1: C52H58; tri-tert-butyl phosphine; hydrogen / hexane / 24 h / 30003 Torr 2: tetrabutyl ammonium fluoride / toluene; pentane; tetrahydrofuran / 0.5 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: bis(pentafluorophenyl)borohydride; C52H58; tri-tert-butyl phosphine; hydrogen / toluene; pentane / 24 h / 50 °C / 30003 Torr / Autoclave 2: tetrabutyl ammonium fluoride / toluene; pentane; tetrahydrofuran / 0.5 h / 20 °C View Scheme

: 917-54-4
methyllithium

: 100-52-7
benzaldehyde

: 1517-69-7
(R)-1-phenylethanol

Conditions

Conditions	Yield
With triisopropoxytitanium(IV) chloride; (Sa)-2'-((S)-hydroxy(phenyl)methyl)-[1,1'-binaphthalen]-2-ol In diethyl ether; hexane at -20℃; for 0.166667h; Reagent/catalyst; enantioselective reaction;	90%

: 98-85-1, 13323-81-4
1-Phenylethanol

A: 1517-69-7
(R)-1-phenylethanol

B: 98-86-2
acetophenone

Conditions

Conditions	Yield
With Candida albicans CCT 0776 In water at 30℃; for 144h; Time; Resolution of racemate; Enzymatic reaction; enantioselective reaction;	A 89% B 11%
With Sphingomonas paucimobilis NCIMB 8195 In water; N,N-dimethyl-formamide for 144h;	A 81% B 14%
With Candida albicans CCT 0776 whole cells at 28℃; for 2.5h; pH=7; aq. phosphate buffer; Enzymatic reaction; optical yield given as %ee;	A 48% B 50%

: 108-05-4
vinyl acetate

: 98-85-1, 13323-81-4
1-Phenylethanol

A: 1445-91-6
(S)-1-phenylethanol

B: 1517-69-7
(R)-1-phenylethanol

C: 16197-92-5
(R)-1-phenethyl acetate

Conditions

Conditions	Yield
With Novozym 435; potassium tert-butylate; sodium carbonate; [2,3,4,5-Ph4(η5-C4CNH(i-Pr))]Ru(CO)2Cl In toluene at 25℃; for 96h;	A n/a B n/a C 89%
With lipase PS from Burkholderia cepacia at 35℃; Ionic liquid; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;	A n/a B n/a C 58%
With IL1; Lipase PS-C In di-isopropyl ether at 35℃; for 2h; Product distribution; Enzyme kinetics; Kinetics; Further Variations:; Reagents; time;	A n/a B n/a C 39%

...Expand

: 1517-69-7
(R)-1-phenylethanol

: 25197-75-5
(S)-chlorofluoroacetic acid

: (S)-Chloro-fluoro-acetic acid (R)-1-phenyl-ethyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Esterification;	100%

: 1191-99-7
2,3-dihydro-2H-furan

: 1517-69-7
(R)-1-phenylethanol

: (S)-2-((R)-1-Phenyl-ethoxy)-tetrahydro-furan

Conditions

Conditions	Yield
chiral ruthenium(II)(NO+)Cl(salen) In chlorobenzene at 20℃; for 24h; Irradiation;	100%

: 674-82-8
4-methyleneoxetan-2-one

: 1517-69-7
(R)-1-phenylethanol

: 123261-65-4
(R)-1-phenylethyl acetoacetate

Conditions

Conditions	Yield
With dmap In tetrahydrofuran at 20℃;	100%

: 1517-69-7
(R)-1-phenylethanol

: C11H8ClFO2

: (1R,4S)-((R)-1-phenylethyl) 8-fluoro-1,2,3,4-tetrahydro-1,4-epoxynaphthalene-1-carboxylate

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃;	99%

: 1517-69-7
(R)-1-phenylethanol

: 3756-41-0
(S)-(1-chloroethyl)benzene

Conditions

Conditions	Yield
With oxalyl dichloride; 2,3-bis(4-methoxyphenyl)cyclopropenone In dichloromethane at 30℃; for 1h; Inert atmosphere; optical yield given as %ee;	98%
With thionyl chloride In dichloromethane at 0 - 50℃; for 3h; Inert atmosphere;	66%
With thionyl chloride In dichloromethane at 0 - 50℃; Inert atmosphere;	66%

: 1517-69-7
(R)-1-phenylethanol

: 79-08-3
bromoacetic acid

: 287400-47-9
(R)-methylbenzyloxyacetic acid

Conditions

Conditions	Yield
With potassium hydride In tetrahydrofuran for 20h; Alkylation; Heating;	98%

: 3002-78-6
5-methyl-1,10-phenanthroline

: 766-85-8
3-methoxy-1-iodobenzene

: 1517-69-7
(R)-1-phenylethanol

: 3-(R-1-phenylethoxy)anisole

Conditions

Conditions	Yield
With CuI; caesium carbonate In toluene	98%

...Expand

: 1517-69-7
(R)-1-phenylethanol

: 16420-13-6
N,N-Dimethylthiocarbamoyl chloride

: (R)-O-(1-phenylethyl) N,N-dimethylthiocarbamate

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; mineral oil at 25℃; for 1h; Inert atmosphere;	98%

: 1517-69-7
(R)-1-phenylethanol

: 4755-77-5
Ethyl oxalyl chloride

: 890048-81-4
ethyl (R)-1-phenylethyl oxalate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃;	97%
With pyridine In dichloromethane at 20℃;	97%

: 1517-69-7
(R)-1-phenylethanol

: 920-46-7
Methacryloyl chloride

: 17199-94-9
(R)-α-methylbenzyl methacrylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 6h; Inert atmosphere;	97%

: 1517-69-7
(R)-1-phenylethanol

: C20H17ClO3

: C28H26O4

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 24h;	97%

: 1517-69-7
(R)-1-phenylethanol

: 530-62-1
1,1'-carbonyldiimidazole

: 1247028-03-0
(R)-1-phenylethyl 1H-imidazole-1-carboxylate

Conditions

Conditions	Yield
In ethyl acetate for 20h; Reflux; Inert atmosphere;	96%
In ethyl acetate for 20h; Inert atmosphere; Reflux;	96%
In dichloromethane at 0 - 20℃; for 17h; Inert atmosphere;	90%
In dichloromethane at 20℃; for 0.5h;

: 445003-37-2
4-bromo-2-methyl-benzoic acid tert-butyl ester

: 1517-69-7
(R)-1-phenylethanol

: 1246560-92-8
tert-butyl 3-methyl-2'-[(1R)-1-hydroxyethyl]biphenyl-4-carboxylate

Conditions

Conditions	Yield
Stage #1: (R)-1-phenylethanol With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In hexane at 50℃; for 1h; Cooling with ice; Inert atmosphere; Stage #2: With Triisopropyl borate In hexane at 20 - 40℃; for 2h; Inert atmosphere; Stage #3: 4-bromo-2-methyl-benzoic acid tert-butyl ester With potassium phosphate; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran; water at 20 - 65℃; for 2.5h; Suzuki Coupling; Inert atmosphere;	95.5%

Yield

Stage #1: (R)-1-phenylethanol With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In hexane at 50℃; for 1h; Cooling with ice; Inert atmosphere;
Stage #2: With Triisopropyl borate In hexane at 20 - 40℃; for 2h; Inert atmosphere;
Stage #3: 4-bromo-2-methyl-benzoic acid tert-butyl ester With potassium phosphate; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran; water at 20 - 65℃; for 2.5h; Suzuki Coupling; Inert atmosphere;

95.5%

: 62055-46-3
3-ethoxy-2-methylacrolein

: 1517-69-7
(R)-1-phenylethanol

: 130814-73-2
(E)-(1'R)-2-Methyl-3-(1'-phenylethoxy)-propenal

Conditions

Conditions	Yield
With toluene-4-sulfonic acid under 1 Torr;	95%
With toluene-4-sulfonic acid under 0.05 Torr; for 3h; Ambient temperature;	93%

(R)-(+)-1-Phenylethanol Chemical Properties

Molecular Formula: C₈H₁₀O

Formula Weight: 122.16
mp of (R)-(+)-1-Phenylethanol (1517-69-7): 9-11 ^°C(lit.)
bp : 88-89^°C 10 mm Hg(lit.)
density of (R)-(+)-1-Phenylethanol (1517-69-7): 1.012 g/mL at 20^°C(lit.)
refractive index : n20/D 1.528
Fp of (R)-(+)-1-Phenylethanol (1517-69-7): 85 ^°C
storage temp. : 2-8^°C
Appearence: Colorless to light yellow liquid

(R)-(+)-1-Phenylethanol Toxicity Data With Reference

ORL-RAT LD₅₀: 400 mg kg^-1
ORL-MUS LD₅₀: 558 mg kg^-1
SKN-GPG LD₅₀: > 15 mg kg^-1SCU-MUS LD₅₀: 250 mg kg^-1Toxic. May act as a carcinogen. Irritant. Severe eye irritant.

(R)-(+)-1-Phenylethanol Safety Profile

Hazard Codes : Xn (Harmful)
Risk Statements : 22-38-41-36/37/38 (Harmful if swallowed; Irritating to the skin; Risk of serious damage to eyes; Irritating to eyes, respiratory system and skin)
Safety Statements : 26-39-37/39 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear eye/face protection; Wear suitable gloves and eye/face protection)
RIDADR : UN 2937 6.1/PG 3
WGK Germany : 3
HazardClass : 6.1
PackingGroup : III

(R)-(+)-1-Phenylethanol Specification

Storage of (R)-(+)-1-Phenylethanol (1517-69-7): Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from sources of ignition. Keep away from heat, sparks, and flame.

Product Name

(R)-(+)-1-Phenylethanol

Synthetic route

(R)-(+)-1-Phenylethanol Chemical Properties

(R)-(+)-1-Phenylethanol Toxicity Data With Reference

(R)-(+)-1-Phenylethanol Safety Profile

(R)-(+)-1-Phenylethanol Specification

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