1-(1,4-Benzodioxane-2-carbonyl)piperazine supplier

Name
1-(1,4-Benzodioxane-2-carbonyl)piperazine
EINECS 415-660-9
CAS No. 70918-00-2
Article Data12
CAS DataBase
Density 1.246 g/cm³
Solubility
Melting Point 141 °C
Formula C₁₃H₁₆N₂O₃
Boiling Point 437.2 °C at 760 mmHg
Molecular Weight 248.282
Flash Point 218.2 °C
Transport Information
Appearance
Safety 53-45-61
Risk Codes Xi:;
Molecular Structure
Hazard Symbols Xi
Synonyms Piperazine,1-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]- (9CI);1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine;
PSA 50.80000
LogP 0.52490

Synthetic route

: 110-85-0
piperazine

: 3663-80-7, 34385-93-8, 70918-53-5, 70918-54-6
1,4-benzodioxane-2-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

Conditions

Conditions	Yield
Stage #1: 1,4-benzodioxane-2-carboxylic acid With N-Bromosuccinimide; triphenylphosphine In dichloromethane at 0 - 5℃; for 0.25h; Stage #2: piperazine With pyridine In dichloromethane at 20℃; for 0.5h;	96%
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In dichloromethane at 20℃; for 0.166667h;	95%
With 1,1,1,3,3,3-hexamethyl-disilazane at 110℃; for 5h;	91%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	84%
With 1,1,1,3,3,3-hexamethyl-disilazane at 110℃; for 15h;	32%

: C18H24N2O5

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 1.25h;	96%

: 110-85-0
piperazine

: 4739-94-0
ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

Conditions

Conditions	Yield
at 110℃; for 3h;	94%
In methanol; isopropyl alcohol Heating;	73.13%
at 75℃; for 4 - 10h;	30%

: 110-85-0
piperazine

: 4739-94-0
ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate

A: 1,4-bis-(2,3-dihydro-benzo[1,4]dioxin-2-carbonyl)-piperazine

B: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

Conditions

Conditions	Yield
at 75 - 80℃; for 10h;	A 11% B 89%
at 70 - 80℃; for 6h;	A 12% B 65%

...Expand

: 110-85-0
piperazine

: C12H16O4Si

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

Conditions

Conditions	Yield
at 110℃; for 5h;

: 120-80-9
benzene-1,2-diol

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 85 percent / potassium hydroxide; polyethylene glycol-400; potassium carbonate / toluene / 3.75 h / Heating 2: 65 percent / 6 h / 70 - 80 °C View Scheme

: 3663-80-7, 34385-93-8, 70918-53-5, 70918-54-6
1,4-benzodioxane-2-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2 h / 110 °C 2: 5 h / 110 °C View Scheme
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate / dichloromethane / -15 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 1.25 h / 0 - 20 °C View Scheme

: 3663-82-9
2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium hydroxide; potassium permanganate / water / 0 °C 2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate / dichloromethane / -15 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 1.25 h / 0 - 20 °C View Scheme

: 533-58-4
2-Iodophenol

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: potassium carbonate / N,N-dimethyl-formamide; water; ethyl acetate / 24 h / 50 °C 2: sodium tetrahydroborate / tetrahydrofuran; methanol / 6 h / 0 °C 3: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / toluene / 90 °C / Sealed tube; Inert atmosphere 4: potassium hydroxide; potassium permanganate / water / 0 °C 5: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate / dichloromethane / -15 °C / Inert atmosphere 6: trifluoroacetic acid / dichloromethane / 1.25 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 6 steps
1: potassium carbonate / N,N-dimethyl-formamide; water; ethyl acetate / 24 h / 50 °C
2: sodium tetrahydroborate / tetrahydrofuran; methanol / 6 h / 0 °C
3: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / toluene / 90 °C / Sealed tube; Inert atmosphere
4: potassium hydroxide; potassium permanganate / water / 0 °C
5: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate / dichloromethane / -15 °C / Inert atmosphere
6: trifluoroacetic acid / dichloromethane / 1.25 h / 0 - 20 °C
View Scheme

: C13H15IO5

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: sodium tetrahydroborate / tetrahydrofuran; methanol / 6 h / 0 °C 2: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / toluene / 90 °C / Sealed tube; Inert atmosphere 3: potassium hydroxide; potassium permanganate / water / 0 °C 4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate / dichloromethane / -15 °C / Inert atmosphere 5: trifluoroacetic acid / dichloromethane / 1.25 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 5 steps
1: sodium tetrahydroborate / tetrahydrofuran; methanol / 6 h / 0 °C
2: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / toluene / 90 °C / Sealed tube; Inert atmosphere
3: potassium hydroxide; potassium permanganate / water / 0 °C
4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate / dichloromethane / -15 °C / Inert atmosphere
5: trifluoroacetic acid / dichloromethane / 1.25 h / 0 - 20 °C
View Scheme

: 2-(2-iodophenoxy)propane-1,3-diol

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / toluene / 90 °C / Sealed tube; Inert atmosphere 2: potassium hydroxide; potassium permanganate / water / 0 °C 3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate / dichloromethane / -15 °C / Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 1.25 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 4 steps
1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / toluene / 90 °C / Sealed tube; Inert atmosphere
2: potassium hydroxide; potassium permanganate / water / 0 °C
3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate / dichloromethane / -15 °C / Inert atmosphere
4: trifluoroacetic acid / dichloromethane / 1.25 h / 0 - 20 °C
View Scheme

: 20197-86-8
2-chloro-4-hydroxyl-6,7-dimethoxyquinazoline

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: C23H24N4O6

Conditions

Conditions	Yield
In butan-1-ol for 1h; Temperature; Solvent; Reflux;	95%

: 1146300-32-4
7-chloro-1-(2,4-difluorophenyl)-1,4-dihydro-8-methyl-6-nitro-4-oxoquinolone-3-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 1146300-55-1
1-(2,4-difluorophenyl)-1,4-dihydro-7-(4-(2,3-dihydrobenzo[b][1,4]dioxin-2-oyl)piperazin-1-yl)-8-methyl-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide Microwave irradiation;	93%

: 1146300-33-5
1-tert-butyl-7-chloro-1-1,4-dihydro-8-methyl-6-nitro-4-oxoquinolone-3-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 1146300-72-2
1-tert-butyl-1,4-dihydro-8-methyl-7-(4-(2,3-dihydrobenzo[b][1,4]dioxin-2-oyl)piperazin-1-yl)-8-methyl-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide Microwave irradiation;	91%

: 1146300-31-3
7-chloro-1-cyclopropyl-1,4-dihydro-8-methyl-6-nitro-4-oxoquinolone-3-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 1146300-38-0
1-cyclopropyl-1,4-dihydro-7-(4-(2,3-dihydrobenzo[b][1,4]dioxin-2-oyl)piperazin-1-yl)-8-methyl-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide Microwave irradiation;	90%

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: N-(4-chlorophenyl)-4-(2,3-dihydrobenzo[b][1,4]-dioxine-2-carbonyl)piperazine-1-carbothioamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; Cooling;	90%

: 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 70918-01-3
4-amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline hydrochloride

Conditions

Conditions	Yield
In butan-1-ol for 3.5h; Heating;	88%
In butan-1-ol for 5h; Heating;
In N-methyl-acetamide; water; butan-1-ol

: 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 74191-85-8
doxazosin

Conditions

Conditions	Yield
In butan-1-ol Reflux;	88%
In butan-1-ol for 5h; Heating;	83%

: 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: UK-36528-27(R)

Conditions

Conditions	Yield
In butan-1-ol Reflux;	87.9%

: 960313-86-4
1-(4-fluorophenyl)-1,4-dihydro-7-methoxy-6-nitro-4-oxo-1,8-naphthyridine-3-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: C28H22FN5O8

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide microwave irradiation;	85%

: 236743-93-4
(S)-9,10-difluoro-3-methyl-8-nitro-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: C26H23FN4O9

Conditions

Conditions	Yield
In dimethyl sulfoxide microwave irradiation;	83%

: 112811-77-5
1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-nitro-8-methoxy-4-oxoquinoline-3-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 1018937-62-6
C27H25FN4O9

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	83%

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 368839-20-7
7-chloro-1-(4-fluorophenyl)-1,4-dihydro-6-nitro-4-oxoquinoline-3-carboxylic acid

: 1119087-42-1
7-(4-(2,3-dihydrobenzo[b][1,4]dioxin-2-ylcarbonyl)piperazin-1-yl)-1-(4-fluorophenyl)-1,4-dihydro-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
In dimethyl sulfoxide Microwave irradiation;	83%

: 50-00-0
formaldehyd

: propargyl ether mycophenolate

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: mycophenoyl methyl ester-7-(butynyloxy-N-(benzodioxylcarbonylpiperazine))

Conditions

Conditions	Yield
With copper(l) iodide In 1,4-dioxane at 120℃; for 1h;	81%

...Expand

: 960313-85-3
1-cyclopropyl-1,4-dihydro-7-methoxy-6-nitro-4-oxo-1,8-naphthyridine-3-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: C25H23N5O8

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide microwave irradiation;	77%

: 102614-43-7
2-chloro-3-fluoro-5,12-dihydro-5-oxobenzothiazolo<3,2-a>quinoline-6-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 1028202-94-9
C29H22FN3O6S

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide microwave irradiation;	77%

: 1028202-77-8
2-chloro-3-nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 1028202-95-0
C29H22N4O8S

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide microwave irradiation;	75%

: 960313-87-5
1-tert-butyl-1,4-dihydro-7-methoxy-6-nitro-4-oxo-1,8-naphthyridine-3-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: C26H27N5O8

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide microwave irradiation;	73%

: 494204-73-8
1-tert-butyl-7-chloro-1,4-dihydro-6-nitro-4-oxoquinoline-3-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 1119087-94-3
1-tert-butyl-7-(4-(2,3-dihydrobenzo[b][1,4]dioxin-2-ylcarbonyl)piperazin-1-yl)-1,4-dihydro-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
In dimethyl sulfoxide Microwave irradiation;	71%

: 100986-89-8
levofloxacin Q-acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: C26H24FN3O7

Conditions

Conditions	Yield
In dimethyl sulfoxide microwave irradiation;	70%

: 93107-29-0
1-cyclopropyl-6-nitro-4-oxo-7-chloro-1,4-dihydroquinoline-3-carboxylic acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 1119086-90-6
1-cyclopropyl-7-(4-(2,3-dihydrobenzo[b][1,4]dioxin-2-ylcarbonyl)piperazin-1-yl)-1,4-dihydro-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
In dimethyl sulfoxide Microwave irradiation;	70%

: 1446090-67-0
4-chloro-5-(4-chlorophenyl)thieno[2,3-d]pyrimidine-6-carbonitrile

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 1446090-60-3
5-(4-chlorophenyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-3-yl)(piperazin-1-yl)methanone-thieno[2,3-d]pyrimidine-6-carbonitrile

Conditions

Conditions	Yield
In neat (no solvent) at 120 - 130℃; for 6h; Sealed tube;	66%

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1018937-59-1
C27H26FN3O7

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	64%

: 5-bromo-4,4-dimethyl-6-methylene-5,6-dihydro-1H-pyrrolo-[3,2,1-ij ]quinoline-1,2(4H)-dione

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: 4,4-dimethyl-6-{[4-(2,3-dihydrobenzo[b][1,4]dioxino-2-carbnyl)piperazin-1-yl]methyl}-4H-pyrrolo[3,2,1-ij]quinoline-1,2-dione

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile Reflux;	57%

: 147-71-7
D-tartaric acid

: 70918-00-2
(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone

: (S)-N-(1,4-benzodioxan-2-carbonyl)piperazine D-tartrate

Conditions

Conditions	Yield
In water; acetonitrile at 80℃;	50%

1-(1,4-Benzodioxane-2-carbonyl)piperazine Chemical Properties

Molecular Structure of Methanone,(2,3-dihydro-1,4-benzodioxin-2-yl)-1-piperazinyl- (CAS NO.70918-00-2):

Molecular Formula: C₁₃H₁₆N₂O₃
Molecular Weight: 248.2777
IUPAC Name: 2,3-Dihydro-1,4-benzodioxin-3-yl(piperazin-1-yl)methanone
Synonyms of Methanone,(2,3-dihydro-1,4-benzodioxin-2-yl)-1-piperazinyl- (CAS NO.70918-00-2): 1-(1,4-Benzodioxane-2-carbonyl)piperazine ; 1-[(2,3-Dihydro-1,4-benzodiaxan-2-yl)carbonyl]piperazine
CAS NO: 70918-00-2
Index of Refraction: 1.565
Molar Refractivity: 64.95 cm³
Molar Volume: 199.1 cm³
Surface Tension: 47 dyne/cm
Density: 1.246 g/cm³
Flash Point: 218.2 °C
Enthalpy of Vaporization: 69.38 kJ/mol
Boiling Point: 437.2 °C at 760 mmHg
Vapour Pressure: 7.62E-08 mmHg at 25°C

1-(1,4-Benzodioxane-2-carbonyl)piperazine Safety Profile

Hazard Codes of Methanone,(2,3-dihydro-1,4-benzodioxin-2-yl)-1-piperazinyl- (CAS NO.70918-00-2): Xi
HazardClass: IRRITANT

Product Name

1-(1,4-Benzodioxane-2-carbonyl)piperazine

Synthetic route

1-(1,4-Benzodioxane-2-carbonyl)piperazine Chemical Properties

1-(1,4-Benzodioxane-2-carbonyl)piperazine Safety Profile

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