Conditions | Yield |
---|---|
With phosphorus tribromide In pyridine 0 deg C, 1 h; r.t., 3 h; | 44% |
With phosphorus; bromine | |
With sulfuric acid; water; sodium bromide |
Conditions | Yield |
---|---|
Stage #1: benzyloxyacetic acid With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -70 - -30℃; for 1h; Stage #2: 1.3-chlorobromopropane In tetrahydrofuran; hexane at -70 - 20℃; for 2.5h; | 32% |
Conditions | Yield |
---|---|
With water; sodium bromide; sodium chloride anschliessenden Erwaermen des Reaktionsprodukts mit Schwefelsaeure; |
Conditions | Yield |
---|---|
With chlorine im Licht; | |
With sulfuryl dichloride; dibenzoyl peroxide |
Conditions | Yield |
---|---|
With sulfuric acid; water; hydrogen bromide at 150℃; |
Conditions | Yield |
---|---|
With 1,4-dibromo-butane; tetrabutylammomium bromide at 100℃; for 19.5h; | 49.7 % Chromat. |
Conditions | Yield |
---|---|
unter Belichtung; |
1-bromo-butane
sulfuryl dichloride
dibenzoyl peroxide
4-chlorobutyl bromide
n-Butyl chloride
A
4-chlorobutyl bromide
B
1-bromo-1-chlorobutane
C
2-bromo-4-chloro-butane
D
2-bromo-1-chlorobutane
Conditions | Yield |
---|---|
With carbon tetrabromide; {[PhSiO1.5]2CuO}n at 150℃; for 10h; Product distribution; Further Variations:; Catalysts; |
1-bromo-butane
A
4-chlorobutyl bromide
B
1-bromo-3-chlorobutane
C
1-bromo-2-chlorobutane
Conditions | Yield |
---|---|
With perchloric acid; 1-chloro-cis-2,6-dimethylpiperidine In dichloromethane; water at 0℃; for 2h; Irradiation; Sealed tube; Inert atmosphere; Overall yield = 53 percent; |
4-chlorobutyl bromide
silver trifluoromethanesulfonate
4-chlorobutanol-1-trifluoromethanesulfonate
Conditions | Yield |
---|---|
In tetrachloromethane for 0.166667h; | 100% |
4-chlorobutyl bromide
2-methyl-2,3,4,5-tetrahydropyrrolo[2,3-e][1,2]thiazin-4-one 1,1-dioxide
5-(4-chlorobutyl)-2-methyl-2,3,4,5-tetrahydropyrrolo[2,3-e][1,2]thiazin-4-one 1,1-dioxide
Conditions | Yield |
---|---|
With potassium carbonate In butanone | 100% |
Conditions | Yield |
---|---|
Stage #1: 4-chlorobutyl bromide With magnesium In tetrahydrofuran; diethyl ether for 0.5h; Heating / reflux; Stage #2: 5-phenylpentanoic acid-methoxy-methyl-amide In tetrahydrofuran; diethyl ether at 5 - 55℃; for 3.5h; | 100% |
Stage #1: 4-chlorobutyl bromide With magnesium In tetrahydrofuran Inert atmosphere; Reflux; Stage #2: In tetrahydrofuran; diethyl ether for 0.5h; Stage #3: 5-phenylpentanoic acid-methoxy-methyl-amide In tetrahydrofuran; diethyl ether at 5 - 55℃; for 3.5h; | 100% |
4-chlorobutyl bromide
N-methoxy-N-methyl-4-phenylbutanamide
8-Chloro-1-phenyl-octan-4-one
Conditions | Yield |
---|---|
Stage #1: 4-chlorobutyl bromide With magnesium In diethyl ether at 20℃; for 1h; Heating / reflux; Stage #2: N-methoxy-N-methyl-4-phenylbutyramide In tetrahydrofuran; diethyl ether at 0 - 50℃; for 4.25h; | 100% |
Stage #1: 4-chlorobutyl bromide With magnesium In diethyl ether at 20℃; for 1h; Reflux; Stage #2: N-methoxy-N-methyl-4-phenylbutyramide In tetrahydrofuran; diethyl ether at 0 - 50℃; | 100% |
4-chlorobutyl bromide
N(1)-ethyl-N(1),N(3)-bis(2-nitrobenzenesulfonyl)propane-1,3-diamine
N(1)-(4-chlorobutyl)-N(3)-ethyl-N(1),N(3)-bis(2-nitrobenzenesulfonyl)propane-1,3-diamine
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 65h; | 100% |
4-chlorobutyl bromide
N-hydroxyphthalimide
2-(2-chlorobutoxy)isoindoline-1,3-dione
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 20℃; | 100% |
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 60℃; Inert atmosphere; | 100% |
4-chlorobutyl bromide
2-hydroxypyrazolo<1,5-α>pyridine
2-(4-chlorobutoxy)pyrazolo[1,5-a]pyridine
Conditions | Yield |
---|---|
With sodium iodide In N,N-dimethyl-formamide at 20℃; for 18h; | 100% |
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 20℃; for 18h; | 100% |
4-chlorobutyl bromide
tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate
Conditions | Yield |
---|---|
Stage #1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; Inert atmosphere; Stage #2: 4-chlorobutyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; Inert atmosphere; Stage #3: With sodium azide In N,N-dimethyl-formamide at 50℃; Inert atmosphere; | 100% |
4-chlorobutyl bromide
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 80℃; | 100% |
4-chlorobutyl bromide
1-azido-4-chloro-butane
Conditions | Yield |
---|---|
With sodium azide In N,N-dimethyl-formamide at 20℃; | 99% |
With sodium azide In N,N-dimethyl-formamide at 20℃; for 24h; | 95% |
With sodium azide In N,N-dimethyl-formamide at 20℃; for 20h; | 94% |
4-chlorobutyl bromide
methyl cyclopentane carboxylate
1-(4-Chlorobutyl)cyclopentanecarboxylic acid, methyl ester
Conditions | Yield |
---|---|
With N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium chloride; lithium diisopropyl amide | 99% |
Stage #1: methyl cyclopentane carboxylate With lithium diisopropyl amide In tetrahydrofuran at -70 - -50℃; for 1h; Stage #2: 4-chlorobutyl bromide at -70 - 20℃; for 15h; | 64% |
64% |
4-chlorobutyl bromide
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 51h; Heating; | 99% |
4-chlorobutyl bromide
N‐methoxy‐N‐methyl‐2‐phenoxyacetamide
C12H15ClO2
Conditions | Yield |
---|---|
Stage #1: 4-chlorobutyl bromide With magnesium In tetrahydrofuran; diethyl ether at 20℃; for 0.5h; Heating / reflux; Stage #2: N‐methoxy‐N‐methyl‐2‐phenoxyacetamide In tetrahydrofuran; diethyl ether at 5 - 50℃; for 4h; | 99% |
4-chlorobutyl bromide
N-(tert-butoxycarbonyl)-N'-(2-nitrobenzenesulfonyl)-1,3-propanediamine
{3-[(4-chlorobutyl)(2-nitrobenzenesulfonyl)amino]propyl}carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 65℃; for 20h; | 99% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 1h; | 98% |
With potassium carbonate In dimethyl sulfoxide at 20 - 50℃; for 2.16667h; Inert atmosphere; | 94% |
Stage #1: thiophenol With sodium hydroxide In ethanol; water at 20℃; for 0.166667h; Stage #2: 4-chlorobutyl bromide In ethanol; water at 25℃; for 8h; | 92% |
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 6h; Heating / reflux; | 98% |
With potassium carbonate In acetone for 6h; Heating / reflux; | 98% |
With potassium carbonate In acetone Heating; | 98% |
4-chlorobutyl bromide
1-(3-chloro-propyl)-5-pyridin-3-yl-1H-pyrimidine-2,4-dione
3-benzoyl-1-(4-chloro-butyl)-5-iodo-1H-pyrimidine-2,4-dione
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 98% |
4-chlorobutyl bromide
5-hydroxy-1,3-dihydro-1-isoindolone
5-(4-chloro-butoxy)-2,3-dihydro-isoindol-1-one
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile for 18h; Heating / reflux; | 98% |
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran at -78℃; | 98% |
4-chlorobutyl bromide
3-(4-((benzyl(ethyl)amino)methyl)phenyl)-7-hydroxy-2H-chromen-2-one
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 20h; Reflux; | 98% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; | 98% |
Product Name: 1-Bromo-4-chlorobutane (CAS NO.6940-78-9)
Molecular Formula: C4H8BrCl
Molecular Weight: 171.46g/mol
Mol File: 6940-78-9.mol
EINECS: 230-089-3
Appearance: clear liquid
Boiling point: 164.3 °C at 760 mmHg
Flash Point: 60 °C
Density: 1.439 g/cm3
Refractive index: n20/D 1.4875(lit.)
Water Solubility: SLIGHTLY SOLUBLE
Index of Refraction: 1.468
Molar Refractivity: 33.16 cm3
Molar Volume: 119.1 cm3
Surface Tension: 31.3 dyne/cm
Enthalpy of Vaporization: 38.44 kJ/mol
Vapour Pressure: 2.59 mmHg at 25°CXLogP3-AA: 2.3
H-Bond Donor: 0
H-Bond Acceptor: 0
Structure Descriptors of 1-Bromo-4-chlorobutane (CAS NO.6940-78-9):
IUPAC Name: 1-bromo-4-chlorobutane
Canonical SMILES: C(CCBr)CCl
InChI: InChI=1S/C4H8BrCl/c5-3-1-2-4-6/h1-4H2
InChIKey: NIDSRGCVYOEDFW-UHFFFAOYSA-N
Product Categories: Drug Intermediates; BROMO CHLORO; omega-Functional Alkanols, Carboxylic Acids, Amines & Halides; omega-Haloalkyl Chlorides
Safety Information of 1-Bromo-4-chlorobutane (CAS NO.6940-78-9):
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 23-24/25-37/39-26
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
HazardClass: 3
PackingGroup: III
HS Code: 29034980
1-Bromo-4-chlorobutane , its CAS NO. is 6940-78-9, the synonyms are 1-Chloro-4-bromobutane ; 4-Bromo-1-chlorobutane ; Tetramethylene chlorobromide ; Butane, 1-bromo-4-chloro- .
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View