Product Name

  • Name

    TRIFLUOROACETALDEHYDE METHYL HEMIACETAL

  • EINECS
  • CAS No. 431-46-9
  • Article Data15
  • CAS DataBase
  • Density 1.317g/cm3
  • Solubility
  • Melting Point
  • Formula C3H5 F3 O2
  • Boiling Point 43°Cat760mmHg
  • Molecular Weight 130.067
  • Flash Point 24.1°C
  • Transport Information
  • Appearance
  • Safety Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of F.
  • Risk Codes 10-20/21/22
  • Molecular Structure Molecular Structure of 431-46-9 (TRIFLUOROACETALDEHYDE METHYL HEMIACETAL)
  • Hazard Symbols
  • Synonyms 1-Methoxy-2,2,2-trifluoroethanol;2,2,2-Trifluoro-1-methoxyethanol; Fluoral methyl hemiacetal;Trifluoroacetaldehyde methyl hemiacetal
  • PSA 29.46000
  • LogP 0.51350

1-Methoxy-2,2,2-trifluoroethanol Chemical Properties

Molecular Structure of 1-Methoxy-2,2,2-trifluoroethanol (CAS NO.431-46-9):


IUPAC: 2,2,2-Trifluoro-1-methoxy-ethanol
Molecular Formula:C3H5F3O2
Molecular Weight:130.07
EINECS:207-072-4
Density:1.36 g/cm3
Flash Point:24.1o
Boiling Point:43oC at 760 mmHg 
SMILES:FC(F)(F)C(O)OC 
InChI:InChI=1/C3H5F3O2/c1-8-2(7)3(4,5)6/h2,7H,1H3 
InChIKey:GWTBCUWZAVMAQV-UHFFFAOYAC 
Refractive index:1.33
Molar Volume:98.6 cm3
Surface Tension: 20 dyne/cm 
Molar Refractivity:19.64 cm3
Enthalpy of Vaporization:33.48 kJ/mol 
Vapour Pressure:336 mmHg at 25o

1-Methoxy-2,2,2-trifluoroethanol Toxicity Data With Reference

1.    

orl-mus LD50:750 mg/kg

    JMCMAR    Journal of Medicinal Chemistry. 13 (1970),1212.
2.    

ipr-mus LD50:550 mg/kg

    JMCMAR    Journal of Medicinal Chemistry. 13 (1970),1212.

1-Methoxy-2,2,2-trifluoroethanol Consensus Reports

Reported in EPA TSCA Inventory.

1-Methoxy-2,2,2-trifluoroethanol Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of F.
Safty informations about 1-Methoxy-2,2,2-trifluoroethanol (CAS NO.431-46-9):
Hazard Codes:TToxic,FFlammable
Risk Statements:10-20/21/22
R10:Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements:16-26-36/37/39
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR:1993
RTECS:KL6600000
Hazard Note:Toxic
TSCA:T
HazardClass:3
PackingGroup:III

1-Methoxy-2,2,2-trifluoroethanol Specification

 1-Methoxy-2,2,2-trifluoroethanol with cas registry number of 431-46-9 is also known as 1-Methoxy-2,2,2-trifluoro-ethano ; 1-Methoxy-2,2,2-trifluoroethanol ; 2,2,2-Trifluoro-1-methoxy-ethano ; Fluoralmethylhemiacetal ; Fluoral hemimethylacetal ; Trifuoroacetaldehyde hemimethylacetal ; Trifluoroacetaldehyde hemimethyl acetal ; Trifluoroacetaldehyde methyl hemiacetal . It is an alternative to gaseous unstable trifluoroacetaldehyde. It is used to prepare a-trifluoromethylated alcohols for antifungals, antitumor, and chemotherapeutic agents and as a building block in the synthesis of fluorinated molecules.

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