1-Methyl-1H-pyrazol-3-amine supplier

Name
1-Methyl-1H-pyrazol-3-amine
EINECS
CAS No. 1904-31-0
Article Data11
CAS DataBase
Density 1.224 g/cm³
Solubility Slightly soluble in water.
Melting Point
Formula C₄H₇N₃
Boiling Point 231.414 °C at 760 mmHg
Molecular Weight 97.1197
Flash Point 93.756 °C
Transport Information
Appearance Colorless to light yellow liquid
Safety 26-36/37/39
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn，Xi
Synonyms 1-methyl-1H-pyrazol-3-amine;
PSA 43.84000
LogP 0.58350

Synthetic route

: 54210-32-1
1-methyl-3-nitro-1H-pyrazole

A: 132038-69-8
1,1'-dimethyl-3-azoxypyrazole

B: 1904-31-0
methyl-1 amino-3 pyrazole

Conditions

Conditions	Yield
With hydrazine hydrate; nickel In ethanol Heating;	A 54% B 7.1 g

: 75092-34-1
4-iodo-1-methyl-3-nitro-1H-pyrazole

: 1904-31-0
methyl-1 amino-3 pyrazole

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride In water at 30℃; for 2h; Reduction;	51%

: 91027-92-8
N-(1-methyl-3-pyrazolyl)-acetoacetamide

A: 73810-75-0
2,4-dimethyl-2H-pyrazolo<3,4-b>pyridin-6(7H)-one

B: 1904-31-0
methyl-1 amino-3 pyrazole

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 3h; Heating;	A 21% B 15%

: 54210-32-1
1-methyl-3-nitro-1H-pyrazole

: 1904-31-0
methyl-1 amino-3 pyrazole

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride Reduction;
With hydrogen In methanol for 3h;

: 3282-30-2
pivaloyl chloride

: 1904-31-0
methyl-1 amino-3 pyrazole

: 1135343-82-6
C9H15N3O

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃;	100%

: 75-36-5
acetyl chloride

: 1904-31-0
methyl-1 amino-3 pyrazole

: N-(1-methyl-1H-pyrazol-3-yl)-acetamide hydrochlorid

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 2h;	100%
In tetrahydrofuran at 0 - 20℃; for 2h;	100%

: 2489-52-3
3-(chlorosulfonyl)benzenesulfonyl fluoride

: 1904-31-0
methyl-1 amino-3 pyrazole

: 3-(N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)benzene-1-sulfonyl fluoride

Conditions

Conditions	Yield
With pyridine In chloroform at 20℃; for 48h; chemoselective reaction;	99%

: 4-(chlorosulfonyl)benzenesulfonyl fluoride

: 1904-31-0
methyl-1 amino-3 pyrazole

: C10H10FN3O4S2

Conditions

Conditions	Yield
With pyridine In chloroform at 20℃; for 48h; chemoselective reaction;	99%

: 106-39-8
bromochlorobenzene

: 1904-31-0
methyl-1 amino-3 pyrazole

: N-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-amine

Conditions

Conditions	Yield
With copper(l) iodide; N-(2,6-dimethylphenyl)-6-hydroxypicolinamide; potassium carbonate In dimethyl sulfoxide at 110℃;	99%

: 110-13-4
2,5-hexanedione

: 1904-31-0
methyl-1 amino-3 pyrazole

: 34605-66-8
3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole

Conditions

Conditions	Yield
toluene-4-sulfonic acid In toluene for 4h; Reflux;	98%
With acetic acid In toluene at 155℃;	98.1%
With toluene-4-sulfonic acid In benzene at 115℃; for 4h;	94%

: 1904-31-0
methyl-1 amino-3 pyrazole

: 34605-66-8
3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole

Conditions

Conditions	Yield
With acetic acid In toluene at 155℃;	98.1%

: 1-(2-bromophenyl)pyrazole

: 1904-31-0
methyl-1 amino-3 pyrazole

: N-(2-(1H-pyrazol-1-yl)phenyl)-1-methyl-1H-pyrazol-3-amine

Conditions

Conditions	Yield
With copper(l) iodide; N-(2,6-dimethylphenyl)-6-hydroxypicolinamide; potassium carbonate In dimethyl sulfoxide at 110℃;	98%

: 40473-07-2
6-bromo-2-methoxypyridine

: 1904-31-0
methyl-1 amino-3 pyrazole

: 6-methoxy-N-(1-methyl-1H-pyrazol-3-yl)pyridin-2-amine

Conditions

Conditions	Yield
With copper(l) iodide; N-(2,6-dimethylphenyl)-6-hydroxypicolinamide; potassium carbonate In dimethyl sulfoxide at 110℃;	98%

: 1267993-72-5
4-chloro-7-isothiocyanato-7-de(acetamide)colchicine

: 1904-31-0
methyl-1 amino-3 pyrazole

: 1267992-51-7
4-chloro-N-[(1-methylpyrazole-3-yl)thiocarbamoyl]deacetyl colchicine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere;	96%

: 1904-31-0
methyl-1 amino-3 pyrazole

: 1-methyl-1H-pyrazole-3-diazonium haxafluorophosphate

Conditions

Conditions	Yield
With hexafluorophosphoric acid; isopentyl nitrite In methanol at -20℃; for 1h;	95%

: 19241-36-2
5-chloro-2-methylphenylisothiocyanate

: 1904-31-0
methyl-1 amino-3 pyrazole

: 221089-29-8
1-(5-chloro-2-methyl-phenyl)-3-(1-methyl-1H-pyrazol-3-yl)-thiourea

Conditions

Conditions	Yield
	95%

: 1033780-31-2
(E)-(3-chloro-4-methanesulfonyl-phenyl)-isobutoxyimino-acetic acid

: 1904-31-0
methyl-1 amino-3 pyrazole

: 1033780-09-4
(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-2-isobutoxyimino-N-(1-methyl-1H-pyrazol-3-yl)-acetamide

Conditions

Conditions	Yield
Stage #1: (E)-(3-chloro-4-methanesulfonyl-phenyl)-isobutoxyimino-acetic acid; methyl-1 amino-3 pyrazole With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 0℃; for 2h; Stage #2: With sodium hydrogencarbonate In water	95%

: 1428775-55-6
2-chloro-5-fluoro-4-(3-nitrophenoxy)-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

: 1904-31-0
methyl-1 amino-3 pyrazole

: 1428775-56-7
5-fluoro-N-(1-methyl-1H-pyrazol-3-yl)-4-(3-nitrophenoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 140℃; for 0.75h; Inert atmosphere; Microwave irradiation;	95%

: bis(2,4,6-trichlorophenyl) 2-(3,5-dichlorophenyl)propanedioate

: 1904-31-0
methyl-1 amino-3 pyrazole

: 6-(3,5-dichlorophenyl)-5-hydroxy-1-methylpyrazolo[1,5-a]pyrimidin-7-one

Conditions

Conditions	Yield
In toluene for 1h; Reflux;	94%

: 1904-31-0
methyl-1 amino-3 pyrazole

: 4-iodo-1-methyl-3-amino-1H-pyrazole

Conditions

Conditions	Yield
With dihydrogen peroxide; iodine In ethanol; water at 15 - 35℃; for 6h;	93.1%

: 1904-31-0
methyl-1 amino-3 pyrazole

: 89088-58-4
5-methylpyrazolodithiazolium chloride

Conditions

Conditions	Yield
With disulfur dichloride In acetic acid 1) 0 deg C to ambient temp. 2) up to 65 deg C, 3h 3) 65 deg C, 2h;	93%

: 1232365-39-7
2-(1-((tert-butoxycarbonyl)amino)cyclobutyl)-2-hydroxyacetic acid

: 1904-31-0
methyl-1 amino-3 pyrazole

: 1232365-56-8
{1-[hydroxy-(1-methyl-1H-pyrazol-3-ylcarbamoyl)methyl]cyclobutyl}carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: 2-(1-((tert-butoxycarbonyl)amino)cyclobutyl)-2-hydroxyacetic acid; methyl-1 amino-3 pyrazole With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: With HATU In N,N-dimethyl-formamide at 20℃; for 2h;	92%
Stage #1: 2-(1-((tert-butoxycarbonyl)amino)cyclobutyl)-2-hydroxyacetic acid; methyl-1 amino-3 pyrazole With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: With HATU In N,N-dimethyl-formamide at 20℃; for 2h;	92%

: 1232365-45-5
2-(1-(tert-butoxycarbonylamino)-3,3-difluorocyclobutyl)-2-hydroxyacetic acid

: 1904-31-0
methyl-1 amino-3 pyrazole

: 1311321-33-1
{3,3-difluoro-1-[hydroxy-(1-methyl-1H-pyrazol-3-ylcarbamoyl)methyl]cyclobutyl}carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; for 2h;	92%

: 638-07-3
ethyl (2-chloroaceto)acetate

: 1904-31-0
methyl-1 amino-3 pyrazole

: 104164-03-6
5-Chloromethyl-1-methyl-1H-pyrazolo[1,5-a]pyrimidin-7-one

Conditions

Conditions	Yield
With PPA at 100℃;	91%

: 883907-39-9
3-[(1S)-2-tert-butoxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]benzoic acid

: 1904-31-0
methyl-1 amino-3 pyrazole

: 883907-34-4
3-[(1S)-2-tert-butoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)-5-[4-(methylsulfonyl)phenoxy]benzamide

Conditions

Conditions	Yield
Stage #1: 3-[(1S)-2-tert-butoxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]benzoic acid With 1,1'-carbonyldiimidazole In acetonitrile at 25℃; for 2h; Stage #2: methyl-1 amino-3 pyrazole In acetonitrile at 60℃; for 18h; Product distribution / selectivity;	91%
Stage #1: 3-[(1S)-2-tert-butoxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]benzoic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 1.08333h; Stage #2: methyl-1 amino-3 pyrazole In tetrahydrofuran; toluene at 60℃; for 18h; Product distribution / selectivity;

: 937842-58-5
3-[4-(azetidin-1-ylcarbonyl)phenoxy]-5-[(1S)-2-tert-butoxy-1-methylethoxy]benzoic acid

: 1904-31-0
methyl-1 amino-3 pyrazole

: 937842-59-6
3-[4-(Azetidin-1-ylcarbonyl)phenoxy]-5-[(1S)-2-tert-butoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Conditions

Conditions	Yield
Stage #1: 3-[4-(azetidin-1-ylcarbonyl)phenoxy]-5-[(1S)-2-tert-butoxy-1-methylethoxy]benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In acetonitrile at 0 - 20℃; for 1.3h; Stage #2: methyl-1 amino-3 pyrazole In acetonitrile at 20℃; for 0.333333h; Product distribution / selectivity;	90%
Stage #1: 3-[4-(azetidin-1-ylcarbonyl)phenoxy]-5-[(1S)-2-tert-butoxy-1-methylethoxy]benzoic acid With 1,1'-carbonyldiimidazole In acetonitrile at 25℃; for 1.08333h; Stage #2: methyl-1 amino-3 pyrazole In acetonitrile at 50℃; Product distribution / selectivity;	89%

: 1904-31-0
methyl-1 amino-3 pyrazole

: 146941-72-2
4-bromo-1-methyl-1H-pyrazol-3-ylamine

Conditions

Conditions	Yield
With bromine In ethanol at 0 - 15℃; for 1h;	89.4%
With sodium hydroxide; bromine In dichloromethane; water

: 7697-26-9
3-bromo-4-methylbenzoic acid

: 1904-31-0
methyl-1 amino-3 pyrazole

: 3 -bromo-4-methyl-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 15℃; for 12h;	89.2%

: 18698-97-0
ortho-bromophenylacetic acid

: 1904-31-0
methyl-1 amino-3 pyrazole

: 1609551-50-9
2-(2-bromophenyl)-N-(1-methyl-1H-pyrazol-3-yl)acetamide

Conditions

Conditions	Yield
Stage #1: ortho-bromophenylacetic acid With oxalyl dichloride In dichloromethane at 0 - 20℃; for 2h; Stage #2: methyl-1 amino-3 pyrazole In dichloromethane at 0 - 20℃;	88%

: 6-chloro-4-(2-methylpyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

: 1904-31-0
methyl-1 amino-3 pyrazole

: 6-[(1-methyl-1H-pyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate In toluene at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Sealed tube;	88%

: 372-31-6
ethyl 4,4,4-trifluoroacetoacetate

: 1904-31-0
methyl-1 amino-3 pyrazole

: 4-trifluoromethyl-6-hydroxy-2-methylpyrazolo<3,4-b>pyridine

Conditions

Conditions	Yield
In acetic acid for 4h; Heating;	87.4%

: 13716-10-4
di(tert-butyl)chlorophosphine

: 1904-31-0
methyl-1 amino-3 pyrazole

: 1367863-21-5
P,P-di(tert-butyl)-N-(1-methyl-1H-pyrazol-3-yl)phosphinous amide

Conditions

Conditions	Yield
With triethylamine at 125℃; for 72h; Inert atmosphere;	87%

: 2-[(3-bromo-4-nitrophenoxy)methyl]quinoline

: 1904-31-0
methyl-1 amino-3 pyrazole

: 1-methyl-N-[2-nitro-5-(quinolin-2-ylmethoxy)phenyl]-1H-pyrazol-3-amine

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 85℃; for 2h; Buchwald-Hartwig Coupling; Inert atmosphere;	87%

: 1428775-59-0
tert-butyl {3-[(2-chloro-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}carbamate

: 1904-31-0
methyl-1 amino-3 pyrazole

: tert-butyl (3-((2-((1-methyl-1H-pyrazol-3-yl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)carbamate

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 140℃; for 0.75h; Buchwald-Hartwig Coupling; Microwave irradiation;	87%

1-Methyl-1H-pyrazol-3-amine Chemical Properties

The molecular formula of 3-amino-1-methylpyrazole(1904-31-0) is C₄H₇N₃ and its formula weight is 97.12.
3-amino-1-methylpyrazole(1904-31-0) has a boiling point of 93 °C.
The chemical synonyms of 3-amino-1-methylpyrazole(1904-31-0) are 1-METHYL-1H-PYRAZOL-3-AMINE;1-METHYL-1H-PYRAZOL-3-YLAMINE;3-AMINO-1-METHYLPYRAZOLE;AKOS B014443;BUTTPARK 83\09-99;ART-CHEM-BB B014443;1-methyl-3-aminopyrazole;3-Amino-1-methyl-1H-pyrazole
The molecular structure of 3-amino-1-methylpyrazole(1904-31-0):

1-Methyl-1H-pyrazol-3-amine Safety Profile

Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 26-36/37/39
Hazard Note Irritant

Product Name

1-Methyl-1H-pyrazol-3-amine

Synthetic route

1-Methyl-1H-pyrazol-3-amine Chemical Properties

1-Methyl-1H-pyrazol-3-amine Safety Profile

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