19-Norethindrone acetate supplier

Name
19-Norethindrone acetate
EINECS 200-132-0
CAS No. 51-98-9
Article Data25
CAS DataBase
Density 1.14 g/cm³
Solubility 3.162mg/L(10 oC)
Melting Point 161-162°
Formula C₂₂H₂₈O₃
Boiling Point 454.7 °C at 760 mmHg
Molecular Weight 340.463
Flash Point 197.1 °C
Transport Information
Appearance
Safety 36/37
Risk Codes 40-48
Molecular Structure
Hazard Symbols Xn
Synonyms 19-Nor-17a-pregn-4-en-20-yn-3-one,17-hydroxy-, acetate (6CI,8CI);17-Acetoxy-19-nor-17a-pregn-4-en-20-yn-3-one;17a-Ethinyl-19-nortestosteroneacetate;17a-Ethinyl-4-estrene-17b-ol-acetate-3-one;17b-Acetoxy-17a-ethinyl-4-estren-3-one;17b-Hydroxy-19-nor-17a-pregn-4-en-20-yn-3-one acetate;19-Norethynyltestosterone acetate;Aygestin;Estalis;Gynovlane;Milli-Anovlar;Milligynon;Miniphase;NSC 22844;Norethindrone 17-acetate;Norethindrone acetate;Norethynyltestosteroneacetate;Norlutate;Norlutin acetate;Orlutate;Primolut-Nor;19-Norpregn-4-en-20-yn-3-one,17-(acetyloxy)-, (17a)-;
PSA 43.37000
LogP 4.06330

Synthetic route

: 68-22-4
norethisterone

: 64-19-7
acetic acid

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
With sodium carbonate; trifluoroacetic anhydride In benzene for 0.5h; Ambient temperature;	96.5%
Stage #1: acetic acid With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In chloroform at 20℃; for 0.5h; Inert atmosphere; Stage #2: norethisterone With dmap In chloroform for 18h; Inert atmosphere; Reflux;	93%
With dmap; dicyclohexyl-carbodiimide In chloroform at 20℃;	91.6%
In trifluoroacetic acid	90%
With benzenesulfonyl chloride In pyridine for 48h;	79%

: 68-22-4
norethisterone

: 75-36-5
acetyl chloride

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
With pyridine; dmap In 1,2-dichloro-ethane at 0℃;	92%

: 68-22-4
norethisterone

: 108-24-7
acetic anhydride

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 50℃;	91%
scandium tris(trifluoromethanesulfonate) In acetonitrile	86%
With dmap In toluene at 80 - 90℃; for 3h;	28 g

: 2205-78-9
3,17-diacetoxy-19-nor-17βH-pregna-3,5-dien-20-yne

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
With tetrahydrofuran; potassium hydroxide
With hydrogenchloride

: 68-22-4
norethisterone

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: methanol.KOH; THF View Scheme
Multi-step reaction with 2 steps 1: acetic anhydride; toluene-4-sulfonic acid 2: tetrahydrofuran; methanol View Scheme

methanolic potassium hydroxide: methanolic potassium hydroxide

ether-light petroleum ether: ether-light petroleum ether

: 2205-78-9
3,17-diacetoxy-19-nor-17βH-pregna-3,5-dien-20-yne

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
In tetrahydrofuran; methanol
In tetrahydrofuran; methanol

...Expand

: 111-87-5
octanol

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: ammonium chloride; lithium / tetrahydrofuran; ethanol; ammonia; water 2: aluminum isopropoxide; sodium sulfate / methanol; water; cyclohexanone; toluene 3: 1,4-dioxane; methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ISOPROPYLAMIDE 4: hydrogenchloride / methanol; water 5: acetic anhydride; toluene-4-sulfonic acid 6: tetrahydrofuran; methanol View Scheme

: 1091-93-6
3-methoxy-17-hydroxyestra-2,5(10)-diene

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: aluminum isopropoxide; sodium sulfate / methanol; water; cyclohexanone; toluene 2: 1,4-dioxane; methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ISOPROPYLAMIDE 3: hydrogenchloride / methanol; water 4: acetic anhydride; toluene-4-sulfonic acid 5: tetrahydrofuran; methanol View Scheme

: 17976-32-8
3-methoxyestra-2,5(10)-dien-17-one

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 1,4-dioxane; methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ISOPROPYLAMIDE 2: hydrogenchloride / methanol; water 3: acetic anhydride; toluene-4-sulfonic acid 4: tetrahydrofuran; methanol View Scheme

: 19357-36-9
3-methoxy-19-nor-17βH-pregna-2,5(10)-dien-20-yn-17-ol

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride / methanol; water 2: acetic anhydride; toluene-4-sulfonic acid 3: tetrahydrofuran; methanol View Scheme

: 96487-85-3
3-ethoxy-17α-ethynyl-19-desmethylpregna-3,5-diene-17β-ol

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride / acetone; water / 10 °C 2: dmap; pyridine / 1,2-dichloro-ethane / 0 °C View Scheme
Multi-step reaction with 2 steps 1: hydrogenchloride / acetone; water / 10 °C 2: dmap; dicyclohexyl-carbodiimide / chloroform / 20 °C View Scheme
Multi-step reaction with 2 steps 1: hydrogenchloride / acetone; water / 10 °C 2: dmap; triethylamine / dichloromethane / 50 °C View Scheme

: C24H33NO

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid / water; 2-methyltetrahydrofuran / 0 °C 2: dmap; pyridine / 1,2-dichloro-ethane / 0 °C View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid / water; 2-methyltetrahydrofuran / 0 °C 2: dmap; dicyclohexyl-carbodiimide / chloroform / 20 °C View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid / water; 2-methyltetrahydrofuran / 0 °C 2: dmap; triethylamine / dichloromethane / 50 °C View Scheme

: 734-32-7
estra-4-ene-3,17-dione

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: pyridine hydrochloride / 30 °C 2: potassium tert-butylate / acetone / 0 °C 3: hydrogenchloride / tetrahydrofuran; water / 50 °C 4: dmap; pyridine / 1,2-dichloro-ethane / 0 °C View Scheme
Multi-step reaction with 4 steps 1: pyridine hydrochloride / 30 °C 2: potassium tert-butylate / acetone / 0 °C 3: hydrogenchloride / tetrahydrofuran; water / 50 °C 4: dmap; dicyclohexyl-carbodiimide / chloroform / 20 °C View Scheme
Multi-step reaction with 4 steps 1: pyridine hydrochloride / 30 °C 2: potassium tert-butylate / acetone / 0 °C 3: hydrogenchloride / tetrahydrofuran; water / 50 °C 4: dmap; triethylamine / dichloromethane / 50 °C View Scheme

: 17976-34-0
3-methoxy-19-norandrosta-3,5-dien-17-one

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium tert-butylate / acetone / 0 °C 2: hydrogenchloride / tetrahydrofuran; water / 50 °C 3: dmap; pyridine / 1,2-dichloro-ethane / 0 °C View Scheme
Multi-step reaction with 3 steps 1: potassium tert-butylate / acetone / 0 °C 2: hydrogenchloride / tetrahydrofuran; water / 50 °C 3: dmap; dicyclohexyl-carbodiimide / chloroform / 20 °C View Scheme
Multi-step reaction with 3 steps 1: potassium tert-butylate / acetone / 0 °C 2: hydrogenchloride / tetrahydrofuran; water / 50 °C 3: dmap; triethylamine / dichloromethane / 50 °C View Scheme

: 2863-88-9
3-ethoxy-19-nor-3,5-androstadiene-17-one

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium 2-methylpropan-2-olate / tetrahydrofuran / 20 °C 2: hydrogenchloride / acetone; water / 10 °C 3: dmap; pyridine / 1,2-dichloro-ethane / 0 °C View Scheme
Multi-step reaction with 3 steps 1: potassium 2-methylpropan-2-olate / tetrahydrofuran / 20 °C 2: hydrogenchloride / acetone; water / 10 °C 3: dmap; dicyclohexyl-carbodiimide / chloroform / 20 °C View Scheme
Multi-step reaction with 3 steps 1: potassium 2-methylpropan-2-olate / tetrahydrofuran / 20 °C 2: hydrogenchloride / acetone; water / 10 °C 3: dmap; triethylamine / dichloromethane / 50 °C View Scheme

: (8R,9S,10R,13S,14S)-13-Methyl-3-pyrrolidin-1-yl-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydro-cyclopenta[a]phenanthren-17-one

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium ethoxide / toluene / 50 °C 2: sulfuric acid / water; 2-methyltetrahydrofuran / 0 °C 3: dmap; pyridine / 1,2-dichloro-ethane / 0 °C View Scheme
Multi-step reaction with 3 steps 1: potassium ethoxide / toluene / 50 °C 2: sulfuric acid / water; 2-methyltetrahydrofuran / 0 °C 3: dmap; dicyclohexyl-carbodiimide / chloroform / 20 °C View Scheme
Multi-step reaction with 3 steps 1: potassium ethoxide / toluene / 50 °C 2: sulfuric acid / water; 2-methyltetrahydrofuran / 0 °C 3: dmap; triethylamine / dichloromethane / 50 °C View Scheme

: C21H28O2

: 51-98-9
norethisterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride / tetrahydrofuran; water / 50 °C 2: dmap; pyridine / 1,2-dichloro-ethane / 0 °C View Scheme
Multi-step reaction with 2 steps 1: hydrogenchloride / tetrahydrofuran; water / 50 °C 2: dmap; dicyclohexyl-carbodiimide / chloroform / 20 °C View Scheme
Multi-step reaction with 2 steps 1: hydrogenchloride / tetrahydrofuran; water / 50 °C 2: dmap; triethylamine / dichloromethane / 50 °C View Scheme

: 51-98-9
norethisterone acetate

: 40228-41-9
17β-acetoxy-21,21-dibromo-19-nor-17α-pregn-4-ene-3,20-dione

Conditions

Conditions	Yield
With water; N-bromoacetamide In tert-butyl alcohol for 4h; Ambient temperature;	96%

: 51-98-9
norethisterone acetate

: 17β-acetoxy-17α-iodoethynyl-4-estren-3-one

Conditions

Conditions	Yield
With silver nitrate In tetrahydrofuran	81%

: 51-98-9
norethisterone acetate

: 445379-31-7
3,21-dioxo-19-norpregna-4,17(20)-dien-20-yl acetate

Conditions

Conditions	Yield
With oxygen; potassium tetrabromopalladate In 1,2-dimethoxyethane; water at 65℃; for 3h;	80%

: 51-98-9
norethisterone acetate

: 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate

: C28H38O3

Conditions

Conditions	Yield
With copper(I) phenylacetylenide; copper acetylacetonate; triethylamine; copper(l) chloride In tetrahydrofuran at 25℃; for 16h; Irradiation; Inert atmosphere;	78%

: 51-98-9
norethisterone acetate

: 93066-93-4
methyl 3-azidobenzoate

: methyl 3-[4-(17-acetoxy-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazol-1-yl]benzoate

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In water; tert-butyl alcohol at 20℃; for 8h; Inert atmosphere;	75%

: 624-38-4
para-diiodobenzene

: 51-98-9
norethisterone acetate

: 1239157-10-8
1,4-bis(19-nor-17α-ethynyltestosterone-17β-acetate)benzene

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 4h; Sonogashira coupling; Inert atmosphere; Reflux;	71%

: 1843-35-2
3-azidobenzoic acid

: 51-98-9
norethisterone acetate

: 3-[4-(17-acetoxy-13-methyl-3-oxo-2,3,6,7,8, 9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazol-1-yl]benzoic acid

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In water; tert-butyl alcohol at 20℃; for 8h; Inert atmosphere;	70%

: 51-98-9
norethisterone acetate

: 99998-43-3
17,17a-dimethyl-D-homogona-4,13,15,17(17a)-tetraen-3-one

Conditions

Conditions	Yield
With formic acid at 90℃; for 1h; Heating;	60%

: 20442-96-0
methyl 4-azidobenzoate

: 51-98-9
norethisterone acetate

: methyl 4-[4-(17-acetoxy-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazol-1-yl]benzoate

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In water; tert-butyl alcohol at 20℃; for 8h; Inert atmosphere;	60%

: 6427-66-3
4-azidobenzoic acid

: 51-98-9
norethisterone acetate

: 4-[4-(17-acetoxy-13-methyl-3-oxo-2,3,6,7,8, 9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazol-1-yl]benzoic acid

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In water; tert-butyl alcohol at 20℃; for 8h; Inert atmosphere;	55%

: 51-98-9
norethisterone acetate

: 16714-23-1
2-azido-benzoic acid methyl ester

: methyl 2-[4-(17-acetoxy-13-methyl-3-oxo 2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazol-1-yl]benzoate

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In water; tert-butyl alcohol at 20℃; for 8h; Inert atmosphere;	50%

: 31162-13-7
2-azidobenzoic acid

: 51-98-9
norethisterone acetate

: 2-[4-(17-acetoxy-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1H-1,2,3-triazol-1-yl]benzoic acid

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In water; tert-butyl alcohol at 20℃; for 8h; Inert atmosphere;	45%

: 4165-56-4
1,4-dibromotetradeuterobenzene

: 51-98-9
norethisterone acetate

: 1239157-15-3
C50H54(2)H4O6

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 10h; Sonogashira coupling; Inert atmosphere; Reflux;	43%

: 51-98-9
norethisterone acetate

: 79-15-2
N-bromoacetamide

: 66964-58-7
17-acetoxy-19-nor-17βH-pregn-4-ene-3,20-dione

Conditions

Conditions	Yield
With tert-butyl alcohol und Erwaermen des Reaktionsprodukts mit Zink, Essigsaeure und Natriumacetat;

: 71-41-0
pentan-1-ol

: 51-98-9
norethisterone acetate

: Acetic acid (8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-pentyloxy-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Conditions

Conditions	Yield
(i) HC(OEt)3, TsOH, EtOH, THF, (ii) /BRN= 1730975/, benzene; Multistep reaction;

: 111-70-6
n-heptan1ol

: 51-98-9
norethisterone acetate

: Acetic acid (8R,9S,10R,13S,14S,17R)-17-ethynyl-3-heptyloxy-13-methyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Conditions

Conditions	Yield
(i) HC(OEt)3, TsOH, EtOH, THF, (ii) /BRN= 1731686/, benzene; Multistep reaction;

: 96-41-3
Cyclopentanol

: 51-98-9
norethisterone acetate

: 3-(cyclopentyloxy)-19-nor-17α-pregna-3,5-dien-20-yn-17-ol acetate

Conditions

Conditions	Yield
(i) HC(OEt)3, TsOH, EtOH, THF, (ii) /BRN= 1900556/, benzene; Multistep reaction;

: 51-98-9
norethisterone acetate

: 17α-Ethinyl-17β-acetoxy-Δ4-oestren-3-N-chlorimin

Conditions

Conditions	Yield
(i) MeNH2, MeOH, (ii) aq. Ca(OCl)2, NH3, OTs; Multistep reaction;

: 51-98-9
norethisterone acetate

: 4124-31-6
trichloroacetic acid anhydride

: 22223-94-5
17β-Acetoxy-17α-ethinyl-3-trichloracetoxy-Δ3.5-oestradien

: 67-66-3
chloroform

: 51-98-9
norethisterone acetate

: 16375-03-4
17α-Aethinyl-6-formyl-3-chlor-19-nor-Δ3.5-androstadien-17β-ol-acetat

Conditions

Conditions	Yield
With N,N-dimethyl-formamide; trichlorophosphate In Trichloroethylene

: 51-98-9
norethisterone acetate

: 13647-61-5
17α-Ethinyl-3-chlor-19-nor-Δ3,5-androstadien-17β-ol-acetat

Conditions

Conditions	Yield
With N,N-dimethyl-formamide; trichlorophosphate In chloroform; Trichloroethylene

: 51-98-9
norethisterone acetate

: 42224-77-1
21-hydroxy-19-norpregna-4,16-diene-3,20-dione

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 80 percent / O2 / K2[PdBr4] / H2O; 1,2-dimethoxy-ethane / 3 h / 65 °C 2: 80 percent / DBU / ethyl acetate / 60 °C 3: 85 percent / K2CO3; water / methanol; tetrahydrofuran / 0.25 h / 20 °C View Scheme

: 51-98-9
norethisterone acetate

: 148022-19-9
16α,17α,21-trihydroxy-19-norpregn-4-ene-3,20-dione

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 80 percent / O2 / K2[PdBr4] / H2O; 1,2-dimethoxy-ethane / 3 h / 65 °C 2: 80 percent / DBU / ethyl acetate / 60 °C 3: 85 percent / K2CO3; water / methanol; tetrahydrofuran / 0.25 h / 20 °C 4: 55 percent / OsO4 / pyridine View Scheme
Multi-step reaction with 4 steps 1: 80 percent / O2 / K2[PdBr4] / H2O; 1,2-dimethoxy-ethane / 3 h / 65 °C 2: 80 percent / DBU / ethyl acetate / 60 °C 3: 85 percent / formic acid; KMnO4 / acetone; H2O / 0 °C 4: 84 percent / K2CO3; water / methanol; tetrahydrofuran / 0.25 h / 20 °C View Scheme

: 51-98-9
norethisterone acetate

: 40228-35-1
3,20-dioxo-19-norpregna-4,16-dien-21-yl acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / O2 / K2[PdBr4] / H2O; 1,2-dimethoxy-ethane / 3 h / 65 °C 2: 80 percent / DBU / ethyl acetate / 60 °C View Scheme
Multi-step reaction with 3 steps 1: 96 percent / N-bromoacetamide, water / 2-methyl-propan-2-ol / 4 h / Ambient temperature 2: 98 percent / trimethyl phosphite / nitromethane / 1 h / Ambient temperature 3: 63 percent / dimethylformamide / 2 h / 120 °C View Scheme

19-Norethindrone acetate Consensus Reports

IARC Cancer Review: Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 21 (1979),p. 441.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 6 (1974),p. 179.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

19-Norethindrone acetate Specification

1. Introduction of 19-Norethindrone acetate
19-Norethindrone acetate is one kind of white or almost white crystalline. The IUPAC name of this chemical is [(8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate. We can also call it "Norethindrone Acetate". It belongs to Active Pharmaceutical Ingredients;Acetylenes;Biochemistry;Functionalized Acetylenes;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone. Solubility: Insoluble in cold water, hot water. Besides, it should be stored in a closed cool and dry place.

2. Properties of 19-Norethindrone acetate
Physical properties about 19-Norethindrone acetate are:
(1)ACD/LogP: 3.99; (2)ACD/LogD (pH 5.5): 3.99; (3)ACD/LogD (pH 7.4): 3.99; (4)ACD/BCF (pH 5.5): 632.47; (5)ACD/BCF (pH 7.4): 632.47; (6)ACD/KOC (pH 5.5): 3520.35; (7)ACD/KOC (pH 7.4): 3520.35; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 2; (10)Polar Surface Area: 43.37 Å²; (11)Index of Refraction: 1.555; (12)Molar Refractivity: 95.13 cm³; (13)Molar Volume: 296.1 cm³; (14)Polarizability: 37.71×10^-24cm³; (15)Surface Tension: 46.1 dyne/cm; (16)Density: 1.14 g/cm³; (17)Flash Point: 197.1 °C; (18)Enthalpy of Vaporization: 71.43 kJ/mol; (19)Boiling Point: 454.7 °C at 760 mmHg; (20)Vapour Pressure: 1.87E-08 mmHg at 25°C.

3. Structure Descriptors of 19-Norethindrone acetate
(1)SMILES: O=C4\C=C3/[C@@H]([C@H]2CC[C@]1([C@@H](CC[C@]1(C#C)OC(=O)C)[C@@H]2CC3)C)CC4
(2)InChI: InChI=1/C22H28O3/c1-4-22(25-14(2)23)12-10-20-19-7-5-15-13-16(24)6-8-17(15)18(19)9-11-21(20,22)3/h1,13,17-20H,5-12H2,2-3H3/t17-,18+,19+,20-,21-,22-/m0/s1
(3)InChIKey: IMONTRJLAWHYGT-ZCPXKWAGBE
(4)Std. InChI: InChI=1S/C22H28O3/c1-4-22(25-14(2)23)12-10-20-19-7-5-15-13-16(24)6-8-17(15)18(19)9-11-21(20,22)3/h1,13,17-20H,5-12H2,2-3H3/t17-,18+,19+,20-,21-,22-/m0/s1
(5)Std. InChIKey: IMONTRJLAWHYGT-ZCPXKWAGSA-N

4. Physical Properties of 19-Norethindrone acetate

Physical Property	Value	Units	Temp (deg C)	Source
Melting Point	161.5	deg C		EXP
log P (octanol-water)	3.990	(none)		EST
Water Solubility	5.35	mg/L	25	EXP
Atmospheric OH Rate Constant	1.10E-10	cm3/molecule-sec	25	EST

5. Safety Information of 19-Norethindrone acetate
Risk Codes:40-48
40: Limited evidence of a carcinogenic effect
41: Risk of serious damage to eyes
42: May cause sensitization by inhalation
43: May cause sensitization by skin contact
44: Risk of explosion if heated under confinement
45: May cause cancer
46: May cause heritable genetic damage
48: Danger of serious damage to health by prolonged exposure
Safety Statements 36/37
36: Wear suitable protective clothing
37: Wear suitable gloves
Hence, When you are using this chemical, please be cautious about it as the following: It is danger of serious damage to health by prolonged exposure. When you are using it, wear suitable protective clothing and gloves.

6. Use of 19-Norethindrone acetate
19-Norethindrone acetate can be used as progesterone medicines for irregular menstruation, uterine functional bleeding, endometriosis proge. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen.

7. Preparation of 19-Norethindrone acetate
Norethindrone and Acetic anhydride can used to produce 19-Norethindrone acetate under the consideration of DMAP.

Product Name

19-Norethindrone acetate

Synthetic route

19-Norethindrone acetate Consensus Reports

19-Norethindrone acetate Specification

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