2-(Methylthio)benzaldehyde supplier

Name
2-(METHYLTHIO) BENZALDEHYDE
EINECS
CAS No. 7022-45-9
Article Data48
CAS DataBase
Density 1.13 g/cm³
Solubility
Melting Point
Formula C₈H₈OS
Boiling Point 248.6 °C at 760 mmHg
Molecular Weight 152.217
Flash Point 117.4 °C
Transport Information UN 3334
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Benzaldehyde,o-(methylthio)- (7CI,8CI);2-(Methylthio)benzaldehyde;2-Formylthioanisole;2-Methylsulfanylbenzaldehyde;NSC 144623;o-(Methylthio)benzaldehyde;
PSA 42.37000
LogP 2.22100

Synthetic route

: 33384-77-9
2-(methylthio)benzyl alcohol

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
With dimethylsulfide; N-succinimide; triethylamine In toluene	94%
With pyridinium chlorochromate In dichloromethane at 20℃; for 1h;	69%
With pyridinium chlorochromate In dichloromethane at 0 - 20℃; for 12h;	65%

: 67-68-5
dimethyl sulfoxide

: 6630-33-7
ortho-bromobenzaldehyde

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide at 130℃; for 12h; Sealed tube; Inert atmosphere;	93%

: 89-98-5
2-chloro-benzaldehyde

: 5188-07-8
sodium thiomethoxide

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide for 5h; Heating;	86%
In N,N-dimethyl-formamide at 20℃; for 44h;	44%

: 446-52-6
2-Fluorobenzaldehyde

: 5188-07-8
sodium thiomethoxide

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; N,N-dimethyl-formamide at 55℃; for 24h; Inert atmosphere;	85%
In N,N-dimethyl-formamide at 0.15℃; Inert atmosphere;	85%
In acetonitrile Heating;

: 74-93-1
methylthiol

: 446-52-6
2-Fluorobenzaldehyde

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 24h;	85%
Stage #1: methylthiol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 1.5h; Inert atmosphere; Stage #2: 2-Fluorobenzaldehyde In N,N-dimethyl-formamide; mineral oil at -40℃; for 2h; Inert atmosphere;

methyl sodium sulfide: methyl sodium sulfide

: 446-52-6
2-Fluorobenzaldehyde

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; N,N-dimethyl-formamide	85%

: 74-93-1
methylthiol

2-halobenzaldehyde: 2-halobenzaldehyde

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 55 - 80℃; for 24h; Inert atmosphere;	85%

: 67-68-5
dimethyl sulfoxide

: 446-52-6
2-Fluorobenzaldehyde

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In water at 189℃; for 24h;	64%

: 67-68-5
dimethyl sulfoxide

: 552-89-6
2-nitro-benzaldehyde

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In water at 189℃; for 15h;	56%

: 77418-23-6
2-(Methylthio)thiobenzoesaeure-S-mesitylester

A: 53271-52-6
2.2'-Bis(methylthio)benzil

B: 7022-45-9
2-(methylsulfanyl)benzaldehyde

C: 1483-92-7
bis(2,4,6-trimethylphenyl)disulfide

Conditions

Conditions	Yield
In benzene at 20℃; for 70h; Irradiation;	A 22% B 11% C 41%

...Expand

: 75087-02-4
<2-methylthio-α-oxo-phenylmethan>-diphenylphosphin

A: 7022-45-9
2-(methylsulfanyl)benzaldehyde

B: 75087-03-5
<2-Methylthio-α-hydroxyphenylmethan>-diphenyl-phosphinoxid

Conditions

Conditions	Yield
In benzene at 22℃; for 120h; Irradiation;	A 16% B 14%

: 77408-42-5
2-Methylthiobenzoesaeuremesitylester

A: 53271-52-6
2.2'-Bis(methylthio)benzil

B: 7022-45-9
2-(methylsulfanyl)benzaldehyde

C: 2-Methylthio-2'.4'.6'-trimethyl-biphenyl

Conditions

Conditions	Yield
In benzene at 20℃; for 77h; Irradiation;	A 9% B 7% C 5%

...Expand

: 92580-60-4
N'-p-Toluolsulfonyl-N-<2-methylmercapto-benzoyl>-hydrazin

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
With sodium carbonate In ethylene glycol at 160℃;
With sodium carbonate In diethylene glycol

: 26190-68-1
1-chloromethyl-2-methylsulfanylbenzene

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
With hexamethylenetetramine; acetic acid

: 7022-44-8
2-Methylmercaptobenzoesaeure-methylanilid

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran
(i) LiAlH4, THF, (ii) aq. HCl; Multistep reaction;

: 624-92-0
Dimethyldisulphide

: 23229-37-0
1,3-dimethyl-2-phenylimidazolidine

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
Yield given. Multistep reaction;

: 624-92-0
Dimethyldisulphide

: 23229-37-0
1,3-dimethyl-2-phenylimidazolidine

A: 7022-45-9
2-(methylsulfanyl)benzaldehyde

B: 1-(Bis-methylsulfanyl-methyl)-2-methylsulfanyl-benzene

Conditions

Conditions	Yield
Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: C8H10OS*C5H5N*Br3H

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
In acetic acid at 19.9℃; Rate constant; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.), var. temp.;

: 77408-41-4
2-(Methylsulfinyl)thiobenzoesaeure-S-mesitylester

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2 percent / benzene / 70 h / 20 °C / Irradiation 2: 11 percent / benzene / 70 h / 20 °C / Irradiation View Scheme

: 1442-03-1
2-methylsulfanyl-benzoyl chloride

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 56 percent / toluene / 2 h / Heating 2: 7 percent / benzene / 77 h / 20 °C / Irradiation View Scheme
Multi-step reaction with 2 steps 1: 42 percent / toluene / 2 h / Heating 2: 11 percent / benzene / 70 h / 20 °C / Irradiation View Scheme
Multi-step reaction with 2 steps 1: 40 percent / diethyl ether 2: 16 percent / benzene / 120 h / 22 °C / Irradiation View Scheme
Multi-step reaction with 2 steps 1: aq. NaOH / dioxane 2: LiAlH4 / tetrahydrofuran View Scheme

: 1442-00-8
ethyl 2-(methylthio)benzoate

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: LiAlH4 / tetrahydrofuran 2: SOCl2 / benzene 3: hexamethylenetetramine, aq. AcOH View Scheme

: 118-92-3
anthranilic acid

deuterium oxide: deuterium oxide

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: (i) (diazotization), (ii) aq. Na2S2, (iii) aq. Na2S2O4,(iv) (methylation) 2: (i) SOCl2, (ii) /BRN= 1718733/ 3: LiAlH4 / tetrahydrofuran 4: SOCl2 / benzene 5: hexamethylenetetramine, aq. AcOH View Scheme

: 3724-10-5
2-(methylthio)benzoic acid

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: (i) SOCl2, (ii) /BRN= 1718733/ 2: LiAlH4 / tetrahydrofuran 3: SOCl2 / benzene 4: hexamethylenetetramine, aq. AcOH View Scheme
Multi-step reaction with 2 steps 1: (i) SOCl2, benzene, (ii) /BRN= 741982/ 2: (i) LiAlH4, THF, (ii) aq. HCl View Scheme
Multi-step reaction with 3 steps 1: SOCl2 2: aq. NaOH / dioxane 3: LiAlH4 / tetrahydrofuran View Scheme

: 885949-42-8
2-methylthiobenzohydrazide

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Py 2: Na2CO3 / ethane-1,2-diol / 160 °C View Scheme

: [Rh(mer-κ3-DPEphos)(H)(C(O)C6H4SMe)][CB11H12]

: 49571-45-1
2-(methylthio)cyclohex-1-ene-1-carbaldehyde

A: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: [Rh(mer-κ3-DPEphos)(H)(C(O)C6H8SMe)][CB11H12]

Conditions

Conditions	Yield
at 24.84℃; for 0.0833333h; Inert atmosphere; Schlenk technique; Glovebox;

...Expand

: 5188-07-8
sodium thiomethoxide

2-halidebenzaldehyde: 2-halidebenzaldehyde

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
In N,N-dimethyl-formamide

: 3704-28-7
methyl 2-(methylthio)benzoate

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C 2: pyridinium chlorochromate / dichloromethane / 12 h / 0 - 20 °C View Scheme

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 62351-49-9
2-(methylsulfinyl)benzaldehyde

Conditions

Conditions	Yield
With C42H70O35*Br3Fe; ferric nitrate In acetonitrile at 20℃; for 3h; chemoselective reaction;	100%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃;	89%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃;	89%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 20439-47-8
(1R,2R)-1,2-diaminocyclohexane

: 1383610-91-0
(1R,2R)-N,N'-bis[(2-(methylthio)benzylidene)]-1,2-cyclohexanediamine

Conditions

Conditions	Yield
In ethanol at 80℃;	100%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 3-amino-2-(3,4-dichlorophenyl)-1-(2-(methylthio)phenyl)propan-1-ol

Conditions

Conditions	Yield
Stage #1: 3,4-dichloro-benzeneacetonitrile With n-butyllithium In tetrahydrofuran at -75℃; for 0.333333h; Stage #2: 2-(methylsulfanyl)benzaldehyde In tetrahydrofuran at -75℃; for 0.5h; Stage #3: With borane-THF In tetrahydrofuran at -75℃; Temperature; Reflux;	100%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 104-94-9
4-methoxy-aniline

: (E)-N-(4-methoxyphenyl)-1-(2-(methylthio)phenyl)methanimine

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 18h; Inert atmosphere; Molecular sieve;	100%

: 1173936-61-2
1,1-pentamethylene-1,2-nonadiene

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 1173936-88-3
2-(cyclohexylidenemethyl)-1-(2-(methylthio)phenyl)octan-1-one

Conditions

Conditions	Yield
With [Rh(dppe)]ClO4 In acetone at 55℃; Inert atmosphere; regioselective reaction;	99%

: 1173936-62-3
C13H18O

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 1173936-89-4
(E)-2-(2-(furan-2-yl)vinyl)-1-(2-(methylthio)phenyl)octan-1-one

Conditions

Conditions	Yield
With [Rh(dppe)]ClO4 In acetone at 55℃; Inert atmosphere; regioselective reaction;	99%

: 1173936-63-4
C13H18S

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 1173936-90-7
(E)-1-(2-(methylthio)phenyl)-2-(2-(thiophen-2-yl)vinyl)octan-1-one

Conditions

Conditions	Yield
With [Rh(dppe)]ClO4 In acetone at 55℃; Inert atmosphere; regioselective reaction;	99%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 141821-03-6
(4-methylpenta-1,2-dien-1-yl)benzene

: 1173936-86-1
(E)-2-isopropyl-1-(2-(methylthio)phenyl)-4-phenylbut-3-en-1-one

Conditions

Conditions	Yield
With [Rh(dppe)]ClO4 In acetone at 55℃; Inert atmosphere; regioselective reaction;	99%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 141821-06-9
buta-1,2-diene-1,4-diyldibenzene

: 1173936-85-0
(E)-2-benzyl-1-(2-(methylthio)phenyl)-4-phenylbut-3-en-1-one

Conditions

Conditions	Yield
With [Rh(dppe)]ClO4 In acetone at 55℃; Inert atmosphere; regioselective reaction;	99%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 1362860-09-0
[Rh(bis(di-tert-butylphosphino)methane)(cyclooctene)(NCCH2BF3)]

: 67-64-1
acetone

: [Rh(bis(di-tert-butylphosphino)methane)(hydrido)(κ2-(S,C)-2-SMe-C6H4CO)(NCCH2BF3)]

Conditions

Conditions	Yield
In acetone	99%

...Expand

: 1038779-13-3
(4-bromo-2-ethynylphenyl)carbamic acid 1,1-dimethylethyl ester

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: tert-butyl (E)-(4-bromo-2-(3-(2-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenyl)carbamate

Conditions

Conditions	Yield
With bis(norbornadiene)rhodium(l)tetrafluoroborate; bis(dicyclohexylphosphino)methane In acetone at 20℃; for 0.333333h; Inert atmosphere;	99%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: C14H21BO3S

Conditions

Conditions	Yield
With C28H26FeN2S4 In benzene-d6 at 20℃; for 0.5h;	99%
With [CoCl2(4'-(4-pyridyl)-2,2':6',2''-terpyridine)]·2H2O; potassium tert-butylate In tetrahydrofuran at 25℃; for 16h; Inert atmosphere; Glovebox;	95 %Chromat.
With two-dimensional iron(II) coordination polymer based on a divergent 4'-(4-diphenylamino)phenyl-4,2';6',4''-terpyridine ligand; potassium tert-butylate In neat (no solvent) at 20℃; for 0.5h; Green chemistry; chemoselective reaction;	88 %Chromat.
With potassium tert-butylate; Mn(2+)C20H14N42Cl(1-) In tetrahydrofuran at 25℃; for 2h; Inert atmosphere; Glovebox;
With 0.55C27H43N3Si3V*0.45C27H44N3Si3V In diethyl ether at 20℃; for 2h; Inert atmosphere; Glovebox; Schlenk technique; chemoselective reaction;

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 129113-00-4
2-ethynyl-6-methoxynaphthalene

: C21H18O2S

Conditions

Conditions	Yield
Stage #1: 2-ethynyl-6-methoxynaphthalene With n-butyllithium In tetrahydrofuran Stage #2: 2-(methylsulfanyl)benzaldehyde In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere;	99%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 705-31-7
4-trifluoromethylphenylacetylene

: C17H13F3OS

Conditions

Conditions	Yield
Stage #1: 4-trifluoromethylphenylacetylene With n-butyllithium In tetrahydrofuran Stage #2: 2-(methylsulfanyl)benzaldehyde In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere;	99%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 4301-14-8
acetylenemagnesium bromide

: C10H10OS

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 4h; Inert atmosphere;	99%

: 478701-44-9
2-tert-butyl-5-methoxy-phenylamine

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: (2-tert-butyl-5-methoxy-phenyl)-(2-thiomethyl-benzylidene)-amine

Conditions

Conditions	Yield
In toluene Heating;	98%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 6310-21-0
2-(1,1-dimethylethyl)-benzenamine

: 958877-81-1
(2-tert-butylphenyl)-(2-thiomethyl-benzylidene)-amine

Conditions

Conditions	Yield
In toluene Heating;	98%

: 111-66-0
oct-1-ene

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 1085561-73-4
1-(2-(methylthio)phenyl)nonan-1-one

Conditions

Conditions	Yield
With C21H44N2P2Rh*C32H12BF24 In acetone at 55℃; for 3h; Inert atmosphere;	98%
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; silver perchlorate; bis[2-(diphenylphosphino)phenyl] ether In acetone at 55℃; for 24h; Inert atmosphere;	73%
With potassium phosphate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (11aR)-(+)-10,11,12,13-tetrahydrodiindeno[7,1-de:1', 7'-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine In 1,2-dichloro-ethane at 70℃; for 72h; Inert atmosphere;	48%
With [Rh(η6-C6H5F)(bis(dicyclohexylphosphino)methane)][B(C6H3-3,5-(CF3)2)4] In 1,2-dichloro-ethane at 80℃; for 2h; Inert atmosphere;
With C29H39FO2P2Rh(1+)*C32H12BF24(1-) In acetone at 24.84℃; for 0.0833333h; Reagent/catalyst;

: 1173936-60-1
C11H20

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 1173936-82-7
(E)-2-(3-methylbut-1-enyl)-1-(2-(methylthio)phenyl)heptan-1-one

Conditions

Conditions	Yield
With [Rh(dppe)]ClO4 In acetone at 55℃; Inert atmosphere; regioselective reaction;	98%

: 930-88-1
N-methylmaleimide

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 1362860-36-3
1-methyl-3-(2-(methylthio)benzoyl)pyrrolidine-2,5-dione

Conditions

Conditions	Yield
With C29H39FO2P2Rh(1+)*C32H12BF24(1-) In acetone at 55℃; for 3h; Inert atmosphere; Glovebox;	98%
With C29H52N2P2Rh*C32H12BF24 In acetone at 55℃; for 3h; Inert atmosphere;	81%

: 2049-80-1
(2-propenyl)propanedioic acid diethyl ester

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 1362860-33-0
1,3-diethyl 2-(4-(2-(methylthio)phenyl)-4-oxobutyl)malonate

Conditions

Conditions	Yield
With C21H44N2P2Rh*C32H12BF24 In acetone at 55℃; for 3h; Inert atmosphere;	98%
With [Rh(η6-C6H5F)(bis(dicyclohexylphosphino)methane)][B(C6H3-3,5-(CF3)2)4] In 1,2-dichloro-ethane at 80℃; for 2h; Inert atmosphere;

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: tert-butyl (5-chloro-2-ethynylphenyl)carbamate

: tert-butyl (E)-(5-chloro-2-(3-(2-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenyl)carbamate

Conditions

Conditions	Yield
With bis(norbornadiene)rhodium(l)tetrafluoroborate; bis(dicyclohexylphosphino)methane In acetone at 20℃; for 2h; Inert atmosphere;	98%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: tert-butyl (4-acetyl-2-ethynylphenyl)carbamate

: tert-butyl (E)-(4-acetyl-2-(3-(2-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenyl)carbamate

Conditions

Conditions	Yield
With bis(norbornadiene)rhodium(l)tetrafluoroborate; bis(dicyclohexylphosphino)methane In acetone at 20℃; for 0.5h; Inert atmosphere;	98%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: tert-butyl (2-ethynyl-4-nitrophenyl)carbamate

: tert-butyl (E)-(2-(3-(2-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)-4-nitrophenyl)carbamate

Conditions

Conditions	Yield
With bis(norbornadiene)rhodium(l)tetrafluoroborate; bis(dicyclohexylphosphino)methane In acetone at 20℃; for 0.333333h; Inert atmosphere;	98%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 107-15-3
ethylenediamine

: 90148-99-5
N,N-bis[(2-methylthio)phenylmethylene]-1,2-ethanediamine

Conditions

Conditions	Yield
In acetonitrile	97%
In ethanol at 80℃; Inert atmosphere;

: 16433-96-8
2-ethynyl-1-nitrobenzene

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: (E)-3-(4-methoxy-2-nitrophenyl)-1-(2-(methylthio)phenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With bis(norbornadiene)rhodium(l)tetrafluoroborate; bis(dicyclohexylphosphino)methane In acetone at 55℃; for 0.25h; Inert atmosphere;	97%

: 889134-73-0
1-ethynyl-4-methoxy-2-nitrobenzene

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: (E)-3-(4-methoxy-2-nitrophenyl)-1-(2-(methylthio)phenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With bis(norbornadiene)rhodium(l)tetrafluoroborate; bis(dicyclohexylphosphino)methane In acetone at 55℃; for 0.333333h; Inert atmosphere;	97%

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 26833-02-3
o-Methylthio-zimtsaeure-aethylester

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 12h;	97%

: 33863-95-5
3-Aethyl-1.1-diphenylallen

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 1173936-87-2
2-ethyl-1-(2-(methylthio)phenyl)-4,4-diphenylbut-3-en-1-one

Conditions

Conditions	Yield
With [Rh(dppe)]ClO4 In acetone at 55℃; Inert atmosphere; regioselective reaction;	96%

: 67237-53-0
3-ethynylthiophene

: 7022-45-9
2-(methylsulfanyl)benzaldehyde

: 1311381-67-5
(E)-1-(2-(methylthio)phenyl)-3-(thiophen-3-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With bis(norbornadiene)rhodium(l)tetrafluoroborate; 1,2-bis-(dicyclohexylphosphino)ethane In acetone at 20℃; for 2h; Inert atmosphere; regioselective reaction;	96%

2-(Methylthio)benzaldehyde Specification

The CAS register number of 2-(methylthio) Benzaldehyde is 7022-45-9. It also can be called as Benzaldehyde,2-(methylthio)- and the IUPAC name about this chemical is 2-methylsulfanylbenzaldehyde. The molecular formula about this chemical is C₈H₈OS and the molecular weight is 152.21. It belongs to the following product categories which include Aldehydes; C8; Carbonyl Compounds and so on.

Physical properties about 2-(methylthio) Benzaldehyde are: (1)ACD/LogP: 2.33; (2)#H bond acceptors: 1; (3)#Freely Rotating Bonds: 2; (4)Polar Surface Area: 42.37Å²; (5)Index of Refraction: 1.577; (6)Molar Refractivity: 44.36 cm³; (7)Molar Volume: 133.7 cm³; (8)Polarizability: 17.58x10^-24cm³; (9)Surface Tension: 43.3 dyne/cm; (10)Flash Point: 117.4 °C; (11)Enthalpy of Vaporization: 48.58 kJ/mol; (12)Boiling Point: 248.6 °C at 760 mmHg; (13)Vapour Pressure: 0.0241 mmHg at 25°C.

Preparation: this chemical can be prepared by 2-Methylthio-benzylalkohol. This reaction will need reagent N-succinimide, dimethyl sulfide, triethylamine and solvent toluene. The yield is about 94%.

Uses of 2-(methylthio) Benzaldehyde: it can be used to produce 2.2'-Bis(methylthio)benzoin at heating. This reaction will need reagent KCN and solvent ethanol, H₂O with reaction time of 2 hours. The yield is about 42%.

You can still convert the following datas into molecular structure:
(1)SMILES: O=Cc1ccccc1SC
(2)InChI: InChI=1/C8H8OS/c1-10-8-5-3-2-4-7(8)6-9/h2-6H,1H3
(3)InChIKey: XIOBUABQJIVPCQ-UHFFFAOYAH
(4)Std. InChI: InChI=1S/C8H8OS/c1-10-8-5-3-2-4-7(8)6-9/h2-6H,1H3
(5)Std. InChIKey: XIOBUABQJIVPCQ-UHFFFAOYSA-N

Product Name

2-(METHYLTHIO) BENZALDEHYDE

Synthetic route

2-(Methylthio)benzaldehyde Specification

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