2(1H)-Pyridinone,1-hydroxy- supplier

Name
OXY-PYRION? 1-HYDROXY-2(1H)-PYRIDINONE SPECIALITY CHEMICALS
EINECS 212-506-0
CAS No. 822-89-9
Article Data12
CAS DataBase
Density 1.431 g/cm³
Solubility
Melting Point 149-150 °C
Formula C₅H₅NO₂
Boiling Point 252.3 °C at 760 mmHg
Molecular Weight 111.1
Flash Point 106.4 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2(1H)-Pyridone,1-hydroxy- (6CI,7CI,8CI);1-Hydroxy-2(1H)-pyridinone;1-Hydroxy-2(1H)-pyridone;1-Hydroxy-2-pyridinone;1-Hydroxy-2-pyridone;N-Hydroxy-2-pyridone;
PSA 42.23000
LogP 0.08560

Synthetic route

: 67-56-1
methanol

: 220196-57-6
1-(9-anthryl)methyloxy-2-pyridone

A: 142-08-5
2-Pyridone

B: 822-89-9
1-Hydroxy-2-pyridon

C: 2584-79-4
9-(methoxymethyl)anthracene

Conditions

Conditions	Yield
In methanol Ambient temperature; Irradiation;	A n/a B n/a C 30%

...Expand

: 67-56-1
methanol

: 220196-58-7
1-(pyren-1-ylmethyloxy)-2-pyridone

A: 142-08-5
2-Pyridone

B: 822-89-9
1-Hydroxy-2-pyridon

C: 91385-15-8
methyl 1-pyrenylmethyl ether

Conditions

Conditions	Yield
Ambient temperature; Irradiation;	A 19.4% B 5% C 4.1%

...Expand

: 220196-58-7
1-(pyren-1-ylmethyloxy)-2-pyridone

A: 142-08-5
2-Pyridone

B: 822-89-9
1-Hydroxy-2-pyridon

C: 3029-19-4
pyrene-1-aldehyde

D: 24463-15-8
1-pyrenemethanol

Conditions

Conditions	Yield
In methanol Ambient temperature; Irradiation;	A 19.4% B 5% C 17.3% D 3%

...Expand

: 220196-58-7
1-(pyren-1-ylmethyloxy)-2-pyridone

A: 142-08-5
2-Pyridone

B: 822-89-9
1-Hydroxy-2-pyridon

C: 3029-19-4
pyrene-1-aldehyde

D: 91385-15-8
methyl 1-pyrenylmethyl ether

Conditions

Conditions	Yield
In methanol Ambient temperature; Irradiation;	A 19.4% B 5% C 4.1% D 17.3%

...Expand

: 220196-58-7
1-(pyren-1-ylmethyloxy)-2-pyridone

A: 142-08-5
2-Pyridone

B: 822-89-9
1-Hydroxy-2-pyridon

C: 24463-15-8
1-pyrenemethanol

D: 91385-15-8
methyl 1-pyrenylmethyl ether

Conditions

Conditions	Yield
In methanol Ambient temperature; Irradiation;	A 19.4% B 5% C 3% D 17.3%

...Expand

: 142-08-5
2-Pyridone

: 822-89-9
1-Hydroxy-2-pyridon

Conditions

Conditions	Yield
With Perbenzoic acid; chloroform

: 3445-09-8
2-ethoxylpyridine N-oxide

: 822-89-9
1-Hydroxy-2-pyridon

Conditions

Conditions	Yield
With hydrogenchloride; water

: 5280-02-4
1-(benzyloxy)pyridin-2(1H)-one

: 822-89-9
1-Hydroxy-2-pyridon

Conditions

Conditions	Yield
With palladium on activated charcoal; ethanol Hydrogenation;

: 2683-67-2
2-benzyloxypyridine 1-oxide

: 822-89-9
1-Hydroxy-2-pyridon

Conditions

Conditions	Yield
With palladium on activated charcoal; ethanol Hydrogenation;
With hydrogenchloride; water

: 220196-57-6
1-(9-anthryl)methyloxy-2-pyridone

A: 142-08-5
2-Pyridone

B: 822-89-9
1-Hydroxy-2-pyridon

C: 1468-95-7
9-hydroxymethylanthracene

D: 642-31-9
9-anthracene aldehyde

Conditions

Conditions	Yield
In methanol Ambient temperature; Irradiation;

...Expand

2-bromo-pyridine-1-oxide-hydrochloride: 2-bromo-pyridine-1-oxide-hydrochloride

: 822-89-9
1-Hydroxy-2-pyridon

Conditions

Conditions	Yield
With sodium hydroxide; water

: 67-56-1
methanol

: 220196-57-6
1-(9-anthryl)methyloxy-2-pyridone

A: 142-08-5
2-Pyridone

B: 822-89-9
1-Hydroxy-2-pyridon

C: 1468-95-7
9-hydroxymethylanthracene

D: 2584-79-4
9-(methoxymethyl)anthracene

Conditions

Conditions	Yield
at 20℃; for 0.5h; Product distribution; Further Variations:; irradiation time; Irradiation;	A 8.3 % Chromat. B 22.9 % Chromat. C 6.0 % Chromat. D 22.4 % Chromat.

...Expand

: 67-56-1
methanol

: 220196-58-7
1-(pyren-1-ylmethyloxy)-2-pyridone

A: 142-08-5
2-Pyridone

B: 822-89-9
1-Hydroxy-2-pyridon

C: 3029-19-4
pyrene-1-aldehyde

D: 91385-15-8
methyl 1-pyrenylmethyl ether

Conditions

Conditions	Yield
at 20℃; Product distribution; Irradiation;	A 19.4 % Chromat. B 5.0 % Chromat. C 17.3 % Chromat. D 4.1 % Chromat.

...Expand

: 109-04-6
2-bromo-pyridine

: 822-89-9
1-Hydroxy-2-pyridon

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: ethanol 2: acetic acid; hydrogen peroxide 3: hydrochloric acid; water View Scheme

: 2402-95-1
2-chloropyridine-N-oxide

: 822-89-9
1-Hydroxy-2-pyridon

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: benzyl alcohol; coal 2: palladium/charcoal; ethanol / Hydrogenation View Scheme

: 14529-53-4
2-ethoxypyridine

: 822-89-9
1-Hydroxy-2-pyridon

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid; hydrogen peroxide 2: hydrochloric acid; water View Scheme

: 40864-08-2
2-benzyloxypyridine

: 822-89-9
1-Hydroxy-2-pyridon

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: chloroform 2: hydrochloric acid; water View Scheme

: 1254765-78-0
1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)pyridin-2(1H)-one

: 822-89-9
1-Hydroxy-2-pyridon

Conditions

Conditions	Yield
With water; dihydrogen peroxide In water at 20℃; for 24h; pH=7.5; Kinetics; Time; Concentration; aq. buffer;
Multi-step reaction with 2 steps 1: hydrogenchloride; water / 3 h 2: dihydrogen peroxide / 0.5 h / 20 °C / pH 7.5 / HEPES buffer View Scheme

: 91248-78-1
1-hydroxypyridin-2(1H)-one-β-D-glucopyranoside

: 822-89-9
1-Hydroxy-2-pyridon

Conditions

Conditions	Yield
With almond β-glucosidase at 37℃; for 1h; pH=7.5; aq. buffer; Enzymatic reaction;

: 1325206-84-5
4-(((2-oxopyridin-1(2H)-yl)oxy)methyl)phenylboronic acid

: 822-89-9
1-Hydroxy-2-pyridon

Conditions

Conditions	Yield
With dihydrogen peroxide at 20℃; for 0.5h; pH=7.5; Kinetics; HEPES buffer;

: 822-89-9
1-Hydroxy-2-pyridon

: 501-52-0
3-Phenylpropionic acid

: 124552-53-0
2(1H)-oxo-1-pyridyl 3-phenylpropanoate

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane	100%

: 822-89-9
1-Hydroxy-2-pyridon

: 76-86-8
Triphenylsilyl chloride

: Ph3Si(1-oxo-2-pyridinone)

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Glovebox;	100%

: 822-89-9
1-Hydroxy-2-pyridon

: 18395-90-9
Di-tert-butyldichlorosilane

: cis-tBu2Si(1-oxo-2-pyridinone)2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 70℃; for 5h; Inert atmosphere; Glovebox;	98%

: 822-89-9
1-Hydroxy-2-pyridon

: 994-30-9
triethylsilyl chloride

: 1526929-10-1
Et3Si(1-oxo-2-pyridinone)

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 48h; Inert atmosphere; Glovebox;	98%

: 822-89-9
1-Hydroxy-2-pyridon

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 2-Pyridon-1-yl diphenyl phosphate

Conditions

Conditions	Yield
With hydrogenchloride; sodium bicarbonate; triethylamine In dichloromethane	96%
With triethylamine In dichloromethane for 0.5h; Ambient temperature;	95%

: 822-89-9
1-Hydroxy-2-pyridon

: 1203555-59-2
2',3',5'-tris-O-(tert-butyldimethylsilyl)-O6-(mesitylsulfonyl)-2-fluoro-inosine

: 1203555-60-5
2',3',5'-tris-O-(tert-butyldimethylsilyl)-2-fluoro-O6-(2-oxopyridin-1(2H)-yl)inosine

Conditions

Conditions	Yield
Stage #1: 2',3',5'-tris-O-(tert-butyldimethylsilyl)-O6-(mesitylsulfonyl)-2-fluoro-inosine With 1,4-diaza-bicyclo[2.2.2]octane In 1,4-dioxane at 20℃; for 1h; Inert atmosphere; Stage #2: 1-Hydroxy-2-pyridon In 1,4-dioxane at 20℃; for 3.5h; Inert atmosphere;	96%

: 822-89-9
1-Hydroxy-2-pyridon

: 75-78-5
dimethylsilicon dichloride

: 1526929-19-0
Me2Si(1-oxo-2-pyridinone)Cl

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Glovebox;	96%

: 822-89-9
1-Hydroxy-2-pyridon

: 1719-53-5
diethyldichlorosilane

: cis-Et2Si(1-oxo-2-pyridinone)2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Glovebox;	95%

: 822-89-9
1-Hydroxy-2-pyridon

: (TpPh,Me)ZnOH

: (TpPh,Me)Zn(1-hydroxy-2(1H)-pyridinone)

Conditions

Conditions	Yield
In methanol; dichloromethane at 20℃;	94%

: 822-89-9
1-Hydroxy-2-pyridon

: hydrotris(3,5-methylphenylpyrazolyl)boratozinc(II) hydroxide

: [(hydrotris(3,5-phenylmethylpyrazolyl)borate)Zn(1-hydroxy-2(1H)-pyridinone)]

Conditions

Conditions	Yield
In methanol; dichloromethane to soln. ((Tp(Ph,Me))ZnOH) in CH2Cl2 soln. 1-hydroxy-2(1H)-pyridinone inMeOH and stirred overnight under N2 atm.; soln. was evapd. to dryness, residue was dissolved in benzene and filtered, pentane diffusion; elem. anal.;	94%

: 822-89-9
1-Hydroxy-2-pyridon

: 1203555-56-9
2',3',5'-tris-O-(tert-butyldimethylsilyl)-N2-cyclopropyl-O6-(mesitylsulfonyl)guanosine

: 1203555-58-1
2',3',5'-tris-O-(tert-butyldimethylsilyl)-N2-cyclopropyl-O6-(2-oxopyridin-1(2H)-yl)guanosine

Conditions

Conditions	Yield
Stage #1: 2',3',5'-tris-O-(tert-butyldimethylsilyl)-N2-cyclopropyl-O6-(mesitylsulfonyl)guanosine With 1,4-diaza-bicyclo[2.2.2]octane In 1,4-dioxane at 20℃; for 1h; Inert atmosphere; Stage #2: 1-Hydroxy-2-pyridon With 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 20℃; for 3.5h; Inert atmosphere;	94%

: 822-89-9
1-Hydroxy-2-pyridon

: 150884-25-6
3',5'-bis-O-(tert-butyldimethylsilyl)-O6-[(2,4,6-trimethylphenyl)sulfonyl]-2'-deoxyguanosine

: 1203555-49-0
3',5'-bis-O-(tert-butyldimethylsilyl)-O6-(2-oxopyridin-1(2H)-yl)-2'-deoxyguanosine

Conditions

Conditions	Yield
Stage #1: 3',5'-bis-O-(tert-butyldimethylsilyl)-O6-[(2,4,6-trimethylphenyl)sulfonyl]-2'-deoxyguanosine With 1,4-diaza-bicyclo[2.2.2]octane In 1,4-dioxane at 20℃; for 1h; Inert atmosphere; Stage #2: 1-Hydroxy-2-pyridon With 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 20℃; for 3.5h; Inert atmosphere;	94%

: 822-89-9
1-Hydroxy-2-pyridon

: 7751-38-4
Diisopropylsilyl dichloride

: cis-iPr2Si(1-oxo-2-pyridinone)2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Glovebox;	93%

: 822-89-9
1-Hydroxy-2-pyridon

: 2351-33-9
1,1-dichlorosilacyclobutane

: (CH2)3Si(1-oxo-2-pyridinone)2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Glovebox;	93%

: 822-89-9
1-Hydroxy-2-pyridon

: 75-77-4
chloro-trimethyl-silane

: Me3Si(1-oxo-2-pyridinone)

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Glovebox;	92%
With triethylamine In tetrahydrofuran	70%

: 822-89-9
1-Hydroxy-2-pyridon

: [(hydrotris(3,5-phenylmethylpyrazolyl)borato)CoCl]

: [(hydrotris(3,5-phenylmethylpyrazolyl)borato)Co(1,2-HOPO)]

Conditions

Conditions	Yield
With (C2H5)3N In methanol; dichloromethane (C2H5)3N added to a soln. of Co complex, a soln. of ligand in MeOH added, stirred at room temp. under N2; evapd. (vac.), dissolved in C6H6, filtered, crystd. by diffusion of the soln. with pentane; elem. anal.;	92%

: 822-89-9
1-Hydroxy-2-pyridon

: 1719-53-5
diethyldichlorosilane

: 1526929-20-3
Et2Si(1-oxo-2-pyridinone)Cl

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 1.33333h; Inert atmosphere; Glovebox;	92%

: 9-{2-deoxy-3,5-bis-O-[(1,1-dimethylethyl)(dimethyl)silyl]-β-D-erythro-pentofuranosyl}-6-{[(2,4,6-trimethylphenyl)sulfonyl]oxy}-9H-purin-2-amine

: 822-89-9
1-Hydroxy-2-pyridon

: 1203555-50-3
2',3',5'-tris-O-(tert-butyldimethylsilyl)-O6-(2-oxopyridin-1(2H)-yl)guanosine

Conditions

Conditions	Yield
Stage #1: 9-{2-deoxy-3,5-bis-O-[(1,1-dimethylethyl)(dimethyl)silyl]-β-D-erythro-pentofuranosyl}-6-{[(2,4,6-trimethylphenyl)sulfonyl]oxy}-9H-purin-2-amine With 1,4-diaza-bicyclo[2.2.2]octane In 1,4-dioxane at 20℃; for 1h; Inert atmosphere; Stage #2: 1-Hydroxy-2-pyridon With 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 20℃; for 3.5h; Inert atmosphere;	91%

: 822-89-9
1-Hydroxy-2-pyridon

: 4548-45-2
2-chloro-5-nitropyridine

: 1346257-87-1
1-(5-nitro-2-pyridyloxy)pyridin-2(1H)-one

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	90.13%

: 822-89-9
1-Hydroxy-2-pyridon

: 24672-87-5
4-methoxy-2-(2-methoxy-2-oxoethyl)benzoic acid

: 221133-91-1
4-Methoxy-2-methoxycarbonylmethylbenzoic acid 2-oxo-1,2-dihydropyridin-1-yl ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane for 3h; Ambient temperature;	89%

: 822-89-9
1-Hydroxy-2-pyridon

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1235983-29-5
(9H-fluoren-9-yl)methyl 2-oxopyridin-1(2H)-yl carbonate

Conditions

Conditions	Yield
With sodium carbonate In dichloromethane; water at 0 - 20℃;	89%

: 822-89-9
1-Hydroxy-2-pyridon

: 93-11-8
2-Naphthalenesulfonyl chloride

: 1243301-72-5
2-oxopyridin-1(2H)-yl naphthalene-2-sulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	88%

: 822-89-9
1-Hydroxy-2-pyridon

: 138500-85-3
4-bromomethylphenylboronic acid pinacol ester

: 1254765-78-0
1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)pyridin-2(1H)-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 12h; Inert atmosphere;	87%

: 822-89-9
1-Hydroxy-2-pyridon

: 97-00-7
1-chloro-2,4-dinitro-benzene

: 1346257-82-6
1-(2,4-dinitrophenoxy)pyridin-2(1H)-one

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	86.64%

: 822-89-9
1-Hydroxy-2-pyridon

: 3140-73-6
2-chloro-4,6-dimethoxy-1 ,3,5-triazine

: 1259296-16-6
1-(4,6-dimethoxy-1,3,5-triazin-2-yloxy)pyridin-2(1H)-one

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	85%

: 822-89-9
1-Hydroxy-2-pyridon

: 100-39-0
benzyl bromide

: 5280-02-4
1-(benzyloxy)pyridin-2(1H)-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 16h;	84%

: 822-89-9
1-Hydroxy-2-pyridon

: 75-78-5
dimethylsilicon dichloride

: cis-Me2Si(1-oxo-2-pyridinone)2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Glovebox;	84%

: 822-89-9
1-Hydroxy-2-pyridon

: 64-19-7
acetic acid

: 1742-79-6
2-oxopyridin-1(2H)-yl acetate

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran for 24h; Ambient temperature;	82%

: 822-89-9
1-Hydroxy-2-pyridon

: N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate

: 364047-51-8
[O-(1,2-dihydro-2-oxo-pyridyl)-N,N,N',N'-tetramethyluronium]hexafluorophosphate

Conditions

Conditions	Yield
In acetonitrile at 0 - 20℃;	82%

: 822-89-9
1-Hydroxy-2-pyridon

: 98-59-9
p-toluenesulfonyl chloride

: 5087-06-9
2-oxopyridin-1(2H)-yl 4-methylbenzene sulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	81%
Stage #1: 1-Hydroxy-2-pyridon With triethylamine In dichloromethane at 0℃; Inert atmosphere; Stage #2: p-toluenesulfonyl chloride In dichloromethane at 0 - 20℃; for 2.5h; Inert atmosphere;	78%

2(1H)-Pyridinone,1-hydroxy- Specification

The 2(1H)-Pyridinone,1-hydroxy-, with the CAS registry number 822-89-9, is also known as 1-Hydroxy-1H-pyridin-2-one. It belongs to the product category of Heterocycles. Its EINECS registry number is 212-506-0. This chemical's molecular formula is C₅H₅NO₂ and molecular weight is 111.0987. What's more, its IUPAC name is called 1-Hydroxypyridin-2-one.

Physical properties about 2(1H)-Pyridinone,1-hydroxy- are: (1) ACD/LogP: -0.65; (2) # of Rule of 5 Violations: 0; (3) ACD/LogD (pH 5.5): -0.77; (4) ACD/LogD (pH 7.4): -2.07; (5) ACD/BCF (pH 5.5): 1; (6) ACD/BCF (pH 7.4): 1; (7) ACD/KOC (pH 5.5): 7.97; (8) ACD/KOC (pH 7.4): 1; (9) #H bond acceptors: 3; (10) #H bond donors: 1; (11) #Freely Rotating Bonds: 1; (12) Polar Surface Area: 29.54 Å²; (13) Index of Refraction: 1.628; (14) Molar Refractivity: 27.55 cm³; (15) Molar Volume: 77.5 cm³; (16) Surface Tension: 69.8 dyne/cm; (17) Density: 1.431 g/cm³; (18) Flash Point: 106.4 °C; (19) Enthalpy of Vaporization: 56.89 kJ/mol; (20) Boiling Point: 252.3 °C at 760 mmHg; (21) Vapour Pressure: 0.00304 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C1/C=C\C=C/N1O
(2) InChI: InChI=1/C5H5NO2/c7-5-3-1-2-4-6(5)8/h1-4,8H
(3) InChIKey: SNUSZUYTMHKCPM-UHFFFAOYAA

Product Name

OXY-PYRION? 1-HYDROXY-2(1H)-PYRIDINONE SPECIALITY CHEMICALS

Synthetic route

2(1H)-Pyridinone,1-hydroxy- Specification

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