2,2-Dimethyl-1,3-propanediamine supplier

Name
2,2-Dimethyl-1,3-propanediamine
EINECS 230-819-0
CAS No. 7328-91-8
Article Data19
CAS DataBase
Density 0.862 g/cm³
Solubility
Melting Point 29-31 °C(lit.)
Formula C₅H₁₄N₂
Boiling Point 150.4 °C at 760 mmHg
Molecular Weight 102.18
Flash Point 47.2 °C
Transport Information UN 2921 8/PG 2
Appearance clear to yellow liquid or semi-solid
Safety 16-26-27-36/37/39-45
Risk Codes 10-34
Molecular Structure
Hazard Symbols C
Synonyms (3-Amino-2,2-dimethylpropyl)amine;1,2-Diamino-2,2-dimethylpropane;1,3-Diamino-2,2-dimethylpropane;2,2-Dimethyltrimethylenediamine;NSC 17719;
PSA 52.04000
LogP 1.33060

Synthetic route

: 41882-44-4
2,2-dimethylmalonamide

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
With dimethylsulfide borane complex In tetrahydrofuran for 2h; Heating;	75%

: 67744-70-1
3-amino-2,2-dimethyl-propionitrile

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
With methanol; nickel Hydrogenation;

: 2,2-dimethyl-1,3-diphthalimido-propane

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
With potassium hydroxide; water

: 762-98-1
2,2-dimethyl-1,3-dinitropropane

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
With hydrogenchloride; water; iron at 100℃; durch Reduktion;
With methanol; nickel under 30891.3 Torr; Hydrogenation;
With methanol; nickel at 50 - 75℃; under 51485.6 Torr; Hydrogenation;
With hydrogen; nickel

: 762-98-1
2,2-dimethyl-1,3-dinitropropane

A: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

B: 41882-44-4
2,2-dimethylmalonamide

Conditions

Conditions	Yield
With ethanol; nickel at 60℃; under 51485.6 Torr; Hydrogenation;
With ethanol; nickel at 60℃; under 51485.6 Torr; Hydrogenation;

: 31044-89-0
1,3-diazido-2,2-dimethyl-propane

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 18h; Heating;

: 126-30-7
2,2-Dimethyl-1,3-propanediol

A: 26734-09-8
3-amino-2,2-dimethylpropan-1-ol

B: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
With ammonia; hydrogen; Co-Fe catalyst at 210℃; under 37503 - 112509 Torr; Product distribution;

: 7647-01-0
hydrogenchloride

: 859065-87-5
2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide

: 60-29-7
diethyl ether

: 64-17-5
ethanol

A: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

B 2,2-dimethyl-3-oxo-propionic acid amide (as 2,4-dinitro-phenyl hydrazone isolated): 2,2-dimethyl-3-oxo-propionic acid amide (as 2,4-dinitro-phenyl hydrazone isolated)

...Expand

: 64-17-5
ethanol

: 762-98-1
2,2-dimethyl-1,3-dinitropropane

Raney nickel: Raney nickel

A: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

B: 41882-44-4
2,2-dimethylmalonamide

Conditions

Conditions	Yield
at 60℃; under 51485.6 Torr; Hydrogenation;
at 60℃; under 51485.6 Torr; Hydrogenation;

...Expand

: 7647-01-0
hydrogenchloride

: 114583-17-4
α-(nitromethyl)isobutyronitrile

iron powder: iron powder

A: 859065-87-5
2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide

B: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

C: 67744-70-1
3-amino-2,2-dimethyl-propionitrile

D: 324763-51-1
aminopivalinamide

Conditions

Conditions	Yield
at 60 - 70℃;
at 60 - 70℃;

...Expand

: 67-56-1
methanol

: 114583-17-4
α-(nitromethyl)isobutyronitrile

palladium-CaCO3: palladium-CaCO3

A: 859065-87-5
2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide

B: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

C: 67744-70-1
3-amino-2,2-dimethyl-propionitrile

D: 324763-51-1
aminopivalinamide

Conditions

Conditions	Yield
Hydrogenation;
Hydrogenation;

...Expand

: 67-56-1
methanol

: 114583-17-4
α-(nitromethyl)isobutyronitrile

Raney nickel: Raney nickel

A: 859065-87-5
2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide

B: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

C: 67744-70-1
3-amino-2,2-dimethyl-propionitrile

D: 324763-51-1
aminopivalinamide

Conditions

Conditions	Yield
Hydrogenation;
Hydrogenation;

...Expand

: 114583-17-4
α-(nitromethyl)isobutyronitrile

Raney nickel: Raney nickel

methanolic NH3: methanolic NH3

A: 859065-87-5
2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide

B: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

C: 67744-70-1
3-amino-2,2-dimethyl-propionitrile

D: 324763-51-1
aminopivalinamide

Conditions

Conditions	Yield
at 100℃; Hydrogenation;
at 100℃; Hydrogenation;

...Expand

: 5659-93-8
2,2-Dimethylmalonyl chloride

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 82 percent / 28percent NH3 2: 75 percent / BH3*SMe2 / tetrahydrofuran / 2 h / Heating View Scheme

: 595-46-0
2,2-dimethylmalonic acid

l-trans-caronic acid: l-trans-caronic acid

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 71 percent / SOCl2 / 20 h / Heating 2: 82 percent / 28percent NH3 3: 75 percent / BH3*SMe2 / tetrahydrofuran / 2 h / Heating View Scheme

: 114583-17-4
α-(nitromethyl)isobutyronitrile

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: iron; aqueous HCl / 60 - 70 °C 2: Raney nickel; methanol / Hydrogenation View Scheme

: 31044-87-8
neopentyl glycol bis(benzenesulfonate)

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaN3 / bis-(2-hydroxy-ethyl) ether / 16 h / 135 °C 2: LiAlH4 / tetrahydrofuran / 18 h / Heating View Scheme

: 126-30-7
2,2-Dimethyl-1,3-propanediol

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridine / 24 h / 10 °C 2: NaN3 / bis-(2-hydroxy-ethyl) ether / 16 h / 135 °C 3: LiAlH4 / tetrahydrofuran / 18 h / Heating View Scheme

: 922-84-9
ethane-1,1,2-tricarboxylic acid

: platinum(II) chloride

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
With silver nitrate In sodium hydroxide; water

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 40244-90-4
Chlorodiisopropylphosphane

: 596106-62-6
N,N'-1,3-bis(P,P'-diisopropylthiophosphinic)-2,2-dimethylpropylene diamine

Conditions

Conditions	Yield
Stage #1: 2,2-Dimethyl-1,3-diaminopropane; Chlorodiisopropylphosphane With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 23℃; Stage #2: With sulfur at 80℃; for 0.5h;	100%
Stage #1: 2,2-Dimethyl-1,3-diaminopropane; Chlorodiisopropylphosphane With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 25℃; Stage #2: With sulfur In dichloromethane at 20℃; for 2h;	72%
Stage #1: 2,2-Dimethyl-1,3-diaminopropane; Chlorodiisopropylphosphane With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Stage #2: With sulfur In dichloromethane at 20℃; for 2h;	68%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 123-11-5
4-methoxy-benzaldehyde

: 1295636-73-5
C21H26N2O2

Conditions

Conditions	Yield
In ethanol at 20℃; for 4h; Reflux;	100%
With formic acid In methanol for 24h; Reflux; Inert atmosphere;	54%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 188482-90-8
N,N′-bis(3-methoxysalicylidene)-2,2-dimethyl-1,3-propanediamine

Conditions

Conditions	Yield
In methanol at 22℃; for 4h;	100%
In ethanol for 1h; Reflux;	92%
In ethanol for 1h; Reflux;	92%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 383-63-1
ethyl trifluoroacetate,

: 1321622-57-4
N-(3-amino-2,2-dimethylpropyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 15h; Inert atmosphere;	100%
In tetrahydrofuran at 20℃; for 14.5h; Cooling with ice;

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: C40H76N2O2(2+)*2NO3(1-)

: 563-63-3
silver(I) acetate

: 71-48-7, 917-69-1, 5931-89-5, 55881-15-7, 68931-68-0, 68931-69-1, 93029-27-7
cobalt(II) acetate

: C87H163CoN6O4(4+)*4NO3(1-)

Conditions

Conditions	Yield
Stage #1: 2,2-Dimethyl-1,3-diaminopropane; C40H76N2O2(2+)*2NO3(1-) In dichloromethane at 20℃; Stage #2: cobalt(II) acetate In dichloromethane at 20℃; for 12h; Stage #3: silver(I) acetate In dichloromethane for 12h;	100%

...Expand

: 98-03-3
thiophene-2-carbaldehyde

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: C15H18N2S2

Conditions

Conditions	Yield
In ethanol at 20℃; for 4h; Reflux;	100%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: (1R)-dispiro[adamantane-2,3'-[1,2,4]trioxolane-5',1'-cyclohexan]-3'-yl (4-nitrophenyl)carbonate

: (1R,3'R)-dispiro[adamantane-2,3'-[1,2,4]trioxolane-5',1'-cyclohexan]-3'-yl (3-amino-2,2-dimethylpropyl)carbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 3h;	100%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 135636-66-7
butane-2,3-dione mono-oxime

: C13H24N4O2

Conditions

Conditions	Yield
With calcium hydride In acetonitrile at 0℃; Reflux;	99.23%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 14562-10-8
2-hydroxy-3-phenylbenzaldehyde

: 1,3-diamino-2,2-dimethyl-N,N'-bis(3-phenylsalicylidene)propane

Conditions

Conditions	Yield
In ethanol at 20℃;	99%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 90-02-8
salicylaldehyde

: 2,2′-((1E,1′ E)-((2,2-dimethylpropane-1,3diyl)bis(azaneylylidene))bis(methaneylylidene))diphenol

Conditions

Conditions	Yield
In ethanol at 20℃;	99%
In methanol at 20℃; for 0.333333h;	75%
In methanol
In methanol for 2h; Reflux;
In methanol at 20℃; for 0.5h;

: 591-80-0
pent-4-enoic acid

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 1446746-88-8
C15H26N2O2

Conditions

Conditions	Yield
Stage #1: pent-4-enoic acid With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.5h; Stage #2: 2,2-Dimethyl-1,3-diaminopropane In dichloromethane at 20℃;	99%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 134296-07-4
6-formyl-2,2'-bipyridine

: C27H26N6

Conditions

Conditions	Yield
In methanol for 3h;	99%

: 140840-53-5
3-(tert-butyldimethylsilyl)-2-hydroxybenzaldehyde

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: N,N'-bis[3-(tert-butyldimethylsilyl)salicylidene]-2,2-dimethyl-1,3-propanediamine

Conditions

Conditions	Yield
In ethanol at 20℃;	98%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 1211569-73-1
tert-butyl [4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]methylcarbamate

: 1211569-84-4
tert-butyl [4-(5,5-dimethyl-1,4,5,6-tetrahydropyrimidin-2-yl)benzyl]methylcarbamate

Conditions

Conditions	Yield
at 155℃; for 1h;	98%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 37942-07-7
3,5-di-tert-butyl-2-hydroxybenzaldehyde

: 175291-16-4
(2,2-dimethylpropandiyl)bis(nitrilomethylidyne)bis(2,4-di-tert-butyl)phenol

Conditions

Conditions	Yield
In ethanol at 20℃;	98%
In ethanol at 50 - 70℃; for 2.25h;	90%
	88%

: lanthanum(III) nitrate hexahydrate

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 5970-45-6
zinc(II) acetate dihydrate

: 148063-59-6
3,6-diformylcatechol

: C39H42LaN6O6Zn3(3+)*3NO3(1-)

Conditions

Conditions	Yield
Stage #1: lanthanum(III) nitrate hexahydrate; zinc(II) acetate dihydrate; 3,6-diformylcatechol In methanol; chloroform; water at 20℃; for 0.5h; Stage #2: 2,2-Dimethyl-1,3-diaminopropane In chloroform at 20℃; for 18h;	98%

...Expand

: 573675-27-1
3-amino-5-bromopyridine-2-carbonitrile

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 5-bromo-2-(5,5-dimethyl-4,6-dihydro-1H-pyrimidin-2-yl)pyridin-3-amine

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at 160℃; Sealed tube;	98%

: zinc(II) nitrate hexahydrate

: cerium(III) acetate monohydrate

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 148063-59-6
3,6-diformylcatechol

: C39H42CeN6O6Zn3(3+)*3NO3(1-)

Conditions

Conditions	Yield
Stage #1: zinc(II) nitrate hexahydrate; cerium(III) acetate monohydrate; 3,6-diformylcatechol In methanol; chloroform; water at 20℃; for 17h; Stage #2: 2,2-Dimethyl-1,3-diaminopropane In methanol at 20℃; for 1h;	98%

...Expand

: 83-72-7
2-Hydroxy-1,4-naphthoquinone

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 403-32-7
(4-fluorophenyl)glyoxal

: 13623-94-4
1,1-di(methylsulfanyl)-2-nitroethylene

: 2-[6-(4-fluoro-phenyl)-3,3-dimethyl-8-nitro-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrimidin-7-yl]-3-hydroxy-[1,4]naphthoquinone

Conditions

Conditions	Yield
Stage #1: 2,2-Dimethyl-1,3-diaminopropane; 1,1-di(methylsulfanyl)-2-nitroethylene In ethanol; water for 4h; Reflux; Stage #2: 2-hydroxynaphtho-1,4-quinone; (4-fluorophenyl)glyoxal In ethanol; water at 60℃; for 0.0833333h; regioselective reaction;	97%

...Expand

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: (-)-menthyl 3-formyl-4-hydroxy-5-methoxybenzoate

: C43H62N2O8

Conditions

Conditions	Yield
In ethanol for 5h; Reflux;	97%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 201288-39-3
bis(chlorotriazine)

: 321898-29-7
C56H78N14O4

Conditions

Conditions	Yield
at 90℃;	96%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 1499-21-4
Diphenylphosphinic chloride

: 596106-64-8
N,N'-bis(P,P-diphenylphosphinoyl)-2,2-dimethyl-1,3-propanediamine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;	96%
With triethylamine at 0℃; for 6h;

: 865075-67-8
[bis(1H-benzotriazol-1-yl)methylidene](4-chlorophenyl)amine

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 4-chloro-N-[3,4,5,6-tetrahydro-5,5-dimethyl-1H-pyrimidin-2-ylidene]aniline

Conditions

Conditions	Yield
In toluene for 1h; Heating;	96%

: 107-20-0
2-chloroethanal

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 298-14-6
potassium hydrogencarbonate

: 1580482-20-7
(RS)-3,3-dimethylhexahydro[1,3]oxazolo[3,4-a]pyrimidin-6-one

Conditions

Conditions	Yield
In water at 20℃; for 10h; Green chemistry;	96%

...Expand

: 140840-53-5
3-(tert-butyldimethylsilyl)-2-hydroxybenzaldehyde

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: C31H50N2O2Si2

Conditions

Conditions	Yield
In ethanol at 20 - 80℃; for 2h; Inert atmosphere;	96%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: (E)-2-hydroxy-3-methoxy-5-( p-tolyldiazenyl)benzaldehyde

: C20H26N4O2

Conditions

Conditions	Yield
In methanol at 20℃; for 4h;	96%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 24424-99-5
di-tert-butyl dicarbonate

: di-tert-butyl 2,2-dimethylpropane-1,3-diyldicarbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	96%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: C98H152O11

: C201H314N2O20

Conditions

Conditions	Yield
With acetic acid In ethanol	96%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 67-64-1
acetone

: 31892-16-7
N,N'-diisipropyl-2,2-dimethyl-1,3-diaminopropane

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol under 51714.8 Torr;	95%

: 7328-91-8
2,2-Dimethyl-1,3-diaminopropane

: 57943-60-9
4-hydroxybenzimidic acid methyl ester hydrochloride

: 4-(1,4,5,6-tetrahydro-5,5-dimethyl-2-pyrimidinyl)phenol

Conditions

Conditions	Yield
In ethanol for 18h; cycloamynation; Pinner synthesis; Heating;	95%

2,2-Dimethyl-1,3-propanediamine Specification

The CAS registry number of Neopentyldiamine is 7328-91-8. Its EINECS registry number is 230-819-0. The IUPAC name is 2,2-dimethylpropane-1,3-diamine. In addition, the molecular formula is C₅H₁₄N₂ and the molecular weight is 102.18. It is also called 1,3-propanediamine,2,2-dimethyl-. What's more, it belongs to the classes of Amine Monomers; Monomers; Primary Amines. And it should be stored in a cool and dry place.

Physical properties about this chemical are: (1)ACD/LogP: -0.73; (2)ACD/LogD (pH 5.5): -4.82; (3)ACD/LogD (pH 7.4): -4.55; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 6.48 Å²; (12)Index of Refraction: 1.456; (13)Molar Refractivity: 32.24 cm³; (14)Molar Volume: 118.4 cm³; (15)Polarizability: 12.78 ×10^-24cm³; (16)Surface Tension: 33.1 dyne/cm; (17)Density: 0.862 g/cm³; (18)Flash Point: 47.2 °C; (19)Enthalpy of Vaporization: 38.72 kJ/mol; (20)Boiling Point: 150.4 °C at 760 mmHg; (21)Vapour Pressure: 3.86 mmHg at 25°C.

Preparation of Neopentyldiamine: it can be prepared by dimethyl-malonic acid diamide. This reaction will need reagent BH₃*SMe₂ and solvent tetrahydrofuran. The reaction time is 2 hours by heating. The yield is about 75%.

Neopentyldiamine can be prepared by dimethyl-malonic acid diamide

Uses of Neopentyldiamine: it can react with formaldehyde to get 5,5-dimethylhexahydropyrimidine. This reaction will need solvent H₂O. The reaction time is 24 hours at reaction temperature of 20 °C. The yield is about 88%.

Neopentyldiamine can react with formaldehyde to get 5,5-dimethylhexahydropyrimidine

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable and can cause burns. During using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell, seek medical advice immediately (show label where possible). What's more, you should keep away from sources of ignition and no smoking. And you should take off immediately all contaminated clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: NCC(C)(C)CN
(2)InChI: InChI=1/C5H14N2/c1-5(2,3-6)4-7/h3-4,6-7H2,1-2H3
(3)InChIKey: DDHUNHGZUHZNKB-UHFFFAOYAL

Product Name

2,2-Dimethyl-1,3-propanediamine

Synthetic route

2,2-Dimethyl-1,3-propanediamine Specification

Related Products

Hot Products