2-Bromopropionyl chloride supplier

Name
2-Bromopropionyl chloride
EINECS 230-466-2
CAS No. 7148-74-5
Article Data52
CAS DataBase
Density 1.712 g/cm³
Solubility soluble in water and react with water
Melting Point
Formula C₃H₄BrClO
Boiling Point 133.858 °C at 760 mmHg
Molecular Weight 171.421
Flash Point 34.756 °C
Transport Information UN 2920 8/PG 2
Appearance clear yellow liquid
Safety 16-26-27-36/37/39-45-25
Risk Codes 10-34-36/37
Molecular Structure
Hazard Symbols C
Synonyms Bromopropionyl chloride;Propionylchloride, 2-bromo- (6CI,8CI);2-Bromopropionicacid chloride;NSC 64455;α-Bromopropanoyl chloride;α-Bromopropionic acid chloride;α-Bromopropionyl chloride;
PSA 17.07000
LogP 1.53520

Synthetic route

: 598-72-1
2-Bromopropionic acid

: 7148-74-5
2-Bromopropionyl chloride

Conditions

Conditions	Yield
With oxalyl dichloride for 6h; Heating;	78%
With phosphorus trichloride
With phosphorus pentachloride In dichloromethane

: 79-03-8
propionyl chloride

: 7148-74-5
2-Bromopropionyl chloride

Conditions

Conditions	Yield
With phosphorus; bromine
With N-Bromosuccinimide; hydrogen bromide In tetrachloromethane at 85℃; for 4h; Yield given;
With N-Bromosuccinimide; hydrogen bromide In dichloromethane

: 79-03-8
propionyl chloride

A: 563-76-8
α-bromopropionyl bromide

B: 7148-74-5
2-Bromopropionyl chloride

Conditions

Conditions	Yield
With bromine am besten im Sonnenlicht;

: 7726-95-6
bromine

: 79-03-8
propionyl chloride

A: 563-76-8
α-bromopropionyl bromide

B: 7148-74-5
2-Bromopropionyl chloride

...Expand

: 802294-64-0
propionic acid

: 7148-74-5
2-Bromopropionyl chloride

Conditions

Conditions	Yield
Stage #1: propionic acid With thionyl chloride at 60℃; for 1h; Stage #2: With hydrogen bromide; bromine In water at 60 - 70℃;

: 1188535-15-0
C14H20Cl2N2O2

: 7148-74-5
2-Bromopropionyl chloride

: 1188535-16-1
C17H23BrCl2N2O3

Conditions

Conditions	Yield
With triethylamine In toluene at 20℃;	100%

: tert-butyl 3-(5-((methylamino)methyl)-1H-imidazol-2-yl)azetidine-1-carboxylate

: 7148-74-5
2-Bromopropionyl chloride

: tert-butyl 3-(5-((2-bromo-N-methylpropanamido)methyl)-1H-imidazol-2-yl)azetidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	100%

: tert-butyl 5-formyl-2-(4-methyltetrahydro-2H-pyran-4-yl)-1H-imidazole-1-carboxylate

: 74-89-5
methylamine

: 7148-74-5
2-Bromopropionyl chloride

: 2-bromo-N-methyl-N-((2-(4-methyltetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)methyl)propanamide

Conditions

Conditions	Yield
Stage #1: tert-butyl 5-formyl-2-(4-methyltetrahydro-2H-pyran-4-yl)-1H-imidazole-1-carboxylate; methylamine In tetrahydrofuran; methanol at 0 - 20℃; for 18h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at 0 - 20℃; for 0.5h; Stage #3: 2-Bromopropionyl chloride With triethylamine In dichloromethane at 20℃; for 2h;	100%

...Expand

: 28165-50-6
2-amino-6-bromophenol

: 7148-74-5
2-Bromopropionyl chloride

: 868371-90-8
2-bromo-N-(3-bromo-2-hydroxyphenyl)propionamide

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; ethyl acetate at 0℃; for 3h;	99%
With sodium hydrogencarbonate In water; ethyl acetate at 0℃; for 3h;	73%

: 1120-48-5
n-dioctylamine

: 7148-74-5
2-Bromopropionyl chloride

: 2-bromo-N,N-dioctylpropanamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane for 2h;	98%

: 59-48-3
2-oxoindole

: 7148-74-5
2-Bromopropionyl chloride

: 65435-05-4
5-<(2-bromo-1-oxo)propyl>-1,3-dihydro-2H-indol-2-one

Conditions

Conditions	Yield
With aluminium trichloride In N,N-dimethyl-formamide 1) RT, 18h, 2) 40 deg C, 1h;	97%
With aluminum (III) chloride In dichloromethane for 6h; Reflux;	75%
AlCl3 In dichloromethane

: 106-40-1
4-bromo-aniline

: 7148-74-5
2-Bromopropionyl chloride

: 42276-46-0
2-bromo-N-(4-bromophenyl)propanamide

Conditions

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane at 0 - 20℃;	97%
In dichloromethane at 20℃;
With triethylamine In dichloromethane at 0 - 20℃;

: 75-08-1
ethanethiol

: 7148-74-5
2-Bromopropionyl chloride

: 209597-98-8
S-ethyl 2-bromopropanethioate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 1.66667h;	96%
With triethylamine In dichloromethane Ambient temperature; Yield given;

: (1S)-1-(4-chloro-3-fluorophenyl)ethan-1-amine hydrochloride

: 7148-74-5
2-Bromopropionyl chloride

: 2-bromo-N-[(1S)-1-(4-chloro-3-fluorophenyl)ethyl]propanamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 3h; Inert atmosphere;	96%

2N-NaOH: 2N-NaOH

: 103-01-5
N-Phenylglycine

: 7148-74-5
2-Bromopropionyl chloride

A: N-(2-bromopropionylphenyl)glycine

B: 861570-46-9
N-(2-bromo-propionyl)-N-phenyl-glycine

Conditions

Conditions	Yield
	A 94.8% B n/a

...Expand

: N-methyl-1-(2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)methanamine hydrochloride

: 7148-74-5
2-Bromopropionyl chloride

: 2-bromo-N-methyl-N-((2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)methyl)propanamide

Conditions

Conditions	Yield
With triethylamine In chloroform at 0℃; for 0.5h;	94%

: 21392-51-8
2-amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile

: 7148-74-5
2-Bromopropionyl chloride

: 77995-60-9
2-(2-bromopropionamido)-3-cyano-4,5-dimethylpyrrole

Conditions

Conditions	Yield
With pyridine In acetone for 0.333333h; Ambient temperature;	93.1%

: 62-53-3
aniline

: 7148-74-5
2-Bromopropionyl chloride

: 42308-20-3
2-bromopropionanilide

Conditions

Conditions	Yield
In benzene for 5h; Ambient temperature;	93%
With benzene
With triethylamine In dichloromethane at 0 - 20℃; for 20h;
In dichloromethane at 20℃;

: 123-75-1
pyrrolidine

: 7148-74-5
2-Bromopropionyl chloride

: 54537-48-3
2-bromo-1-(pyrrolidin-1-yl)propan-1-one

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 2.5h;	93%

: 1008-78-2
5-amino-3-phenyl-1,2,3-oxadiazol-3-ium chloride

: 7148-74-5
2-Bromopropionyl chloride

: C11H10BrN3O2

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -30℃;	93%

: 78773-69-0
N-cyclopentylglycine tert-butyl ester

: 7148-74-5
2-Bromopropionyl chloride

: 85101-47-9
tert-butyl N-(2-bromopropanoyl)-N-cyclopentylglycinate

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane for 16h;	92%

: 7148-74-5
2-Bromopropionyl chloride

: (2R,3S)-2-((R)-5-Benzyloxy-1-hydroxy-pentyl)-3-methyl-3-[(E)-3-(toluene-4-sulfonyl)-allyl]-cyclopentanone

: 2-Bromo-propionic acid (R)-5-benzyloxy-1-{(1R,2S)-2-methyl-5-oxo-2-[(E)-3-(toluene-4-sulfonyl)-allyl]-cyclopentyl}-pentyl ester

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; Acylation;	92%

: 100-46-9
benzylamine

: 7148-74-5
2-Bromopropionyl chloride

: 6653-71-0
N-benzyl-2-bromopropanamide

Conditions

Conditions	Yield
In benzene for 5h; Ambient temperature;	91%
With triethylamine In dichloromethane at 20℃; for 0.166667h;	83%
With triethylamine In dichloromethane at 0 - 20℃; for 20h; Reflux;
With triethylamine In dichloromethane at 0 - 20℃; for 2h;

: 7148-74-5
2-Bromopropionyl chloride

: (2R,3S)-2-((S)-5-Benzyloxy-1-hydroxy-pentyl)-3-methyl-3-[(E)-3-(toluene-4-sulfonyl)-allyl]-cyclopentanone

: 2-Bromo-propionic acid (S)-5-benzyloxy-1-{(1R,2S)-2-methyl-5-oxo-2-[(E)-3-(toluene-4-sulfonyl)-allyl]-cyclopentyl}-pentyl ester

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; Acylation;	91%

: 7148-74-5
2-Bromopropionyl chloride

: 6004-44-0
prop-1-en-1-one

Conditions

Conditions	Yield
With {bis(triphenylphosphine)nitrogen}{manganese(carbonyl)5} In chloroform at 0℃; under 0.1 - 20 Torr; for 3h;	90%

: 103181-68-6, 119562-05-9, 119562-07-1
2-(2-methoxy-phenoxymethyl)-1,3-thiazolidine

: 7148-74-5
2-Bromopropionyl chloride

: 3-α-bromopropionyl-2-(o-methoxyphenoxy)methyl-thiazolidine

Conditions

Conditions	Yield
With triethylamine In acetone at 0 - 5℃; for 1h;	90%
With triethylamine In dichloromethane

: 35613-44-6
2-aminophenylacetic acid methyl ester

: 7148-74-5
2-Bromopropionyl chloride

: methyl 2-(2-(2-bromopropionamido)phenyl)acetate

Conditions

Conditions	Yield
With sodium carbonate In tetrahydrofuran at -78℃; for 1.5h;	90%

: 92-52-4
biphenyl

: 7148-74-5
2-Bromopropionyl chloride

: 73932-64-6
1-(4-biphenylyl)-2-bromo-1-propanone

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide for 1h; Ambient temperature;	89%

: 7148-74-5
2-Bromopropionyl chloride

: 50892-62-1
8-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

: 98374-57-3
5-(2-Bromo-propionyl)-8-chloro-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one

Conditions

Conditions	Yield
In toluene for 7h; Heating;	89%

: 7148-74-5
2-Bromopropionyl chloride

: 71-43-2
benzene

: 2114-00-3
2-bromo-1-phenyl-1-propanone

Conditions

Conditions	Yield
With aluminium trichloride In 1,1,2,2-tetrachloroethylene at 50℃; for 4h;	89%

: 7148-74-5
2-Bromopropionyl chloride

: 599-04-2
(R)-Pantolacton

: 690271-97-7
2-Bromo-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -20℃; for 0.333333h;	89%

: 5466-88-6
3,4-dihydro-3-oxo-2H-1,4-benzoxazine

: 7148-74-5
2-Bromopropionyl chloride

: 58819-99-1
6-(2-bromopropanoyl)-2H-1,4-benzoxazin-3(4H)-one

Conditions

Conditions	Yield
With aluminum (III) chloride In 1,2-dichloro-ethane at 20℃; for 12h;	89%

: 13726-14-2
4-chloro-m-anisidine

: 7148-74-5
2-Bromopropionyl chloride

: 2-bromo-N-(4-chloro-3-methoxyphenyl)propanamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 0 - 20℃; Inert atmosphere;	89%

: 5123-98-8
5-amino-3-isopropyl-[1,2,3]oxadiazolium; chloride

: 7148-74-5
2-Bromopropionyl chloride

: C8H12BrN3O2

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -30℃;	89%

: 2-(nitromethylene)thiazolidine

: 7148-74-5
2-Bromopropionyl chloride

: N-(2-bromopropionyl)-2-nitromethylenethiazolidine

Conditions

Conditions	Yield
With piperidine In chloroform at 20 - 30℃; for 1.5h;	88.9%

2-Bromopropionyl chloride Specification

The 2-Bromopropionyl chloride, with the CAS registry number 7148-74-5, is also known as α-Bromopropanoyl chloride. It belongs to the product categories of Aromatic Propionic Acids; Acid Halides; Carbonyl Compounds; Organic Building Blocks. Its EINECS number is 230-466-2. This chemical's molecular formula is C₃H₄BrClO and molecular weight is 171.42. What's more, its systematic name is 2-Bromopropanoyl chloride. This chemical should be sealed and stored in a cool and dry place.

Physical properties of 2-Bromopropionyl chloride are: (1)ACD/LogP: 1.109; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.11; (4)ACD/LogD (pH 7.4): 1.11; (5)ACD/BCF (pH 5.5): 4.10; (6)ACD/BCF (pH 7.4): 4.10; (7)ACD/KOC (pH 5.5): 95.61; (8)ACD/KOC (pH 7.4): 95.61; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 17.07 Å²; (13)Index of Refraction: 1.481; (14)Molar Refractivity: 28.517 cm³; (15)Molar Volume: 100.119 cm³; (16)Polarizability: 11.305×10^-24cm³; (17)Surface Tension: 35.6 dyne/cm; (18)Density: 1.712 g/cm³; (19)Flash Point: 34.756 °C; (20)Enthalpy of Vaporization: 37.135 kJ/mol; (21)Boiling Point: 133.858 °C at 760 mmHg; (22)Vapour Pressure: 8.3 mmHg at 25°C.

Preparation of 2-Bromopropionyl chloride: this chemical can be prepared by alpha-Bromopropanoic acid at the ambient temperature. This reaction will need reagents oxalyl chloride, DMF and solvent benzene. The yield is about 63%.

2-Bromopropionyl chloride can be prepared by alpha-Bromopropanoic acid at the ambient temperature

Uses of 2-Bromopropionyl chloride: it can be used to produce 2-(alpha-Bromopropionyl)aminobenzamide at the ambient temperature. It will need regent pyridine and solvent CH₂Cl₂ with the reaction time of 24 hours. The yield is about 79%.

2-Bromopropionyl chloride can be used to produce 2-(alpha-Bromopropionyl)aminobenzamide at the ambient temperature

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable, so you should keep it away from sources of ignition - No smoking. It can cause burns and is irritating to eyes and respiratory system. You should avoid contact with eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. You must take off immediately all contaminated clothing. When using it, you need wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, you need to seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: BrC(C(Cl)=O)C
(2)Std. InChI: InChI=1S/C3H4BrClO/c1-2(4)3(5)6/h2H,1H3
(3)Std. InChIKey: OZGMODDEIHYPRY-UHFFFAOYSA-N

Product Name

2-Bromopropionyl chloride

Synthetic route

2-Bromopropionyl chloride Specification

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