Conditions | Yield |
---|---|
With sulfonic group functionalized polyacrylonitrile preoxidated nanofiber mat In cyclohexane at 150℃; for 2h; Dean-Stark; | 99.6% |
With phosphorus modified SO4(2-)/TiO2 In cyclohexane for 2h; Dean-Stark; Reflux; | 99% |
With polyacrylonitrile hybrid fiber mat supported solid acid catalyst In cyclohexane Reflux; | 97.85% |
chloroacetaldehyde dimethyl acetal
ethylene glycol
2-chloromethyl-1,3-dioxolane
Conditions | Yield |
---|---|
Substitution; | 94% |
With Dowex 50(H+) at 120℃; for 1h; | 93% |
With sulfuric acid |
Conditions | Yield |
---|---|
With 1,4-dioxane; platinum Hydrogenation; |
1,2-dichloro-1-(2-chloro-ethoxy)-ethane
ethylene glycol
2-chloromethyl-1,3-dioxolane
Conditions | Yield |
---|---|
Unter vermindertem Druck; | |
With cation exchanger Unter vermindertem Druck; |
ethylene glycol
chloroacetaldehyde diethyl acetal
2-chloromethyl-1,3-dioxolane
Conditions | Yield |
---|---|
With hydrogenchloride | |
With sulfuric acid |
Conditions | Yield |
---|---|
With sodium carbonate In ethylene glycol |
Conditions | Yield |
---|---|
Stage #1: benzoimidazole With potassium hydroxide In dimethyl sulfoxide at 50℃; for 2h; Schlenk technique; Inert atmosphere; Stage #2: 2-chloromethyl-1,3-dioxolane In dimethyl sulfoxide at 80℃; for 72h; Schlenk technique; Inert atmosphere; | 94% |
With potassium hydroxide In dimethyl sulfoxide |
Conditions | Yield |
---|---|
Stage #1: theophylline With tetrabutyl-ammonium chloride; sodium hydroxide In acetone for 0.333333h; Industrial scale; Stage #2: 2-chloromethyl-1,3-dioxolane In acetone for 6h; Reagent/catalyst; Solvent; Industrial scale; | 90% |
2-chloromethyl-1,3-dioxolane
acetic anhydride
2,5-diacetoxy-1-chloro-3-oxapentane
Conditions | Yield |
---|---|
With zinc(II) chloride In acetic acid 1.)20 deg C, 2 h 2.)overnight; | 87% |
Conditions | Yield |
---|---|
With potassium tert-butylate; Aliquat 336 In tetrahydrofuran at 20℃; Dehydrochlorination; Heating; | 85% |
With potassium tert-butylate In tetrahydrofuran at 90℃; for 5h; Inert atmosphere; | 24% |
With potassium tert-butylate; tert-butyl alcohol |
2-chloromethyl-1,3-dioxolane
methyl phosphonous acid O,O-dipropyl ester
Conditions | Yield |
---|---|
at 120℃; for 9h; Inert atmosphere; | 84.6% |
2-chloromethyl-1,3-dioxolane
2-aminopyridine
acetonitrile
imidazo[1,2-α]pyridin-3-yl-acetic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: 2-chloromethyl-1,3-dioxolane; 2-aminopyridine With triethylamine In tetrahydrofuran Reflux; Stage #2: acetonitrile In tetrahydrofuran | 82.9% |
2-chloromethyl-1,3-dioxolane
methyl phosphonous acid O,O-dibutyl ester
Conditions | Yield |
---|---|
In acetonitrile at 80℃; for 12h; Inert atmosphere; | 78.8% |
2-chloromethyl-1,3-dioxolane
diphenylphosphane
(diphenylphosphino)acetaldehyde ethylene acetal
Conditions | Yield |
---|---|
With n-butyllithium In diethyl ether; hexane 1.) 1.5 h, -30 deg C 2.) 15 h, -30 - 20 deg C; | 76% |
Conditions | Yield |
---|---|
With bismuth(lll) trifluoromethanesulfonate In acetonitrile at 80℃; for 6h; | 75% |
Conditions | Yield |
---|---|
With bismuth(III) chloride In acetonitrile at 80℃; for 3h; | 72% |
2-chloromethyl-1,3-dioxolane
Conditions | Yield |
---|---|
In toluene at 110℃; for 4h; Arbuzov Reaction; | 62.8% |
2-chloromethyl-1,3-dioxolane
sodium acetate
2-acetoxymethyl-[1,3]dioxolane
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 48h; Heating; | 45% |
2-chloromethyl-1,3-dioxolane
thiophenol
dioxolanne de l'α-phenylthioacetaldehyde
Conditions | Yield |
---|---|
With triethylamine In diethyl ether at 20℃; for 168h; | 43% |
Conditions | Yield |
---|---|
With n-butyllithium In diethyl ether; hexane 1.) 1.5 h, -30 deg C 2.) 15 h, -30 - 20 deg C; | 40% |
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 50℃; | 30% |
2-chloromethyl-1,3-dioxolane
hetacillin
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 5h; 1.9 0-5 deg C, 5 h, 2.) RT; | 15% |
piperidine
2-chloromethyl-1,3-dioxolane
1-((1,3-dioxolan-2-yl)methyl)piperidine
Conditions | Yield |
---|---|
With ethanol |
Conditions | Yield |
---|---|
With ethanol; sodium ethanolate at 180℃; |
Conditions | Yield |
---|---|
With hydrogenchloride; acetone |
Conditions | Yield |
---|---|
With potassium hydroxide at 160℃; |
2-chloromethyl-1,3-dioxolane
chloroacetic acid ethylene glycol
Conditions | Yield |
---|---|
With ozone In tetrachloromethane at 0℃; Rate constant; |
2-chloromethyl-1,3-dioxolane
A
C4H6ClO2
B
2-methylene-1,3-dioxolane radical cation
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate; acetone In water at 3℃; Product distribution; Irradiation; |
2-chloromethyl-1,3-dioxolane
A
ethylene glycol
B
2-(2-Chloroethoxy)ethanol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; boron trichloride 1.) CH2Cl2, 0.2 h, 2.) Et2O, 30 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; boron trichloride 1.) CH2Cl2, 0.2 h, 2.) Et2O, 30 min; Yield given. Multistep reaction; |
The Molecular Structure of 1,3-Dioxolane,2-(chloromethyl)- (CAS NO.2568-30-1):
Empirical Formula: C4H7ClO2
Molecular Weight: 122.5502
IUPAC Name: 2-(chloromethyl)-1,3-dioxolane
Product Categories: Dioxanes & Dioxolanes;Dioxolanes
Nominal Mass: 122 Da
Average Mass: 122.5502 Da
Monoisotopic Mass: 122.013457 Da
Index of Refraction: 1.428
Molar Refractivity: 26.58 cm3
Molar Volume: 103.2 cm3
Surface Tension: 35.5 dyne/cm
Density: 1.186 g/cm3
Flash Point: 60 °C
Enthalpy of Vaporization: 37.57 kJ/mol
Boiling Point: 155.1 °C at 760 mmHg
Vapour Pressure: 3.97 mmHg at 25°C
InChI
InChI=1/C4H7ClO2/c5-3-4-6-1-2-7-4/h4H,1-3H2
Smiles
O1CCOC1CCl
Safety Statements: 23-24/25
S23: Do not breathe vapour
S24/25: Avoid contact with skin and eyes
RIDADR: 1993
WGK Germany :3
F: 10-21
F10: Keep under argon
F21: Sensitive to humidity
HazardClass: 3.2
PackingGroup: III
1,3-Dioxolane,2-(chloromethyl)- (CAS NO.2568-30-1) is also called as 2-(Chloromethyl)-1,3-dioxolane ; 2-(Chloromethyl)-m-dioxane ; AI3-08042 ; Chloroacetaldehyde ethylene acetal ; EINECS 219-908-5 ; NSC 319115 .
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