diisopropylamine
2-chloro-ethanol
1-chloro-2-diisopropylaminoethane hydrochloride
Conditions | Yield |
---|---|
Stage #1: diisopropylamine; 2-chloro-ethanol for 5h; Reflux; Stage #2: With thionyl chloride at 20℃; for 12h; | 38% |
Conditions | Yield |
---|---|
With thionyl chloride; chloroform | |
With thionyl chloride; benzene | |
With thionyl chloride Chlorination; Vogel method; | |
With thionyl chloride In chloroform Reflux; Cooling with ice; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 200 °C 2: benzene; SOCl2 View Scheme |
B
1-chloro-2-diisopropylaminoethane hydrochloride
B
1-chloro-2-diisopropylaminoethane hydrochloride
Conditions | Yield |
---|---|
In ethanol for 48h; Reflux; | 99% |
With sodium carbonate In acetonitrile for 24h; Reflux; | 97% |
In ethanol for 12h; Heating; | 95% |
In ethanol for 48h; Reflux; | 89% |
With sodium carbonate In acetonitrile for 24h; Inert atmosphere; Reflux; | 87% |
1-chloro-2-diisopropylaminoethane hydrochloride
1-t-Butoxycarbonylpiperazine
Conditions | Yield |
---|---|
With potassium carbonate In water; acetone at 20℃; for 4h; | 99% |
2,6-dibromo-4-iodophenol
1-chloro-2-diisopropylaminoethane hydrochloride
[2-(2,6-dibromo-4-iodo-phenoxy)-ethyl]-diisopropyl-amine
Conditions | Yield |
---|---|
With caesium carbonate; sodium iodide In acetonitrile at 65℃; for 12h; | 98% |
N,N-dimethyl-ethanamine
1-chloro-2-diisopropylaminoethane hydrochloride
1-(2-diisopropylaminoethyl)dimethylethylammonium chloride
Conditions | Yield |
---|---|
With sodium carbonate In acetonitrile for 24h; Reflux; | 98% |
7-hydroxy-2H-chromen-2-one
1-chloro-2-diisopropylaminoethane hydrochloride
7-[2-(N,N-diisopropylamino)ethoxy]chromen-2-one
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 35 - 40℃; for 0.1h; Microwave irradiation; | 97% |
piperazine
piperazine dihydrochloride
1-chloro-2-diisopropylaminoethane hydrochloride
Conditions | Yield |
---|---|
Stage #1: piperazine; piperazine dihydrochloride In water at 65℃; for 0.5h; Stage #2: 1-chloro-2-diisopropylaminoethane hydrochloride In water at 70℃; for 1h; Stage #3: With sodium hydroxide In water at 20℃; Product distribution / selectivity; | 96.5% |
methyl 7-isatincarboxylate
1-chloro-2-diisopropylaminoethane hydrochloride
Conditions | Yield |
---|---|
94.6% |
1-chloro-2-diisopropylaminoethane hydrochloride
3-benzyloxy-1-(2-diisopropylaminoethyl)-5-nitro-1H-indazole hydrochloride
Conditions | Yield |
---|---|
Stage #1: 1-chloro-2-diisopropylaminoethane hydrochloride; 3-Benzyloxy-5-nitro-1H-indazole With potassium carbonate In butanone for 24h; Reflux; Stage #2: With hydrogenchloride In water | 94% |
1-chloro-2-diisopropylaminoethane hydrochloride
Conditions | Yield |
---|---|
In isopropyl alcohol at 53 - 55℃; for 3h; | 91.6% |
1,3,4-thiadiazolidine-2,5-dithione
1-chloro-2-diisopropylaminoethane hydrochloride
{2-[5-(2-Diisopropylamino-ethylsulfanyl)-[1,3,4]thiadiazol-2-ylsulfanyl]-ethyl}-diisopropyl-amine
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol for 8h; Heating; | 91% |
Conditions | Yield |
---|---|
Stage #1: piperazine With hydrogenchloride In water for 0.5h; Stage #2: 1-chloro-2-diisopropylaminoethane hydrochloride In water at 70℃; for 1h; Stage #3: With sodium hydroxide In water at 20℃; Product distribution / selectivity; | 90.9% |
7-chloro-8-hydroxybenzo[4,5]furo[3,2-g]quinoline-5,11-dione
1-chloro-2-diisopropylaminoethane hydrochloride
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In chloroform; water Heating; | 89.2% |
1-chloro-2-diisopropylaminoethane hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 5h; Reflux; | 89.2% |
2-(N,N-dimethylamino)ethanol
1-chloro-2-diisopropylaminoethane hydrochloride
(5-diisopropylamino-3-oxapentyl)dimethylamine
Conditions | Yield |
---|---|
Stage #1: 2-(N,N-dimethylamino)ethanol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 1-chloro-2-diisopropylaminoethane hydrochloride In tetrahydrofuran; mineral oil at 0℃; for 4h; Reflux; Inert atmosphere; Stage #3: With water In tetrahydrofuran; mineral oil at 0℃; | 89% |
1-chloro-2-diisopropylaminoethane hydrochloride
N-(2-azidoethyl)-N-isopropylpropan-2-amine
Conditions | Yield |
---|---|
With sodium azide In water at 80℃; | 87% |
With sodium azide In water at 75℃; for 15h; |
5-methoxy-2-(3-phenylisoxazol-5-yl)phenol
1-chloro-2-diisopropylaminoethane hydrochloride
N-isopropyl-N-(2-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)ethyl)propan-2-amine
Conditions | Yield |
---|---|
With potassium carbonate In acetone Williamson type O-alkylation; Reflux; | 86.4% |
Conditions | Yield |
---|---|
86.2% |
1-chloro-2-diisopropylaminoethane hydrochloride
potassium thiotosylate
β-(Diisopropylamino)ethyl p-toluenethiosulfonate
Conditions | Yield |
---|---|
With Adogen-464; potassium tert-butylate In various solvent(s) for 15h; Ambient temperature; | 86% |
3-hydroxybenzo[b]naphtho[2,3-d]furane-6,11-dione
1-chloro-2-diisopropylaminoethane hydrochloride
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In chloroform; water Heating; | 84.3% |
10H-phenothiazine
1-chloro-2-diisopropylaminoethane hydrochloride
10-(2-diisopropylaminoethyl)phenothiazine
Conditions | Yield |
---|---|
With potassium hydroxide; Aliquat 336 at 80℃; for 1h; | 84% |
Conditions | Yield |
---|---|
82.9% |
5-methyl-indole-2,3-dione
1-chloro-2-diisopropylaminoethane hydrochloride
1-(2-diisopropylaminoethyl)-5-methylisatin
Conditions | Yield |
---|---|
82% |
3-(4-methoxybenzyloxy)-5-nitro-1H-indazole
1-chloro-2-diisopropylaminoethane hydrochloride
1-(2-diisopropylaminoethyl)-3-(4-methoxybenzyloxy)-5-nitroindazole
Conditions | Yield |
---|---|
With potassium carbonate In butanone for 6h; Reflux; | 82% |
1,2-dimethyl-1H-imidazole
1-chloro-2-diisopropylaminoethane hydrochloride
C13H26N3(1+)*ClH*Cl(1-)
Conditions | Yield |
---|---|
In acetonitrile for 120h; Inert atmosphere; Reflux; | 80% |
2-chlorophenothiazine
1-chloro-2-diisopropylaminoethane hydrochloride
2-chloro-10-(2-diisopropylaminoethyl)phenothiazine
Conditions | Yield |
---|---|
With potassium hydroxide; Aliquat 336 at 80℃; for 1h; | 79% |
2-methoxy-4-nitrophenol
1-chloro-2-diisopropylaminoethane hydrochloride
N,N-diisopropyl-N-[2-(2-methoxy-4-nitrophenoxy)ethyl]amine
Conditions | Yield |
---|---|
With potassium carbonate In 1,2-dimethoxyethane at 20℃; | 79% |
With potassium carbonate In acetone | |
With potassium carbonate In acetone at 20℃; for 18h; |
1-chloro-2-diisopropylaminoethane hydrochloride
2-(4-methoxy-benzenesulfonyl)-3-phenyl-propionic acid ethyl ester
Conditions | Yield |
---|---|
79% | |
79% |
4-((1-benzyl-1H-pyrrol-2-yl)(4-methoxyphenyl)methyl)phenol
1-chloro-2-diisopropylaminoethane hydrochloride
N-(2-(4-((1-benzyl-1H-pyrrol-2-yl)(4-methoxyphenyl)methyl)phenoxy)ethyl)-N-isopropylpropan-2-amine
Conditions | Yield |
---|---|
With potassium carbonate In acetone Reflux; | 79% |
7-hydroxy-4-methyl-chromen-2-one
1-chloro-2-diisopropylaminoethane hydrochloride
7-[2-(N,N-diisopropylamino)ethoxy]-4-methylchromen-2-one
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 35 - 45℃; for 0.35h; Microwave irradiation; | 79% |
1-chloro-2-diisopropylaminoethane hydrochloride
1,3-dihydroxybenzo[b]naphtho[2,3-d]furan-6,11-dione
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In chloroform; water at 20℃; Reflux; | 78% |
With potassium carbonate In chloroform for 6h; Heating; | 59% |
Chemical Name: 2-Diisopropylaminoethyl chloride hydrochloride
IUPAC NAME: N-(2-chloroethyl)-N-propan-2-ylpropan-2-amine hydrochloride
CAS No.: 4261-68-1
EINECS: 224-238-1
RTECS: TX1521900
RTECS Class: Primary Irritant
Molecular Formula: C8H19Cl2N
Molecular Weight: 200.15 g/mol
Melting Point: 129-132 °C(lit.)
The white to yellow crystalline powder is hygroscopic,soluble in water,and the solubility is equal to 0.1 g/mL,the structure of 2-CHLOROETHYLDIISOPROPYLAMINE HYDROCHLORIDE(4261-68-1) as follows:
The chemical synonymous of are (beta-chloroethyl)diisopropylaminehydrochloride;2’’-chloro-1,1’-dimethyl-triethylaminhydrochloride;n-(2-chloroethyl)-n-(1-methylethyl)-2-propanaminehydrochloride;n-(2-chloroethyl)-n-(1-methylethyl)-2-propanaminhydrochloride;n-(chloroethyl)diisopropylaminehydrochloride;N-(2-CHLOROETHYL)DIISOPROPYLAMINE HYDROCHLORIDE;2-DIISOPROPYLAMINOETHYL CHLORIDE HYDROCHLORIDE;2-CHLOROETHYL(DIISOPROPYL)AMINE HYDROCHLORIDE
2-CHLOROETHYLDIISOPROPYLAMINE HYDROCHLORIDE(4261-68-1) is used for the synthesis of pharmaceutical intermediates.
1. | skn-rbt 500 mg/24H SEV | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0539176 . | ||
2. | eye-rbt 100 mg SEV | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0539176 . | ||
3. | orl-rat LD50:96,750 µg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0539176 . | ||
4. | ihl-rat LC50:12 mg/m3/4H | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0539177 . | ||
5. | skn-rbt LD50:197 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0539176 . |
A poison by is, inhalation, and skin contact. A severe skin and eye irritant. When heated to decomposition it emits toxic vapors of NOx, HCl, and Cl−.
Hazard Codes:
T: Toxic
C: Corrosive
T+: Very toxic
Risk Statements about 2-CHLOROETHYLDIISOPROPYLAMINE HYDROCHLORIDE(4261-68-1):
R26 Very toxic by inhalation.
R34 Causes burns.
R24/25 Toxic in contact with skin and if swallowed.
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
R36/37/38 Irritating to eyes, respiratory system and skin.
Safety Statements about 2-CHLOROETHYLDIISOPROPYLAMINE HYDROCHLORIDE(4261-68-1):
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S38 In case of insufficient ventilation, wear suitable respiratory equipment.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
S28A After contact with skin, wash immediately with plenty of water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
1. Storage: Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.
2. Handling: Wash thoroughly after handling. Use with adequate ventilation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
3. Personal Protection: Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
4. Fire Fighting: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes. Extinguishing media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
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