2-Fluoro-4-iodoaniline supplier

Name
2-Fluoro-4-iodoaniline
EINECS
CAS No. 29632-74-4
Article Data8
CAS DataBase
Density 2.008 g/cm³
Solubility insoluble in water
Melting Point 55-57 °C(lit.)
Formula C₆H₅FIN
Boiling Point 248.6 °C at 760 mmHg
Molecular Weight 237.015
Flash Point 104.2 °C
Transport Information
Appearance off-white to brown powder
Safety 26-36-37/39-26/37/39
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn, T, Xi
Synonyms 2-fluoro-4-iodin anline;
PSA 26.02000
LogP 2.59370

Synthetic route

: 348-54-9
2-Fluoroaniline

: 29632-74-4
2-fluro-4-iodoaniline

Conditions

Conditions	Yield
With iodine; sodium hydrogencarbonate In water at 60 - 80℃; for 2h;	77%
With iodine; sodium hydrogencarbonate In water at 60℃; for 3h;	76%
Stage #1: 2-Fluoroaniline With n-butyllithium In diethyl ether; hexane at -78℃; for 1h; Stage #2: With poly[4-(dibutyliodostannyl)butyl]styrene In diethyl ether; hexane at 20℃; for 18h; Stage #3: With Iodine monochloride In diethyl ether; hexane at -78 - 20℃;	67%

: 29632-74-4
2-fluro-4-iodoaniline

: 1066-54-2
trimethylsilylacetylene

: 518342-58-0
2-fluoro-4-((trimethylsilyl)ethynyl)aniline

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 21h; Sonogashira Cross-Coupling; Inert atmosphere;	100%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; Inert atmosphere;	100%
With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide at 20℃; for 15h; Sonogashira Coupling;	88%

: 867130-26-5
4-chloro-1-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid

: 29632-74-4
2-fluro-4-iodoaniline

: 934664-24-1
4-(2-fluoro-4-iodophenylamino)-1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 4-chloro-1-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid; 2-fluro-4-iodoaniline With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 4h; Stage #2: With hydrogenchloride In tetrahydrofuran; water Product distribution / selectivity;	100%
Stage #1: 4-chloro-1-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid; 2-fluro-4-iodoaniline With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 4.08333h; Stage #2: With hydrogenchloride In tetrahydrofuran; water Product distribution / selectivity;	100%
Stage #1: 4-chloro-1-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid; 2-fluro-4-iodoaniline With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 4.08333h; Stage #2: With hydrogenchloride In tetrahydrofuran; water Product distribution / selectivity;	100%

: 463-71-8
thiophosgene

: 29632-74-4
2-fluro-4-iodoaniline

: 945530-32-5
2-fluoro-4-iodo-1-isothiocyanatobenzene

Conditions

Conditions	Yield
In chloroform; water at 20℃; for 16h;	100%
In chloroform; water at 20℃; for 16h;	100%
In dichloromethane; water at 20℃;	96.8%

: 50-00-0
formaldehyd

: 29632-74-4
2-fluro-4-iodoaniline

: 791112-16-8
N-(4-iodo-2-fluorophenyl)formamide

Conditions

Conditions	Yield
With acetic anhydride In tetrahydrofuran; toluene at 20℃;	100%

: 29632-74-4
2-fluro-4-iodoaniline

: 140-90-9
sodium O-ethyl dithiocarbonate

: 54420-94-9
6-iodobenzo[d]thiazole-2-thiol

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 95℃; for 5h;	100%

: 29632-74-4
2-fluro-4-iodoaniline

: 61079-72-9
2,3,4,-trifluorobenzoic acid

: 391211-97-5
3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid

Conditions

Conditions	Yield
With lithium amide In tetrahydrofuran	99%
With lithium amide In N,N-dimethyl-formamide Inert atmosphere;	85%
With lithium amide In tetrahydrofuran at 45 - 55℃; for 1.25 - 2.5h; Product distribution / selectivity;	80%

: 29632-74-4
2-fluro-4-iodoaniline

: 945559-14-8
1-azido-2-fluoro-4-iodobenzene

Conditions

Conditions	Yield
Stage #1: 2-fluro-4-iodoaniline With trifluoroacetic acid; sodium nitrite at 0℃; for 0.5h; Stage #2: With sodium azide In water at 0℃; for 1h;	99%
Stage #1: 2-fluro-4-iodoaniline With hydrogenchloride; sodium nitrite In water at -5℃; for 0.5h; Stage #2: With sodium azide In water at -5℃; for 1h;	97%

: 910209-21-1
sodium cyclopropylsulfinate

: 29632-74-4
2-fluro-4-iodoaniline

: 1147558-09-5
C9H10FNO2S

Conditions

Conditions	Yield
With N,N`-dimethylethylenediamine; copper (I) trifluoromethane sulfonate benzene In dimethyl sulfoxide at 120℃; for 16h;	99%
copper(I) trifluoromethanesulfonate benzene complex; N,N`-dimethylethylenediamine In dimethyl sulfoxide at 120℃; for 16h;	99%
With N,N`-dimethylethylenediamine; copper(I) trifluoromethanesulfonate benzene In dimethyl sulfoxide at 120℃; for 16h;	99%

: 29632-74-4
2-fluro-4-iodoaniline

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1061683-60-0
N-(2-fluoro-4-iodophenyl)cyclopropanecarboxamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃;	99%

: 29632-74-4
2-fluro-4-iodoaniline

: 530-62-1
1,1'-carbonyldiimidazole

: 871700-48-0
1-(2-fluoro-4-iodophenyl)urea

Conditions

Conditions	Yield
Stage #1: 2-fluro-4-iodoaniline; 1,1'-carbonyldiimidazole With triethylamine In chloroform at 0 - 20℃; for 4.25h; Stage #2: With ammonia In chloroform; water at 0 - 20℃; for 1.5h;	98.8%
With triethylamine In chloroform at 0 - 30℃; for 4h; Inert atmosphere;
With triethylamine In chloroform at 0 - 20℃; for 4.25h;

: 29632-74-4
2-fluro-4-iodoaniline

: 110-13-4
2,5-hexanedione

: 217314-30-2
1-(2-fluoro-4-iodophenyl)-2,5-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
toluene-4-sulfonic acid In toluene for 1h; Heating / reflux;	98%
With toluene-4-sulfonic acid In toluene at 110℃; for 1h;	49%
With p-toluenesulfonic acid monohydrate In toluene at 110℃; for 1h; Dean-Stark;	67.5 g

: 29632-74-4
2-fluro-4-iodoaniline

: 124-63-0
methanesulfonyl chloride

: 143937-74-0
2-fluoro-4-iodo-1-methanesulfonylaminobenzene

Conditions

Conditions	Yield
With pyridine at 20℃; for 2h;	98%
In pyridine at 20℃; for 2h;	98%
With pyridine at 20℃; for 2h;	95%

: 29632-74-4
2-fluro-4-iodoaniline

: 2-fluoro-4-iodobenzenediazonium tetrafluoroborate

Conditions

Conditions	Yield
With tert.-butylnitrite; boron trifluoride diethyl etherate In tetrahydrofuran; diethyl ether at -10 - 0℃;	98%

: 29632-74-4
2-fluro-4-iodoaniline

: C14H9F3O2

: C20H13F3INO2

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 60℃; for 6h;	97.6%

: 64-18-6
formic acid

: 29632-74-4
2-fluro-4-iodoaniline

: 791112-16-8
N-(4-iodo-2-fluorophenyl)formamide

Conditions

Conditions	Yield
Stage #1: formic acid; 2-fluro-4-iodoaniline With acetic anhydride In tetrahydrofuran; toluene at 20℃; Stage #2: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate; toluene	97%

: 52449-98-6
tetrahydrofuran-2-carbonyl chloride

: 29632-74-4
2-fluro-4-iodoaniline

: 641612-64-8
tetrahydro-furan-2-carboxylic acid (2-fluoro-4-iodophenyl)amide

Conditions

Conditions	Yield
With dmap In dichloromethane at 20℃; for 18h;	96%
With dmap In dichloromethane

: 29632-74-4
2-fluro-4-iodoaniline

: 536-74-3
phenylacetylene

: 1241745-70-9
2-fluoro-4-phenylethynyl-phenylamine

Conditions

Conditions	Yield
With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride In acetonitrile at 20℃; for 18h; Inert atmosphere;	95%

: 29632-74-4
2-fluro-4-iodoaniline

: 75264-92-5
tetramethylammonium trifluoromethylselenate(0)

: 15946-31-3
1-amino-2-fluoro-4-[(trifluoromethyl)seleno]benzene

Conditions

Conditions	Yield
With palladium(l) tri-tert-butylphosphine iodide dimer In toluene at 40℃; for 24h; Glovebox; Inert atmosphere;	95%

: 109-11-5
morpholine-3-one

: 29632-74-4
2-fluro-4-iodoaniline

: 742073-22-9
4-(4-amino-3-fluoro-phenyl)-morpholin-3-one

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In toluene at 160℃; under 4500.45 - 5250.53 Torr; for 2h; Ullmann-Goldberg Substitution; Microwave irradiation;	94%
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In 1,4-dioxane Reflux; Inert atmosphere;	74%
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In 1,4-dioxane Reflux; Inert atmosphere;	74%
With potassium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide In toluene at 140℃; for 2h; microwave;	33%
With copper(l) iodide; N,N`-dimethylethylenediamine In 1,4-dioxane at 120℃; for 16h;

: 29632-74-4
2-fluro-4-iodoaniline

: 393-53-3
3-fluoroisonicotinic acid

: 885588-03-4
3-((2-fluoro-4-iodophenyl)amino)isonicotinic acid

Conditions

Conditions	Yield
Stage #1: 2-fluro-4-iodoaniline With lithium hexamethyldisilazane In tetrahydrofuran at -55℃; Inert atmosphere; Stage #2: 3-fluoroisonicotinic acid In tetrahydrofuran at 20℃; for 96h; Stage #3: With hydrogenchloride In water pH=2;	94%
Stage #1: 2-fluro-4-iodoaniline; 3-fluoroisonicotinic acid With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 20℃; Stage #2: With ammonium chloride In tetrahydrofuran for 1h; Product distribution / selectivity;	33%
Stage #1: 2-fluro-4-iodoaniline With lithium hexamethyldisilazane In tetrahydrofuran at -67 - -59℃; for 2.5h; Inert atmosphere; Stage #2: 3-fluoroisonicotinic acid In tetrahydrofuran for 96h;

: 848852-32-4
2,3,4-trifluoro-5-vinylbenzoic acid

: 29632-74-4
2-fluro-4-iodoaniline

: 848852-33-5
3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-5-vinylbenzoic acid

Conditions

Conditions	Yield
With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 20℃;	94%
With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 20℃; for 5.75h; Inert atmosphere;	94%
With lithium diisopropyl amide In tetrahydrofuran at -78 - 20℃;	35%

: 5963-77-9
pent-2-ynoic acid

: 29632-74-4
2-fluro-4-iodoaniline

: 1276538-16-9
4-(4-ethyl-1H-1,2,3-triazol-1-yl)-2-fluoroaniline

Conditions

Conditions	Yield
With sodium azide; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; potassium carbonate; L-proline In water; dimethyl sulfoxide at 65℃;	94%

: 29632-74-4
2-fluro-4-iodoaniline

: 693-13-0
diisopropyl-carbodiimide

: 1436412-58-6
2-(2-fluoro-4-iodophenyl)-1,3-diisopropylguanidine

Conditions

Conditions	Yield
at 130℃; for 15h; Inert atmosphere;	94%
With dichloro bis(acetonitrile) palladium(II) In toluene at 130℃; under 1500.15 Torr; for 16h; Inert atmosphere;	72%

: 288-13-1
NH-pyrazole

: 29632-74-4
2-fluro-4-iodoaniline

: 1147557-79-6
2-fluoro-4-(1H-pyrazol-1-yl)aniline

Conditions

Conditions	Yield
With copper(l) iodide; 8-quinolinol; potassium carbonate In dimethylsulfoxide-d6 at 120℃; for 16h; Inert atmosphere;	94%
With copper(l) iodide; caesium carbonate; trans-1,2-cyclohexanediamine In 1,2-dimethoxyethane at 25 - 86℃; for 72.3333h; Inert atmosphere;	650 g

: 29632-74-4
2-fluro-4-iodoaniline

: 7486-35-3
tri-n-butyl(vinyl)tin

: 2-fluoro-4-vinylaniline

Conditions

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol; tetrakis(triphenylphosphine) palladium(0) In toluene at 100℃; for 1h;	93%
tetrakis(triphenylphosphine) palladium(0); 2,6-di-tert-butyl-4-methyl-phenol In toluene at 100℃; for 1h;	93%

: 1227054-00-3
(R)-5-chloro-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-8-methylpyrido[2,3-d]pyrimidine-4,7-(3H,8H)-dione

: 29632-74-4
2-fluro-4-iodoaniline

: 1227054-01-4
(R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido-[2,3-d]pyrimidine-4,7(3H,8H)-dione

Conditions

Conditions	Yield
With lithium hexamethyldisilazane In tetrahydrofuran at -5 - 20℃; Large scale;	93%
With 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate; palladium diacetate In 1,4-dioxane at 85℃; for 2h; Product distribution / selectivity; De-gassed solvent;

: 29632-74-4
2-fluro-4-iodoaniline

: 530-62-1
1,1'-carbonyldiimidazole

: 74-89-5
methylamine

: 871700-37-7
N-(2-fluoro-4-iodophenyl)-N'-methylurea

Conditions

Conditions	Yield
Stage #1: 2-fluro-4-iodoaniline; 1,1'-carbonyldiimidazole With triethylamine In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere; Stage #2: methylamine In water; N,N-dimethyl-formamide at 0 - 20℃;	93%
Stage #1: 2-fluro-4-iodoaniline; 1,1'-carbonyldiimidazole With triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 16h; Inert atmosphere; Stage #2: methylamine In water; N,N-dimethyl-formamide at 0 - 20℃; for 1h;	93%
Stage #1: 2-fluro-4-iodoaniline; 1,1'-carbonyldiimidazole With triethylamine In N,N-dimethyl-formamide at 0 - 20℃; Stage #2: methylamine In methanol; N,N-dimethyl-formamide at 0 - 20℃;	92%

...Expand

: 29632-74-4
2-fluro-4-iodoaniline

: 108-24-7
acetic anhydride

: 97760-94-6
N-(2-fluoro-4-iodo-phenyl)-acetamide

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 25℃; for 2.16667h;	92%
In tetrahydrofuran at 0 - 25℃; for 2.16667h;	92%
In tetrahydrofuran at 0 - 25℃; for 2.16667h;	92%

: 2637-34-5
pyridine-2-thione

: 29632-74-4
2-fluro-4-iodoaniline

: 2-fluoro-4-(pyridin-2-ylsulfanyl)-phenylamine

Conditions

Conditions	Yield
With 8-quinolinol; copper(l) iodide In dimethyl sulfoxide at 130℃;	92%

: 1003-56-1
3-Methyl-1H-pyridin-2-one

: 29632-74-4
2-fluro-4-iodoaniline

: 1-(4-amino-3-fluorophenyl)-3-methylpyridin-2(1H)-one

Conditions

Conditions	Yield
With copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate In tert-Amyl alcohol at 100℃; for 5h; Inert atmosphere; Glovebox;	92%
With 8-quinolinol; copper(l) iodide In dimethyl sulfoxide at 130℃;	78%

2-Fluoro-4-iodoaniline Chemical Properties

The Molecular formula of 2-Fluoro-4-iodoaniline(29632-74-4) : C₆H₅FIN
The Molecular Weight of 2-Fluoro-4-iodoaniline(29632-74-4) : 237.01
Molecular Structure :

Melting point: 55-57 °C(lit.)
Flash point: >230 °F
WATER Solubility: insoluble
Sensitive: Light Sensitive
Appearaance: light brown to brown Solid
Synonyms: 2-FLUORO-4-IODOBENZENAMINE;2-FLUORO-4-IODO-PHENYLAMINE;2-Fluoro-4-idioaniline;2-Fluoro-4-iodoaniline 98%;2-FLUORO-4-IODOANILINE;2-Fluoro-4-iodoaniline98%;

2-Fluoro-4-iodoaniline Safety Profile

The Hazard Codes of 2-Fluoro-4-iodoaniline(29632-74-4):

Xi,Xn ,

T
The Risk Statements information of 2-Fluoro-4-iodoaniline(29632-74-4):
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2-Fluoro-4-iodoaniline(29632-74-4):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR: PG3
WGK Germany: 3
Hazard Note: Toxic

Product Name

2-Fluoro-4-iodoaniline

Synthetic route

2-Fluoro-4-iodoaniline Chemical Properties

2-Fluoro-4-iodoaniline Safety Profile

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