Product Name

  • Name

    2-Hydroxyethyl salicylate

  • EINECS 201-737-2
  • CAS No. 87-28-5
  • Article Data22
  • CAS DataBase
  • Density 1.244g/cm3
  • Solubility
  • Melting Point 25°C
  • Formula C9 H10 O4
  • Boiling Point 294.3 °C at 760 mmHg
  • Molecular Weight 182.176
  • Flash Point 128.3 °C
  • Transport Information
  • Appearance Colorless oily liquid or low melting solid
  • Safety
    Hazard Codes Xn
    Risk Statements 22
    WGK Germany 3
  • Risk Codes R22
  • Molecular Structure Molecular Structure of 87-28-5 (2-Hydroxyethyl salicylate)
  • Hazard Symbols HarmfulXn
  • Synonyms Salicylic acid,2-hydroxyethyl ester (6CI,7CI,8CI);Ethylene glycol, monosalicylate (8CI);2-Hydroxyethyl 2-hydroxybenzoate;2-Hydroxyethyl salicylate;Espirosal;Ethylene glycol salicylate;GL 7;Glycol monosalicylate;Glycol salicylate;Glysal;Monoglycol salicylate;Norgesic;Rheumacyl;Saliment;Sarocol;Spirosal;b-Hydroxyethyl salicylate;
  • PSA 66.76000
  • LogP 0.54130

Synthetic route

2-methyl-benzyl alcohol
89-95-2

2-methyl-benzyl alcohol

ethylene glycol
107-21-1

ethylene glycol

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

Conditions
ConditionsYield
With aluminum oxide; methanesulfonic acid at 80℃; for 3h;84%
potassium salicylate
578-36-9

potassium salicylate

2-chloro-ethanol
107-07-3

2-chloro-ethanol

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

Conditions
ConditionsYield
triethylamine at 130 - 135℃; for 3.5h;83.5%
ethylene glycol
107-21-1

ethylene glycol

methyl salicylate
119-36-8

methyl salicylate

A

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

B

ethane-1,2-diyl bis(2-hydroxybenzoate)
20210-97-3

ethane-1,2-diyl bis(2-hydroxybenzoate)

Conditions
ConditionsYield
With sodium at 100 - 160℃; for 0.25h; Microwave irradiation;A 16%
B 22%
2-chloroethyl salicylate
64496-78-2

2-chloroethyl salicylate

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

Conditions
ConditionsYield
With water; sodium salicylate
With disodium hydrogenphosphate; water
With sodium acetate; acetic acid at 130℃; im Rohr;
sodium salicylate
54-21-7

sodium salicylate

ethylene glycol
107-21-1

ethylene glycol

ethylene dibromide
106-93-4

ethylene dibromide

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

Conditions
ConditionsYield
With water
ethylene glycol
107-21-1

ethylene glycol

salicylic acid
69-72-7

salicylic acid

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

Conditions
ConditionsYield
With sulfuric acid at 120℃; for 2.5h;
With sulfuric acid
With sulfuric acid
With dmap; dicyclohexyl-carbodiimide In acetonitrile at 0 - 20℃; for 6h;
sodium salicylate
54-21-7

sodium salicylate

1,2-dichloro-ethane
107-06-2

1,2-dichloro-ethane

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

Conditions
ConditionsYield
With water; salicylic acid
sodium salicylate
54-21-7

sodium salicylate

ethylene dibromide
106-93-4

ethylene dibromide

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

Conditions
ConditionsYield
With water; salicylic acid
sodium salicylate
54-21-7

sodium salicylate

2-chloro-ethanol
107-07-3

2-chloro-ethanol

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

Conditions
ConditionsYield
at 140 - 150℃;
With diethylamine at 130℃;
at 140 - 150℃;
sodium salicylate
54-21-7

sodium salicylate

2-chloro-ethanol
107-07-3

2-chloro-ethanol

A

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

B

ethane-1,2-diyl bis(2-hydroxybenzoate)
20210-97-3

ethane-1,2-diyl bis(2-hydroxybenzoate)

Conditions
ConditionsYield
With copper at 140℃;
phenyl Salicylate
118-55-8

phenyl Salicylate

ethylene glycol
107-21-1

ethylene glycol

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

Conditions
ConditionsYield
With sodium hydroxide; water In acetonitrile at 35℃; Rate constant; effect of H2O concentration; effect of Li+, urea;
sulfuric acid
7664-93-9

sulfuric acid

ethylene glycol
107-21-1

ethylene glycol

salicylic acid
69-72-7

salicylic acid

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

sodium salicylate
54-21-7

sodium salicylate

2-chloro-ethanol
107-07-3

2-chloro-ethanol

copper-powder

copper-powder

A

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

B

ethane-1,2-diyl bis(2-hydroxybenzoate)
20210-97-3

ethane-1,2-diyl bis(2-hydroxybenzoate)

Conditions
ConditionsYield
at 140℃;
dioxacarb
6988-21-2

dioxacarb

A

2-(1,3-dioxolan-2-yl)phenol
6988-19-8

2-(1,3-dioxolan-2-yl)phenol

B

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

C

salicylaldehyde
90-02-8

salicylaldehyde

Conditions
ConditionsYield
With dihydrogen peroxide; iron; sodium chloride In water at 25℃; Activation energy; Product distribution; Further Variations:; Temperatures; Electrolysis;
ethylene glycol
107-21-1

ethylene glycol

methyl salicylate
119-36-8

methyl salicylate

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

Conditions
ConditionsYield
With potassium carbonate; 2-Methoxybenzoic acid at 110℃; for 24h;
hexafluoropropene-diethylamine adduct
309-88-6

hexafluoropropene-diethylamine adduct

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

A

N,N-diethyl 2,3,3,3-tetrafluoropropionamide

N,N-diethyl 2,3,3,3-tetrafluoropropionamide

B

1,2-benzo-3-oxo-8-tetrafluoroethylidene-4,7,9-trioxacyclononane

1,2-benzo-3-oxo-8-tetrafluoroethylidene-4,7,9-trioxacyclononane

Conditions
ConditionsYield
In dichloromethane for 3h; Ambient temperature;A n/a
B 65%
phosgene
75-44-5

phosgene

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

carbonic acid bis-[2-(2-hydroxy-ethoxycarbonyl)-phenyl ester]

carbonic acid bis-[2-(2-hydroxy-ethoxycarbonyl)-phenyl ester]

Conditions
ConditionsYield
With potassium hydroxide; acetone
2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

ethane-1,2-diyl bis(2-hydroxybenzoate)
20210-97-3

ethane-1,2-diyl bis(2-hydroxybenzoate)

Conditions
ConditionsYield
at 300℃;
2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

phosphoric acid phenyl ester-bis-(2-salicyloyloxy-ethyl ester)
125644-21-5

phosphoric acid phenyl ester-bis-(2-salicyloyloxy-ethyl ester)

Conditions
ConditionsYield
With pyridine
2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

phosphoric acid diphenyl ester-(2-salicyloyloxy-ethyl ester)
116929-80-7

phosphoric acid diphenyl ester-(2-salicyloyloxy-ethyl ester)

Conditions
ConditionsYield
With pyridine
4-Chlorophenoxyacetic acid
122-88-3

4-Chlorophenoxyacetic acid

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

2-Hydroxy-benzoic acid 2-[2-(4-chloro-phenoxy)-acetoxy]-ethyl ester
63293-47-0

2-Hydroxy-benzoic acid 2-[2-(4-chloro-phenoxy)-acetoxy]-ethyl ester

Clofibric acid
882-09-7

Clofibric acid

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

2-Hydroxy-benzoic acid 2-[2-(4-chloro-phenoxy)-2-methyl-propionyloxy]-ethyl ester
52161-14-5

2-Hydroxy-benzoic acid 2-[2-(4-chloro-phenoxy)-2-methyl-propionyloxy]-ethyl ester

Bis-(p-chlorophenoxy)-essigsaeure
29815-94-9

Bis-(p-chlorophenoxy)-essigsaeure

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

2-Hydroxy-benzoic acid 2-[2,2-bis-(4-chloro-phenoxy)-acetoxy]-ethyl ester
63293-57-2

2-Hydroxy-benzoic acid 2-[2,2-bis-(4-chloro-phenoxy)-acetoxy]-ethyl ester

2-(4-chlorophenoxy)propionic acid
3307-39-9

2-(4-chlorophenoxy)propionic acid

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

2-Hydroxy-benzoic acid 2-[2-(4-chloro-phenoxy)-propionyloxy]-ethyl ester
63293-48-1

2-Hydroxy-benzoic acid 2-[2-(4-chloro-phenoxy)-propionyloxy]-ethyl ester

2-(4-Chlorophenoxy)propionic acid chloride
4878-20-0

2-(4-Chlorophenoxy)propionic acid chloride

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

2-[2-(4-Chloro-phenoxy)-propionyloxy]-benzoic acid 2-hydroxy-ethyl ester
63293-59-4

2-[2-(4-Chloro-phenoxy)-propionyloxy]-benzoic acid 2-hydroxy-ethyl ester

2-(4-Chlorophenoxy)propionic acid chloride
4878-20-0

2-(4-Chlorophenoxy)propionic acid chloride

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

2-[2-(4-Chloro-phenoxy)-propionyloxy]-benzoic acid 2-[2-(4-chloro-phenoxy)-propionyloxy]-ethyl ester
63293-62-9

2-[2-(4-Chloro-phenoxy)-propionyloxy]-benzoic acid 2-[2-(4-chloro-phenoxy)-propionyloxy]-ethyl ester

clofibryl chloride
5542-60-9

clofibryl chloride

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

2-[2-(4-Chloro-phenoxy)-2-methyl-propionyloxy]-benzoic acid 2-hydroxy-ethyl ester
63293-50-5

2-[2-(4-Chloro-phenoxy)-2-methyl-propionyloxy]-benzoic acid 2-hydroxy-ethyl ester

clofibryl chloride
5542-60-9

clofibryl chloride

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

2-[2-(4-Chloro-phenoxy)-2-methyl-propionyloxy]-benzoic acid 2-[2-(4-chloro-phenoxy)-2-methyl-propionyloxy]-ethyl ester
63293-52-7

2-[2-(4-Chloro-phenoxy)-2-methyl-propionyloxy]-benzoic acid 2-[2-(4-chloro-phenoxy)-2-methyl-propionyloxy]-ethyl ester

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

bis-(p-chlorophenoxy)acetyl chloride
34840-10-3

bis-(p-chlorophenoxy)acetyl chloride

2-[2,2-Bis-(4-chloro-phenoxy)-acetoxy]-benzoic acid 2-[2,2-bis-(4-chloro-phenoxy)-acetoxy]-ethyl ester
63293-63-0

2-[2,2-Bis-(4-chloro-phenoxy)-acetoxy]-benzoic acid 2-[2,2-bis-(4-chloro-phenoxy)-acetoxy]-ethyl ester

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

4-chlorophenyloxyacetyl chloride
4122-68-3

4-chlorophenyloxyacetyl chloride

2-[2-(4-Chloro-phenoxy)-acetoxy]-benzoic acid 2-hydroxy-ethyl ester
63293-58-3

2-[2-(4-Chloro-phenoxy)-acetoxy]-benzoic acid 2-hydroxy-ethyl ester

2-hydroxyethyl salicylate
87-28-5

2-hydroxyethyl salicylate

4-chlorophenyloxyacetyl chloride
4122-68-3

4-chlorophenyloxyacetyl chloride

2-[2-(4-Chloro-phenoxy)-acetoxy]-benzoic acid 2-[2-(4-chloro-phenoxy)-acetoxy]-ethyl ester
63293-51-6

2-[2-(4-Chloro-phenoxy)-acetoxy]-benzoic acid 2-[2-(4-chloro-phenoxy)-acetoxy]-ethyl ester

2-Hydroxyethyl salicylate Specification

The 2-Hydroxyethyl salicylate with cas registry number of 87-28-5, it has a lots of synonyms: (1)SALICYLIC ACID ETHYLENE GLYCOL ESTER ; (2)SALICYLIC ACID 2-HYDROXYETHYL ESTER ; (3)1,2-Ethylene glycol monosalicylate ; (4)2-Hydroxybenzoic acid 2-hydroxyethyl ester ; (5)2-hydroxy-benzoicaci2-hydroxyethylester ; (6)Benzoic acid, 2-hydroxy-, 2-hydroxyethyl ester ; (7)beta-Hydroxyethyl salicylate ; (8)Espirosal ; (9)Ethylene glycol salicylate ; (10)GL 7 ; (11)Monoglycol salicylate ; (12)Phlogont (salve) ; (13)Rheumacyl ; (14)Sarocol ; (15)Spirosal ; (16)2-HYDROXYETHYL SALICYLATE ; (17)ETHYLENE GLYCOL MONOSALICYLATE ; (18)GLYSAL ; (19)GLYCOL SALICYLATE ; (20)GLYCOL MONOSALICYLATE ; (21)2-HYDROXYETHYL SALICYLATE 97% ; (22)Ethylene glycol monosalicylate, Salicylic acid ethylene glycol ester ; (23)2-hydroxyethyl 2-hydroxybenzoate .

The 2-Hydroxyethyl salicylate belongs to the following product categories: (1)Heterocyclic Compounds; (2)Ethylene Glycols & Monofunctional Ethylene Glycols; (3)Monofunctional Ethylene Glycols .

Physical properties of 2-Hydroxyethyl salicylate :(1)ACD/LogP: 1.16; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.16; (4)ACD/LogD (pH 7.4): 1.07; (5)ACD/BCF (pH 5.5): 4.45; (6)ACD/BCF (pH 7.4): 3.63; (7)ACD/KOC (pH 5.5): 101.32; (8)ACD/KOC (pH 7.4): 82.62; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 44.76 Å2; (13)Index of Refraction: 1.573; (14)Molar Refractivity: 46.07 cm3; (15)Molar Volume: 139.7 cm3; (16)Polarizability: 18.26×10-24cm3; (17)Surface Tension: 56.7 dyne/cm; (18)Enthalpy of Vaporization: 56.39 kJ/mol; (19)Vapour Pressure: 0.000741 mmHg at 25°C .

When you are using this chemical, please be cautious about it as the following: 2-Hydroxyethyl salicylate is harmful and toxic if swallowed.

You can still convert the following datas into molecular structure: (1)SMILES:O=C(OCCO)c1ccccc1O; (2)InChI:InChI=1/C9H10O4/c10-5-6-13-9(12)7-3-1-2-4-8(7)11/h1-4,10-11H,5-6H2; (3)InChIKey:LVYLCBNXHHHPSB-UHFFFAOYAW; (4)Std. InChI:InChI=1S/C9H10O4/c10-5-6-13-9(12)7-3-1-2-4-8(7)11/h1-4,10-11H,5-6H2; (5)Std. InChIKey:LVYLCBNXHHHPSB-UHFFFAOYSA-N.

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