2-Piperidineethanol supplier

Name
2-Piperidineethanol
EINECS 216-059-2
CAS No. 1484-84-0
Density 0.939 g/cm³
Solubility soluble in water
Melting Point 38-40 °C(lit.)
Formula C₇H₁₅NO
Boiling Point 234.5 °C at 760 mmHg
Molecular Weight 129.202
Flash Point 102.2 °C
Transport Information UN 3263 8/PG 2
Appearance off-white solid
Safety 26-27-28-36/37/39-45-24/25
Risk Codes 20/21/22-34-36/37/38
Molecular Structure
Hazard Symbols C,Xi
Synonyms 2-(2-Hydroxyethyl)piperidine;2-(2-Piperidinyl)ethanol;2-Piperidine-2-yl-ethanol;NSC 9261;
PSA 32.26000
LogP 0.83970

Synthetic route

: 103-74-2
2-(2-Hydroxyethyl)pyridine

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
With 1,4-dioxane; nickel at 160℃; under 191232 Torr; Hydrogenation;
With ethanol; nickel at 150℃; under 95616 Torr; Hydrogenation;
With acetic acid; platinum Hydrogenation;

: 134256-32-9, 134256-31-8, 134256-33-0, 119204-13-6
N-benzyl-2-(2-hydroxyethyl)piperidine

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
With palladium on activated charcoal; ammonium formate In methanol for 12h; Heating; Yield given;

α-picolylcarbinol: α-picolylcarbinol

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
With ethanol; sodium

α-picolyl-carbinol: α-picolyl-carbinol

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
With ethanol; sodium

: 110-89-4
piperidine

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 30 percent / H2O2, sodium tungstate dihydrate / methanol / under 5 deg C, then Rt, 24 h 2: CH2Cl2 / 12 h / Heating 3: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h 4: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating View Scheme

: 119204-12-5
2-isobutoxyhexahydroisoxazolo<2,3-a>-pyridine

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: CH2Cl2 / 12 h / Heating 2: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h 3: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating View Scheme

: 119204-19-2
(2S,3aR)-8-Benzyl-2-isobutoxy-hexahydro-isoxazolo[2,3-a]pyridin-8-ium; bromide

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h 2: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating View Scheme

: 1885-14-9
phenyl chloroformate

A: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

B 3-(dimethylamino)propyl 2-[2-(hydroxyethyl)]piperidinecarboxylate: 3-(dimethylamino)propyl 2-[2-(hydroxyethyl)]piperidinecarboxylate

Conditions

Conditions	Yield
pyridine

: 1885-14-9
phenyl chloroformate

A: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

B 3-chloropropyl 2-[2-(hydroxyethyl)]piperidinecarboxylate: 3-chloropropyl 2-[2-(hydroxyethyl)]piperidinecarboxylate

: 103-74-2
2-(2-Hydroxyethyl)pyridine

: 7440-18-8
ruthenium

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 24424-99-5
di-tert-butyl dicarbonate

: 118811-03-3
tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 4h;	100%
With triethylamine In dichloromethane at 20℃;	99%
With sodium carbonate In dichloromethane; water at 20℃; for 24h; Inert atmosphere;	98%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 55661-08-0
4-methoxy-2,6-dimethylbenzenesulfonyl chloride

: 1186241-09-7
C16H25NO4S

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%
With triethylamine In dichloromethane at 0 - 20℃;	100%
With triethylamine In dichloromethane at 0 - 20℃;
With triethylamine In dichloromethane at 0℃; for 1h;
With triethylamine In dichloromethane at 0 - 20℃;

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 41840-28-2
S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine

: 118811-03-3
tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
In chloroform	99.9%
In chloroform

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 501-53-1
benzyl chloroformate

: 39945-50-1
2-(2-hydroxyethyl)-piperidine-1-carboxylic acid benzyl ester

Conditions

Conditions	Yield
With potassium carbonate In ethanol; water at 0 - 20℃; for 3.25h;	99%
With sodium carbonate In dichloromethane for 1h; Ambient temperature;	87%
Stage #1: 2(RS)-(2-hydroxyethyl)piperidine With sodium hydrogencarbonate In dichloromethane at 20℃; Stage #2: benzyl chloroformate In dichloromethane at 0℃; for 1h;	63%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 616-38-6
carbonic acid dimethyl ester

: 134415-15-9
hexahydro-3H-pyrido<1,2-c><1,3>oxazin-1-one

Conditions

Conditions	Yield
With sodium methylate In methanol for 144h; Ambient temperature;	98%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 153108-62-4
2-<2-(tert-butyldimethylsiloxy)ethyl>piperidine

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 4h;	98%
With 1H-imidazole In dichloromethane at 20℃; for 4.5h;	98%
With 1H-imidazole In dichloromethane at 20℃; for 4h;	90%
With 1H-imidazole In dichloromethane Inert atmosphere;	78%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 5535-48-8
PVS

: 640297-00-3
2-[1-(2-benzenesulfonyl-ethyl)-piperidin-2-yl]-ethanol

Conditions

Conditions	Yield
In xylene for 48h; Heating;	95%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 5-benzoyl-3-(cyclopent-1-en-1-yl)-5-phenyl-1,5-dihydro-4H-pyrazol-4-one

: 66120-20-5
N-benzoyl-2-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 12h; regioselective reaction;	95%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 38533-61-8
2-chloro-6-methoxy-3-nitropyridine

: 2-(6'-methoxy-3'-nitro-3,4,5 6-tetrahydro-2H-[1,2']bipyridylyl-2-yl)ethanol

Conditions

Conditions	Yield
In ethanol for 2h; Heating / reflux;	94.1%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 99-61-6
3-nitro-benzaldehyde

: 2-(3-nitrophenyl)-3-oxa-1-azabicyclo[4.4.0]decane

Conditions

Conditions	Yield
	94%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 60012-49-9
2-(2-Chloroethyl)piperidine Hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In chloroform for 2h; Heating;	93%
With thionyl chloride In dichloromethane for 12h; Reflux;	89%
With hydrogenchloride; chloroform Anschliessendes Erwaermen mit Thionylchlorid.;
With thionyl chloride In chloroform at 20℃; for 24h; Inert atmosphere; Cooling with ice;

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 638-29-9
n-valeryl chloride

: 1-pentanoyl-2-(2-hydroxyethyl)-piperidine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 18h; Acylation;	93%
With sodium hydroxide; triethylamine In tetrahydrofuran; ethanol; dichloromethane

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 39945-50-1
2-(2-hydroxyethyl)-piperidine-1-carboxylic acid benzyl ester

Conditions

Conditions	Yield
In 1,4-dioxane; water at 25℃; for 24h;	93%
With triethylamine In dichloromethane at 23℃; for 18h;	43%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 167772-41-0
3-bromo-2-isopropyl-5-methylthiophene-1,1-dioxide

: 203716-19-2
2-[1-((2E,4Z)-4-Bromo-6-methyl-hepta-2,4-dienyl)-piperidin-2-yl]-ethanol

Conditions

Conditions	Yield
In xylene at 116℃; for 7.5h; Product distribution; other amines; amine-induced ring-opening reaction of 2-alkyl-3-bromo-5-methylthiophene-1,1-dioxides; optimization and mechanistic considerations; kinetic study; deuterium incorporation experiments; kinetic isotope effect;	91%
In xylene at 116℃; for 7.5h;	91%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 111-36-4
n-butyl isocyanide

: 1-(Butylaminocarbonyl)-2-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
In toluene at 20℃; for 1h; Addition;	91%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 62-53-3
aniline

: 26934-01-0
N-(2-piperidin-2-yl-ethyl)-aniline

Conditions

Conditions	Yield
With cesiumhydroxide monohydrate; oxygen In 1,3,5-trimethyl-benzene at 180℃; for 24h;	88%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 3282-30-2
pivaloyl chloride

: 118671-56-0
2-(2-Hydroxyethyl)-1-(2,2-dimethylpropanoyl)piperidine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 18h; Acylation;	87%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 592-34-7
carbonochloridic acid, butyl ester

: 1-(Butoxycarbonyl)-2-(2-hydroxyethyl)-piperidine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 18h; Carboxylation;	85%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 102774-86-7
9-fluorenylmethyl N-succinimidyl carbonate

: 2-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 0.5h;	85%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 1201-45-2
Bis-(dimethylamino)-phenylboran

: 66737-44-8
2-phenyl-1,3,2-oxazaborabicyclo[4.4.0]decane

Conditions

Conditions	Yield
In benzene byproducts: MeNH2; absence of air; refluxing (5 h); solvent removal, distn.; elem. anal.;	85%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 108-23-6
isopropyl chloroformate

: KBR 3023

Conditions

Conditions	Yield
With sodium hydroxide In toluene at 20℃; for 2h; Carboxylation;	84%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 1120-71-4
1,3-propanesultone

: 3-[2-(2-hydroxyethyl)piperidin-1-yl]-1-propanesulfonic acid

Conditions

Conditions	Yield
In tetrahydrofuran for 15h; Heating / reflux;	84%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 4-((7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl)amino)benzonitrile

: 4-((7-(3-(2-(2-hydroxyethyl)piperidin-1-yl)propoxy)-6-methoxyquinazolin-4-yl)amino)benzonitrile

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 60 - 80℃;	84%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 19832-04-3
2-(piperidin-2-yl)acetic acid

Conditions

Conditions	Yield
Stage #1: 2(RS)-(2-hydroxyethyl)piperidine With chromium(VI) oxide; sulfuric acid In water at 0 - 20℃; for 4.5h; Stage #2: With barium dihydroxide In water Stage #3: With carbon dioxide In water	83%
Stage #1: 2(RS)-(2-hydroxyethyl)piperidine With hydrogenchloride; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide In water; ethyl acetate at 5 - 20℃; for 0.833333h; pH=8.0 - 9.0; Stage #2: With hydrogenchloride; sodium chlorite In water; ethyl acetate at 20 - 33℃; for 16.5h; pH=5.0;	78%
With chromium(VI) oxide; sulfuric acid at 0 - 20℃; for 15.25h; Jones oxidation;	68%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 83-38-5
2,6-dichlorobenzaldehyde

: 104062-11-5
α-(2,6-dichlorophenyl)-2-(2-hydroxyethyl)-1-piperidineacetonitrile

Conditions

Conditions	Yield
With potassium cyanide In hydrogenchloride	83%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 98-88-4
benzoyl chloride

A: 66120-20-5
N-benzoyl-2-(2-hydroxyethyl)piperidine

B: Benzoic acid 2-(1-benzoyl-piperidin-2-yl)-ethyl ester

Conditions

Conditions	Yield
With di(n-butyl)tin oxide; triethylamine In toluene for 0.15h; Irradiation;	A 82% B 11%
With di(n-butyl)tin oxide; triethylamine In toluene for 0.15h; Irradiation;	A 76% B 19%
With triethylamine In tetrahydrofuran for 48h;

...Expand

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 118811-03-3
tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
	82%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 1564-77-8
2-(2-bromoethyl)piperidine hydrobromide

Conditions

Conditions	Yield
With hydrogen bromide In water for 24h; Reflux;	82%
With hydrogen bromide In water Reflux;

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: N1-(2-chloro-9-isopropyl-9H-purin-6-yl)benzene-1,3-diamine

: 2-(1-(6-((3-aminophenyl)amino)-9-isopropyl-9H-purin-2-yl)piperidin-2-yl)ethan-1-ol

Conditions

Conditions	Yield
With potassium fluoride In 1-methyl-pyrrolidin-2-one Heating;	81%

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 123-11-5
4-methoxy-benzaldehyde

: 1-(4-methoxyphenyl)octahydropyrido[1,2-c][1,3]oxazine

Conditions

Conditions	Yield
	80%

2-Piperidineethanol Chemical Properties

Structure of 2-Piperidineethanol (CAS NO.1484-84-0):

IUPAC Name: 2-piperidin-2-ylethanol
Empirical Formula: C₇H₁₅NO
Molecular Weight: 129.2001
EINECS: 216-059-2
Index of Refraction: 1.454
Molar Refractivity: 37.26 cm³
Molar Volume: 137.5 cm³ Polarizability: 14.77×10^-24cm³
Surface Tension: 34.6 dyne/cm
Density: 0.939 g/cm³
Flash Point: 102.2 °C
Enthalpy of Vaporization: 54.78 kJ/mol
Melting Point: 38-40 °C(lit.)
Boiling Point: 234.5 °C at 760 mmHg
Vapour Pressure: 0.00967 mmHg at 25°C
Water Solubility: soluble
Physical Appearance: Off-White Solid
Product Categories: Alcohols and Derivatives;Heterocycles;Piperidine;Alkohols;Amines;Chiral Reagents
Synonyms of 2-Piperidineethanol (CAS NO.1484-84-0): 2-(2-Hydroxyethyl)piperidine ; 2-Piperidine ethanol ; 2-Piperidin-2-ylethanol .

2-Piperidineethanol Uses

2-Piperidineethanol (CAS NO.1484-84-0) is used in preparation of a novel class of pyrazolopyrimidines as inhibitors of protein and checkpoint kinases, also used in treatment and prophylaxis of HCV infection and other diseases such as cancer.

2-Piperidineethanol Safety Profile

Hazard Codes: Corrosive C, Irritant Xi
Risk Statements: 20/21/22-34-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-27-28-36/37/39-45-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S24/25:Avoid contact with skin and eyes.
RIDADR: UN 3263 8/PG 2
WGK Germany: 3

Product Name

2-Piperidineethanol

Synthetic route

2-Piperidineethanol Chemical Properties

2-Piperidineethanol Uses

2-Piperidineethanol Safety Profile

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