2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole supplier

Name
2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
EINECS 604-866-6
CAS No. 152628-02-9
Article Data22
CAS DataBase
Density 1.23 g/cm³
Solubility
Melting Point 130-135 °C(Solv: tetrahydrofuran (109-99-9))
Formula C₁₉H₂₀N₄
Boiling Point 584.802 °C at 760 mmHg
Molecular Weight 304.395
Flash Point 307.477 °C
Transport Information
Appearance grey powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1,7'-Dimethyl-2'-propyl-2,5'-bibenzimidazole;4-Methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazole;1H-Benzimidazole-2-n-propyl-4-methyl-6-(1'-methylbenzimidazole-2'-yl);
PSA 46.50000
LogP 4.37750

Synthetic route

: 25148-68-9
N-methylbenzene-1,2-diamine dihydrochloride

: 152628-03-0
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
With methanesulfonic acid In i-Amyl alcohol at 130 - 135℃; for 18h; Temperature; Solvent; Reagent/catalyst;	93%
Stage #1: N-methylbenzene-1,2-diamine dihydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With PPA at 70 - 135℃; for 13.5h; Stage #2: With ammonia In water at 30 - 90℃; for 1h; pH=8.0 - 8.5;	77.4%
With PPA at 150℃; for 20h;	5.86 g
With polyphosphoric acid at 150℃; for 14h;

: C19H21IN4

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
With copper(l) iodide; caesium carbonate In dimethyl sulfoxide at 130℃;	93%

: C19H21BrN4

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
With copper(l) iodide; caesium carbonate In dimethyl sulfoxide at 130℃;	92%

: 4760-34-3
N-methyl-1,2-phenylenediamine

: 152628-03-0
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Stage #1: N-methyl-1,2-phenylenediamine; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With methanesulfonic acid; phosphorus pentoxide at 75 - 145℃; Stage #2: With sodium hydroxide In water pH=< 3; Product distribution / selectivity;	90%
With polyphosphoric acid at 150 - 155℃; for 4h; Inert atmosphere;	80%
With PPA at 150 - 155℃; Inert atmosphere;
Stage #1: N-methyl-1,2-phenylenediamine; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid at 70 - 130℃; for 8.5h; Stage #2: With hydrogenchloride In methanol; water at 25℃; for 0.166667h; Stage #3: With ammonium hydroxide In methanol; water at 25℃; for 1h; Reagent/catalyst;

: C26H28N4O3S

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
With sodium hydroxide In water; acetonitrile at 20℃;	90%

: 2-n-propyl-4-methyl-6-formylchlorobenzimidazole

: N-methyl-o-phenylenediamine hydrochloride

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Stage #1: 2-n-propyl-4-methyl-6-formylchlorobenzimidazole; N-methyl-o-phenylenediamine hydrochloride With triethylamine In dichloromethane at 40℃; for 3h; Large scale; Stage #2: With acetic acid In dichloromethane at 60℃; for 5h; Temperature; Reagent/catalyst; Solvent; Large scale;	89.96%

: C19H22N4O

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
With p-toluenesulfonyl chloride In water; acetonitrile at 0 - 20℃;	88%
Multi-step reaction with 2 steps 1: triethylamine / acetonitrile / 0 - 20 °C 2: sodium hydroxide / acetonitrile; water / 20 °C View Scheme

: 1345840-05-2
2-methyl-4-(1-methyl-1H-benzimidazol-2-yl)-6-nitrobenzenamine

: 123-72-8
butyraldehyde

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
With sodium dithionite In methanol; water for 12h; Reflux;	85%

: C19H21N3O*ClH

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Stage #1: C19H21N3O*ClH With bis(trichloromethyl) carbonate; N,N-dimethyl-formamide In acetonitrile at 80 - 85℃; for 2h; Stage #2: With hydroxylamine In acetonitrile at 20℃; for 1h; Stage #3: With triethylamine; p-toluenesulfonyl chloride at 0 - 20℃;	85%
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide; bis(trichloromethyl) carbonate / acetonitrile / 2 h / 80 - 85 °C 2: p-toluenesulfonyl chloride / acetonitrile; water / 0 - 20 °C View Scheme
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide; bis(trichloromethyl) carbonate / acetonitrile / 2 h / 80 - 85 °C 2: triethylamine / acetonitrile / 0 - 20 °C 3: sodium hydroxide / acetonitrile; water / 20 °C View Scheme

: 81684-80-2
N1-methylbenzene-1,2-diamine hydrochloride

: 152628-03-0
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

A: 884330-09-0
desmethyl dibenzimidazole

B: 884330-18-1
7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide

C: 884330-17-0
3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide

D: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
With polyphosphoric acid at 150 - 155℃;	A n/a B n/a C n/a D 84%

...Expand

: 1083158-66-0
N-[2-methyl-4-(1-methylbenzimidazole)-2-yl-6-nitrophenyl]-butanamide

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In isopropyl alcohol at 100℃; under 6000.6 Torr; for 12h; Temperature; Solvent; Reagent/catalyst; Autoclave;	82.3%

: 81684-80-2
N1-methylbenzene-1,2-diamine hydrochloride

: 152628-03-0
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Stage #1: N1-methylbenzene-1,2-diamine hydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With phosphorus pentoxide; phosphoric acid at 70 - 130℃; Stage #2: With ammonia In water; ethyl acetate for 3h; pH=9 - 10; Product distribution / selectivity; Cooling with ice;	82%
Stage #1: N1-methylbenzene-1,2-diamine hydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With PPA; Polyphosphoric acid (PPA) In water at 90 - 155℃; for 5.75 - 7h; Stage #2: With sodium hydroxide In water pH=5.5 - 6; Product distribution / selectivity;

: 4760-34-3
N-methyl-1,2-phenylenediamine

: 152628-00-7
4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
With polyphosphoric acid at 150℃; for 12h;	62%

: C19H21BrN4

A: C15H14BrN3

B: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
With caesium carbonate; copper(II) oxide In dimethyl sulfoxide at 130℃; for 8h;	A 19.9% B 61.3%

: 3-methyl-5-(1-methyl-1H-benzoimidazol-2-yl)-benzene-1,2-diamine

: 107-92-6
butyric acid

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
With polyphosporic acid at 120℃; for 4h;	47%

: C19H21ClN4

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
With copper(l) iodide; caesium carbonate In dimethyl sulfoxide at 130℃;	13%

: 18595-14-7
methyl 4-amino-3-methylbenzoate

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: chlorobenzene / 100 °C 2: fuming HNO3, 60percent H2SO4 / 0 °C 3: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 4: glacial CH3COOH / 1.5 h / Heating 5: 5.46 g / aq. NaOH / methanol / 2 h / Heating 6: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme
Multi-step reaction with 6 steps 1: triethylamine / dichloromethane / 0 °C 2: sulfuric acid; nitric acid 3: hydrogen / methanol / 100 °C / 3750.38 Torr 4: acetic acid / 1 h / Reflux 5: sodium hydroxide / water; methanol / 2 h / Reflux 6: polyphosphoric acid / 14 h / 150 °C View Scheme

: 301533-59-5
methyl 4-(n-butyrylamino)-3-methylbenzoate

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: fuming HNO3, 60percent H2SO4 / 0 °C 2: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 3: glacial CH3COOH / 1.5 h / Heating 4: 5.46 g / aq. NaOH / methanol / 2 h / Heating 5: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme
Multi-step reaction with 5 steps 1: sulfuric acid; nitric acid 2: hydrogen / methanol / 100 °C / 3750.38 Torr 3: acetic acid / 1 h / Reflux 4: sodium hydroxide / water; methanol / 2 h / Reflux 5: polyphosphoric acid / 14 h / 150 °C View Scheme

: 152628-00-7
4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 5.46 g / aq. NaOH / methanol / 2 h / Heating 2: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme
Multi-step reaction with 2 steps 1.1: sodium hydroxide; water / methanol / 80 °C 2.1: phosphorus pentoxide; phosphoric acid / 70 - 130 °C 2.2: 3 h / pH 9 - 10 / Cooling with ice View Scheme
Multi-step reaction with 2 steps 1: sodium hydroxide / water; methanol / 2 h / Reflux 2: polyphosphoric acid / 14 h / 150 °C View Scheme

: 675882-71-0
methyl 4-(n-butyrylamino)-3-methyl-5-aminobenzoate

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: glacial CH3COOH / 1.5 h / Heating 2: 5.46 g / aq. NaOH / methanol / 2 h / Heating 3: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme
Multi-step reaction with 3 steps 1: acetic acid / 1 h / Reflux 2: sodium hydroxide / water; methanol / 2 h / Reflux 3: polyphosphoric acid / 14 h / 150 °C View Scheme

: 152628-01-8
4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 2: glacial CH3COOH / 1.5 h / Heating 3: 5.46 g / aq. NaOH / methanol / 2 h / Heating 4: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme
Multi-step reaction with 2 steps 1.1: water; sodium dithionite / 70 - 100 °C 2.1: phosphorus pentoxide; phosphoric acid / 70 - 130 °C 2.2: 3 h / pH 9 - 10 / Cooling with ice View Scheme
Multi-step reaction with 3 steps 1.1: sodium dithionite / water / 70 - 100 °C 2.1: sodium hydroxide; water / methanol / 80 °C 3.1: phosphorus pentoxide; phosphoric acid / 70 - 130 °C 3.2: 3 h / pH 9 - 10 / Cooling with ice View Scheme
Multi-step reaction with 4 steps 1: hydrogen / methanol / 100 °C / 3750.38 Torr 2: acetic acid / 1 h / Reflux 3: sodium hydroxide / water; methanol / 2 h / Reflux 4: polyphosphoric acid / 14 h / 150 °C View Scheme

: 884330-17-0
3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Stage #1: 3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide With PPA at 150 - 155℃; Stage #2: With sodium hydroxide In water at 70 - 80℃; for 0.5 - 0.75h; pH=5 - 6; Product distribution / selectivity;

: 884330-18-1
7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Stage #1: 7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide With PPA at 150 - 155℃; Stage #2: With sodium hydroxide In water at 70 - 80℃; for 0.5 - 0.75h; pH=5 - 6; Product distribution / selectivity;

: 1345840-14-3
C15H13N3O3

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 1.2: 3.5 h / 5 - 20 °C 2.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 3.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme

: 1345840-21-2
2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzimidazole

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 2: sodium dithionite / methanol; water / 12 h / Reflux View Scheme

: 15174-69-3
4-hydroxy-3-methyl-benzaldehyde

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: nitric acid / 1.67 h / -15 °C 2.1: sodium hydroxide / water / 0.5 h 2.2: 6.25 h / 0 - 70 °C 3.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C 4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 4.2: 3.5 h / 5 - 20 °C 5.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 6.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme

Yield

Multi-step reaction with 6 steps
1.1: nitric acid / 1.67 h / -15 °C
2.1: sodium hydroxide / water / 0.5 h
2.2: 6.25 h / 0 - 70 °C
3.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h
4.2: 3.5 h / 5 - 20 °C
5.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave
6.1: sodium dithionite / methanol; water / 12 h / Reflux
View Scheme

: 54674-91-8
4-hydroxy-3-methyl-5-nitrobenzaldehyde

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: sodium hydroxide / water / 0.5 h 1.2: 6.25 h / 0 - 70 °C 2.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 3.2: 3.5 h / 5 - 20 °C 4.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 5.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme

: 861792-67-8
4-methoxy-3-methyl-5-nitrobenzaldehyde

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 2.2: 3.5 h / 5 - 20 °C 3.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 4.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme

: 95-48-7
ortho-cresol

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: sodium hydroxide / water / 6.5 h / 60 °C 2.1: nitric acid / 1.67 h / -15 °C 3.1: sodium hydroxide / water / 0.5 h 3.2: 6.25 h / 0 - 70 °C 4.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C 5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 5.2: 3.5 h / 5 - 20 °C 6.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 7.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme

Yield

Multi-step reaction with 7 steps
1.1: sodium hydroxide / water / 6.5 h / 60 °C
2.1: nitric acid / 1.67 h / -15 °C
3.1: sodium hydroxide / water / 0.5 h
3.2: 6.25 h / 0 - 70 °C
4.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h
5.2: 3.5 h / 5 - 20 °C
6.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave
7.1: sodium dithionite / methanol; water / 12 h / Reflux
View Scheme

: 668276-43-5
methyl 3,4-diamino-5-methylbenzoate

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: polyphosphoric acid / 0.17 h / 150 °C / 1551.49 Torr / Irradiation 2: polyphosphoric acid / 12 h / 150 °C View Scheme

: 114772-38-2
Methyl 4'-(bromomethyl)biphenyl-2-carboxylate

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 528560-93-2
4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In dimethyl sulfoxide; isopropyl alcohol Inert atmosphere; Stage #2: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate In dimethyl sulfoxide; isopropyl alcohol at 30 - 35℃; for 6h; Inert atmosphere;	95.1%
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 0 - 10℃; for 3.416h; Solvent; Reagent/catalyst; Temperature;	95%
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In dimethyl sulfoxide; isopropyl alcohol at 45℃; for 1h; Stage #2: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate In dimethyl sulfoxide; isopropyl alcohol at 30℃; for 6h;	94.8%

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 150766-86-2
4'-bromomethylbiphenyl-2-carboxylic acid

: 144701-48-4
telmisatran

Conditions

Conditions	Yield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 1h; Stage #2: 4'-bromomethylbiphenyl-2-carboxylic acid In N,N-dimethyl-formamide at 10℃; Solvent; Reagent/catalyst; Temperature;	95%

: 4'-chloromethylbiphenyl-2-carboxylic acid methyl ester

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 528560-93-2
4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In acetonitrile for 0.166667h; Stage #2: 4'-chloromethylbiphenyl-2-carboxylic acid methyl ester In acetonitrile	92%

: 1241048-04-3
(4-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: [4-[[2-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole-1-yl]methyl]-1H-indol-1-yl](phenyl)methanone

Conditions

Conditions	Yield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In tetrahydrofuran; mineral oil at 50℃; for 0.5h; Stage #2: (4-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone In tetrahydrofuran; mineral oil at 50℃; for 3h;	91.9%

: 773-64-8
2-mesitylenesulphonyl chloride

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 3-(mesitylsulfonyl)-1,7-dimethyl-2-propyl-1H,3H-2,5-bibenzo[d]imidazole

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium hydroxide In benzene at 0 - 20℃;	90%

: 114772-38-2
Methyl 4'-(bromomethyl)biphenyl-2-carboxylate

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 144701-48-4
telmisatran

Conditions

Conditions	Yield
Stage #1: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate; 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In dimethyl sulfoxide at 25 - 50℃; for 4h; Stage #2: With water; acetic acid In water; dimethyl sulfoxide at 20℃; pH=3.8 - 4; Product distribution / selectivity;	88%
Stage #1: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate; 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydroxide In dimethyl sulfoxide at 25 - 50℃; for 4h; Stage #2: With water; acetic acid In water; dimethyl sulfoxide pH=4.2; Product distribution / selectivity;	80%

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 144702-27-2
4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl

Conditions

Conditions	Yield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In ISOPROPYLAMIDE at 20℃; for 1h; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In ISOPROPYLAMIDE at 5 - 10℃; for 2h;	87.5%
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In ISOPROPYLAMIDE at 20℃; for 1h; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In ISOPROPYLAMIDE at 5 - 10℃; for 2h;	87.5%
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In acetone at 20 - 25℃; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In acetone at 20 - 25℃; Product distribution / selectivity;	87.73%

: 5402-73-3
2,5-dichlorobenzenesulphonyl chloride

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 3-(2,5-dichlorophenylsulfonyl)-1,7-dimethyl-2-propyl-1H,3H-2,5-bibenzo[d]imidazole

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium hydroxide In benzene at 0 - 20℃;	87%

: 114772-40-6
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 144702-26-1
tert-butyl 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate

Conditions

Conditions	Yield
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 10℃; for 4h;	86%
With sodium In methanol at 70℃; Reagent/catalyst; Temperature; Solvent;	71%
With potassium tert-butylate In N,N-dimethyl acetamide at 75 - 80℃; for 3h; Inert atmosphere;	70%
With potassium tert-butylate 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h; Multistep reaction;
With potassium tert-butylate In dimethyl sulfoxide at 25 - 30℃; for 3.5h; Product distribution / selectivity;

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 145303-52-2
(5-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone

: [5-[[2-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole-1-yl]methyl]-1H-indol-1-yl](phenyl)methanone

Conditions

Conditions	Yield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In tetrahydrofuran; mineral oil at 50℃; for 0.5h; Stage #2: (5-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone In tetrahydrofuran; mineral oil at 50℃; for 3h;	85.6%

: 158144-51-5
2-(4'-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 1191259-51-4
3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole

Conditions

Conditions	Yield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: 2-(4'-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole In tetrahydrofuran; N,N-dimethyl acetamide at 20℃; Reflux; Inert atmosphere;	85%

: 158144-52-6
4,4-dimethyl-2-(4'-methanesulfonyloxymethylbiphenyl-2-yl)oxazoline

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 1191259-51-4
3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole

Conditions

Conditions	Yield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: 4,4-dimethyl-2-(4'-methanesulfonyloxymethylbiphenyl-2-yl)oxazoline In tetrahydrofuran; N,N-dimethyl acetamide at 20℃; Inert atmosphere; Reflux;	85%

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 98-58-8
4-bromobenzenesulfonyl chloride

: 3-(4-bromophenylsulfonyl)-1,7-dimethyl-2-propyl-1H,3H-2,5-bibenzo[d]imidazole

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium hydroxide In benzene at 0 - 20℃;	84%

: 667457-41-2
4-(chloromethyl)biphenyl-2'-carboxylic acid

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 144701-48-4
telmisatran

Conditions

Conditions	Yield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Cooling with ice; Stage #2: 4-(chloromethyl)biphenyl-2'-carboxylic acid In N,N-dimethyl-formamide at 20 - 50℃; for 5h; Reagent/catalyst; Temperature;	84%

: 98-59-9
p-toluenesulfonyl chloride

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 1,7-dimethyl-2-propyl-3-tosyl-1H,3H-2,5-bibenzo[d]imidazole

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium hydroxide In benzene at 0 - 20℃;	83%

: 589-15-1
1-bromomethyl-4-bromobenzene

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 3'-(4-bromobenzyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide at 25 - 35℃; Inert atmosphere;	80%
With potassium carbonate In ISOPROPYLAMIDE at 20℃; for 8h;

: 1187523-96-1
2-Bromo-4'-(bromomethyl)biphenyl

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 1206701-77-0
3'-((2'-bromobiphenyl-4-yl)methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole

Conditions

Conditions	Yield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In ISOPROPYLAMIDE at 20 - 30℃; Stage #2: 2-Bromo-4'-(bromomethyl)biphenyl In ISOPROPYLAMIDE at 5 - 10℃;	75.4%

: 4'-chloromethylbiphenyl-2-carboxylic acid methyl ester

: 152628-02-9
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

: 144701-48-4
telmisatran

Conditions

Conditions	Yield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In acetonitrile for 0.166667h; Stage #2: 4'-chloromethylbiphenyl-2-carboxylic acid methyl ester In acetonitrile Stage #3: With hydrogenchloride In water	75.1%

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Chemical Properties

Molecular structure of 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole (CAS NO.152628-02-9) is:

Product Name: 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
CAS Registry Number: 152628-02-9
Molecular Formula: C₁₉H₂₀N₄
Molecular Weight: 304.39
Surface Tension: 45.191 dyne/cm
Density: 1.234 g/cm³
Flash Point: 307.477 °C
Enthalpy of Vaporization: 87.377 kJ/mol
Boiling Point: 584.802 °C at 760 mmHg
Product Categories: Chemical intermediate for Telmisartan;Intermediatesof;Imidazol&Benzimidazole;Imidazoles;(intermediate of telmisartan);Intermediates & Fine Chemicals;Pharmaceuticals;pharmaceutical intermediates

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Specification

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole , its cas register number is 152628-02-9. It also can be called 1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole .It is a grey powder.

Product Name

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

Synthetic route

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Chemical Properties

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Specification

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