1H-indole-5-carbonitrile
4-Chlorobutanoyl chloride
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at 0 - 20℃; | 93% |
With titanium tetrachloride In chloroform at 0℃; for 20h; Solvent; Temperature; | 90% |
Stage #1: 4-Chlorobutanoyl chloride With aluminum (III) chloride In 1,2-dichloro-ethane at 0℃; for 1h; Stage #2: 1H-indole-5-carbonitrile In 1,2-dichloro-ethane at 0 - 20℃; for 2.5h; | 87.4% |
1H-indole-5-carbonitrile
4-Chlorobutanoyl chloride
B
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
With isobutylaluminum dichloride In dichloromethane Friedel-Crafts Acylation; |
SD-169
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / dichloromethane / 1 h / 5 °C / Cooling with ice; Large scale 1.2: 20 °C / Cooling with ice; Large scale 2.1: trichlorophosphate / dichloromethane / 10 °C / Cooling with ice; Large scale View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
With trichlorophosphate In dichloromethane at 10℃; Cooling with ice; Large scale; | 51 kg |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With chloro-trimethyl-silane; sodium cyanoborohydride In acetonitrile at 0 - 30℃; | 87.2% |
Stage #1: 3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile With aluminum (III) chloride In tetrahydrofuran for 0.5h; Cooling with ice; Stage #2: With sodium tetrahydroborate In tetrahydrofuran Reagent/catalyst; | 80% |
With iron(III) chloride; borane-THF; hydrogen In tetrahydrofuran at 20℃; Reagent/catalyst; Temperature; Inert atmosphere; Flow reactor; | 71% |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With triethylamine; potassium iodide In N,N-dimethyl-formamide at 20 - 90℃; for 49h; Inert atmosphere; | 85% |
With tributyl-amine In 1-methyl-pyrrolidin-2-one at 25 - 130℃; for 24h; | 7% |
2-Naphthalenesulfonyl chloride
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Stage #2: 2-Naphthalenesulfonyl chloride In N,N-dimethyl-formamide at 0 - 20℃; for 16h; | 82% |
p-toluenesulfonyl chloride
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
1-p-toluenesulfonyl-3-(4-chlorobutyryl)-5-cyanoindole
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane at 20℃; for 5h; | 81% |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
With triethylamine In water; acetonitrile at 80 - 85℃; for 5h; | 81% |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
3-(4-hydroxybutyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
With sodium tetrahydroborate; isopropyl alcohol at 0 - 80℃; for 6h; | 80% |
With sodium tetrahydroborate In isopropyl alcohol at 80℃; for 6h; | 80.6% |
With sodium tetrahydroborate In isopropyl alcohol at 0 - 80℃; for 6h; | 80% |
With sodium tetrahydroborate; isopropyl alcohol at 0 - 80℃; for 6h; Inert atmosphere; | 80% |
With sodium tetrahydroborate; isopropyl alcohol at 0 - 80℃; for 6h; | 80% |
1-Naphthalenesulfonyl chloride
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Stage #2: 1-Naphthalenesulfonyl chloride In N,N-dimethyl-formamide at 0 - 20℃; | 76% |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
3-(4-chloro-1-hydroxy-butyl)-1H-indol-5-carbonitrile
Conditions | Yield |
---|---|
With sodium tetrahydroborate; water; sodium hydroxide In tetrahydrofuran at 30 - 35℃; for 3h; | 73.5% |
With sodium tetrahydroborate; water; sodium hydroxide In tetrahydrofuran at 30 - 35℃; for 3h; | 73.5% |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: 60 percent / K2CO3; KI / dimethylformamide / 12 h / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
vilazodone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; Et3N / acetonitrile / 12 h / Heating 3: KOH / methanol / 3 h / Heating 4: 72 percent / 1-methyl-2-chloropyridinium iodide; Et2NiPr; NH3(g) / 1-methyl-pyrrolidin-2-one View Scheme | |
Multi-step reaction with 3 steps 1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran 2: potassium carbonate / acetonitrile 3: potassium hydroxide / methanol View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran 2.1: potassium carbonate / acetonitrile 3.1: potassium hydroxide / methanol 4.1: 1,1'-carbonyldiimidazole / methanol / 1 h / 20 °C / Reflux; Large scale 4.2: 0.5 h / Large scale View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; KI / dimethylformamide / Heating View Scheme |
This product is an organic compound with the formula C13H11ClN2O. The systematic name of this chemical is 3-(4-Chloro-1-oxo-butyl)-1H-indol-5-carbonitrile. With the CAS registry number 276863-95-7, it is also named as 1H-Indole-5-carbonitrile, 3-(4-chloro-1-oxobutyl)-. In addition, the molecular weight is 246.69.
Physical properties of 3-(4-Chloro-1-oxo-butyl)-1H-indol-5-carbonitrile are: (1)ACD/LogP: 2.80; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3; (4)ACD/LogD (pH 7.4): 3; (5)ACD/BCF (pH 5.5): 171; (6)ACD/BCF (pH 7.4): 171; (7)ACD/KOC (pH 5.5): 1380; (8)ACD/KOC (pH 7.4): 1380; (9)#H bond acceptors: 3; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 56.65 Å2; (13)Index of Refraction: 1.624; (14)Molar Refractivity: 66.27 cm3; (15)Molar Volume: 187.701 cm3; (16)Polarizability: 26.271×10-24cm3; (17)Surface Tension: 59.763 dyne/cm; (18)Density: 1.314 g/cm3; (19)Flash Point: 250.053 °C; (20)Enthalpy of Vaporization: 75.625 kJ/mol; (21)Boiling Point: 489.85 °C at 760 mmHg.
You can still convert the following datas into molecular structure:
(1)SMILES: ClCCCC(=O)c2c1cc(C#N)ccc1nc2
(2)Std. InChI: InChI=1S/C13H11ClN2O/c14-5-1-2-13(17)11-8-16-12-4-3-9(7-15)6-10(11)12/h3-4,6,8,16H,1-2,5H2
(3)Std. InChIKey: DFORIOBMTPKWPE-UHFFFAOYSA-N
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