3,3-Diphenylpropylamine supplier

Name
3,3-Diphenylpropylamine
EINECS 226-984-3
CAS No. 5586-73-2
Article Data18
CAS DataBase
Density 1.024 g/cm³
Solubility
Melting Point 29-31 °C(lit.)
Formula C₁₅H₁₇N
Boiling Point 331.9 °C at 760 mmHg
Molecular Weight 211.307
Flash Point 155.2 °C
Transport Information
Appearance clear yellow liquid after melting
Safety 26-37/39-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Propylamine,3,3-diphenyl- (6CI,7CI,8CI);1-Amino-3,3-diphenylpropane;3,3-Diphenyl-1-propanamine;Diphenylpropylamine;IEM 2011;NSC 137832;
PSA 26.02000
LogP 3.86760

Synthetic route

: 2286-54-6
3,3-diphenyl-propionitrile

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether at 35℃; for 4h;	86%
With sulfuric acid; acetic acid; platinum Hydrogenation;

: 4279-81-6
3,3-diphenylpropanal

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
With ammonia; hydrogen In tert-butyl alcohol at 120℃; for 15h;	86%

: 3531-24-6
3,3-diphenylacrylonitrile

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
With sulfuric acid; acetic acid; platinum Hydrogenation;
With sodium hydroxide; ammonia; hydrogen; nickel In methanol
Multi-step reaction with 2 steps 1: amalgamated aluminium 2: platinum; acetic acid; H2SO4 / Hydrogenation View Scheme

: 2286-54-6
3,3-diphenyl-propionitrile

A: 5586-73-2
3-diphenylpropyl amine

B: 41140-46-9
bis-(3,3-diphenyl-propyl)-amine

Conditions

Conditions	Yield
With ethanol; ammonia; nickel at 100℃; under 117681 Torr; Hydrogenation;
With ethanol; nickel at 100℃; under 117681 Torr; Hydrogenation;

: 7474-19-3
3,3-diphenylpropionamide

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

: 3531-23-5
3-hydroxy-3,3-diphenylpropanenitrile

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
With sulfuric acid; acetic acid; platinum Hydrogenation;
Multi-step reaction with 3 steps 1: P2O5; benzene 2: amalgamated aluminium 3: platinum; acetic acid; H2SO4 / Hydrogenation View Scheme
Multi-step reaction with 2 steps 1: P2O5; benzene 2: platinum; acetic acid; H2SO4 / Hydrogenation View Scheme
Multi-step reaction with 2 steps 1: POCl3 / benzene 2: H2, NH3, NaOH / Raney-Ni / methanol View Scheme

: 28793-03-5
3,3-Diphenyl-1-benzenesulfonamidopropane

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
With hydrogenchloride

: 2677-69-2
3-amino-1-phenyl-propan-1-one

: phenylmagnesium bromide

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
With diethyl ether beim Erhitzen des Reaktionsprodukts mit Polyphosphorsaeure und anschliessenden Hydrieren an Palladium in Methanol;

: 55281-16-8
3,3-diphenyl-allylamine; hydrochloride

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
With ethanol; palladium Hydrogenation;

: 119-61-9
benzophenone

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: sodium amide; diethyl ether 2: P2O5; benzene 3: amalgamated aluminium 4: platinum; acetic acid; H2SO4 / Hydrogenation View Scheme
Multi-step reaction with 3 steps 1: sodium amide; diethyl ether 2: P2O5; benzene 3: platinum; acetic acid; H2SO4 / Hydrogenation View Scheme
Multi-step reaction with 2 steps 1: sodium amide; diethyl ether 2: platinum; acetic acid; H2SO4 / Hydrogenation View Scheme

: 5120-12-7
1-Benzenesulfonyl-2-(bromomethyl)ethylenimine

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 2: aqueous HCl View Scheme

: 71-43-2
benzene

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 2: aqueous HCl View Scheme
Multi-step reaction with 2 steps 1: trifluorormethanesulfonic acid / 1 h / 20 °C 2: lithium aluminium tetrahydride / diethyl ether / 4 h / 35 °C View Scheme

: ethyl 4-[(3,3-diphenylpropyl)amino]-1-piperidinecarboxylate

: 100-39-0
benzyl bromide

A: 204065-02-1
Ethyl 4[N-benzyl-N(3,3-diphenylpropyl)amino]-1-piperidinecarboxylate

B: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide

...Expand

: 4360-47-8
cinnamonitrile

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: trifluorormethanesulfonic acid / 1 h / 20 °C 2: lithium aluminium tetrahydride / diethyl ether / 4 h / 35 °C View Scheme

: 28446-70-0
(E/Z)-3-(4-methylphenyl)propenenitrile

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aluminum tri-bromide / 1 h / 20 °C 2: lithium aluminium tetrahydride / diethyl ether / 4 h / 35 °C View Scheme

: 624-31-7
4-tolyl iodide

: 5586-73-2
3-diphenylpropyl amine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: palladium diacetate; triphenylphosphine; potassium carbonate / N,N-dimethyl-formamide / 125 - 127 °C / Inert atmosphere 2: aluminum tri-bromide / 1 h / 20 °C 3: lithium aluminium tetrahydride / diethyl ether / 4 h / 35 °C View Scheme

: 5586-73-2
3-diphenylpropyl amine

: 79-04-9
chloroacetyl chloride

: 137075-21-9
methyl chloride

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 0.75h;	100%
With triethylamine In dichloromethane at 0 - 25℃; for 20h; Inert atmosphere;	84%
With TEA In chloroform for 18h; Ambient temperature;
With triethylamine In tetrahydrofuran at 0℃; for 2h;

: 5586-73-2
3-diphenylpropyl amine

: C55H70O10*C24H20F10O4

: C42H52N2O2*C55H70O10

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; Inert atmosphere;	99%

: 5586-73-2
3-diphenylpropyl amine

: 3848-42-8
O-(4-nitrophenyl)-N-(4-tolyl)carbamate

: 1-(3,3-diphenyl-propyl)-3-p-tolyl-urea

Conditions

Conditions	Yield
In tetrahydrofuran for 0.5h; Ambient temperature;	98%

: 5586-73-2
3-diphenylpropyl amine

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 574008-69-8
N-(3,3-diphenylpropyl)-2-nitrobenzenesulfonamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;	98%

: 5586-73-2
3-diphenylpropyl amine

: 108-18-9
diisopropylamine

: 159149-65-2
N-isopropyl-3,3-diphenylpropan-1-amine

Conditions

Conditions	Yield
With μ-diiodo-di((η5-pentamethylcyclopentadienyl)(iodo)iridium) In 5,5-dimethyl-1,3-cyclohexadiene at 155℃; for 10h; Inert atmosphere;	98%

: 4530-20-5
BOC-glycine

: 5586-73-2
3-diphenylpropyl amine

: 1002567-00-1
[(3,3-diphenyl-propylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h; Inert atmosphere;	97%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h;	90%

: 5586-73-2
3-diphenylpropyl amine

: 401573-42-0
N-(4-isothiocyanatomethylphenyl)methanesulfonamide

: N-{4-[3-(3,3-diphenyl-propyl)-thioureidomethyl]-phenyl}-methanesulfonamide

Conditions

Conditions	Yield
In dichloromethane at 20℃;	96%

: 5586-73-2
3-diphenylpropyl amine

: 7699-03-8
2-(4-hydroxyphenyl)-2-phenylacetic acid

: 1061757-69-4
N-(3,3-diphenylpropyl)-2-(4-hydroxyphenyl)-2-phenylacetamide

Conditions

Conditions	Yield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 12h; Schlenk technique; Inert atmosphere;	95%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 4h;	71%

: 5586-73-2
3-diphenylpropyl amine

: 10191-60-3
dimethyl N-cyanodithioiminocarbonate

: 136604-79-0
N-cyano-N'-(3,3-diphenylpropyl)-S-methylisothiourea

Conditions

Conditions	Yield
In dichloromethane for 0.5h;	94%

: 5586-73-2
3-diphenylpropyl amine

: 5,5-diallylcyclopent-1-en-1-yl trifluoromethanesulfonate

: (±)-(2SR,3aSR)-3a-allyl-N-(3,3-diphenylpropyl)-1,2,3,3a,4,5-hexahydropentalen-2-amine

Conditions

Conditions	Yield
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; palladium diacetate; lithium tert-butoxide In toluene at 95℃; for 16h; Schlenk technique; Inert atmosphere; diastereoselective reaction;	94%

: 5586-73-2
3-diphenylpropyl amine

: C24H26N4O12*C55H70O10

: C42H52N2O2*C55H70O10

Conditions

Conditions	Yield
With triethylamine In chloroform for 1h; Reflux; Inert atmosphere;	94%

: 5586-73-2
3-diphenylpropyl amine

: 140886-77-7
(3aRS,7aRS)-7a-(3-bromopropyl)-3a,4,7,7a-tetrahydroisobenzofuranone

: (6RS, 7RS)-N-(3',3'-diphenylpropyl)-7-hydroxymeth4l-2-azaspiro<5.5>undec-9-enone

Conditions

Conditions	Yield
In toluene for 16h; Heating;	93%

: 5586-73-2
3-diphenylpropyl amine

: 76-93-7
Benzilic acid

: 1061757-58-1
C29H27NO2

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃;	93%

: 5586-73-2
3-diphenylpropyl amine

: 555-16-8
4-nitrobenzaldehdye

: N-(p-nitrobenzylidene)-N-(3,3-diphenylpropyl)amine

Conditions

Conditions	Yield
In ethanol Heating;	92%

: 890713-73-2
5-[2-[(4-biphenylylcarbonyl)amino]ethyl]-1,2,4-oxadiazole-3-carboxylic acid ethyl ester

: 5586-73-2
3-diphenylpropyl amine

: 5-[2-[(4-biphenylylcarbonyl)amino]ethyl]-N-(3,3-diphenylpropyl)-1,2,4-oxadiazole-3-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 24h; Heating / reflux;	92%

: 50-00-0
formaldehyd

: 4648-54-8
trimethylsilylazide

: 5586-73-2
3-diphenylpropyl amine

: 14542-93-9
1,1,3,3-tetramethylbutane isonitrile

: 1340483-84-2
(3,3-diphenylpropyl)-[(1-(1,1,3,3-tetramethylbutyl)-1H-tetrazol-5-yl)methyl]amine

Conditions

Conditions	Yield
In methanol at 80℃; for 1.5h; Ugi condensation; Inert atmosphere; Microwave irradiation; Sealed tube;	92%

...Expand

: 5586-73-2
3-diphenylpropyl amine

: (4-fluorophenyl)(3,3,3-trifluoroprop-1-en-2-yl)iodonium trifluoromethane sulfonate

: 1-(3,3-diphenylpropyl)-2-(trifluoromethyl)aziridine

Conditions

Conditions	Yield
Stage #1: 3-diphenylpropyl amine With sodium carbonate In dichloromethane at 25℃; for 0.0166667h; Stage #2: (4-fluorophenyl)(3,3,3-trifluoroprop-1-en-2-yl)iodonium trifluoromethane sulfonate In dichloromethane at 25℃; for 2.5h;	92%

: 5586-73-2
3-diphenylpropyl amine

: 79463-77-7
N-cyanodiphenylcarbonimidate

: 136604-66-5
1-cyano-3-(3,3-diphenylpropyl)-2-phenylisourea

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 1h;	91%

: 5586-73-2
3-diphenylpropyl amine

: 67-64-1
acetone

: 159149-65-2
N-isopropyl-3,3-diphenylpropan-1-amine

Conditions

Conditions	Yield
Stage #1: 3-diphenylpropyl amine; acetone With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 0.0833333h; Stage #2: In tetrahydrofuran; 1,2-dichloro-ethane at 20℃; for 3h;	90.9%

: 5586-73-2
3-diphenylpropyl amine

: 623-27-8
terephthalaldehyde,

: N,N'-Bis-3,3-diphenylpropyl-p-phenylendimethanimin

Conditions

Conditions	Yield
	90%

: 5586-73-2
3-diphenylpropyl amine

: N-3,3-diphenylpropyl-O-succinimidyl carbamate

: 100938-83-8
1,3-Bis(3,3-diphenylpropyl)harnstoff

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	90%

: 32384-42-2
(1S,3R,4S,5R)-3,4-O-isopropylidene-1,5-quinic lactone

: 5586-73-2
3-diphenylpropyl amine

: C25H31NO5

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 60℃; for 0.0833333h; Microwave irradiation;	90%

: 124-38-9
carbon dioxide

: 5586-73-2
3-diphenylpropyl amine

: 41346-83-2
N-(3,3-diphenylpropyl)formamide

Conditions

Conditions	Yield
With 1,3-dimethylbenzimidazolium-2-carboxylate; phenylsilane In acetonitrile at 25℃; under 750.075 Torr; for 24h; Catalytic behavior;	90%

: 5586-73-2
3-diphenylpropyl amine

: 65-85-0
benzoic acid

: 100938-80-5
N-(3,3-diphenylpropyl)benzamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	89.5%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	88%

: 5586-73-2
3-diphenylpropyl amine

: 35468-69-0
2-hydroxy-2-phenylbutanoic acid

: N-(3,3-diphenyl-propyl)-2-hydroxy-2-phenyl-butyramide

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-2-phenylbutanoic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1.5h; Stage #2: 3-diphenylpropyl amine In dichloromethane at 20℃; for 10h;	89%

: 5586-73-2
3-diphenylpropyl amine

: 182317-03-9
3-ethoxy-4,5,6,7-tetrahydro-1,2-benzisoxazol-4-one

: (RS)-4-N-(3,3-diphenylprop-1-yl)amino-3-ethoxy-4,5,6,7-tetrahydrobenzo[d]isoxazole

Conditions

Conditions	Yield
With 3 A molecular sieve; sodium cyanoborohydride In methanol at 20℃; for 16h;	89%

: 5586-73-2
3-diphenylpropyl amine

: 35949-53-2
(-)-4,5-cyclohexylidenequinic acid lactone

: C28H35NO5

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 60℃; for 0.0833333h; Microwave irradiation;	88%

: 5586-73-2
3-diphenylpropyl amine

: 65662-67-1
2-hydroxy-2-phenyl-heptanoic acid

: 2-hydroxy-2-phenyl-heptanoic acid (3,3-diphenyl-propyl)-amide

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-2-phenyl-heptanoic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1.5h; Stage #2: 3-diphenylpropyl amine In dichloromethane at 20℃; for 10h;	87%

: 5586-73-2
3-diphenylpropyl amine

: 210096-14-3
3-(anthracen-9-yl)-2-hydroxybenzaldehyde

: N-3,3-diphenylpropyl 3-(9-anthracenyl)-2-hydroxybenzaldimine

Conditions

Conditions	Yield
With formic acid In ethanol	87%

: 5586-73-2
3-diphenylpropyl amine

: 100-10-7
4-dimethylamino-benzaldehyde

: N-[(p-dimethylamino)benzylidene]-N-(3,3-diphenylpropyl)amine

Conditions

Conditions	Yield
In ethanol Heating;	87%

3,3-Diphenylpropylamine Chemical Properties

Molecular Structure:

Molecular Formula: C₁₅H₁₇N
Molecular Weight: 211.3022
IUPAC Name: 3,3-Diphenylpropan-1-amine
Synonyms of 3,3-Diphenylpropylamine (CAS NO.5586-73-2): EINECS 226-984-3 ; NSC 137832
CAS NO: 5586-73-2
Classification Code: Amines ; C11 to C38 ; Nitrogen Compounds
Melting point: 29-31 °C
Index of Refraction: 1.577
Molar Refractivity: 68.37 cm³
Molar Volume: 206.2 cm³
Surface Tension: 42.1 dyne/cm
Density: 1.024 g/cm³
Flash Point: 155.2 °C
Enthalpy of Vaporization: 57.46 kJ/mol
Boiling Point: 331.9 °C at 760 mmHg
Vapour Pressure: 0.000151 mmHg at 25°C

3,3-Diphenylpropylamine Uses

3,3-Diphenylpropylamine (CAS NO.5586-73-2) is used as synthetic drugs heartache flat.

3,3-Diphenylpropylamine Safety Profile

Hazard Codes of 3,3-Diphenylpropylamine (CAS NO.5586-73-2): Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39: Wear suitable gloves and eye/face protection.
S36: Wear suitable protective clothing.
WGK Germany: 3
Hazard Note: Irritant

3,3-Diphenylpropylamine Specification

Fire Fighting: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Personal Protection: Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Product Name

3,3-Diphenylpropylamine

Synthetic route

3,3-Diphenylpropylamine Chemical Properties

3,3-Diphenylpropylamine Uses

3,3-Diphenylpropylamine Safety Profile

3,3-Diphenylpropylamine Specification

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