3,5-Dibromoaniline supplier

Name
3,5-Dibromoaniline
EINECS
CAS No. 626-40-4
Article Data29
CAS DataBase
Density 2.022g/cm3
Solubility
Melting Point 56.5oC
Formula C6H5 Br2 N
Boiling Point 296.8oC at 760 mmHg
Molecular Weight 250.92
Flash Point 133.3oC
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms Aniline,3,5-dibromo- (6CI,7CI,8CI); 3,5-Dibromoaniline; 3,5-Dibromobenzenamine; NSC6216
PSA 26.02000
LogP 3.37500

Synthetic route

: 6311-60-0
3,5-dibromonitrobenzene

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
With hydrogenchloride; tin at 90℃; for 7h;	99%
With hydrogenchloride; hydrogen; nickel In ethanol	96%
Stage #1: 3,5-dibromonitrobenzene With tin(II) chloride dihdyrate In tetrahydrofuran; methanol at 60℃; for 20h; Stage #2: With water; sodium hydroxide for 2h;	90%

: 626-39-1
1,3,5-trisbromobenzene

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
With bis(triphenylphosphine)nickel(II) chloride; lithium hexamethyldisilazane In toluene at 100℃; for 2h; Glovebox; Sealed tube;	81%

: 3,5-dibromophenylboronic acid

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
With O-(2,4-dinitrophenyl)hydroxylamine In toluene at 100℃; for 30h; Inert atmosphere;	56%

: 7647-01-0
hydrogenchloride

: 5326-51-2
N,N'-bis-(3,5-dibromo-phenyl)-hydrazine

A: 626-40-4
3,5-dibromoaniline

B: 38292-74-9
3,3′,5,5′-tetrabromo-1,1′-azobenzene

Conditions

Conditions	Yield
at 150℃; im Rohr;

...Expand

: 5326-51-2
N,N'-bis-(3,5-dibromo-phenyl)-hydrazine

: 7664-93-9
sulfuric acid

A: 626-40-4
3,5-dibromoaniline

B: 860599-94-6
2,6,2',6'-tetrabromo-benzidine

C: 854242-36-7
4,6,2',6'-tetrabromo-biphenyl-2,4'-diyldiamine

D: 38292-74-9
3,3′,5,5′-tetrabromo-1,1′-azobenzene

...Expand

: 6311-60-0
3,5-dibromonitrobenzene

acid: acid

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
bei der Reduktion;

: 64-17-5
ethanol

: 6311-60-0
3,5-dibromonitrobenzene

Na2S2: Na2S2

A: 626-40-4
3,5-dibromoaniline

B: bis-(3,5-dibromo-phenyl)-diazene-N-oxide

...Expand

: 827-94-1
2,6-dibromo-4-nitroaniline

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: NaNO2; H2SO4; aq. H3PO4 / 2 h 1.2: urea; H2SO4; aq. H3PO4 / 20 °C 1.3: 85 percent / H2SO4; aq. H3PO4 / 0 - 20 °C 2.1: 99 percent / tin; aq. HCl / 7 h / 90 °C View Scheme
Multi-step reaction with 2 steps 1: 80 percent / H2SO4; NaNO2 / ethanol / 36 h / 90 °C 2: 89 percent / SnCl2*2H2O / ethanol; tetrahydrofuran / 20 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: 97 percent / NaNO2, H2SO4 / ethanol 2: 96 percent / 1.) H2; 2.) aq. HCl / Raney Ni / ethanol View Scheme

: 100-01-6
4-nitro-aniline

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 97 percent / Br2 / acetic acid / 4 h / 65 °C 2: 80 percent / H2SO4; NaNO2 / ethanol / 36 h / 90 °C 3: 89 percent / SnCl2*2H2O / ethanol; tetrahydrofuran / 20 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1: diluted hydrochloric acid; bromine 3: tin; hydrochloric acid View Scheme
Multi-step reaction with 3 steps 1: aqueous sulfuric acid; bromine 3: iron; diluted sulfuric acid View Scheme
Multi-step reaction with 3 steps 1.1: acetic acid; bromine / 4 h / 65 °C 2.1: sulfuric acid; sodium nitrite / ethanol / 40 h / 80 °C 3.1: tin(II) chloride dihdyrate / methanol; tetrahydrofuran / 20 h / 60 °C 3.2: 2 h View Scheme

: 100-01-6
4-nitro-aniline

4-nitro-toluenediazonium sulfate-(2): 4-nitro-toluenediazonium sulfate-(2)

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 98 percent / Br2 / acetic acid 2: 97 percent / NaNO2, H2SO4 / ethanol 3: 96 percent / 1.) H2; 2.) aq. HCl / Raney Ni / ethanol View Scheme

: 100-01-6
4-nitro-aniline

Rest of peptide structure not given: Rest of peptide structure not given

: 626-40-4
3,5-dibromoaniline

: 108-36-1
1,3-dibromobenzene

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: beim Nitrieren 2: alcohol; ammonia / 160 °C 3: hydrochloric acid; bromine 5: alcohol; ammonia / 150 °C 7: tin; hydrochloric acid View Scheme

: 31106-74-8
1,3-dibromo-2-methoxy-5-nitrobenzene

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: alcohol; ammonia / 180 °C 3: tin; hydrochloric acid View Scheme

: 3460-20-6
1,2,3-tribromo-5-nitrobenzene

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: alcohol; ammonia / 150 °C 3: tin; hydrochloric acid View Scheme

: 610-38-8
4-bromo-1,2-dinitrobenzene

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: alcohol; ammonia / >180 2: hydrochloric acid; bromine 4: alcohol; ammonia / 150 °C 6: tin; hydrochloric acid View Scheme

: 51686-78-3
2,4-dibromonitrobenzene

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: alcohol; ammonia / 160 °C 2: hydrochloric acid; bromine 4: alcohol; ammonia / 150 °C 6: tin; hydrochloric acid View Scheme

: 116529-58-9
2,3,5-tribromonitrobenzene

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: alcohol; ammonia / 140 °C 3: tin; hydrochloric acid View Scheme

: 5228-61-5
5-bromo-2-nitroaniline

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: hydrochloric acid; bromine 3: alcohol; ammonia / 150 °C 5: tin; hydrochloric acid View Scheme

: 827-23-6
2,4-dibromo-6-nitroaniline

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: tin; hydrochloric acid View Scheme

: 2,3,4-tribromo-6-nitro-aniline

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 2: alcohol; ammonia / 150 °C 4: tin; hydrochloric acid View Scheme

: 725241-64-5
4,6-dibromo-2-nitroanisole

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: alcohol; ammonia / 170 °C 3: tin; hydrochloric acid View Scheme

: 88-74-4
2-nitro-aniline

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Bromieren 3: tin; hydrochloric acid View Scheme

: 103-84-4
Acetanilid

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: nitric acid / Verseifen das entstandene Gemisch mit Kalilauge und destillieren mit Wasserdampf 2: Bromieren 4: tin; hydrochloric acid View Scheme

: 528-29-0
1,2-Dinitrobenzene

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: alcoholic ammonium sulfide 2: Bromieren 4: tin; hydrochloric acid View Scheme

: 71-43-2
benzene

: 626-40-4
3,5-dibromoaniline

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: concentrated sulfuric acid; fuming nitric acid 2: alcoholic ammonium sulfide 3: Bromieren 5: tin; hydrochloric acid View Scheme

: 626-40-4
3,5-dibromoaniline

: 108-72-5
1,3,5-triaminobenzene

Conditions

Conditions	Yield
With C24H12Cu2F9N4O7; tetrabutylammomium bromide; ammonia; caesium carbonate In water at 110 - 140℃; for 16h;	100%

: sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate

: 225931-80-6
bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II)

: 626-40-4
3,5-dibromoaniline

: C58H73Br2NO10P2Pd2S2(2-)*2Na(1+)

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 1h;	99%

...Expand

: 492-61-5
β-D-glucose

: 626-40-4
3,5-dibromoaniline

: (-)-(3R,4S,5S,6R)-2-(3,5-dibromophenylamino)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions

Conditions	Yield
In methanol for 12h; Reflux;	97%

: 626-40-4
3,5-dibromoaniline

: 108-24-7
acetic anhydride

: 119430-40-9
acetic acid-(3,5-dibromo-anilide)

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃;	96%

: 50-00-0
formaldehyd

: 626-40-4
3,5-dibromoaniline

: 64230-29-1
3,5-dibromo-N,N-dimethylaniline

Conditions

Conditions	Yield
Stage #1: formaldehyd With sulfuric acid In tetrahydrofuran; water at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 3,5-dibromoaniline With sodium tetrahydroborate In tetrahydrofuran; water at 0 - 20℃; for 2h; Inert atmosphere;	96%

: 626-40-4
3,5-dibromoaniline

: 14047-29-1
4-carboxyphenylboronic acid

: C20H15NO4

Conditions

Conditions	Yield
Stage #1: 3,5-dibromoaniline; 4-carboxyphenylboronic acid With potassium carbonate In water; acetonitrile for 1h; Schlenk technique; Inert atmosphere; Stage #2: With bis-triphenylphosphine-palladium(II) chloride In water; acetonitrile at 100℃; for 48h; Schlenk technique; Inert atmosphere; Sealed tube;	96%
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In water; acetonitrile at 100℃; for 48h; Sealed tube; Inert atmosphere;	79%

: 626-40-4
3,5-dibromoaniline

: 406935-63-5
C6H3Br2NOS

Conditions

Conditions	Yield
With thionyl chloride Michaelis reaction;	95%

: 50-00-0
formaldehyd

: 626-40-4
3,5-dibromoaniline

: 77767-17-0
1,5-Bis(3,5-dibromphenyl)-3,7-dioxa-1,5-diazacyclooctan

Conditions

Conditions	Yield
With sulfuric acid In 1,4-dioxane; water for 2h; Ambient temperature;	91%

: 626-40-4
3,5-dibromoaniline

: 21615-34-9
2-Methoxybenzoyl chloride

: 2-methoxy-N-(3,5-dibromophenyl)benzamide

Conditions

Conditions	Yield
In tetrahydrofuran for 1h;	91%

: 626-40-4
3,5-dibromoaniline

: 532-55-8
Benzoyl isothiocyanate

: 1000289-38-2
1-benzoyl-3-(3,5-dibromophenyl)thiourea

Conditions

Conditions	Yield
In acetone at 20℃; for 0.5h;	90%

: 626-40-4
3,5-dibromoaniline

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 5‘-amino-3,3“,4,4“,5,5“-hexamethoxy-1,1‘:3‘,1“-terphenyl

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In 1,4-dioxane; water Reflux;	90%

: 626-40-4
3,5-dibromoaniline

: 312-94-7
2-trifluoromethylbenzoyl chloride

: 2-trifluoromethyl-N-(3,5-dibromophenyl)benzamide

Conditions

Conditions	Yield
In tetrahydrofuran for 1h;	88%

: 64-18-6
formic acid

: 626-40-4
3,5-dibromoaniline

: 16582-45-9
N-(3,5-dibromophenyl)formamide

Conditions

Conditions	Yield
Reflux;	87%

: 626-40-4
3,5-dibromoaniline

: 56-81-5
glycerol

: 34522-69-5
5,7-dibromoquinoline

Conditions

Conditions	Yield
With sulfuric acid; sodium 3-nitrobenzenesulfonate at 100 - 135℃; for 3h;	87%
Stage #1: 3,5-dibromoaniline With methanesulfonic acid; iron(ll)sulfate heptahydrate; sodium 3-nitrobenzenesulfonate at 120℃; Stage #2: glycerol at 130℃; Skraup Quinoline Synthesis;	56%
With sulfuric acid; nitrobenzene

: 932378-94-4
benzene-1,3-dicarboxylethylester-5-boronic acid

: 626-40-4
3,5-dibromoaniline

: 3′-amino-1,1′:4′,1″-terphenyl-3,3″,5,5″-tetracarboxylate

Conditions

Conditions	Yield
With palladium diacetate; sodium carbonate In water; N,N-dimethyl-formamide at 60℃; Inert atmosphere;	86%

: 591-50-4
iodobenzene

: 626-40-4
3,5-dibromoaniline

: 63006-66-6
N'-phenyl-(1,1';3',1'-terphenyl)-5'-amine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 5h;	86%

: 626-40-4
3,5-dibromoaniline

: 98-88-4
benzoyl chloride

: N-(3,5-dibromophenyl)benzamide

Conditions

Conditions	Yield
With pyridine In dichloromethane for 18h;	85%

: 626-40-4
3,5-dibromoaniline

: 411235-57-9
cyclopropylboronic acid

: 41381-24-2
3,5-dicyclopropylaniline

Conditions

Conditions	Yield
With tricyclohexylphosphine In water; toluene at 20 - 100℃; for 18h; Inert atmosphere;	85%

: 626-40-4
3,5-dibromoaniline

: 98-09-9
benzenesulfonyl chloride

: N-(3,5-dibromophenyl)benzenesulfonamide

Conditions

Conditions	Yield
With pyridine In dichloromethane for 18h;	83%
With pyridine; acetone
With sodium acetate; acetic acid

: 698-72-6
2,4-dichloro-6-ethyl-1,3,5-triazine

: 626-40-4
3,5-dibromoaniline

: 2-ethyl-4,6-bis[(3,5-dibromophenyl)amino]-1,3,5-triazine

Conditions

Conditions	Yield
In tetrahydrofuran for 18h; Reflux;	83%

: 626-40-4
3,5-dibromoaniline

: 19752-57-9
1,3-dibromo-5-iodobenzene

Conditions

Conditions	Yield
With hydrogenchloride; potassium iodide; sodium nitrite In water; acetonitrile at 0℃;	82%
Stage #1: 3,5-dibromoaniline With sulfuric acid; sodium nitrite at 0 - 50℃; Stage #2: With potassium iodide In water at 0 - 80℃; for 1.25h;	80%
Stage #1: 3,5-dibromoaniline With phosphoric acid; sulfuric acid; sodium nitrite at 0 - 20℃; Stage #2: With sulfuric acid; urea; potassium iodide; phosphoric acid at 20 - 50℃;	72%
Stage #1: 3,5-dibromoaniline With sulfuric acid; sodium nitrite at 0℃; for 2h; Stage #2: With potassium iodide at 80℃; for 0.25h; Sandmeyer reaction;	70%
Diazotization;

: 626-40-4
3,5-dibromoaniline

: 4334-88-7
p-ethoxycarbonylphenylboronic acid

: C24H23NO4

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran at 80℃; for 72h; Schlenk technique; Inert atmosphere;	82%

: 2905-62-6
3,5-dichlorobenzoyl chloride

: 626-40-4
3,5-dibromoaniline

: 3,5-dichloro-N-(3,5-dibromophenyl)benzamide

Conditions

Conditions	Yield
In tetrahydrofuran for 1h;	81%

: 5600-21-5
2-amino-6-methyl-4-chloropyrimidine

: 626-40-4
3,5-dibromoaniline

: N4-(3,5-dibromophenyl)-6-methylpyrimidine-2,4-diamine

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 140℃; for 1.5h; Microwave irradiation; Sealed tube;	81%

: 626-40-4
3,5-dibromoaniline

: 3-aminophenylboronic acid hydrochloric salt

: [1,1':3',1''-terphenyl]-3,3",5'-triamine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); Aliquat 336; potassium carbonate In tetrahydrofuran at 75℃; for 24h; Reflux; Inert atmosphere;	81%

: 626-40-4
3,5-dibromoaniline

: 73852-19-4
3,5-bis-trifluromethylphenylboronic acid

: 3,3'',5,5''-tetrakis(trifluoromethyl)-[1,1':3',1''-terphenyl]-5'-amine

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate In tetrahydrofuran; water Inert atmosphere; Reflux;	81%

: 626-40-4
3,5-dibromoaniline

: 100-39-0
benzyl bromide

: N,N-dibenzyl-3,5-dibromoaniline

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 125℃; for 4h;	80%
With potassium carbonate In acetonitrile at 125℃; for 4h; Inert atmosphere; Schlenk technique;	80%
With potassium carbonate In acetonitrile for 24h; Reflux;	73%
With potassium carbonate In acetonitrile Reflux;	73%

: 626-40-4
3,5-dibromoaniline

: 100074-46-2
3-(4-fluorophenyl)-4-hydroxyfuran-2(5H)-one

: 1283094-23-4
4-(3,5-dibromophenylamino)-3-(4-fluorophenyl)furan-2(5H)-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 90℃; Reflux;	79%

3,5-Dibromoaniline Chemical Properties

IUPAC Name:3,5-dibromoaniline
Molecular Formula:C₆H₅Br₂N
Molecular Weight:250.918600 g/mol
Density:2.022 g/cm³
Flash Point:133.3 °C
Enthalpy of Vaporization:53.66 kJ/mol
Boiling Point:296.8 °C at 760 mmHg
Vapour Pressure:0.0014 mmHg at 25 °C
storage temp.:keep Cold
Synonyms of 3,5-Dibromoaniline(626-40-4):
benzenamine, 3,5-dibromo-;3,5-Dibromoaniline
Categories of 3,5-Dibromoaniline(626-40-4):Amines;blocks;Bromides

3,5-Dibromoaniline Safety Profile

Safety Information of 3,5-Dibromoaniline(626-40-4):
Hazard Codes:Xi

Product Name

3,5-Dibromoaniline

Synthetic route

3,5-Dibromoaniline Chemical Properties

3,5-Dibromoaniline Safety Profile

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