4-(Bromomethyl)pyridine hydrobromide supplier

Name
4-(Bromomethyl)pyridine hydrobromide
EINECS 629-462-7
CAS No. 73870-24-3
Article Data7
CAS DataBase
Density
Solubility Soluble in water
Melting Point 189-192 °C(lit.)
Formula C₆H₆BrN^.HBr
Boiling Point
Molecular Weight 252.936
Flash Point
Transport Information UN 3261
Appearance
Safety 26-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms Pyridine,4-(bromomethyl)-, hydrobromide (6CI,9CI);(4-Pyridyl)methyl bromidehydrobromide;4-(Bromomethyl)pyridine hydrobromide;4-Picolyl bromidehydrobromide;
PSA 12.89000
LogP 2.93460

Synthetic route

: 65737-59-9
4-(hydroxymethyl)pyridine hydrobromide

: 73870-24-3
4-bromomethyl pyridine hydrobromide

Conditions

Conditions	Yield
With phosphorus tribromide In chloroform at 45℃;	93%
With phosphorus tribromide In chloroform for 3h; Heating;	91%
With phosphorus tribromide In chloroform for 4.5h; Reflux;	78%

: 586-95-8
pyridine-4-methanol

: 73870-24-3
4-bromomethyl pyridine hydrobromide

Conditions

Conditions	Yield
With phosphorus pentabromide In chloroform	58.1%
With hydrogen bromide In water at 150℃;	50%
With hydrogen bromide In water for 8h; Product distribution / selectivity; Reflux;
Multi-step reaction with 2 steps 1: hydrogen bromide / water / 4 h / Reflux 2: phosphorus tribromide / chloroform / 4.5 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: hydrogen bromide / 4 h / 100 °C 2: phosphorus tribromide / chloroform / 45 °C View Scheme

: 872-85-5
pyridine-4-carbaldehyde

: 73870-24-3
4-bromomethyl pyridine hydrobromide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium tetrahydroborate / methanol / 2 h / 0 - 25 °C 2: hydrogen bromide / 4 h / 100 °C 3: phosphorus tribromide / chloroform / 45 °C View Scheme

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 864528-34-7
4-(2-azidomethyl)pyridine

Conditions

Conditions	Yield
Stage #1: 4-bromomethyl pyridine hydrobromide With potassium carbonate In N,N-dimethyl-formamide for 0.25h; Stage #2: With sodium azide In N,N-dimethyl-formamide at 20℃; for 3h;	100%
Stage #1: 4-bromomethyl pyridine hydrobromide With potassium carbonate at 20℃; for 0.25h; Inert atmosphere; Stage #2: With sodium azide at 20℃; for 72h; Inert atmosphere;	49%
Stage #1: 4-bromomethyl pyridine hydrobromide With potassium carbonate In N,N-dimethyl-formamide for 0.25h; Stage #2: With sodium azide In N,N-dimethyl-formamide at 20℃; for 4h;

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 22510-08-3
2-fiuoro-5-nitrophenol

: C12H9FN2O3

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 1h;	100%

: 4-(4-chlorophenyl)-1-(2-methoxyethyl)-6-methyl-2-oxo-3,4-dihydropyridine-5-carboxylic acid

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 4-pyridylmethyl 4-(4-chlorophenyl)-1-(2-methoxyethyl)-6-methyl-2-oxo-3,4-dihydropyridine-5-carboxylate

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 1h;	99%

: 1124219-46-0
N-{3-[(4-fluorobenzyl)oxy]phenyl}piperidine-4-carboxamide hydrochloride

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 1472647-67-8
N-{3-[(4-fluorobenzyl)oxy]phenyl}-1-(pyridin-4-ylmethyl)piperidine-4-carboxamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 48h;	97%

: tert-butyl 2-(4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl)acetate

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: rac-tert-butyl 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-(pyridin-4-yl)propanoate

Conditions

Conditions	Yield
With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 2h;	96.53%
Stage #1: tert-butyl 2-(4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl)acetate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.333333h; Inert atmosphere; Stage #2: 4-bromomethyl pyridine hydrobromide In tetrahydrofuran at -78 - 20℃; for 2h;
Stage #1: tert-butyl 2-(4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl)acetate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.333333h; Inert atmosphere; Stage #2: 4-bromomethyl pyridine hydrobromide In tetrahydrofuran at -78 - 20℃; for 2h;
Stage #1: tert-butyl 2-(4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl)acetate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.333333h; Inert atmosphere; Stage #2: 4-bromomethyl pyridine hydrobromide at -78 - 20℃; for 2h;

: 22323-82-6
(S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: (S)-3-(pyridin-4-yl-methoxy)-1,2-O-isopropyliden-propane-1,2-diol

Conditions

Conditions	Yield
Stage #1: (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 0℃; for 0.333333h; Inert atmosphere; Schlenk technique; Stage #2: 4-bromomethyl pyridine hydrobromide In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Inert atmosphere; Schlenk technique;	95%

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 3,6-bis(5-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)thiophen-2-yl)-9H-carbazole

: 9-(pyridin-4-ylmethyl)-3,6-bis(5-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)thiophen-2-yl)-9H-carbazole

Conditions

Conditions	Yield
Stage #1: 3,6-bis(5-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)thiophen-2-yl)-9H-carbazole With sodium hydride In tetrahydrofuran; mineral oil at 0℃; Inert atmosphere; Schlenk technique; Stage #2: 4-bromomethyl pyridine hydrobromide With potassium carbonate In tetrahydrofuran; diethyl ether; water; mineral oil at 20℃; Inert atmosphere; Schlenk technique;	91%

: 1148015-61-5
C62H108N2O17

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 1148015-62-6
DOPU

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 59.84℃; for 2h;	90%

: 952106-37-5
7-Hydroxy-8-methyl-2-(morpholin-4-yl)-4H-1,3-benzoxazin-4-one

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 1257411-71-4
8-methyl-2-morpholin-4-yl-7-(pyridin-4-ylmethoxy)-4H-1,3-benzoxazin-4-one

Conditions

Conditions	Yield
Stage #1: 7-Hydroxy-8-methyl-2-(morpholin-4-yl)-4H-1,3-benzoxazin-4-one With caesium carbonate In acetonitrile for 2h; Reflux; Stage #2: 4-bromomethyl pyridine hydrobromide In acetonitrile for 0.5h; Reflux;	90%

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 526222-96-8
(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester

: 7-benzyl 8-(tert-butyl) (5S,8S)-2,4-dioxo-3-(pyridin-4-ylmethyl)-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;	90%

: 1666-13-3
diphenyl diselenide

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 1268397-89-2
4-(phenylselenomethyl)pyridine

Conditions

Conditions	Yield
With sodium tetrahydroborate; sodium hydroxide In ethanol at 20℃; Inert atmosphere;	89%

: 1358040-39-7
(9H-carbazol-3-yl)(piperidin-1-yl)methanone

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 1358039-43-6
piperidin-1-yl(9-(pyridin-4-ylmethyl)-9H-carbazol-3-yl)methanone

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 48h;	89%

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 7791-71-1
5'-O-tritylthymidine

: 3'-O-(4-picolyl)thymidine

Conditions

Conditions	Yield
Stage #1: 5'-O-tritylthymidine With sodium hydride In tetrahydrofuran for 0.333333h; Inert atmosphere; Sonication; Stage #2: 4-bromomethyl pyridine hydrobromide In tetrahydrofuran; water for 0.75h; Inert atmosphere; Sonication; Stage #3: With hydrogenchloride In ethanol; water at 80℃; for 1h;	88%

: 124-13-0
Octanal

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 1245640-45-2
(R)-2-(pyridin-4-ylmethyl)octanal

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; (2R,5S)-5-benzyl-2,3-dimethylimidazolidin-4-one; tris-(2-phenylpyridinato-C(2),N)iridinium(III) In dimethyl sulfoxide at 20℃; for 3h; Inert atmosphere; Fluorescent light; optical yield given as %ee; enantioselective reaction;	87%

: 75-15-0
carbon disulfide

: 39604-80-3
1-[2-hydroxy-4-(phenylmethoxy)phenyl]-2-phenylethanone

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 746640-15-3
3-phenyl-7-(phenylmethoxy)-2-[(pyridin-4-ylmethyl)thio]-4H-1-benzopyran-4-one

Conditions

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In tetrahydrofuran at 20℃;	86%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In tetrahydrofuran	86%

...Expand

: 75-15-0
carbon disulfide

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 474391-07-6
1-(2-hydroxy-4-methoxyphenyl)-2-(4-methylphenyl)ethanone

: 7-methoxy-3-(4-methylphenyl)-2-[(pyridin-4-ylmethyl)thio]-4H-1-benzopyran-4-one

Conditions

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In tetrahydrofuran at 20℃;	86%

...Expand

: C15H22O4

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: C21H27NO4

Conditions

Conditions	Yield
Stage #1: C15H22O4 With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: 4-bromomethyl pyridine hydrobromide In tetrahydrofuran at 0 - 23℃; Inert atmosphere;	86%

: 75-15-0
carbon disulfide

: 95307-71-4
1-[2-hydroxy-4-(phenylmethoxy)phenyl]-2-(4-methoxyphenyl)ethanone

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 746640-16-4
3-(4-methoxyphenyl)-7-(phenylmethoxy)-2-[(pyridin-4-ylmethyl)thio]-4H-1-benzopyran-4-one

Conditions

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In tetrahydrofuran at 20℃;	84%

...Expand

: 75-15-0
carbon disulfide

: 39604-64-3
1-(2-hydroxy-4-methoxyphenyl)-2-(4-methoxyphenyl)ethanone

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 7-methoxy-3-(4-methoxyphenyl)-2-[(pyridin-4-ylmethyl)thio]-4H-1-benzopyran-4-one

Conditions

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In tetrahydrofuran at 20℃;	82%

...Expand

: 75-15-0
carbon disulfide

: 18439-96-8
1-(2-hydroxy-4-methoxyphenyl)-2-phenylethanone

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: 746640-10-8
7-methoxy-3-phenyl-2-[(pyridin-4-ylmethyl)thio]-4H-1-benzopyran-4-one

Conditions

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In tetrahydrofuran at 20℃;	81%

...Expand

: 472-15-1
Betulinic acid

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: pyridin-4-ylmethyl 3-hydroxylup-20(29)-en-28-oate

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃;	80%

4-(Bromomethyl)pyridine hydrobromide Specification

The 4-(Bromomethyl)pyridine hydrobromide, with CAS registry number 73870-24-3, belongs to the following product categories: (1)Heterocyclic Building Blocks; (2)Halogenated Heterocycles; (3)Pyridines. It has the systematic name of 4-(bromomethyl)pyridine hydrobromide (1:1). And the chemical formula of this chemical is C₆H₆BrN^.HBr.

When you are using this chemical, please be cautious about it as the following:
The 4-(Bromomethyl)pyridine hydrobromide may cause burns. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: c1cnccc1CBr.Br
(2)InChI: InChI=1/C6H6BrN.BrH/c7-5-6-1-3-8-4-2-6;/h1-4H,5H2;1H
(3)InChIKey: VAJUUDUWDNCECT-UHFFFAOYAF
(4)Std. InChI: InChI=1S/C6H6BrN.BrH/c7-5-6-1-3-8-4-2-6;/h1-4H,5H2;1H
(5)Std. InChIKey: VAJUUDUWDNCECT-UHFFFAOYSA-N

Product Name

4-(Bromomethyl)pyridine hydrobromide

Synthetic route

4-(Bromomethyl)pyridine hydrobromide Specification

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