Nanjing Spring & Autumn Biological Engineering Co., Ltd. Which was founded at 2008, has an R & D team composed very experienced natural products chemists. The company is a high-tech enterprise engaged in functional health care products raw ma
Product name: Birch Bark Extract Betulin 70%-98%;Betulinic acid 50%-98% Betulinic acid 50%, 90%, 98% CAS: 472-15-1 Molecular formula: C30H48O3 Molar mass: 456.71 Quality data Identifica
Cas:472-15-1
Min.Order:1 Kilogram
FOB Price: $15.0
Type:Trading Company
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:472-15-1
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryAnalysis tests Standard Results Appearance White or white powder white powder Spectrum detection
Cas:472-15-1
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Trading Company
inquiryCASNumber: 472-15-1 Name: Betulinicacid MolecularStructure: 230)this.width=230;" onerror="javascrip…Appearance:powder Storage:sealed bag Package:bags Application:in pharma or food supplements Transpo
Company profile Xi’an Quanao Biotech Co., Ltd. with 10 years experience in plant extract filed. Focus on the research, production and sale of Plant and Animal extract, Medical intermediate, complete coverage six industries. Product grade: Medic
Cas:472-15-1
Min.Order:10 Gram
FOB Price: $8.5 / 16.8
Type:Manufacturers
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:472-15-1
Min.Order:1 Gram
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Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:472-15-1
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial since 1987. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We can
Cas:472-15-1
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryProduct Name: Betulinic acid Synonyms: 3BETA-HYDROXY-20(29)-LUPENE-28-OIC ACID;3BETA-HYDROXY-20(29)-LUPAENE-28-OIC ACID;3B-HYDROXY-20(29)-LUPENE-28-OIC ACID;3-B-HYDROXY-LUPA-20(30)-ENE 28-OIC ACID;BETULINIC
Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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Min.Order:1 Kilogram
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Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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Type:Trading Company
inquiryName Betulinic acid CAS No 472-15-1 MF C30H48O3 Purity 99% Appearance white powder Appearance: White powder Storage:Store in c
Cas:472-15-1
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiryAppearance:White powder Storage:Room temperature Package:1kg/bag Application:Anticancer and HIV therapy, antioxidant damage and immune modulation Transportation:Express/Sea/Air Port:Any port in china
Cas:472-15-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:472-15-1
Min.Order:10 Gram
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Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At pres
Cas:472-15-1
Min.Order:1 Kilogram
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Type:Trading Company
inquiryBetulinic acid CAS:472-15-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:472-15-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Betulinic acid Basic information Product Name: Betulinic acid Synonyms: Betulinic acid technical grade, 90%;3BETA-HYDROXY-20(29)-LUPENE-28-OIC A
Cas:472-15-1
Min.Order:1 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryChengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic
Cas:472-15-1
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:472-15-1
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry≥98.0% USP standard Appearance:White or off white fine powder Storage:Room temperature Package:as required Application:used in medicine Transportation:by sea by air express Port:China main port
Cas:472-15-1
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd
Conditions | Yield |
---|---|
Stage #1: betulonic acid With aluminum isopropoxide; benzyl alcohol In tetrahydrofuran at 65℃; for 2h; Stage #2: With sodium hydroxide In water; xylene at 130℃; for 1h; Stage #3: With acetic acid In water Conversion of starting material; | 96.3% |
Stage #1: betulonic acid With aluminum isopropoxide; benzyl alcohol In tetrahydrofuran at 65℃; for 2h; Heating / reflux; Stage #2: With sodium hydroxide; water In xylenes at 130℃; for 1h; Stage #3: With acetic acid In water | 96.3% |
With sodium tetrahydroborate; isopropyl alcohol; sodium hydroxide In water for 3h; | 94% |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In tetrahydrofuran Acidic conditions; | 94% |
3-O-acetylbetulinic acid
Betulinic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol for 3h; Heating; | 89% |
With potassium carbonate In methanol for 24h; | 88% |
With potassium hydroxide | |
With potassium hydroxide In methanol |
Conditions | Yield |
---|---|
Stage #1: betulin With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene In acetic acid butyl ester; water; tert-butyl alcohol at 20℃; for 6h; Stage #2: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene In acetic acid butyl ester; water; tert-butyl alcohol Solvent; Concentration; Reagent/catalyst; | 89% |
With 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl; sodium chlorite; tetrabutylammomium bromide; sodium hypochlorite In phosphate buffer at 50℃; | 86% |
With 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl; tetrabutylammomium bromide; sodium hypochlorite In phosphate buffer at 50℃; pH=7.6; | 72% |
betulinic aldehyde
Betulinic acid
Conditions | Yield |
---|---|
With sodium dihydrogenphosphate; sodium permanganate In dichloromethane; water; tert-butyl alcohol at 25℃; for 3h; | 85% |
With sodium chlorite; sodium dihydrogenphosphate; 2-Methyl-1-butene; tert-butyl alcohol In toluene at 21℃; for 22h; Reagent/catalyst; Solvent; Temperature; Time; | 76% |
With potassium permanganate In acetone at 0 - 20℃; | |
With sodium chlorite; sodium dihydrogenphosphate In dichloromethane; tert-butyl alcohol |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In tetrahydrofuran Yields of byproduct given; | A 75% B n/a |
Stage #1: betulonic acid With L-Selectride In tetrahydrofuran at -80℃; for 5h; Stage #2: With sodium hydroxide; dihydrogen peroxide In tetrahydrofuran for 1h; | A 19% B 38% |
With sodium tetrahydroborate In tetrahydrofuran Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
With synthetic air In 1,3,5-trimethyl-benzene at 140℃; under 760.051 Torr; for 6h; Catalytic behavior; | A 20% B 9% C 27% |
With CeO2/TiO2; air In 1,3,5-trimethyl-benzene at 140℃; for 6h; Overall yield = 8 %; |
betulin
A
betulonic aldehyde
B
betulinic aldehyde
C
Betulinic acid
D
betulonic acid
Conditions | Yield |
---|---|
With dipyridinium dichromate In water; N,N-dimethyl-formamide | A 20% B 7% C 8% D 13% |
Conditions | Yield |
---|---|
In 1,3,5-trimethyl-benzene at 140℃; for 4h; | A n/a B 5.3% |
lup-20(29)-en-28-oic-3-O-β-D-glucopyranosyl (2->1)-O-β-D-glucopyranoside
Betulinic acid
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 100℃; for 4h; |
3β-trans-(3,4-dihydroxycinnamoyloxy)-20(29)-lupen-28-oic acid
Betulinic acid
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol for 16h; Ambient temperature; | 220 mg |
α-L-rhamnopyranosyl-3β-hydroxy-lup-20(29)-en-28-oic acid
Betulinic acid
Conditions | Yield |
---|---|
With sulfuric acid for 5h; Heating; |
Betulinic acid
Conditions | Yield |
---|---|
With sulfuric acid In ethanol for 5h; Heating; |
A
D-Glucose
B
L-rhamnose
C
L-arabinose
D
Betulinic acid
Conditions | Yield |
---|---|
With sulfuric acid In water for 6h; Product distribution; Heating; |
Betulinic acid
Conditions | Yield |
---|---|
With sulfuric acid In water for 6h; Heating; |
28-O-β-D-glucopyranosyl 3β-hydroxy-lup-20(29)-en-28-oate
Betulinic acid
Conditions | Yield |
---|---|
With enzyme β-glucosidase In N,N-dimethyl-formamide at 37℃; for 72h; phosphate buffer (pH 5); |
Conditions | Yield |
---|---|
Quantum yield; Product distribution; Further Variations:; Temperatures; Solvents; |
Conditions | Yield |
---|---|
With potassium hydroxide In methanol for 3h; Heating; | A 1.8 mg B 3.1 mg |
A
18-hydroxyoctadec-9-enoic acid
B
9,10-epoxy-18-hydroxyoctadecanoic acid
D
22-hydroxydocosanoic acid
E
Betulinic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water |
A
18-hydroxyoctadec-9-enoic acid
B
9,10-epoxy-18-hydroxyoctadecanoic acid
D
22-hydroxydocosanoic acid
E
Betulinic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water |
betulin monoacetate
Betulinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tert-butyl chromate 2: KOH / methanol View Scheme | |
Multi-step reaction with 2 steps 1: chromium (VI)-oxide; water containing acetic acid 2: ethanolic KOH-solution View Scheme | |
Multi-step reaction with 2 steps 1: chromium (VI)-oxide; water containing acetic acid 2: ethanolic KOH-solution View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / CrO3, H2SO4 / acetone / 1.5 h / 0 °C 2: 88 percent / aq. K2CO3 / methanol / 24 h View Scheme |
3-hydroxy-28-[(tetrahydro-2H-pyran-2-yl)oxy]lup-20(29)-ene
Betulinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 87 percent / pyridine / 36 h / Ambient temperature 2: 95 percent / pyridinium p-toluene sulfonic acid salt / methanol / 36 h / Ambient temperature 3: 80 percent / CrO3, H2SO4 / acetone / 1.5 h / 0 °C 4: 88 percent / aq. K2CO3 / methanol / 24 h View Scheme |
3-O-acetyl-28-O-tetrahydropyranylbetulin
Betulinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 95 percent / pyridinium p-toluene sulfonic acid salt / methanol / 36 h / Ambient temperature 2: 80 percent / CrO3, H2SO4 / acetone / 1.5 h / 0 °C 3: 88 percent / aq. K2CO3 / methanol / 24 h View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: benzene; KOH; ethanol 2: chromium (VI)-oxide; water containing acetic acid 3: ethanolic KOH-solution View Scheme | |
Multi-step reaction with 3 steps 1: benzene; KOH; ethanol 2: chromium (VI)-oxide; water containing acetic acid 3: ethanolic KOH-solution View Scheme |
28-O-β-glucuronide betulinic acid
Betulinic acid
Conditions | Yield |
---|---|
With Escherichia coli β-D-glucuronidase at 37℃; for 1h; |
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene In dichloromethane at 20℃; for 70h; | A n/a B 235 mg |
betulonic aldehyde
betulinic aldehyde
A
Betulinic acid
B
betulonic acid
Conditions | Yield |
---|---|
Stage #1: betulonic aldehyde; betulinic aldehyde With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene In water; tert-butyl alcohol at 20℃; for 18.5h; Inert atmosphere; Stage #2: With sodium hydroxide In water; tert-butyl alcohol at 20℃; for 1.5h; Stage #3: With hydrogenchloride In water for 2.5h; Overall yield = 17.8 g; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 15.5 h / 20 °C / Inert atmosphere 1.2: 1.5 h / 20 °C 1.3: 2.5 h 2.1: sodium hydroxide; sodium tetrahydroborate / water; isopropyl alcohol / 3 h / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / tert-butyl alcohol; water / 0.25 h 1.2: 1 h / Reflux 2.1: sodium tetrahydroborate / tetrahydrofuran View Scheme | |
Multi-step reaction with 2 steps 1: sodium chlorite; dihydrogen peroxide; sodium dihydrogenphosphate / tert-butyl alcohol; water / 0.25 h / 0 - 10 °C 2: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / 0 °C View Scheme |
Betulinic acid
diazomethyl-trimethyl-silane
methyl betulinate
Conditions | Yield |
---|---|
In methanol; benzene | 100% |
In methanol; toluene at 20℃; for 3h; Inert atmosphere; | 97% |
In methanol at 20℃; for 2h; | 96% |
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 3h; Heating / reflux; | 100% |
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 7h; | 85% |
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 7h; | 84% |
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 7h; | 84% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 4h; |
4-methoxycarbonyl-3,3-dimethylbutyryl chloride
Betulinic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; | 100% |
Betulinic acid
Conditions | Yield |
---|---|
Stage #1: Betulinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: With ammonia In water; N,N-dimethyl-formamide at 20℃; for 16h; | 100% |
Multi-step reaction with 3 steps 1.1: triethylamine; dmap; pyridine / 12 h / 25 °C 2.1: oxalyl dichloride / dichloromethane / 2 h / 25 °C / Cooling with ice 2.2: 1 h / 25 °C 3.1: potassium hydroxide / methanol; tetrahydrofuran / 24 h / 25 °C View Scheme |
Betulinic acid
benzyl bromide
benzyl (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 3.5h; Inert atmosphere; | 99% |
With potassium carbonate In acetone at 20℃; for 24h; | 99% |
With potassium carbonate; caesium carbonate In acetone for 10h; Heating; | 98% |
Betulinic acid
3-aminolup-20(29)-en-28-oic acid
Conditions | Yield |
---|---|
With ammonium acetate; sodium cyanoborohydride In methanol for 40h; | 99% |
Stage #1: Betulinic acid With ammonium acetate; sodium cyanoborohydride In methanol for 40h; Stage #2: With hydrogenchloride In methanol; water pH=2; Stage #3: With potassium hydroxide In water pH=10; | 99% |
Multi-step reaction with 2 steps 1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 6 h / 20 °C 2: ammonium acetate; sodium cyanoborohydride / methanol / 12 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; tetrahydrofuran / 6 h / 20 °C 2: ammonium acetate; sodium cyanoborohydride / methanol / 12 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: Jones reagent / acetone / 25 °C 2: ammonium acetate; sodium cyanoborohydride / methanol / 12 h / 25 °C View Scheme |
diazomethane
Betulinic acid
methyl betulinate
Conditions | Yield |
---|---|
Stage #1: diazomethane; Betulinic acid In diethyl ether at 0 - 5℃; Stage #2: With acetic acid | 98% |
In diethyl ether at 0 - 5℃; for 24h; | 90% |
In diethyl ether; chloroform | 87% |
Betulinic acid
benzenesulphonyl isocyanate
3-O-[N-(phenylsulfonyl)carbamoyl-17β-N-(phenylsulfonyl)amide]-betulinic acid
Conditions | Yield |
---|---|
With triethylamine In toluene for 1h; Reflux; | 98% |
Betulinic acid
propargyl bromide
prop-2'-ynyl 3β-hydroxylup-20(29)-en-28-oate
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 14h; Reflux; | 98% |
With potassium carbonate In acetone at 50℃; | 96% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h; | 95% |
Conditions | Yield |
---|---|
Stage #1: Betulinic acid With caesium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 6-bromo-hexanoic acid ethyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; | 98% |
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran at 50℃; | 98% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; acetonitrile at 20℃; for 72h; | 72% |
With potassium carbonate In N,N-dimethyl-formamide at 21℃; for 14h; |
Conditions | Yield |
---|---|
Stage #1: Betulinic acid; acetic anhydride With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 65℃; for 2h; Stage #2: With hydrogenchloride; water at 100℃; for 0.5h; | 97% |
Stage #1: Betulinic acid; acetic anhydride With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 65℃; for 2h; Inert atmosphere; Stage #2: With hydrogenchloride; water at 100℃; for 0.5h; | 97% |
With pyridine at 20℃; for 72h; | 96.2% |
Betulinic acid
Cinnamoyl chloride
(1R,3aS,5aR,5bR,7aR,9R,11aR,11bR,13aR,13bR)-9-(cinnamoyloxy)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid
Conditions | Yield |
---|---|
With dmap In benzene at 60℃; | 97% |
Betulinic acid
benzyl chloride
benzyl (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide | 97% |
With potassium carbonate In acetone at 20℃; for 20h; | 93% |
With potassium carbonate In acetone at 20℃; for 20h; | 93% |
With potassium carbonate In N,N-dimethyl-formamide | |
With potassium carbonate In acetone |
(E)-3-(4-methoxyphenyl)propenoyl chloride
Betulinic acid
Conditions | Yield |
---|---|
With dmap In benzene at 60℃; | 96% |
Betulinic acid
chloroacetyl chloride
(3S)-3-(2-chloroacetyloxy)-lup-20(29)-en-28-oic acid
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; | 96% |
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 2h; Inert atmosphere; | 86% |
With N-ethyl-N,N-diisopropylamine; dmap In tetrahydrofuran Inert atmosphere; | 86% |
In N,N-dimethyl acetamide at 20℃; for 24h; |
Conditions | Yield |
---|---|
Stage #1: Betulinic acid With caesium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 1-Bromo-3-phenylpropane In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; | 96% |
Betulinic acid
Conditions | Yield |
---|---|
With aminosulfonic acid; urea In 1,4-dioxane; N,N-dimethyl-formamide at 65 - 75℃; | 96% |
Betulinic acid
dimethyl L-aspartate hydrochloride
(S)-2-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Hydroxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-succinic acid dimethyl ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 19h; | 95% |
Conditions | Yield |
---|---|
With diazomethyl-trimethyl-silane In hexane; toluene at 20℃; | 95% |
With Penicillium citreonigrum In chloroform; dimethyl sulfoxide Sonication; | 31.6 mg |
piperidine
Betulinic acid
4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran
Conditions | Yield |
---|---|
In chloroform | 95% |
Betulinic acid
Propargylamine
N-propargyl-3β-hydroxy-lup-20(29)-en-28-amide
Conditions | Yield |
---|---|
Stage #1: Betulinic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Stage #2: Propargylamine With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 95% |
Stage #1: Betulinic acid With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: Propargylamine In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere; | 76% |
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran; dichloromethane at 0 - 20℃; for 25h; Inert atmosphere; | 51% |
Betulinic acid
2-(chloromethyl)-3,5,6-trimethylpyrazine
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 12h; Inert atmosphere; | 95% |
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 12h; | 54.1% |
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 12h; |
Betulinic acid
2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
2,3,4,6-tetra-O-acetyl β-D-glucopyranosyl-3β-hydroxylup-20(29)-en-28-oate
Conditions | Yield |
---|---|
With pyridine; silver(l) oxide for 3h; | 94% |
Conditions | Yield |
---|---|
Stage #1: Betulinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: Cyclopropylamine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; | 94% |
Conditions | Yield |
---|---|
Stage #1: Betulinic acid With caesium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 1-Iodooctane In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; | 94% |
Betulinic acid
4-biphenyl isocyanate
3-O-[N-(biphenyl)-p-carbamoyl]betulinic acid
Conditions | Yield |
---|---|
With triethylamine In toluene for 1h; Reflux; | 93.5% |
Conditions | Yield |
---|---|
With pyridinium chlorochromate In chloroform for 2h; Ambient temperature; | 93% |
With Jones reagent In dichloromethane; acetone at 20℃; for 0.25h; Cooling; | 93% |
With Jones reagent In dichloromethane; acetone at 20℃; Cooling; | 93% |
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