4-Amino-3-methylbenzoic acid supplier

Name
4-Amino-3-methylbenzoic acid
EINECS 219-629-9
CAS No. 2486-70-6
Article Data20
CAS DataBase
Density 1.254 g/cm³
Solubility
Melting Point 169-171 °C(lit.)
Formula C₈H₉NO₂
Boiling Point 339.5 °C at 760 mmHg
Molecular Weight 151.165
Flash Point 159.1 °C
Transport Information
Appearance Yellowish or brown powder
Safety 26-37/39-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms m-Toluicacid, 4-amino- (6CI,7CI,8CI);3-Methyl-4-aminobenzoic acid;
PSA 63.32000
LogP 1.85660

Synthetic route

: 3113-71-1
3-methyl-4-nitrobenzoic acid

: 2486-70-6
4-amino 3-methylbenzoic acid

Conditions

Conditions	Yield
With hydrogenchloride; sulfuric acid In water; acetonitrile at 40℃; for 4h; Solvent; Reagent/catalyst; Temperature; Electrolysis;	99%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 1875.19 Torr; for 2h;	98%
With palladium on activated charcoal; hydrogen In methanol at 20℃; for 24h;	96%

: 5855-93-6
4-(4,6-dimethyl-benzothiazol-2-yl)-2-methyl-aniline

A: 2486-70-6
4-amino 3-methylbenzoic acid

B: 56536-88-0
3,5-dimethyl-2-aminobenzenethiol

Conditions

Conditions	Yield
bei der Alkalischmelze;

: 7647-01-0
hydrogenchloride

: 3113-71-1
3-methyl-4-nitrobenzoic acid

tin: tin

: 2486-70-6
4-amino 3-methylbenzoic acid

...Expand

: 99-04-7
m-Toluic acid

: 2486-70-6
4-amino 3-methylbenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: concentrated nitric acid 2: iron sulfate(II) hydrate; ammonia View Scheme
Multi-step reaction with 2 steps 1: fuming nitric acid 2: iron sulfate(II) hydrate; ammonia View Scheme
Multi-step reaction with 2 steps 1: fuming nitric acid 2: iron sulfate(II) hydrate; ammonia View Scheme

: 95-53-4
o-toluidine

: 2486-70-6
4-amino 3-methylbenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 1 h / 36 °C / Inert atmosphere 2: triethylamine / methanol; isopropyl alcohol / 22.67 h / 116 - 140 °C / 5168.35 - 8360.56 Torr View Scheme

: 74965-31-4
N-(tert-butoxycarbonyl)-o-toluidine

: 79-22-1
methyl chloroformate

: 2486-70-6
4-amino 3-methylbenzoic acid

Conditions

Conditions	Yield
With triethylamine In methanol; isopropyl alcohol at 116 - 140℃; under 5168.35 - 8360.56 Torr; for 22.67h; Pressure; Temperature;

: 541-41-3
chloroformic acid ethyl ester

: 74965-31-4
N-(tert-butoxycarbonyl)-o-toluidine

: 2486-70-6
4-amino 3-methylbenzoic acid

Conditions

Conditions	Yield
With ethylenediamine In propan-1-ol; ethanol at 110 - 130℃; under 4560.31 - 6080.41 Torr; for 11.5h;

: 2486-70-6
4-amino 3-methylbenzoic acid

: 532-55-8
Benzoyl isothiocyanate

: 4-[(benzoylcarbamothioyl)amino]-3-methylbenzoic acid

Conditions

Conditions	Yield
In acetone at 60℃; for 0.666667h;	100%

: 64-17-5
ethanol

: 2486-70-6
4-amino 3-methylbenzoic acid

: 40800-65-5
1-amino-2-methylbenzene-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With sulfuric acid for 3h; Reflux;	99%

: 186581-53-3, 908094-01-9
diazomethane

: 2486-70-6
4-amino 3-methylbenzoic acid

: 18595-14-7
methyl 4-amino-3-methylbenzoate

Conditions

Conditions	Yield
In diethyl ether	96%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 171049-35-7
1-tert-butoxycarbonyl-4,4'-bipiperidine

: tert butyl 1'-(4-amino-3-methylbenzoyl)-4,4'-bipiperidine-1-carboxylate

Conditions

Conditions	Yield
With (diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one In dichloromethane at 20℃; for 20h;	96%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 2486-70-6
4-amino 3-methylbenzoic acid

: 892878-63-6
4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbenzoic acid

Conditions

Conditions	Yield
In tetrahydrofuran Inert atmosphere; Reflux;	96%

: 2486-70-6
4-amino 3-methylbenzoic acid

: C8H8N2O3

Conditions

Conditions	Yield
With tartaric acid; sodium nitrite In ethanol; water at 35℃; for 2h; Solvent; Reagent/catalyst;	95.7%

: 67-56-1
methanol

: 2486-70-6
4-amino 3-methylbenzoic acid

: 18595-14-7
methyl 4-amino-3-methylbenzoate

Conditions

Conditions	Yield
With sulfuric acid Reflux; Inert atmosphere;	95%
With thionyl chloride In dichloromethane at 80℃; for 3h;	95%
With thionyl chloride at 20℃; for 12h;	95%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 141-75-3
butyryl chloride

: 1016696-74-4
N-butyryl-4-amino-3-methylbenzoic acid

Conditions

Conditions	Yield
Stage #1: 4-amino 3-methylbenzoic acid; butyryl chloride With pyridine In chloroform for 12h; Reflux; Stage #2: With hydrogenchloride In water at 20℃;	94%
With sodium carbonate In dichloromethane at 40℃; for 4h; Temperature; Solvent; Reagent/catalyst;	84.9%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 108-24-7
acetic anhydride

: 37901-92-1
4-acetamido-3-methylbenzoic acid

Conditions

Conditions	Yield
Stage #1: 4-amino 3-methylbenzoic acid With triethylamine In dichloromethane for 0.5h; Stage #2: acetic anhydride In dichloromethane at 20℃; for 72h;	93%
With triethylamine In dichloromethane Inert atmosphere;	10 g
With triethylamine In dichloromethane at 0 - 20℃;	10 g

: 2486-70-6
4-amino 3-methylbenzoic acid

: 506-59-2
N,N-dimethylammonium chloride

: 953739-92-9
4-amino-N,N,3-trimethylbenzamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;	92%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 2937-50-0
Allyl chloroformate

: 4-(((allyloxy)carbonyl)amino)-3-methylbenzoic acid

Conditions

Conditions	Yield
With sodium carbonate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane; water at 0℃; for 16h;	91%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 7697-28-1
4-bromo-3-methylbenzoic acid

Conditions

Conditions	Yield
Stage #1: 4-amino 3-methylbenzoic acid With hydrogen bromide In water at 25℃; for 1h; Stage #2: With sodium nitrate In water at -2 - -1℃; for 1.75h; Stage #3: With hydrogen bromide; copper(I) bromide In water at -2 - 70℃; for 2h;	90%
Diazotization.Kochen der Diazoverbindung mit Bromwasserstoffsaeure;
With hydrogen bromide; sodium nitrite; copper(I) chloride In water

: 2486-70-6
4-amino 3-methylbenzoic acid

: 708-06-5
2-hydroxynaphthalene-1-carbaldehyde

: (E)-4-(((2-hydroxynaphthalen-1-yl)methylene)amino)-3-methylbenzoic acid

Conditions

Conditions	Yield
With acetic acid In ethanol at 50℃; for 1h;	88%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 6274-29-9
2-amino-5-methoxy-thiophenol

: 247080-26-8
4-(6-methoxybenzothiazol-2-yl)-2-methylphenylamine

Conditions

Conditions	Yield
With melamine formaldehyde resin supported sulfuric acid Microwave irradiation;	87%

: 110-76-9
2-ethoxy-1-ethanamine

: 2486-70-6
4-amino 3-methylbenzoic acid

: 1150617-11-0
4-amino-N-[2-(ethyloxy)ethyl]-3-methylbenzamide

Conditions

Conditions	Yield
With triethylamine; HATU at 20℃; for 4h;	86%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 137-07-5
2-amino-benzenethiol

: 178804-04-1
2-(4'-amino-3'-methylphenyl)-benzothiazole

Conditions

Conditions	Yield
With melamine formaldehyde resin supported sulfuric acid Microwave irradiation;	85%
With PPA at 220℃; for 4h;	58%
With PPA at 220℃;

: 2486-70-6
4-amino 3-methylbenzoic acid

: 41168-79-0
1,1′-bis(2,4-dinitrophenyl)-[4,4′-bipyridine]-1,1′-diium chloride

: 2Cl(1-)*C26H22N2O4(2+)

Conditions

Conditions	Yield
In ethanol Reflux;	82%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 90382-10-8
2-amino-5-ethylbenzothiazole

: 1237737-89-1
4-(6-ethylbenzothiazol-2-yl)-2-methylphenylamine

Conditions

Conditions	Yield
With melamine formaldehyde resin supported sulfuric acid Microwave irradiation;	81%

: 22065-57-2
ethyl 2-phenyldiazoacetate

: 2486-70-6
4-amino 3-methylbenzoic acid

: 4-((2-ethoxy-2-oxo-1-phenylethyl)amino)-3-methylbenzoic acid

Conditions

Conditions	Yield
With C43H37Br2CuN3P2(1+)*ClO4(1-) In methanol at 0 - 20℃; for 6h; Schlenk technique; Inert atmosphere; chemoselective reaction;	81%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 814-68-6
acryloyl chloride

: 4-acrylamido-3-methylbenzoic acid

Conditions

Conditions	Yield
With pyridine In N,N-dimethyl-formamide at 0 - 20℃; for 4h; Temperature;	81%
With pyridine In N,N-dimethyl-formamide at 20℃; for 3h; Temperature;	6%

: 89-32-7
Pyromellitic dianhydride

: 2486-70-6
4-amino 3-methylbenzoic acid

: N,N′-bis(4-carboxy-2-methylphenyl)pyromellitic di-imide

Conditions

Conditions	Yield
In acetic acid at 120℃; for 24h;	79%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 4-amino-3-bromo-5-methylbenzoic acid

Conditions

Conditions	Yield
With N-Bromosuccinimide In N,N-dimethyl-formamide at 100℃; for 1h;	78.3%
With bromine In methanol at 0 - 10℃;	117 g

: 2486-70-6
4-amino 3-methylbenzoic acid

: 58-85-5
biotin

: C18H23N3O4S

Conditions

Conditions	Yield
Stage #1: biotin With tributyl-amine; isobutyl chloroformate In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: 4-amino 3-methylbenzoic acid In N,N-dimethyl-formamide at 0℃; for 2h;	77.6%

: 24424-99-5
di-tert-butyl dicarbonate

: 2486-70-6
4-amino 3-methylbenzoic acid

: 4-tert-butoxyamino-3-methyl-benzoic acid

Conditions

Conditions	Yield
Stage #1: di-tert-butyl dicarbonate; 4-amino 3-methylbenzoic acid With sodium hydroxide In 1,4-dioxane; water at 20℃; for 90h; Stage #2: With hydrogenchloride In 1,4-dioxane; water	77%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 42014-43-7
1H-benzo[d][1,2,3]triazol-1-yl ethyl carbonate

: 1H-1,2,3-benzotriazol-1-yl 4-amino-3-methylbenzoate

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 0 - 10℃; for 2h;	74%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 121-44-8
triethylamine

: 14470-28-1
mono-4-methoxytrityl chloride

: 1471099-03-2
C6H15N*C28H25NO3

Conditions

Conditions	Yield
Stage #1: 4-amino 3-methylbenzoic acid; triethylamine With chloro-trimethyl-silane In dichloromethane at 70℃; for 2h; Stage #2: mono-4-methoxytrityl chloride In dichloromethane for 16h; Reflux;	73%

...Expand

: 2486-70-6
4-amino 3-methylbenzoic acid

: 95-55-6
2-amino-phenol

: 4-(benzo[d]oxazol-2-yl)-2-methylaniline

Conditions

Conditions	Yield
With polyphosphoric acid at 220℃; for 4h;	72%
With polyphosphoric acid at 160℃; for 5h;

: 32315-10-9
bis(trichloromethyl) carbonate

: 2486-70-6
4-amino 3-methylbenzoic acid

: 4,4'-(carbonylbis(azanediyl))bis(3-methylbenzoic acid)

Conditions

Conditions	Yield
With boric acid; sodium hydroxide In tetrahydrofuran; water for 0.666667h; pH=Ca. 9;	70%

: 2486-70-6
4-amino 3-methylbenzoic acid

: 4-amino-3-chloro-5-methylbenzoic acid

Conditions

Conditions	Yield
With N-chloro-succinimide In N,N-dimethyl-formamide at 100℃; for 1h;	69.6%

4-Amino-3-methylbenzoic acid Chemical Properties

IUPAC Name: 4-Amino-3-methylbenzoic acid
Synonyms of 4-Amino-3-methylbenzoic acid (CAS NO.2486-70-6): 3-Methyl-4-aminobenzoic acid ; 4-Amino-m-toluic acid
CAS NO: 2486-70-6
Molecular Formula: C₈H₉NO₂
Molecular Weight: 151.16
Molecular Structure:
EINECS: 219-629-9
H bond acceptors: 3
H bond donors: 3
Freely Rotating Bonds: 2
Polar Surface Area: 29.54 Å²
Index of Refraction: 1.618
Molar Refractivity: 42.24 cm³
Molar Volume: 120.5 cm³
Surface Tension: 58.2 dyne/cm
Density: 1.254 g/cm³
Flash Point: 159.1 °C
Enthalpy of Vaporization: 61.53 kJ/mol
Boiling Point: 339.5 °C at 760 mmHg
Vapour Pressure: 3.55E-05 mmHg at 25°C
Melting Point: 169-171 °C(lit.)
Appearance:beige or light buff to orange
Product Categories of 4-Amino-3-methylbenzoic acid (CAS NO.2486-70-6): CARBOXYLICACID;FINE Chemical & INTERMEDIATES;Amines;blocks;Carboxes;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;pharmacetical;Organic acids;Acids & Esters;Anilines, Amides & Amines;Aromatic Amino Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives

4-Amino-3-methylbenzoic acid Safety Profile

Safety Information about 4-Amino-3-methylbenzoic acid (CAS NO.2486-70-6):
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S24/25: Avoid contact with skin and eyes.
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT

4-Amino-3-methylbenzoic acid Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Keep container closed when not in use.

Product Name

4-Amino-3-methylbenzoic acid

Synthetic route

4-Amino-3-methylbenzoic acid Chemical Properties

4-Amino-3-methylbenzoic acid Safety Profile

4-Amino-3-methylbenzoic acid Specification

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