4-Chlorophenyl isothiocyanate supplier

Name
4-CHLOROPHENYL ISOTHIOCYANATE
EINECS 218-358-3
CAS No. 2131-55-7
Article Data147
CAS DataBase
Density 1.218 g/cm³
Solubility
Melting Point 42-44 °C(lit.)
Formula C₇H₄ClNS
Boiling Point 250.235 °C at 760 mmHg
Molecular Weight 169.634
Flash Point 105.139 °C
Transport Information UN 2206 6.1/PG 2
Appearance light yellow crystalline mass
Safety 22-26-36/37/39-45
Risk Codes 23/24-36/37/38-42
Molecular Structure
Hazard Symbols T
Synonyms Isothiocyanicacid, p-chlorophenyl ester (6CI,8CI);1-Chloro-4-isothiocyanatobenzene;4-Chlorophenyl isothiocyanate;NSC 20213;Sch 20350;p-Chlorophenylisothiocyanate;
PSA 44.45000
LogP 3.07430

Synthetic route

: 28123-63-9
4-chlorobenzohydroximoyl chloride

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With triethylamine; thiourea In tetrahydrofuran Ambient temperature;	100%

: 75-15-0
carbon disulfide

: 31641-65-3
N-p-chlorophenyltriphenylphosphinimine

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
In benzene for 2h; Heating;	96%

: 590-28-3
potassium cyanate

: 1075256-87-9
5-[2-(4-bromophenyl)-2-oxoethyl]-3-(4-chlorophenyl)-2-thioxo-1,3-thiazolidin-4-one

A: 1075256-95-9
2,4-bis[2-(4-bromophenyl)-2-oxoethylidene]cyclobutane-1,3-dione

B: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
In 1,4-dioxane; methanol at 90℃; for 0.416667h;	A n/a B 95%

...Expand

: 43009-19-4
p-chlorophenyldithiocarbamic acid triethylamine salt

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With iodine; triethylamine In acetonitrile at 5℃; Cooling with ice;	94%
With [bis(acetoxy)iodo]benzene; triethylamine In acetonitrile Cooling with ice;	93%
With sodium persulfate; potassium carbonate In water at 20℃; for 1h; Green chemistry; chemoselective reaction;	85%

: 463-71-8
thiophosgene

: 106-47-8
4-chloro-aniline

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane; water at 0 - 20℃; for 1h;	92%
With sodium hydrogencarbonate In dichloromethane; water at 0 - 20℃; for 1.5h;	81%
With sodium hydrogencarbonate In dichloromethane; water at 0 - 20℃; for 1.5h;	81%

: 89913-67-7
4-chlorophenyldithiocarbamate sodium salt

: 4903-36-0
N-phenyl-benzimidoyl chloride

A: 2131-55-7
4-Chlorophenyl isothiocyanate

B: 636-04-4
N-Phenylbenzothioamide

Conditions

Conditions	Yield
In diethyl ether 0 deg C to r.t.;	A 83% B 92%

...Expand

: 75-15-0
carbon disulfide

: 106-47-8
4-chloro-aniline

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
Stage #1: carbon disulfide; 4-chloro-aniline With potassium carbonate In water at 40℃; for 6h; Inert atmosphere; Stage #2: With 1,3,5-trichloro-2,4,6-triazine In dichloromethane; water; N,N-dimethyl-formamide at 0℃; Inert atmosphere; Stage #3: With sodium hydroxide In dichloromethane; water pH=11; Inert atmosphere;	92%
Stage #1: carbon disulfide; 4-chloro-aniline With 1,4-diaza-bicyclo[2.2.2]octane In toluene at 20℃; for 8h; Stage #2: With bis(trichloromethyl) carbonate In dichloromethane at -5℃; Reflux;	84.7%
With potassium hydroxide at 20℃; for 1.5h; Milling; Green chemistry;	75%

: 15867-09-1
(4-chloro-phenyl)-dithiocarbamic acid

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With 1,1'-(ethane-1,2-diyl)dipyridinium bistribromide; triethylamine In acetonitrile Cooling with ice;	92%
With benzene-1,3,5-tricarboxylic acid In dichloromethane
With bis(trichloromethyl) carbonate In dichloromethane
With bis(trichloromethyl) carbonate In dichloromethane at -5℃; for 8h; Reflux;
With cobalt(II) chloride hexahydrate; sodium hydrogencarbonate In ethyl acetate at 20℃; for 1h;

: 705-69-1
N-(4-chlorophenyl)-S-methyldithiocarbamate

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With sodium hydroxide In toluene for 1h; Heating;	91%
With dilauryl peroxide In 1,2-dichloro-ethane for 1h; Reagent/catalyst; Reflux;
Multi-step reaction with 2 steps 1: dilauryl peroxide / 1,2-dichloro-ethane / 1 h / Reflux 2: dilauryl peroxide / 1,2-dichloro-ethane / 1 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: dilauryl peroxide / 1,2-dichloro-ethane / 1 h / Reflux 2: dilauryl peroxide / 1,2-dichloro-ethane / 1 h / Reflux View Scheme
With mercury(II) oxide In diethyl ether at 20℃; for 1h;

: 1885-81-0
p-chlorophenyl isocyanide

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With sulfur; rhodium hydrido (PEt3)3 complex In acetone for 8h; Heating;	87%
With selenium; sulfur; triethylamine In tetrahydrofuran for 1h; Heating;	83%

: 2541-62-0
((4-chlorophenyl)amino)phenoxymethane-1-thione

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane at 20℃; for 1h;	86%
With trichlorosilane; triethylamine In benzene at 20℃; for 1h; Elimination;	80%

: bis[(Z)-1-p-chlorophenylimino-1-methylthiomethyl]disulfide

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With dilauryl peroxide In 1,2-dichloro-ethane for 1h; Reflux;	86%

: 2617-79-0
N-(4-chlorophenyl)formamide

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With bis(trichloromethyl) carbonate; sulfur; triethylamine; selenium In dichloromethane for 7h; Heating;	85%
Multi-step reaction with 2 steps 1.1: KOH / dimethylformamide / 25 - 28 °C 1.2: 42 percent / dimethylformamide / 10 - 40 °C 2.1: sulfuryl chloride View Scheme

: C7H5ClNS2(1-)

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With iron(III) chloride; sodium acetate In acetone at 20℃; for 2h;	85%
With bis(trichloromethyl) carbonate In dichloromethane at 20℃; for 4h;
With p-toluenesulfonyl chloride for 48h; Inert atmosphere;

: (4-chloro-phenyl)-dithiocarbamic acid; compound with 1,4-diaza-bicyclo[2.2.2]octane

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With triethylamine; dimethylsilicon dichloride In dichloromethane at 20℃; for 4h;	84%
With bis(trichloromethyl) carbonate In chloroform at 0 - 20℃; for 4.5h;
With bis(trichloromethyl) carbonate In chloroform at 20℃; for 10h;
With bis(trichloromethyl) carbonate In chloroform for 1h;
With bis(trichloromethyl) carbonate In chloroform at -10 - 20℃; for 0.5h;

: 6,6-diphenyl-5-hexene-1-thiol

: 1885-81-0
p-chlorophenyl isocyanide

A: 50585-09-6
(diphenylmethyl)cyclopentane

B: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) In toluene at 110℃; for 1h;	A 80% B n/a

...Expand

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 106-47-8
4-chloro-aniline

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With sulfur; potassium fluoride In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;	80%

: 421-83-0
trifluoromethane sulfonyl chloride

: 106-47-8
4-chloro-aniline

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With triphenylphosphine; sodium iodide In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;	80%

: 106-47-8
4-chloro-aniline

: 1005-56-7
phenylcarbonochloridothioate

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
In toluene at 115℃; for 24h; Green chemistry;	76%
With sodium hydroxide In dichloromethane at 0 - 20℃; for 73h;	47%

: 705-69-1
N-(4-chlorophenyl)-S-methyldithiocarbamate

A: bis[(Z)-1-p-chlorophenylimino-1-methylthiomethyl]disulfide

B: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With dilauryl peroxide In 1,2-dichloro-ethane for 1h; Reflux;	A 7% B 75%

: 50435-27-3
(4-Chloro-phenyl)-[1,3]dithietan-2-ylidene-amine

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In chloroform 1) 1 h, 10 deg C, 2) 2 h, room temp.;	72%

: 937-64-4
4-chlorophenyl chlorothionoformate

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With copper(l) iodide; aniline; sodium hydroxide In tetrahydrofuran at 100℃; for 12h; Reagent/catalyst;	66.7%

: 75-15-0
carbon disulfide

: 404-25-1
N-(4-chlorophenyl)-2,2,2-trifluoroacetamide

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With sodium hydroxide; potassium carbonate In acetonitrile at 25℃; for 1.5h;	55%

: 540-72-7
sodium thiocyanide

: 4-(chloro)benzenediazonium benzo[d][1,3,2]dithiazol-2-ide-1,1,3,3-tetraoxide

A: 3226-37-7
4-chlorophenyl thiocyanate

B: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With copper In methanol at 20 - 25℃;	A 35% B 35%

...Expand

: 590-28-3
potassium cyanate

: 13037-55-3
3-(4-chloro-phenyl)-2-thioxo-thiazolidin-4-one

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
In 1,4-dioxane; methanol at 90℃; for 0.416667h;	35%

: 447-14-3
1,2,2-trifluorostyrene

: 673-41-6
p-chlorobenzenediazonium tetrafluoroborate

: 333-20-0
potassium thioacyanate

A: 3226-37-7
4-chlorophenyl thiocyanate

B: 2131-55-7
4-Chlorophenyl isothiocyanate

C: 1-Chloro-4-(1,1,2-trifluoro-2-phenyl-2-thiocyanato-ethyl)-benzene

Conditions

Conditions	Yield
at -30 - -15℃;	A n/a B n/a C 30%

...Expand

: 673-41-6
p-chlorobenzenediazonium tetrafluoroborate

: 333-20-0
potassium thioacyanate

A: 3226-37-7
4-chlorophenyl thiocyanate

B: 2131-55-7
4-Chlorophenyl isothiocyanate

C: 1-Chloro-4-(1,1,2-trifluoro-2-phenyl-2-thiocyanato-ethyl)-benzene

Conditions

Conditions	Yield
With 1,2,2-trifluorostyrene at -30 - -15℃;	A n/a B n/a C 30%

...Expand

: 86317-28-4
O-(4-methoxyphenyl) N-4-chlorophenylthioncarbamate

: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
With potassium chloride; water at 25℃; Rate constant; pH=8.5-11.5;

: 75644-25-6
1-(4-chloranilino-thiocarbonyl)-benzimidazolidine-2-thione

A: 583-39-1
2,3-dihydrobenzimidazol-2-thione

B: 2131-55-7
4-Chlorophenyl isothiocyanate

Conditions

Conditions	Yield
In 1,2-dimethoxyethane for 16h; Heating;	A 0.9 g B 1.0 g

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 3696-23-9
N-(4-chlorophenyl)thiourea

Conditions

Conditions	Yield
With ammonium hydroxide In water; acetonitrile at 20℃; for 3h;	100%
With ammonium hydroxide In 1,4-dioxane at 20℃; for 2h; Addition;	78%
With ammonia In 1,4-dioxane; water at 0 - 20℃; for 2h;	78%

: 19731-02-3
2-(1H-benzo[d]imidazol-2-yl)acetohydrazide

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 108784-76-5
C16H14ClN5OS

Conditions

Conditions	Yield
In ethanol for 0.5h; Heating;	100%
In ethanol for 0.5h; Heating;

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 118-92-3
anthranilic acid

: 1028-40-6
3-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

Conditions

Conditions	Yield
In acetic acid for 16h; Reflux;	100%
at 90℃; Green chemistry;	75%
In ethanol Heating;
With acetic acid

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 203444-38-6
4-benzylamino-2-phenyl-2-oxazoline

: 586953-04-0
1-benzyl-3-(4-chloro-phenyl)-1-(2-phenyl-4,5-dihydro-oxazol-4-yl)-thiourea

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 1h;	100%

: 4424-20-8
2,3,4,5-tetrahydro-1H-3-benzazepine

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 915104-43-7
N-(4-Chlorophenyl)-1 ,2,4,5-tetrahydro-3H-3-benzazepine-3-carbothioamide

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 1h;	100%

: 16502-01-5
tetrahydrobetacarboline

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 915104-41-5
N-(4-chlorophenyl)-1,3,4,9-tetrahydro-2H-β-carboline-2-carbothioamide

Conditions

Conditions	Yield
In ethanol	100%

: 129564-34-7
2-(2,6-dichlorophenyl)acetohydrazide

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 894257-94-4
N-(4-chlorophenyl)-2-(2-(2,6-dichlorophenyl)acetyl)hydrazinecarbothioamide

Conditions

Conditions	Yield
In ethanol for 5h; Reflux;	100%
In ethanol for 5h; Reflux;	100%

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 100-61-8
N-methylaniline

: 82745-02-6
N-methyl-N-phenyl-N'-p-chlorophenylthiourea

Conditions

Conditions	Yield
In ethanol at 25 - 30℃; for 1h;	100%

: 131470-74-1
4-(1-benzyl-1H-benzimidazol-2-yl)methyl phenoxy carboxylic acid hydrazide

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 133389-32-9
1-benzyl-2-<4-(p-chlorophenyl thiocarbamoylhydrazinocarbonyl)phenoxymethyl>-1H-benzimidazole

Conditions

Conditions	Yield
In ethanol for 1h; Heating;	99%

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 95-54-5
1,2-diamino-benzene

: 777097-91-3
N1-(2-aminophenyl)-N2-(4-chlorophenyl)thiourea

Conditions

Conditions	Yield
In methanol for 0.5h;	99%
In tetrachloromethane for 1.5h; Heating;
In acetonitrile
In acetonitrile at 20℃; for 0.5h;
In dichloromethane at 25℃;

: 15344-56-6
2-(benzo[d]oxazol-2-yl)acetonitrile

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 2-benzooxazol-2-yl-N-(4-chloro-phenyl)-2-cyano-thioacetamide

Conditions

Conditions	Yield
Stage #1: 2-(benzo[d]oxazol-2-yl)acetonitrile; 4-Chlorophenyl isothiocyanate With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 3h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 0℃; pH=3 - 4;	99%

: 615-43-0
2-iodophenylamine

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 6276-78-4
N-(4-chlorophenyl)benzo[d]thiazol-2-amine

Conditions

Conditions	Yield
With copper(II) nitrate trihydrate; N,N,N,N,-tetramethylethylenediamine; sodium hydrogencarbonate In water at 20℃; for 2h;	99%
With tetrabutylammomium bromide; copper(I) bromide In dimethyl sulfoxide at 40℃; for 20h;	98%
With iron(III) trifluoride; 1,10-Phenanthroline; triethylamine In dimethyl sulfoxide at 80℃; for 2h;	96%

: 16188-57-1
2-iodo-4-methylphenol

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1294010-10-8
4-chloro-N-(5-methylbenzo[d][1,3]oxathiol-2-ylidene)benzenamine

Conditions

Conditions	Yield
With copper(II) nitrate trihydrate; N,N,N,N,-tetramethylethylenediamine; sodium hydrogencarbonate In water at 20℃; for 4h;	99%
With 1,4-diaza-bicyclo[2.2.2]octane; 1,10-Phenanthroline; copper dichloride In water at 80℃; for 24h; Inert atmosphere;	95%
Stage #1: 2-iodo-4-methylphenol With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate at 40℃; for 1h; Ionic liquid; Inert atmosphere; Green chemistry; Stage #2: 4-Chlorophenyl isothiocyanate at 85℃; for 15h; Ionic liquid; Inert atmosphere; Green chemistry;	91%

: 57709-64-5
N1-(2-aminophenyl)-N2-phenylurea

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1401033-04-2
N1-[N-(4-chlorophenyl)thiocarbamoyl]-N2-[N-phenylcarbamoyl]-1,2-diaminobenzene

Conditions

Conditions	Yield
In methanol for 3h;	99%

: 29264-14-0
N1-(4-aminophenyl)-N2-(4-methoxyphenyl)thiourea

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1401033-01-9
N1-[N-(4-chlorophenyl)thiocarbamoyl]-N2-[N-(4-methoxyphenyl)thiocarbamoyl]-1,4-diaminobenzene

Conditions

Conditions	Yield
In methanol for 0.5h;	99%

: N1-(2-aminophenyl)-N2-(4-methoxyphenyl)thiourea

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1401032-97-0
N1-[N-(4-chlorophenyl)thiocarbamoyl]-N2-[N-(4-methoxyphenyl)thiocarbamoyl]-1,2-diaminobenzene

Conditions

Conditions	Yield
In methanol for 3h;	99%

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 95-54-5
1,2-diamino-benzene

: 823219-06-3
N1,N2-bis[N-(4-chlorophenyl)thiocarbamoyl]-1,2-diaminobenzene

Conditions

Conditions	Yield
In methanol for 3h;	99%

: 1613108-50-1
4-amino-3,4-dihydro-2,2-dimethyl-6-ethylsulfonylamino-2H-1-benzopyran

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1613108-43-2
N-4-chlorophenyl-N'-(6-ethylsulfonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea

Conditions

Conditions	Yield
In dichloromethane for 0.5h; Reflux;	99%

: 1519044-08-6
N-(2-aminoethyl)-3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamide

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1519043-06-1
N-(2-(3-(4-chlorophenyl)carbamothioylamino)ethyl)-3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	99%

: 3-(4-methoxyphenyl)-N-methylprop-2-yn-1-amine

: 2131-55-7
4-Chlorophenyl isothiocyanate

: (Z)-N-(4-chlorophenyl)-5-((Z)-4-methoxybenzylidene)-3-methylthiazolidin-2-imine

Conditions

Conditions	Yield
With silica gel In dichloromethane at 20℃; for 2h; Inert atmosphere;	99%

: 114099-32-0
N-deacetyl-10-methylamino-10-demethoxycolchicine

: 2131-55-7
4-Chlorophenyl isothiocyanate

: C27H28ClN3O4S

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	99%

: 76765-85-0
5-(4-chlorophenyl)-2H-tetrazol-2-ylacethydrazide

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 76766-04-6
1-<5-(4-chlorophenyl)-2H-tetrazol-2-ylacetyl>-4-(4-chlorophenyl)thiosemicarbazide

Conditions

Conditions	Yield
In ethanol for 1h; Heating;	98%

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 936-02-7
2-Hydroxybenzoylhydrazine

: 26131-23-7
4-(4-chlorophenyl)-1-(2-hydroxybenzoyl)-3-thiosemicarbazide

Conditions

Conditions	Yield
In ethanol for 1h; Heating;	98%
In ethanol for 0.25h; Reflux;	85%
In methanol at 20℃; under 760.051 Torr; for 24h;	20%

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 52094-94-7
α-(2-chlorophenyloxy)propionyl hydrazine

: 79698-94-5
C16H15Cl2N3O2S

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	98%

: 104-94-9
4-methoxy-aniline

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 81461-67-8
N-(4-chlorophenyl)-N’-(4-methoxyphenyl)thiourea

Conditions

Conditions	Yield
at 20℃;	98%

: 35790-17-1
3-aminopropyl-dimethyl-phosphine oxide

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 3-[(N-4-chlorophenyl-thiocarbamoyl)amino]propyl-dimethyl-phosphine oxide

Conditions

Conditions	Yield
In dichloromethane for 3.16667h;	98%

: 97578-20-6
N-benzylaminomethyl-dimethylphosphine oxide

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1-(4-chlorophenyl)-3-benzyl-3-(dimethylphosphinylmethyl)thiourea

Conditions

Conditions	Yield
In dichloromethane	98%

: 1314406-35-3
(R/S)-4-amino-6-tert-butyloxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1314406-25-1
(RS)-N-4-chlorophenyl-N'-(6-tert-butyloxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)thiourea

Conditions

Conditions	Yield
In dichloromethane for 0.5h;	98%

4-Chlorophenyl isothiocyanate Chemical Properties

Chemical Name: 4-Chlorophenyl isothiocyanate
IUPAC NAME: 1-Chloro-4-isothiocyanatobenzene
CAS No.: 2131-55-7
EINECS: 218-358-3
RTECS: NX8473000
Molecular Formula: C₇H₄ClNS
Molecular Weight: 169.63 g/mol
Melting Point: 42-44 °C(lit.)
Density: 1.21 g/cm³
Flash Point: 105.1 °C
Boiling Point: 250.2 °C at 760 mmHg
Storage temp.: Refrigerator (+4°C)
Sensitive: Moisture Sensitive
Following is the structure of Isothiocyanic acid, p-chlorophenyl ester (2131-55-7):

Product Categories about Isothiocyanic acid, p-chlorophenyl ester (2131-55-7) are Organic Building Blocks ; Protein Sequencing ; Protein Structural Analysis ; Reagents for Protein SequencingOrganic Building Blocks ; Sulfur Compounds ; Thiocyanates/Isothiocyanates
The chemical synonymous of Isothiocyanic acid, p-chlorophenyl ester (2131-55-7) are P-Chlorophenyl isothiocyanate ; 1-Chloro-4-isothiocyanato-benzene ; 4-Chlorophenyl isothiocyanate ; Akos Bbs-00004437 ; Isothiocyanic acid 4-chlorophenyl ester ; 4-Chlor-phenyl-isothiocyanat ; Benzene, 1-chloro-4-isothiocyanato- ; Isothiocyanic acid, P-Chlorophenyl ester

4-Chlorophenyl isothiocyanate Toxicity Data With Reference

1.		ipr-rat LDLo:100 mg/kg		ARZNAD Arzneimittel-Forschung. Drug Research. 16 (1966),870.
2.		ipr-mus LDLo:100 mg/kg		ARZNAD Arzneimittel-Forschung. Drug Research. 21 (1971),121.

4-Chlorophenyl isothiocyanate Safety Profile

Poison by intraperitoneal route. When heated to decomposition it emits very toxic fumes of Cl⁻, NO_x, and SO_x. See also THIOCYANATES.
Hazard Codes:
T: Toxic
Risk Statements about Isothiocyanic acid, p-chlorophenyl ester (2131-55-7):
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
R36/37/38 Irritating to eyes, respiratory system and skin.
R42 May cause sensitization by inhalation.
Safety Statements about Isothiocyanic acid, p-chlorophenyl ester (2131-55-7):
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
sAttention:
1. Storage: Keep refrigerated. (Store below 4°C/39°F.) Store in a tightly closed container. Store in a dry area. Store protected from moisture. Store under an inert atmosphere.
2. Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.

Product Name

4-CHLOROPHENYL ISOTHIOCYANATE

Synthetic route

4-Chlorophenyl isothiocyanate Chemical Properties

4-Chlorophenyl isothiocyanate Toxicity Data With Reference

4-Chlorophenyl isothiocyanate Safety Profile

Related Products

Hot Products