4-Chlorophenylacetic acid supplier

Name
4-Chlorophenylacetic acid
EINECS 217-521-6
CAS No. 1878-66-6
Article Data109
CAS DataBase
Density 1.324 g/cm³
Solubility
Melting Point 102-105 °C(lit.)
Formula C₈H₇ClO₂
Boiling Point 294.1 °C at 760 mmHg
Molecular Weight 170.595
Flash Point 131.7 °C
Transport Information
Appearance white to cream colored powder
Safety 36/37-24/25-36-26
Risk Codes 20/21-36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms (4-chlorophenyl)acetic acid;2-(4-chlorophenyl)acetic acid;2-(p-Chlorophenyl)acetic acid;Acetic acid, (p-chlorophenyl)-;(p-Chloro-phenyl)acetic acid;Benzeneacetic acid, 4-chloro-;2-(4-chlorophenyl)acetate;a-Cyclohexylmandelic acid;p-Chlorophenylacetic acid;
PSA 37.30000
LogP 1.96710

Synthetic route

: 140-53-4
p-chlorobenzyl cyanide

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With water; sodium hydroxide at 110 - 116℃; under 15001.5 Torr; for 0.05h; Concentration; Pressure; Temperature; Flow reactor;	99%
With 1-butyl-3-methylimidazolium hydrogen sulfate; water at 60 - 65℃; for 1.1h; Green chemistry;	96%
With potassium hydroxide In toluene at 160℃; for 0.5h; microwave irradiation;	92%

: 14062-24-9
4-chloro-benzeneacetic acid, ethyl ester

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With water; sodium hydroxide In 1,4-dioxane at 60℃; for 2h; pH=10 - 14;	98%

: 201230-82-2
carbon monoxide

: 622-95-7
4-chlorobenzyl bromide

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium iodide In formic acid at 60℃; under 760 Torr; for 18h; Carbonylation;	95%
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Temperature; Reagent/catalyst; Autoclave;	95.2%
With palladium hydroxide, 20 wt% on carbon; tetrabutylammomium bromide; water In tetrahydrofuran at 110℃; under 7500.75 Torr; for 4h; Sealed tube; Autoclave;	79%
With sodium hydroxide; sodium tetrahydroborate In tetrahydrofuran at 55℃; for 3h;	78%

: 89244-19-9, 89244-20-2
N-[(E)-2-(4-Chloro-phenyl)-1-cyano-vinyl]-4,N-dimethyl-benzamide

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran for 6h; Heating;	95%

: C14H21ClNO3P

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With hydrogen bromide at 100℃; for 0.166667h;	95%
With water; hydrogen bromide at 100℃; for 0.166667h; Inert atmosphere;	95%

: 1575722-27-8
4-Methoxybenzyl 2-(4-chlorophenyl)acetate

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With proton-exchanged montmorillonite In dichloromethane at 20℃;	95%

: 19202-19-8
2-(4-chlorophenyl)-1-(pyrrolidin-1-yl)-ethanone

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane for 30h; Heating;	94%

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 71-36-3
butan-1-ol

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
Stage #1: butan-1-ol With cobalt(II) sulfate at 80℃; under 3750.38 Torr; for 4h; Autoclave; Stage #2: 1-Chloro-4-(chloromethyl)benzene With sodium hydroxide In water at 80℃; under 3750.38 Torr; for 24h; Concentration; Pressure; Temperature; Autoclave;	93.6%

: 201230-82-2
carbon monoxide

: 62037-06-3
1-chloro-4-(dibromomethyl)benzene

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With potassium hydroxide; dicobalt octacarbonyl; N-benzyl-N,N,N-triethylammonium chloride In benzene under 760 Torr; for 8h; Ambient temperature;	92%

: 52449-43-1
(4-chloro-phenyl)-acetic acid methyl ester

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With sodium hydroxide for 2h; Heating;	92%
With potassium hydroxide In methanol for 4h; Ambient temperature;	50%
With water for 36h;	50%

: 4-chloro-N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)phenylglycinonitrile

A: 1878-66-6
4-chlorophenylacetic Acid

B: 888963-33-5
N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)amine

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid In dichloromethane; water at 20℃; for 1h;	A 92% B n/a

: 201230-82-2
carbon monoxide

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Temperature; Reagent/catalyst; Solvent; Autoclave;	90%
Stage #1: carbon monoxide With C28H22CoN4O6 In butan-1-ol at 60℃; under 760.051 Torr; for 2h; Glovebox; High pressure; Green chemistry; Stage #2: 1-Chloro-4-(chloromethyl)benzene With tetra-(n-butyl)ammonium iodide; sodium hydroxide In butan-1-ol at 60℃; under 760.051 Torr; for 22h; Glovebox; High pressure; Green chemistry; regioselective reaction;	86%
With bis-triphenylphosphine-palladium(II) chloride; tetraethylammonium chloride; sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene at 80℃; under 11251.1 Torr; for 20h; Autoclave; regioselective reaction;	86%
With sodium hydroxide; cerium(III) chloride; cetyltrimethylammonim bromide; nickel cyanide In toluene at 85 - 95℃; under 1 Torr; for 6.5h;	82%
With water; palladium diacetate at 110℃; under 37503.8 Torr; for 4h; Ionic liquid;	84 %Chromat.

: 42945-85-7
2-(4-chlorophenyl)-1-(morpholin-4-yl)-ethanethione

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With sodium hydroxide for 0.0166667h; microwave irradiation;	90%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride at 100℃; for 8h;

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With sodium hydroxide; cobalt tetracarbonyl anion In methanol at 55℃; for 4h;	84%
Multi-step reaction with 2 steps 1: dimethylsulfoxide / 5 h / 45 - 50 °C 2: KOH / aq. ethanol / Heating View Scheme
Multi-step reaction with 2 steps 1: alcohol / 120 - 130 °C / im Druckrohr 2: concentrated KOH-solution View Scheme
Multi-step reaction with 2 steps 1: alcohol; water 2: concentrated KOH-solution View Scheme
Multi-step reaction with 2 steps 1: ethanol; H2O / Heating 2: aq. KOH / ethanol / Heating View Scheme

: 124-38-9
carbon dioxide

: 52372-80-2
(4-chlorobenzylidene)hydrazine

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; cesium fluoride In N,N-dimethyl-formamide at 80℃; under 760.051 Torr; for 24h; chemoselective reaction;	82%

: 1073-67-2
4-vinylbenzyl chloride

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With Oxone; iodine In 1,2-dimethoxyethane; water at 20℃; for 3h; regioselective reaction;	77%
With D-glucose; oxygen In aq. phosphate buffer at 30℃; for 10h; pH=8; Green chemistry; Enzymatic reaction; regioselective reaction;	75%

: 201230-82-2
carbon monoxide

: 62037-06-3
1-chloro-4-(dibromomethyl)benzene

A: 1878-66-6
4-chlorophenylacetic Acid

B: 5121-74-4
4,4'-dichlorostylbene

Conditions

Conditions	Yield
With potassium hydroxide; dicobalt octacarbonyl; 18-crown-6 ether; N-benzyl-N,N,N-triethylammonium chloride In benzene under 760 Torr; for 8h; Product distribution; Ambient temperature; other reagent systems, other temp., various benzal bromides;	A 70% B 12%
With potassium hydroxide; dicobalt octacarbonyl; 18-crown-6 ether In benzene under 760 Torr; for 8h; Ambient temperature;	A 32% B 39%

...Expand

: 77295-59-1
1-chloro-4-(2,2-dibromovinyl)benzene

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
Stage #1: 1-chloro-4-(2,2-dibromovinyl)benzene With n-butyllithium In tetrahydrofuran at 0℃; for 1.5h; Stage #2: With 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In tetrahydrofuran for 2h;	67%
With PEG-400; potassium hydroxide; bis[1,2-bis(diphenylphosphino)ethane]palladium(0) In dichloromethane at 60 - 65℃; for 17h;	56%
Multi-step reaction with 2 steps 1: 91 percent / H2O / ethyl acetate / 8 h / 20 °C 2: 94 percent / aq. HCl / dioxane / 30 h / Heating View Scheme

: 140-53-4
p-chlorobenzyl cyanide

A: 1878-66-6
4-chlorophenylacetic Acid

B: 20101-92-2
2-(4-chlorophenyl)acetamide

Conditions

Conditions	Yield
With potassium hydroxide In toluene at 160℃; for 0.166667h; microwave irradiation;	A 65% B 32%
With immobilized activated nitrilase In water Rate constant; Ambient temperature; effect of β-cyclodextrin;

: 517920-59-1
2-[(4-chlorophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 124-38-9
carbon dioxide

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With potassium ethoxide In 1,4-dioxane at 100℃; for 24h;	65%

: 637-87-6
1-Chloro-4-iodobenzene

: 64-19-7
acetic acid

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With silver(I) acetate; sodium acetate; palladium dichloride at 130℃; for 24h; Schlenk technique; Inert atmosphere; chemoselective reaction;	63%

: 592-87-0
lead(II) thiocyanate

: ((2-(4-chlorophenyl)-1-methoxyvinyl)oxy)trimethylsilane

A: 1878-66-6
4-chlorophenylacetic Acid

B: methyl 2-(4-chlorophenyl)-2-thiocyanatoethanoate

Conditions

Conditions	Yield
Stage #1: lead(II) thiocyanate With (Dichloroiodo)benzene In dichloromethane at 0℃; for 0.333333h; Stage #2: ((2-(4-chlorophenyl)-1-methoxyvinyl)oxy)trimethylsilane In dichloromethane at 0 - 20℃; Further stages.;	A 10% B 57%

...Expand

: 373-91-1
hypofluorous acid trifluoromethyl ester

: 75581-01-0
4-(4-chlorobenzylidene)-2,2,6,6-tetramethyl-3,5-dioxa-2,6-disilaheptane

A: 1878-66-6
4-chlorophenylacetic Acid

B: 74590-69-5
4-chloro-α-fluorobenzeneacetic acid

Conditions

Conditions	Yield
In CFCl3; hexane; water	A 53% B n/a

...Expand

: 64-18-6
formic acid

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; α,α′-bis(2-pyridyl(tert-butyl)phosphino)-o-xylene; palladium diacetate In N,N-dimethyl-formamide at 115℃; for 24h; Inert atmosphere;	53%

: 33984-97-3, 33984-98-4
cis-2,3-epoxy-3-(4-chlorophenyl)propanenitrile

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; water In 1,4-dioxane at 175℃; for 0.5h; Microwave irradiation; Green chemistry;	52%

: 1875-88-3
2-(4-Chlorophenyl)ethanol

A: 1878-66-6
4-chlorophenylacetic Acid

B: 60-12-8
2-phenylethanol

C: 65-85-0
benzoic acid

D: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide; oxygen; lead acetate; palladium on activated charcoal In water at 90℃; under 3800 Torr; for 3h;	A 36.5% B 36.8% C 3% D 4.7%

...Expand

: 937-20-2
p-chlorophenacyl chloride

A: 1878-66-6
4-chlorophenylacetic Acid

B: 24314-35-0
1,4-bis(4-chlorophenyl)butane-1,4-dione

C: 99-91-2
para-chloroacetophenone

Conditions

Conditions	Yield
With methyloxirane In water; acetonitrile for 4h; Irradiation;	A 35% B 18% C 6%
With methyloxirane In water; acetone for 4h; Irradiation;	A 14% B 31% C 10%

...Expand

: 124-38-9
carbon dioxide

: 106-43-4
para-chlorotoluene

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With bis(2-pyridyl)methane; xanth-9-one; nickel(II) chloride hexahydrate; potassium tert-butylate In benzene at 20℃; under 760.051 Torr; for 4h; Irradiation; Schlenk technique;	33%

: 80225-01-0
5-p-chlorophenyl-2-phenyl-4-tosyl-2-oxazoline

A: 1878-66-6
4-chlorophenylacetic Acid

B: 80224-89-1
5-(4-chlorophenyl)-2-phenyl-1,3-oxazole

C: 536-57-2
p-toluene sulfinic acid

D: 55-21-0
benzamide

Conditions

Conditions	Yield
With potassium carbonate In methanol for 1.5h; Heating; Yields of byproduct given;	A n/a B 14% C n/a D n/a

...Expand

: 3-(5-aminomethyl-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione hydrochloride

: 39901-94-5
2-picolinoyl chloride hydrochloride

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.25h;	10%

: 1878-66-6
4-chlorophenylacetic Acid

: 67-56-1
methanol

: 52449-43-1
(4-chloro-phenyl)-acetic acid methyl ester

Conditions

Conditions	Yield
With hydrogenchloride for 1h; Heating;	100%
With monoammonium 12-tungstophosphate for 12h; Heating;	98%
With sulfuric acid at 0 - 5℃; for 4.16667h; Reflux;	98%

: 1878-66-6
4-chlorophenylacetic Acid

: 64-17-5
ethanol

: 14062-24-9
4-chloro-benzeneacetic acid, ethyl ester

Conditions

Conditions	Yield
With sulfuric acid In benzene for 6h; Reflux;	100%
sulfuric acid at 20℃;	99%
With monoammonium 12-tungstophosphate for 12h; Heating;	98%

: 1878-66-6
4-chlorophenylacetic Acid

: 25026-34-0
4-chlorophenacetyl chloride

Conditions

Conditions	Yield
With thionyl chloride In dichloromethane	100%
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 23℃;	100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 18h;	90%

: 1878-66-6
4-chlorophenylacetic Acid

: 100-52-7
benzaldehyde

: 10465-70-0, 73720-02-2, 20432-20-6
(2E)-2-(4-chlorophenyl)-3-phenylprop-2-enoic acid

Conditions

Conditions	Yield
With acetic anhydride; triethylamine	100%
In acetic anhydride

: 1878-66-6
4-chlorophenylacetic Acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 381200-35-7
2-(4-chlorobenzyl)-5-aminobenzoxazole

Conditions

Conditions	Yield
With PPA at 195 - 198℃; for 1.5h;	100%
With polyphosphoric acid at 200℃; for 1.5h;	75%
With PPA Heating;

: 1878-66-6
4-chlorophenylacetic Acid

: 95-86-3
2,4-diaminophenol

: 381200-35-7
2-(4-chlorobenzyl)-5-aminobenzoxazole

Conditions

Conditions	Yield
With PPA at 195 - 198℃; for 1.5h;	100%

: 1878-66-6
4-chlorophenylacetic Acid

: 74-88-4
methyl iodide

: 52449-43-1
(4-chloro-phenyl)-acetic acid methyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetone at 60℃;	100%
With potassium carbonate In acetone at 60℃;	100%
Stage #1: 4-chlorophenylacetic Acid With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 20℃; for 1h; Stage #2: methyl iodide In toluene at 20℃; for 48h;	50%

: 1878-66-6
4-chlorophenylacetic Acid

: 101-83-7
N-cyclohexyl-cyclohexanamine

: C8H7ClO2*C12H23N

Conditions

Conditions	Yield
In methanol at 20℃;	100%

: 1878-66-6
4-chlorophenylacetic Acid

: 75-03-6
ethyl iodide

: 14062-24-9
4-chloro-benzeneacetic acid, ethyl ester

Conditions

Conditions	Yield
With 1,5-diazabicyclo[5.4.0]-undec-7-ene In N,N-dimethyl-formamide at 0℃;	99%

: 1878-66-6
4-chlorophenylacetic Acid

: 156-41-2
4-chlorophenylethylamine

: 325164-96-3
2-(4-chlorophenyl)-N-[2-(4-chlorophenyl)ethyl]acetamide

Conditions

Conditions	Yield
In neat (no solvent) at 150℃; for 0.5h; Microwave irradiation;	99%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 18h;	89%

: 1878-66-6
4-chlorophenylacetic Acid

: 94746-87-9
diethyl 5-acetyl-1,6-dihydro-6-oxo-2,3-pyridinedicarboxylate

: 111877-27-1
diethyl 3-(p-chlorophenyl)-4-methyl-2-oxo-2H-pyrano[2,3-b]pyridine-6,7-dicarboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane; acetic anhydride	99%

: 1878-66-6
4-chlorophenylacetic Acid

: 4137-10-4
DIMCARB

: 33297-39-1
2-(4-chlorophenyl)-N,N-dimethylacetamide

Conditions

Conditions	Yield
With zirconium(IV) chloride In toluene at 120℃; for 24h; Inert atmosphere; Molecular sieve;	99%

: 1878-66-6
4-chlorophenylacetic Acid

: 64-04-0
phenethylamine

: 83303-96-2
2-(4-chlorophenyl)-N-(2-phenylethyl)acetamide

Conditions

Conditions	Yield
In neat (no solvent) at 150℃; for 0.5h; Microwave irradiation;	99%

: 1878-66-6
4-chlorophenylacetic Acid

: 55-81-2
4-Methoxyphenethylamine

: 340218-64-6
2-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]acetamide

Conditions

Conditions	Yield
In neat (no solvent) at 150℃; for 0.5h; Microwave irradiation;	99%

: 140-53-4
p-chlorobenzyl cyanide

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With water; sodium hydroxide at 110 - 116℃; under 15001.5 Torr; for 0.05h; Concentration; Pressure; Temperature; Flow reactor;	99%
With 1-butyl-3-methylimidazolium hydrogen sulfate; water at 60 - 65℃; for 1.1h; Green chemistry;	96%
With potassium hydroxide In toluene at 160℃; for 0.5h; microwave irradiation;	92%

: 14062-24-9
4-chloro-benzeneacetic acid, ethyl ester

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With water; sodium hydroxide In 1,4-dioxane at 60℃; for 2h; pH=10 - 14;	98%

: 201230-82-2
carbon monoxide

: 622-95-7
4-chlorobenzyl bromide

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium iodide In formic acid at 60℃; under 760 Torr; for 18h; Carbonylation;	95%
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Temperature; Reagent/catalyst; Autoclave;	95.2%
With palladium hydroxide, 20 wt% on carbon; tetrabutylammomium bromide; water In tetrahydrofuran at 110℃; under 7500.75 Torr; for 4h; Sealed tube; Autoclave;	79%
With sodium hydroxide; sodium tetrahydroborate In tetrahydrofuran at 55℃; for 3h;	78%

: 89244-19-9, 89244-20-2
N-[(E)-2-(4-Chloro-phenyl)-1-cyano-vinyl]-4,N-dimethyl-benzamide

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran for 6h; Heating;	95%

: C14H21ClNO3P

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With hydrogen bromide at 100℃; for 0.166667h;	95%
With water; hydrogen bromide at 100℃; for 0.166667h; Inert atmosphere;	95%

: 1575722-27-8
4-Methoxybenzyl 2-(4-chlorophenyl)acetate

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With proton-exchanged montmorillonite In dichloromethane at 20℃;	95%

: 19202-19-8
2-(4-chlorophenyl)-1-(pyrrolidin-1-yl)-ethanone

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane for 30h; Heating;	94%

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 71-36-3
butan-1-ol

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
Stage #1: butan-1-ol With cobalt(II) sulfate at 80℃; under 3750.38 Torr; for 4h; Autoclave; Stage #2: 1-Chloro-4-(chloromethyl)benzene With sodium hydroxide In water at 80℃; under 3750.38 Torr; for 24h; Concentration; Pressure; Temperature; Autoclave;	93.6%

: 201230-82-2
carbon monoxide

: 62037-06-3
1-chloro-4-(dibromomethyl)benzene

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With potassium hydroxide; dicobalt octacarbonyl; N-benzyl-N,N,N-triethylammonium chloride In benzene under 760 Torr; for 8h; Ambient temperature;	92%

: 52449-43-1
(4-chloro-phenyl)-acetic acid methyl ester

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With sodium hydroxide for 2h; Heating;	92%
With potassium hydroxide In methanol for 4h; Ambient temperature;	50%
With water for 36h;	50%

: 4-chloro-N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)phenylglycinonitrile

A: 1878-66-6
4-chlorophenylacetic Acid

B: 888963-33-5
N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)amine

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid In dichloromethane; water at 20℃; for 1h;	A 92% B n/a

: 201230-82-2
carbon monoxide

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Temperature; Reagent/catalyst; Solvent; Autoclave;	90%
Stage #1: carbon monoxide With C28H22CoN4O6 In butan-1-ol at 60℃; under 760.051 Torr; for 2h; Glovebox; High pressure; Green chemistry; Stage #2: 1-Chloro-4-(chloromethyl)benzene With tetra-(n-butyl)ammonium iodide; sodium hydroxide In butan-1-ol at 60℃; under 760.051 Torr; for 22h; Glovebox; High pressure; Green chemistry; regioselective reaction;	86%
With bis-triphenylphosphine-palladium(II) chloride; tetraethylammonium chloride; sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene at 80℃; under 11251.1 Torr; for 20h; Autoclave; regioselective reaction;	86%
With sodium hydroxide; cerium(III) chloride; cetyltrimethylammonim bromide; nickel cyanide In toluene at 85 - 95℃; under 1 Torr; for 6.5h;	82%
With water; palladium diacetate at 110℃; under 37503.8 Torr; for 4h; Ionic liquid;	84 %Chromat.

: 42945-85-7
2-(4-chlorophenyl)-1-(morpholin-4-yl)-ethanethione

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With sodium hydroxide for 0.0166667h; microwave irradiation;	90%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride at 100℃; for 8h;

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With sodium hydroxide; cobalt tetracarbonyl anion In methanol at 55℃; for 4h;	84%
Multi-step reaction with 2 steps 1: dimethylsulfoxide / 5 h / 45 - 50 °C 2: KOH / aq. ethanol / Heating View Scheme
Multi-step reaction with 2 steps 1: alcohol / 120 - 130 °C / im Druckrohr 2: concentrated KOH-solution View Scheme
Multi-step reaction with 2 steps 1: alcohol; water 2: concentrated KOH-solution View Scheme
Multi-step reaction with 2 steps 1: ethanol; H2O / Heating 2: aq. KOH / ethanol / Heating View Scheme

: 124-38-9
carbon dioxide

: 52372-80-2
(4-chlorobenzylidene)hydrazine

: 1878-66-6
4-chlorophenylacetic Acid

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; cesium fluoride In N,N-dimethyl-formamide at 80℃; under 760.051 Torr; for 24h; chemoselective reaction;	82%

: 1073-67-2
4-vinylbenzyl chloride

: 1878-66-6
4-chlorophenylacetic Acid

4-Chlorophenylacetic acid Chemical Properties

Molecular Structure of p-Chlorophenylacetic acid (CAS NO.1878-66-6):

IUPAC Name: 2-(4-Chlorophenyl)acetic acid
Molecular Formula: C₈H₇ClO₂
Molecular Weight: 170.59
EINECS: 217-521-6
Melting Point: 102-105 °C(lit.)
Index of Refraction: 1.569
Molar Refractivity: 42.26 cm³
Molar Volume: 128.8 cm³
Surface Tension: 49.3 dyne/cm
Density: 1.324 g/cm³
Flash Point: 131.7 °C
Enthalpy of Vaporization: 56.37 kJ/mol
Boiling Point: 294.1 °C at 760 mmHg
Vapour Pressure: 0.000751 mmHg at 25 °C
Water Solubility: 2350 mg/L at 25 °C
Appearance: white to cream colored powder
Classification Code: Drug / Therapeutic Agent
Canonical SMILES: C1=CC(=CC=C1CC(=O)O)Cl
InChI: InChI=1S/C8H7ClO2/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4H,5H2,(H,10,11)
InChIKey: CDPKJZJVTHSESZ-UHFFFAOYSA-N
Product Categories: Phenylacetic acid series; FINE Chemical & INTERMEDIATES; Aromatic Phenylacetic Acids and Derivatives; Phenylacetic acid; Organic acids; C8; Carbonyl Compounds; Carboxylic Acids

4-Chlorophenylacetic acid Uses

p-Chlorophenylacetic acid (CAS NO.1878-66-6) is used for pharmaceutical intermediates.

4-Chlorophenylacetic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	1350mg/kg (1350mg/kg)		Farmaco, Edizione Scientifica. Vol. 13, Pg. 286, 1958.

4-Chlorophenylacetic acid Safety Profile

Safety Information of p-Chlorophenylacetic acid (CAS NO.1878-66-6):
Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 20/21-36/37/38
R20/21:Harmful by inhalation and in contact with skin.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 36/37-24/25-36-26
S36/37:Wear suitable protective clothing and gloves.
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: AG0590000

4-Chlorophenylacetic acid Specification

p-Chlorophenylacetic acid (CAS NO.1878-66-6), its Synonyms are (4-Chlorophenyl)acetic acid ; (p-Chlorophenyl)acetic acid ; 2-(p-Chlorophenyl)acetic acid ; 4-Chlorobenzeneacetic acid ; Acetic acid, (p-chlorophenyl)- ; Benzeneacetic acid, 4-chloro- .

Product Name

4-Chlorophenylacetic acid

Synthetic route

4-Chlorophenylacetic acid Chemical Properties

4-Chlorophenylacetic acid Uses

4-Chlorophenylacetic acid Toxicity Data With Reference

4-Chlorophenylacetic acid Safety Profile

4-Chlorophenylacetic acid Specification

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