4-Chlorophenylhydrazine hydrochloride supplier

Name
4-Chlorophenylhydrazine hydrochloride
EINECS 214-030-9
CAS No. 1073-70-7
Article Data38
CAS DataBase
Density 1.32 g/cm³
Solubility Soluble in hot water, methanol.
Melting Point 216 °C (dec.)(lit.)
Formula C₆H₇ClN₂^.HCl
Boiling Point 265.3 °C at 760 mmHg
Molecular Weight 179.049
Flash Point 114.2 °C
Transport Information 2811
Appearance white to pink crystalline powder
Safety 36/37-36-26
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms P-Chloropheyl hydrazine HCl;Hydrazine,(4-chlorophenyl)-, monohydrochloride (9CI);Hydrazine, (p-chlorophenyl)-,monohydrochloride (8CI);4-Chlorophenylhydrazine hydrochloride;4-Chlorophenylhydrazine monohydrochloride;p-Chlorophenylhydrazinehydrochloride;p-Chlorophenylhydrazine monohydrochloride;
PSA 38.05000
LogP 3.20090

Synthetic route

: 2028-74-2
p-chlorobenzenediazonium chloride

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

Conditions

Conditions	Yield
With 5% active carbon-supported ruthenium; hydrogen at 30℃; under 3750.38 Torr; for 4h; Temperature; Pressure; Reagent/catalyst;	98.2%
With palladium on activated charcoal; hydrogen In water at 10℃; under 22502.3 Torr; Pressure; Temperature; Solvent; Reagent/catalyst;	89.7%

: 829-31-2
3-(4-chlorophenyl)sydnone

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethyl acetate at 60℃; for 0.25h; Ring cleavage;	90%

: 106-47-8
4-chloro-aniline

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

Conditions

Conditions	Yield
Stage #1: 4-chloro-aniline With hydrogenchloride; sodium nitrite In water for 1h; Stage #2: With sodium sulfite at 80℃; for 2.5h; Stage #3: With hydrogenchloride In water at 95℃; for 2h;	88.3%
Stage #1: 4-chloro-aniline With hydrogenchloride; sodium nitrite In water at 5℃; Stage #2: With sodium carbonate; sodium sulfite In water at 5 - 70℃;	65.4%
Stage #1: 4-chloro-aniline With hydrogenchloride; sodium nitrite Stage #2: With tin(ll) chloride	64.3%

: 106-39-8
bromochlorobenzene

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

Conditions

Conditions	Yield
Stage #1: bromochlorobenzene With hydrazine hydrate; copper(II) sulfate; cobalt(II) chloride In propylene glycol at 152℃; for 10h; Stage #2: With hydrogenchloride In water Reagent/catalyst; Temperature; Solvent;	88.1%
Stage #1: bromochlorobenzene With 2,3,5,6,8,9,11,12,14,15-decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecin; hydrazine hydrate; copper(I) bromide In propylene glycol; water at 172℃; for 5h; Stage #2: With hydrogenchloride In water at 70℃; pH=1.8; Reagent/catalyst; Solvent; Temperature; Time; pH-value;	86.3%
Stage #1: bromochlorobenzene With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide In water at 80℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube; Stage #2: With hydrazine hydrate In water at 80℃; Inert atmosphere; Schlenk technique; Sealed tube; Stage #3: With hydrogenchloride In water pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;	85%
Stage #1: bromochlorobenzene With potassium phosphate; N,N'-bis(2,5-dimethylpyrrol-1-yl)oxalamide; cetyltrimethylammonim bromide; copper(I) bromide In water at 110℃; for 0.166667h; Sealed tube; Inert atmosphere; Stage #2: With hydrazine hydrate In water at 110℃; for 1.5h; Sealed tube; Inert atmosphere; Stage #3: With hydrogenchloride In dichloromethane; water	80%

: 64-17-5
ethanol

: 54624-61-2
4-chloro-3-(4-chlorophenyl)sydnone

A: 1073-70-7
4-chlorophenylhydrazine hydrochloride

B: N-(4-Chloro-phenyl)-hydrazinecarboxylic acid ethyl ester; hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

...Expand

: 1352877-23-6
(3R,4S)-4-hydroxy-2-oxotetrahydrofuran-3-yl 2-(2-(4-chlorophenyl)hydrazinyl)-2-oxoacetate

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane; methanol at 90℃; for 2h;

: 36966-92-4
4-Chlor-phenylnitrosamin

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride In water at 0℃;

: 563-80-4
3-methyl-butan-2-one

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 25981-83-3
5-chloro-2,3,3-trimethyl-3H-indole

Conditions

Conditions	Yield
With sulfuric acid In water at 100℃; for 0.166667h; Reagent/catalyst; Temperature; Microwave irradiation; Green chemistry;	100%
With sulfuric acid In water at 100℃; for 0.166667h; Wavelength; Microwave irradiation; Inert atmosphere; Green chemistry;	100%
With perchloric acid In ethanol Fischer indolization; Heating;	88%

: 832-10-0
cyclotridecanone

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 16-chloro-20-aza-tricyclo[11.7.0.014,19]eicosa-1(13),14(19),15,17-tetraene

Conditions

Conditions	Yield
at 250℃; for 0.0166667h; Fischer indole synthesis;	100%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 120-92-3
cyclopentanone

: 302912-35-2
7-chloro-1,2,3,4-tetrahydrocyclopenta[b]indole

Conditions

Conditions	Yield
at 250℃; for 0.0166667h; Fischer indole synthesis;	100%
With acetic acid Fischer Indole Synthesis; Reflux;	10%

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 874968-47-5
ethyl 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylate

Conditions

Conditions	Yield
In acetic acid at 20℃; for 17h; Heating / reflux;	100%
With hydrogenchloride In ethanol; water Fischer Indole Synthesis; Reflux;	64%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 89965-74-2
1,1,1-trifluoro-4-(4-methoxyphenyl)but-3-yn-2-one

: 1-(4’-chlorophenyl)-5-(4’-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 4-chlorophenylhydrazine hydrochloride With 1,8-diazabicyclo[5.4.0]undec-7-ene Stage #2: 1,1,1-trifluoro-4-(4-methoxyphenyl)but-3-yn-2-one at 20℃; for 24h; regioselective reaction;	100%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 93-55-0
1-phenyl-propan-1-one

: 41018-94-4
5-chloro-3-methyl-2-phenyl-1H-indole

Conditions

Conditions	Yield
at 250℃; for 0.0166667h; Fischer indole synthesis;	99%
With toluene-4-sulfonic acid for 0.0833333h; Fischer indole synthesis; Microwave irradiation; neat (no solvent);	95%
With acetic acid at 120℃; Inert atmosphere;
With acetic acid at 120℃; Inert atmosphere;

: 52140-59-7
4H-spiro[cyclohexane-1,3'-indole]-2’,4(1‘H)-dione

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 1456718-41-4
6-chloro-1,2,4,9-tetrahydrospiro[carbazole-3,3'indolin]-2'-one

Conditions

Conditions	Yield
With 1,3,5-trichloro-2,4,6-triazine In ethanol at 80℃; for 3h; Fischer Indole Synthesis;	99%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 125037-37-8
(E)-5-(2-Dimethylamino-vinyl)-1-phenyl-1H-tetrazol

: N-(4-Chloro-phenyl)-N'-[2-(1-phenyl-1H-tetrazol-5-yl)-eth-(E)-ylidene]-hydrazine

Conditions

Conditions	Yield
With water; acetic acid In methanol for 0.0833333h; Heating;	98%

: 5-(2,4-dichlorophenyl)tetrahydrothiophen-3-one

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 1171818-82-8
7-chloro-2-(2,4-dichlorophenyl)-3,4-dihydro-2H-thieno[3,2-b]indole

Conditions

Conditions	Yield
In ethanol at 90℃; under 1500.15 Torr; for 0.0666667h; Fischer indole synthesis; Microwave irradiation;	98%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 5305-40-8
2,6-dichloro-pyrimidine carbaldehyde

: 1429924-38-8
4,6-dichloro-5-((2-(4-chlorophenyl)hydrazono)methyl)pyrimidine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 65℃; for 1h; Temperature; Reagent/catalyst; Inert atmosphere;	98%

: C19H17N3O

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 1605292-96-3
1-benzyl-4-(1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-5-methyl-1H-1,2,3-triazole

Conditions

Conditions	Yield
In water for 1h; Solvent; Reflux; Green chemistry;	98%

: C20H19N3O

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 1605292-98-5
1-benzyl-4-(1-(4-chlorophenyl)-5-p-tolyl-4,5-dihydro-1H-pyrazol-3-yl)-5-methyl-1H-1,2,3-triazole

Conditions

Conditions	Yield
In water for 1.5h; Solvent; Reflux; Green chemistry;	98%

: 617-35-6
2-oxo-propionic acid ethyl ester

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 5296-86-6
2-[(4-chlorophenyl)-hydrazono]-propionic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: 4-chlorophenylhydrazine hydrochloride In ethanol at 50℃; for 1h; Inert atmosphere; Stage #2: 2-oxo-propionic acid ethyl ester In ethanol at 20 - 50℃; for 4h; Inert atmosphere;	98%
In ethanol; water at 80℃; for 3h; Fischer Indole Synthesis; Green chemistry;	91%
In ethanol Reflux;

: 79110-05-7
1-(2-fluoro-5-nitrophenyl)ethanone

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: C14H11ClFN3O2

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 50℃; for 2h; Inert atmosphere;	98%

: C19H16BrN3O

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 1605293-00-2
1-benzyl-4-(5-(4-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)-5-methyl-1H-1,2,3-triazole

Conditions

Conditions	Yield
In water for 1.5h; Solvent; Reflux; Green chemistry;	97%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 3958-60-9
2-nitrophenylmethyl bromide

: 220368-29-6
2-[(N-4-chlorophenyl)-1H-pyrazol-3-yloxymethyl]-1-nitrobenzene

Conditions

Conditions	Yield
In ethanol at 20℃; Solvent;	96.3%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 83611-37-4
(E)-4-(1-Formyl-naphthalen-2-yloxy)-but-2-enenitrile

A: 2-(4-Chloro-phenyl)-2,3,3a,4-tetrahydro-5-oxa-1,2-diaza-cyclopenta[c]phenanthrene-3-carbonitrile

B: 2-(4-Chloro-phenyl)-1,2,3,3a,4,11c-hexahydro-5-oxa-1,2-diaza-cyclopenta[c]phenanthrene-3-carbonitrile; hydrochloride

C: 2-(4-Chloro-phenyl)-1,2,3,3a,4,11c-hexahydro-5-oxa-1,2-diaza-cyclopenta[c]phenanthrene-3-carbonitrile

Conditions

Conditions	Yield
In ethanol Ambient temperature;	A n/a B 96% C n/a

...Expand

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 583-60-8
2-Methylcyclohexanone

A: 78153-05-6
6-chloro-1,2,3,4-tetrahydro-1-methylcarbazole

B: 78153-18-1
6-chloro-2,3,4,4a-tetrahydro-4a-methyl-1H-carbazole

Conditions

Conditions	Yield
In acetic acid for 0.25h; Heating;	A 4% B 96%

...Expand

: 3-(hydroxymethylene)-7-methoxy-2,2-dimethyl-2,3-dihydrochromen-4-one

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

A: 1013658-79-1
C19H17ClN2O2

B: 1013658-72-4
C19H17ClN2O2

Conditions

Conditions	Yield
With acetic acid In methanol at 30℃; for 1h;	A n/a B 96%

...Expand

: 1122-54-9
methyl (4-pyridyl) ketone

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 4-(1-[2-(4-chlorophenyl)hydrazono]ethyl)pyridine

Conditions

Conditions	Yield
With sodium acetate In ethanol at 80℃; for 0.0833333h; Microwave irradiation; air-cooling;	96%
In ethanol for 5h; Reflux;	87%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 541-41-3
chloroformic acid ethyl ester

: 13124-13-5
ethyl 2-(4-chlorophenyl)hydrazinecarboxylate

Conditions

Conditions	Yield
With pyridine In acetonitrile at 0 - 20℃;	96%
With pyridine In acetonitrile at 0 - 20℃; for 1h;

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 91-56-5
indole-2,3-dione

: 100460-67-1
(3Z)-1H-indole-2,3-dione 3-[(4-chlorophenyl)hydrazone]

Conditions

Conditions	Yield
In methanol at 20℃;	96%

: 1224949-36-3
3-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)-1-(p-tolyl)-2-propyn-1-one

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 1224949-55-6
8-(1-(4-chlorophenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-1,4-dioxaspiro[4.5]decan-8-ol

Conditions

Conditions	Yield
Stage #1: 4-chlorophenylhydrazine hydrochloride With triethylamine In ethanol at 20℃; for 0.5h; Stage #2: 3-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)-1-(p-tolyl)-2-propyn-1-one In ethanol at 20℃; for 14h;	96%
Stage #1: 4-chlorophenylhydrazine hydrochloride With triethylamine In ethanol at 20℃; for 0.5h; Stage #2: 3-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)-1-(p-tolyl)-2-propyn-1-one In ethanol at 20℃; for 14h;	96%

: C21H20BrClO2

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: trans-4-(3-bromophenyl)-10-chloro-6-(4-chlorophenyl)-2,3,3a,4-tetrahydro-1H-pyrido[3,2,1-jk]carbazole

Conditions

Conditions	Yield
In water at 130 - 140℃; Microwave irradiation;	96%

: 771-03-9
3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 114658-00-3
dehydroacetic acid (4-chlorophenyl)hydrazone

Conditions

Conditions	Yield
With sodium acetate In methanol for 15h; Ambient temperature;	95%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: potassium salt of 2-formyldimedone

: 308248-82-0
2-((2-(4-chlorophenyl)hydrazinyl)methylene)-5,5-dimethylcyclohexane-1,3-dione

Conditions

Conditions	Yield
In water at 80 - 90℃; Condensation;	95%

: 127143-19-5
N-(5-benzoyl-6-methyl-2-oxo-2H-pyran-3-yl)benzamide

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: (E)-2-(benzoylamino)-3-[1-(4-chlorophenyl)-3-methyl-5-phenyl-1H-pyrazol-4-yl]propenoic acid

Conditions

Conditions	Yield
With pyridine In ethanol for 1.33333h; Heating;	95%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 108-94-1
cyclohexanone

: 36684-65-8
6-chloro-1,2,3,4-tetrahydrocarbazole

Conditions

Conditions	Yield
With 1,3-bis(3-sulfopropyl)-1H-imidazol-3-ium trifluoromethanesulfonate In water at 100℃; for 0.333333h; Fischer Indole Synthesis; Microwave irradiation; Green chemistry;	95%
With acetic acid for 8h; Reflux;	92%
at 250℃; for 0.0166667h; Fischer indole synthesis;	91%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 141-97-9
ethyl acetoacetate

: 13024-90-3
1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one

Conditions

Conditions	Yield
With sodium acetate; acetic acid at 20℃; for 24h;	95%
With sodium acetate In acetic acid Reflux;	80%
With triethylamine In ethanol for 19h; Heating;	60%

4-Chlorophenylhydrazine hydrochloride Chemical Properties

Product Name: 4-Chlorophenylhydrazine hydrochloride
Synonyms: P-CHLOROPHENYLHYDRAZINE HCL;4-CHLOROPHENYLHYDRAZINE HCL;4-CHLOROPHENYLHYDRAZINE HYDROCHLORIDE;LABOTEST-BB LT01147712; P-Chlorophenyluhydrazinehydrochloride;P-CHLOROPHENYLHYDRAZINE HYDROCHLORIDE;1-(4-CHLOROPHENYL)HYDRAZINE HYDROCHLORIDE;CHLOROPHENYLHYDRAZINE(4-) HCL;
The Molecular formula of p-Chlorophenylhydrazine HCl(1073-70-7): C₆H₈Cl₂N₂
The Molecular Weight of p-Chlorophenylhydrazine HCl(1073-70-7): 179.05
Molecular Structure :

EINECS: 214-030-9
Melting point: 216 °C (dec.)(lit.)

4-Chlorophenylhydrazine hydrochloride Uses

p-Chlorophenylhydrazine HCl(1073-70-7) is used for synthetic organic intermediates.

4-Chlorophenylhydrazine hydrochloride Safety Profile

The Hazard Codes of p-Chlorophenylhydrazine HCl(1073-70-7) :

Xn,Xi
The Risk Statements information of p-Chlorophenylhydrazine HCl(1073-70-7):
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of p-Chlorophenylhydrazine HCl(1073-70-7):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
36/37: Wear suitable protective clothing and gloves
Hazard Note: Harmful/Irritant
HazardClass: 6.1(b)
HS Code: 29280090
PackingGroup: III
RIDADR: 2811
WGK Germany: 3

4-Chlorophenylhydrazine hydrochloride Analytical Methods

Liquid chromatographic analysis method.

Product Name

4-Chlorophenylhydrazine hydrochloride

Synthetic route

4-Chlorophenylhydrazine hydrochloride Chemical Properties

4-Chlorophenylhydrazine hydrochloride Uses

4-Chlorophenylhydrazine hydrochloride Safety Profile

4-Chlorophenylhydrazine hydrochloride Analytical Methods

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