4-vinylpyridine
2-(pyridin-4-yl)-ethanesulfonic acid
Conditions | Yield |
---|---|
With sodium hydrogensulfite In water at 20℃; | 90% |
With water; sodium hydrogensulfite | |
With ethanol; sulfur dioxide |
Conditions | Yield |
---|---|
In methanol; water mixt. of 2-(4-pyridyl)ethanesulfonic acid and Ag2O in CH3OH/H2O heated to 40°C for 1 h with vigorously stirring; cooled; filtered; crystals were obtained from mother liquor by slow evapn. at room temp. for several ds; elem. anal.; | 85% |
2-(pyridin-4-yl)-ethanesulfonic acid
Conditions | Yield |
---|---|
With phosphorus pentachloride In trichlorophosphate at 0 - 60℃; for 2h; | 78% |
With trichlorophosphate In tetrachloromethane |
2,4,6-triamino-s-triazine
2-(pyridin-4-yl)-ethanesulfonic acid
melamine-[2-(4-pyridyl)ethanesulfonato-N]-silver(I)
Conditions | Yield |
---|---|
In methanol mixt. of 2-(4-pyridyl)ethanesulfonic acid, melamine and AgClO4 in CH3OH heated to 40°C for 1 h with vigorously stirring; cooled; filtered; ppt. dissolved in DMSO; crystals were obtained by slow evapn. at room temp. for several ds; elem. anal.; | 62% |
1,10-Phenanthroline
2-(pyridin-4-yl)-ethanesulfonic acid
Conditions | Yield |
---|---|
In methanol; water at 130℃; for 72h; Autoclave; | 60% |
2-(pyridin-4-yl)-ethanesulfonic acid
4-hydroxy-benzaldehyde
3-(4-Hydroxyphenyl)-2-(4-pyridinio)-2-propenesulfonate
Conditions | Yield |
---|---|
With piperidine In dimethyl sulfoxide at 110℃; for 12h; | 5% |
2-(pyridin-4-yl)-ethanesulfonic acid
4-methoxy-benzaldehyde
3-(4-Methoxyphenyl)-2-(4-pyridinio)-2-propenesulfonate
Conditions | Yield |
---|---|
With piperidine In dimethyl sulfoxide | 5% |
2-(pyridin-4-yl)-ethanesulfonic acid
Conditions | Yield |
---|---|
With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzyl chloroformate; platinum(IV) oxide |
2-(pyridin-4-yl)-ethanesulfonic acid
water
tetraaquabis[2-(4-pyridyl)ethanesulfonato-N]zinc(II)
Conditions | Yield |
---|---|
With pyridine; water 2-(4-pyridyl)ethanesulfonic acid and Zn(ClO4)2*2H2O added to water and pyridine; soln. was evapd. at room temp. for a few days; |
2-(pyridin-4-yl)-ethanesulfonic acid
benzyl chloroformate
2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}ethanesulfonic acid
Conditions | Yield |
---|---|
Stage #1: 2-(pyridin-4-yl)-ethanesulfonic acid With ammonia; hydrogen; 5% rhodium on activated aluminium oxide In water at 30℃; under 3800.26 Torr; Stage #2: benzyl chloroformate In water at 0 - 20℃; for 1h; |
2-(pyridin-4-yl)-ethanesulfonic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: ammonia; hydrogen / 5% rhodium on activated aluminium oxide / water / 30 °C / 3800.26 Torr 1.2: 1 h / 0 - 20 °C 2.1: thionyl chloride / 4 h / Heating / reflux 3.1: dichloromethane / 2 h / 5 - 20 °C 4.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water / 24 h / 20 °C 5.1: potassium carbonate / acetonitrile / 6 h / Heating / reflux View Scheme |
2-(pyridin-4-yl)-ethanesulfonic acid
2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}ethanesulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: ammonia; hydrogen / 5% rhodium on activated aluminium oxide / water / 30 °C / 3800.26 Torr 1.2: 1 h / 0 - 20 °C 2.1: thionyl chloride / 4 h / Heating / reflux View Scheme |
2-(pyridin-4-yl)-ethanesulfonic acid
benzyl 4-[2-(piperidin-1-ylsulfonyl)ethyl]piperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ammonia; hydrogen / 5% rhodium on activated aluminium oxide / water / 30 °C / 3800.26 Torr 1.2: 1 h / 0 - 20 °C 2.1: thionyl chloride / 4 h / Heating / reflux 3.1: dichloromethane / 2 h / 5 - 20 °C View Scheme |
2-(pyridin-4-yl)-ethanesulfonic acid
1-[(2-piperidin-4-ylethyl)sulfonyl]piperidine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: ammonia; hydrogen / 5% rhodium on activated aluminium oxide / water / 30 °C / 3800.26 Torr 1.2: 1 h / 0 - 20 °C 2.1: thionyl chloride / 4 h / Heating / reflux 3.1: dichloromethane / 2 h / 5 - 20 °C 4.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water / 24 h / 20 °C View Scheme |
2-(pyridin-4-yl)-ethanesulfonic acid
Conditions | Yield |
---|---|
With thionyl chloride; N,N-dimethyl-formamide for 0.5h; Reflux; |
2-(pyridin-4-yl)-ethanesulfonic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: thionyl chloride; N,N-dimethyl-formamide / 0.5 h / Reflux 2: ammonium hydroxide / dichloromethane / 12 h / 0 - 20 °C View Scheme |
2-(pyridin-4-yl)-ethanesulfonic acid
terephthalic acid
hydrogen fluoride
N,N-dimethyl-formamide
Conditions | Yield |
---|---|
at 210℃; for 24h; Autoclave; |
The molecular structure of 4-Pyridineethanesulfonic acid (CAS NO.53054-76-5) is
IUPAC Name: 2-Pyridin-4-ylethanesulfonic acid
Canonical SMILES: C1=CN=CC=C1CCS(=O)(=O)O
Molecular Formula: C7H9 NO3S
Molecular Weight: 187.21
EINECS: 258-331-3
Density: 1.397 g/cm3
Melting Point: 297-299 ºC (dec.)
Solubility: soluble in acid and alkaline, almost insoluble water, cold methanol and ethanol.
Appearance: Off-White to light yellow Powder
Freely Rotating Bonds: 3
Polar Surface Area: 64.64 Å2
Index of Refraction: 1.573
Molar Refractivity: 44.16 cm3
Molar Volume: 134 cm3
Polarizability: 17.5 ×10-24 cm3
Surface Tension: 63.2 dyne/cm
The Cas Register Number of 4-Pyridineethanesulfonic acid is 53054-76-5. The chemical synonyms of 4-Pyridineethanesulfonic acid (CAS NO.53054-76-5) are Pyrid-4-ylethylsulfonic acid ; Pyridin-4-ylethanesulphonic acid ; 4-Pyridyl-2-ethyl sulfonic acid ; 4-Pyridineethenesulfonic acid ; 4-Pyridineethanesulfonic acid .
4-Pyridineethanesulfonic acid (CAS NO.53054-76-5) is used in organic synthesis and as pharmaceutical intermediates, sickle cell hemoglobin gelation inhibitor .
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2585 8/PG 3
WGK Germany: 2
HazardClass: 8
PackingGroup: III
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