5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole supplier

: 133909-97-4
N-(trityl)-5-[4΄-(methyl)biphenyl-2-yl]-2H-tetrazole

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane for 3h; Heating;	92%
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane for 8h; Heating;	92%
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile) In dichloromethane at 28℃; Reflux;	85%

: 114772-53-1
2-Cyano-4'-methylbiphenyl

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: zinc chloride; sodium azide / dimethylformamide / 36 h / Heating 1.2: 96 percent / aq. HCl / dimethylformamide / 1 h / cooling 2.1: 91 percent / aq. NaOH / toluene / 3 h / 20 °C 3.1: 92 percent / N-bromosuccinimide; dibenzoyl peroxide / CCl4 / 8 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 96 percent / ZnCl2; NaN3 / dimethylformamide / 36 h / Heating 2: 91 percent / aq. NaOH / toluene / 3 h / 20 °C 3: 92 percent / N-bromosuccinimide; dibenzoyl peroxide / CCl4 / 8 h / Heating View Scheme
Multi-step reaction with 3 steps 1: trimethyltin azide / toluene / Heating 2: Et3N / CHCl3 3: NBS, AIBN / CCl4 / Heating View Scheme

: 120568-11-8
5-<4'-Methyl-1,1'-biphenyl-2-yl>-1H-tetrazole

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 91 percent / aq. NaOH / toluene / 3 h / 20 °C 2: 92 percent / N-bromosuccinimide; dibenzoyl peroxide / CCl4 / 8 h / Heating View Scheme
Multi-step reaction with 2 steps 1: Et3N / CHCl3 2: NBS, AIBN / CCl4 / Heating View Scheme
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 1.5 h / Heating 2: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 2 h / Heating View Scheme

: 120568-11-8
2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 91 percent / aq. NaOH / toluene / 3 h / 20 °C 2: 92 percent / N-bromosuccinimide; dibenzoyl peroxide / CCl4 / 8 h / Heating View Scheme

: 106-38-7
para-bromotoluene

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Yield

Multi-step reaction with 4 steps
2: 1.) Me3SnN3, 2.) aq. HCl / 1.) toluene, reflux, 24 h, 2.) 25 deg C
3: Et3N / CH2Cl2 / 1.5 h / Heating
4: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 2 h / Heating
View Scheme

Multi-step reaction with 7 steps
1: magnesium / tetrahydrofuran / 2 h / 20 °C
2: tetrahydrofuran / 3 h / 20 °C
3: pyridine; trichlorophosphate / 3 h / 10 - 100 °C
4: sodium azide / toluene / 96 h / 110 °C
5: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C
7: N-Bromosuccinimide; Phthalic acid dibutyl ester / tetrachloromethane / 6 h / Reflux
View Scheme

: 2042-37-7
o-cyanobromobenzene

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 2: 1.) Me3SnN3, 2.) aq. HCl / 1.) toluene, reflux, 24 h, 2.) 25 deg C 3: Et3N / CH2Cl2 / 1.5 h / Heating 4: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 2 h / Heating View Scheme
Multi-step reaction with 5 steps 1: nickel 2: sodium azide / toluene / 96 h / 110 °C 3: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C 5: N-Bromosuccinimide; Phthalic acid dibutyl ester / tetrachloromethane / 6 h / Reflux View Scheme

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: tetrahydrofuran / 2 h / 20 °C 2: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 3: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h 4: 92 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme

: 74201-13-1
N-(2-hydroxy-1,1-dimethyl)-2-methoxybenzamide

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: thionyl chloride / 1 h / 25 °C 2: tetrahydrofuran / 2 h / 20 °C 3: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 4: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h 5: 92 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme

: 84392-32-5
4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 2: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h 3: 92 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
Multi-step reaction with 5 steps 1: pyridine; trichlorophosphate / 3 h / 10 - 100 °C 2: sodium azide / toluene / 96 h / 110 °C 3: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C 5: N-Bromosuccinimide; Phthalic acid dibutyl ester / tetrachloromethane / 6 h / Reflux View Scheme

: 579-75-9
2-Methoxybenzoic acid

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 95 percent / thionyl chloride / 18 h / 20 °C 2: CH2Cl2 / 2 h / 20 °C 3: thionyl chloride / 1 h / 25 °C 4: tetrahydrofuran / 2 h / 20 °C 5: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 6: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h 7: 92 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme

Yield

Multi-step reaction with 7 steps
1: 95 percent / thionyl chloride / 18 h / 20 °C
2: CH2Cl2 / 2 h / 20 °C
3: thionyl chloride / 1 h / 25 °C
4: tetrahydrofuran / 2 h / 20 °C
5: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C
6: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h
7: 92 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating
View Scheme

: 21615-34-9
2-Methoxybenzoyl chloride

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: CH2Cl2 / 2 h / 20 °C 2: thionyl chloride / 1 h / 25 °C 3: tetrahydrofuran / 2 h / 20 °C 4: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 5: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h 6: 92 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme

: 76-83-5
trityl chloride

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 1 h / 20 °C 2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux View Scheme

: 100-47-0
benzonitrile

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: n-butyllithium; 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran; hexane / 0.08 h / -78 - -10 °C / Inert atmosphere 1.2: 5 h / -78 - 20 °C / Inert atmosphere 2.1: toluene / 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethanol; toluene / 4 h / 100 °C / Inert atmosphere 4.1: trimethylsilylazide; trifluoroacetic acid / 36 h / 120 °C / Sealed tube 5.1: triethylamine / dichloromethane / 1 h / 20 °C 6.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux View Scheme

Yield

Multi-step reaction with 6 steps
1.1: n-butyllithium; 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran; hexane / 0.08 h / -78 - -10 °C / Inert atmosphere
1.2: 5 h / -78 - 20 °C / Inert atmosphere
2.1: toluene / 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethanol; toluene / 4 h / 100 °C / Inert atmosphere
4.1: trimethylsilylazide; trifluoroacetic acid / 36 h / 120 °C / Sealed tube
5.1: triethylamine / dichloromethane / 1 h / 20 °C
6.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux
View Scheme

: C13H18BNO2

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: toluene / 20 °C 2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethanol; toluene / 4 h / 100 °C / Inert atmosphere 3: trimethylsilylazide; trifluoroacetic acid / 36 h / 120 °C / Sealed tube 4: triethylamine / dichloromethane / 1 h / 20 °C 5: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux View Scheme

: 214360-47-1
2-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-benzonitrile

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethanol; toluene / 4 h / 100 °C / Inert atmosphere 2: trimethylsilylazide; trifluoroacetic acid / 36 h / 120 °C / Sealed tube 3: triethylamine / dichloromethane / 1 h / 20 °C 4: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux View Scheme

: C26H22Zn

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: nickel 2: sodium azide / toluene / 96 h / 110 °C 3: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C 5: N-Bromosuccinimide; Phthalic acid dibutyl ester / tetrachloromethane / 6 h / Reflux View Scheme

: 4294-57-9
para-methylphenylmagnesium bromide

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: tetrahydrofuran / 3 h / 20 °C 2: pyridine; trichlorophosphate / 3 h / 10 - 100 °C 3: sodium azide / toluene / 96 h / 110 °C 4: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C 5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C 6: N-Bromosuccinimide; Phthalic acid dibutyl ester / tetrachloromethane / 6 h / Reflux View Scheme

: C26H38N4Sn

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C 3: N-Bromosuccinimide; Phthalic acid dibutyl ester / tetrachloromethane / 6 h / Reflux View Scheme

: 83857-96-9
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 133909-99-6
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions

Conditions	Yield
Stage #1: 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde; N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole With potassium carbonate In N,N-dimethyl-formamide at 20 - 22℃; for 3h; Stage #2: With sodium tetrahydroborate In water; N,N-dimethyl-formamide at 48 - 52℃; for 3.08333h;	99.2%
With potassium carbonate In N,N-dimethyl acetamide
With potassium carbonate In N,N-dimethyl acetamide

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 143618-44-4
2-(triphenylmethyl)-5-<(4'-(azidomethyl)biphenyl-2-yl)>-2H-tetrazole

Conditions

Conditions	Yield
With lithium azide In dimethyl sulfoxide for 4h; Ambient temperature;	99%
With sodium azide In N,N-dimethyl-formamide for 16h; Ambient temperature;	89%

: 34541-30-5
2-(2-oxohexyl)pyridine

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: (+/-)-2-<2-oxo-1-<<2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-yl>methyl>hexyl>pyridine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran for 8h;	94%

: 447446-61-9
ethyl 3-(N-pentanoyl)aminobenzoate

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 849419-67-6
ethyl 3-[N-[[4-[2-(3-triphenylmethyl-3H-tetrazol-5-yl)phenyl]phenyl]methyl]-N-pentanoylamino]benzoate

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl acetamide at 50℃; for 3.5h;	93.6%

: 203268-68-2, 161013-20-3
2-mercapto-5-(2-bromophenyl)-1,3,4-oxadiazole

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 882213-53-8
5-{4'-[5-(2-bromo-phenyl)-[1,3,4]oxadiazol-2-ylsulfanylmethyl]-biphenyl-2-yl}-2-trityl-2H-tetrazole

Conditions

Conditions	Yield
Stage #1: 2-mercapto-5-(2-bromophenyl)-1,3,4-oxadiazole With potassium carbonate In acetone for 0.5h; Heating; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetone Heating;	92%

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 168074-28-0
3(R)-3-methyl-N-<2,3,4,5-tetrahydro-2-oxo-(1H)-1-benz-azepin-3-yl>-2-butenamide

: 168074-29-1
3(R)-3-methyl-N-<2,3,4,5-tetrahydro-2-oxo-1-<<<2'-(N-triphenylmethyl)-tetrazol-5-yl><1,1'-biphenyl>-4-yl>-methyl>-1H-1-benzazepin-3-yl>-2-butenamide

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 22℃; for 18h;	91%

: 107-10-8
propylamine

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 143618-24-0
Propyl-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amine

Conditions

Conditions	Yield
In tetrahydrofuran for 4h; Ambient temperature;	89%
In tetrahydrofuran for 2h; Ambient temperature;

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 145486-46-0
[1,1-Dimethyl-2-((R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-ethyl]-sulfamic acid methyl ester

: 174222-36-7
(1,1-Dimethyl-2-{(R)-2-oxo-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl}-ethyl)-sulfamic acid methyl ester

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 0℃;	89%

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 69844-25-3
5-(2-methoxyphenyl)-1,3,4-oxadiazole-2-thiol

: 882213-55-0
5-{4'-[5-(2-methoxy-phenyl)-[1,3,4]oxadiazol-2-ylsulfanylmethyl]-biphenyl-2-yl}-2-trityl-2H-tetrazole

Conditions

Conditions	Yield
Stage #1: 5-(2-methoxyphenyl)-1,3,4-oxadiazole-2-thiol With potassium carbonate In acetone for 0.5h; Heating; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetone Heating;	89%

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 41491-54-7
5-(3-chlorophenyl)-[1,3,4]oxadiazole-2-thiol

: 882213-57-2
5-{4'-[5-(3-chloro-phenyl)-[1,3,4]oxadiazol-2-ylsulfanylmethyl]-biphenyl-2-yl}-2-trityl-2H-tetrazole

Conditions

Conditions	Yield
Stage #1: 5-(3-chlorophenyl)-[1,3,4]oxadiazole-2-thiol With potassium carbonate In acetone for 0.5h; Heating; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetone Heating;	88%

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 15264-63-8
5-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol

: 882213-52-7
4-{5-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethylsulfanyl]-[1,3,4]oxadiazol-2-yl}-pyridine

Conditions

Conditions	Yield
Stage #1: 5-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol With potassium carbonate In acetone for 0.5h; Heating; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetone Heating;	87%

: 2-butyl-5-(4-chlorobenzylidene)-3,5-dihydro-4H-imidazol-4-one

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 2-butyl-4-(4-chlorobenzylidene)-1-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazol-5(4H)-one

Conditions

Conditions	Yield
Stage #1: 2-butyl-5-(4-chlorobenzylidene)-3,5-dihydro-4H-imidazol-4-one With potassium carbonate In acetonitrile at 20℃; for 0.0833333h; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetonitrile for 6h; Reflux; Inert atmosphere;	87%

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 66147-19-1
2-mercapto-5-(3-methylphenyl)-1,3,4-oxadiazole

: 882213-58-3
5-[4'-(5-m-tolyl-[1,3,4]oxadiazol-2-ylsulfanylmethyl)-biphenyl-2-yl]-2-trityl-2H-tetrazole

Conditions

Conditions	Yield
Stage #1: 2-mercapto-5-(3-methylphenyl)-1,3,4-oxadiazole With potassium carbonate In acetone for 0.5h; Heating; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetone Heating;	86%

: 50790-93-7
2-butyl-1H-imidazole

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 1431152-74-7
2-butyl-N,N'-bis{[2'-[2-(trityl)tetrazol-5-yl]biphenyl-4-yl]methyl}imidazolium bromide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 8h; Inert atmosphere;	85%

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 144689-93-0
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

: 172875-59-1
ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 20℃; for 24h;	83%
With potassium tert-butylate 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h; Yield given. Multistep reaction;
Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In N,N-dimethyl-formamide at 20 - 60℃; for 6h;

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 23766-26-9
5‑(4‑methoxyphenyl)‑1,3,4‑oxadiazole‑2‑thiol

: 882213-56-1
5-{4'-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-ylsulfanylmethyl]-biphenyl-2-yl}-2-trityl-2H-tetrazole

Conditions

Conditions	Yield
Stage #1: 5‑(4‑methoxyphenyl)‑1,3,4‑oxadiazole‑2‑thiol With potassium carbonate In acetone for 0.5h; Heating; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetone Heating;	83%

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 114461-19-7
5-(5-Methyl-isoxazol-3-yl)-4-phenyl-4H-[1,2,4]triazole-3-thiol

: 1029889-26-6
C45H34N8OS

Conditions

Conditions	Yield
Stage #1: 5-(5-Methyl-isoxazol-3-yl)-4-phenyl-4H-[1,2,4]triazole-3-thiol With potassium carbonate In acetone for 2h; Heating; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetone Heating; Further stages.;	83%

: 124750-59-0
2-propyl-4,5-bis(methoxycarbonyl)-imidazole

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: dimethyl 2-propyl-1-(4-(2-(trityltetrazol-5-yl)phenyl)phenylmethyl)-imidazole-4,5-dicarboxylate

Conditions

Conditions	Yield
With potassium carbonate In ISOPROPYLAMIDE; acetone at 30 - 61℃; for 5 - 6h; Product distribution / selectivity;	82.8%
With potassium carbonate In N,N-dimethyl-formamide; acetone Reflux;

: 114461-25-5
C13H12N4O2S

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 1029889-50-6
C46H36N8O2S

Conditions

Conditions	Yield
Stage #1: C13H12N4O2S With potassium carbonate In acetone for 2h; Heating; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetone Heating; Further stages.;	81%

: 79047-41-9
2-n-butyl-4-chloro-5-hydroxymethylimidazole

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 133909-99-6
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 10h;	80%

: 4-methyl-2-propyl-N-(R-hydroxymethylbenzyl)-1H-benzimidazole-6-carboxamide

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 4'-[(4-methyl-2-propyl-N-2-(R-hydroxymethylbenzyl)-1H-benzimidazole-6-carboxamido-1-yl)methyl][1,1'-biphenyl]-2-(N-triphenylmethyl)tetrazole

Conditions

Conditions	Yield
Stage #1: 4-methyl-2-propyl-N-(R-hydroxymethylbenzyl)-1H-benzimidazole-6-carboxamide With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Cooling with ice; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In N,N-dimethyl-formamide at 0 - 20℃; for 5h;	79%

: 500016-52-4
C14H14N4OS

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 1029889-56-2
C47H38N8OS

Conditions

Conditions	Yield
Stage #1: C14H14N4OS With potassium carbonate In acetone for 2h; Heating; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetone Heating; Further stages.;	78%

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 4-butyl-1-<<2-(trimethylsilyl)ethoxy>methyl>imidazole

: 1400933-86-9
5-butyl-1-[[(2'-(2-trityl)-tetrazol-5-yl)biphenyl-4-yl]methyl]-3-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazolium bromide

Conditions

Conditions	Yield
In acetonitrile at 70℃; for 3h; Inert atmosphere;	78%

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 146953-86-8
4-n-Butyl-imidazole

: 1431151-99-3
4-butyl-N,N'-bis{[2'-[2-(trityl)tetrazol-5-yl]biphenyl-4-yl]methyl}imidazolium bromide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 8h; Inert atmosphere;	78%

: 50790-93-7
2-butyl-1H-imidazole

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 2-butyl-1-<<2'-<(N-triphenylmethyl)tetrazol-5-yl>biphenyl-4-yl>methyl>imidazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide 1.) 0 deg C, 45 min; 2.) 45 deg C;	77.6%

: 146922-22-7
C13H12N4OS

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 1029889-30-2
C46H36N8OS

Conditions

Conditions	Yield
Stage #1: C13H12N4OS With potassium carbonate In acetone for 2h; Heating; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetone Heating; Further stages.;	77%

: 1029889-22-2
C14H14N4O2S

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 1029889-52-8
C47H38N8O2S

Conditions

Conditions	Yield
Stage #1: C14H14N4O2S With potassium carbonate In acetone for 2h; Heating; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetone Heating; Further stages.;	77%

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 150097-92-0
Methyl 4(5)-(pentafluoroethyl)-2-propylimidazole-5(4)-carboxylate

: 150097-93-1
Methyl 4-(pentafluoroethyl)-2-propyl-1-<<2'-biphenyl-4-yl>methyl>imidazole-5-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 16h; Ambient temperature;	74%

: 31130-15-1
2-mercapto-5-(4-methylphenyl)-1,3,4-oxadiazole

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 882213-59-4
5-[4'-(5-p-tolyl-[1,3,4]oxadiazol-2-ylsulfanylmethyl)-biphenyl-2-yl]-2-trityl-2H-tetrazole

Conditions

Conditions	Yield
Stage #1: 2-mercapto-5-(4-methylphenyl)-1,3,4-oxadiazole With potassium carbonate In acetone for 0.5h; Heating; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In acetone Heating;	74%

Product Name

5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole

Synthetic route

5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole Chemical Properties

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