As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryAssay: 99% up; Stable supply with over 50Mt annually; Appearance:White or off-white powder Storage:room temprature Package:1kg/bag, 25kg/drum Application:Intermediate of Darunavir Port:Beijing/Shanghai/Shenzhen/Hangzhou
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inquiryItems Standard Result Assay 98%min ----------------------------------------------------------------------------------------------
Cas:83857-96-9
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inquiryHigh quality 2-Butyl-4-chloro-5-formylimidazole Cas 83857-96-9 with steady supply Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediate
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inquiryHebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable
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inquiryPromptly delivery Good price Good quality Appearance:white powder Storage:dry condition Package:According to customer Application:intermediate Transportation:by courier or by Sea Port:Shanghai Port
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryProduct Name: 2-Butyl-4-chloro-5-formylimidazole Synonyms: 2-BUTYL-5-CHLOROIMIDAZOLE-4-CARBOXALDEHYDE;2-BUTYL-4-CHLORO-IMIDAZOLE-5-CARBALDEHYDE;2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBALDEHYDE;2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBOXALDEHYDE
Cas:83857-96-9
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inquiryAbout Product Technical Details Mol File: 838
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam
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inquiry2--Butyl-5-chloro-1H-imidazole-4-carbaldehyde Product name : 2--Butyl-5-chloro-1H-imidazole-4-carbaldehyde Molecular weight : 186.64 CAS NO : 83857-96-9 Properties : Yellowish to white crystalline powder Use :
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
Cas:83857-96-9
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inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
Cas:83857-96-9
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:83857-96-9
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inquiryBeluga chemical professional supply High quality 2-Butyl-4-chloro-5-formylimidazole CAS 83857-96-9 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilitie
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryOur Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Professional R&D
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inquirydichloromethane
2-n-butyl-4-chloro-5-hydroxymethylimidazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With potassium hydroxide In water; acetic acid | 92% |
In water; acetic acid |
N,N-dimethyl-formamide
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Stage #1: (1-iminopentyl)glycine tert-butyl ester With trifluoroacetic acid In 1,2-dichloro-ethane at 20℃; for 24h; Large scale; Stage #2: With trichlorophosphate In toluene at 80℃; for 2h; Large scale; Stage #3: N,N-dimethyl-formamide In toluene at 105℃; for 7h; Temperature; Large scale; | 89.2% |
(Z)-2-butyl-4-(dimethylaminomethylene)-2-imidazolin-5-one
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With trichlorophosphate at 100℃; for 1.5h; Substitution; | 88% |
4(5)-bromo-2-butyl-1H-imidazole-5(4)-carboxaldehyde
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With hydrogenchloride for 24h; Heating; | 87% |
2-n-butyl-4-chloro-5-hydroxymethylimidazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With ammonium cerium(IV) nitrate In acetic acid at 25℃; for 3h; | 77% |
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; iodine; sodium hydrogencarbonate In water; toluene at 20℃; for 16h; | 690 mg |
With oxygen; Pt/Bi on graphite In methanol at 60℃; under 2250.23 Torr; for 6h; Product distribution; Further Variations:; Reagents; | |
With manganese dioxide In dichloromethane | 12.81 g (86%) |
methyl pentanimidate
N,N-dimethyl-formamide
glycine
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Stage #1: glycine With sodium hydroxide In methanol at 0℃; for 0.25h; Stage #2: methyl pentanimidate In methanol at 0 - 20℃; for 16.16 - 16.25h; Stage #3: N,N-dimethyl-formamide With sodium hydroxide; water; trichlorophosphate; copper(II) bis(trifluoromethanesulfonate) Product distribution / selectivity; more than 3 stages; | 71% |
Stage #1: glycine With sodium hydroxide In methanol at 0℃; for 0.25h; Stage #2: methyl pentanimidate In methanol at 0 - 20℃; for 16.16 - 16.25h; Stage #3: N,N-dimethyl-formamide With sodium hydroxide; trichlorophosphate Product distribution / selectivity; more than 3 stages; | 66.4% |
Stage #1: methyl pentanimidate; glycine With sodium hydroxide In methanol; water; toluene Stage #2: N,N-dimethyl-formamide With trichlorophosphate In toluene at 100℃; for 2h; | 55% |
N,N-dimethyl-formamide
2-butyl-2-imidazolin-5-one
A
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With trichlorophosphate In toluene at 100℃; for 2h; Dehydrogenation; Vilsmeier formylation; chlorination; | A 55% B n/a C n/a |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With water Yield given; | |
With water Hydrolysis; Acid hydrolysis; |
2-butyl-1H-imidazole-5-carboxaldehyde
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With N-chloro-succinimide Chlorination; |
N,N-dimethyl-formamide
2-butyl-5-chloro-1H-imidazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With trichlorophosphate In chlorobenzene at 100℃; for 4h; Formylation; Vilsmeier reaction; |
N,N-dimethyl-formamide
(pentanimidoylamino)acetic acid
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With trichlorophosphate In toluene at 100℃; for 2h; Cyclization; Vilsmeier formylation; substitution; | 26.0 g |
With trichlorophosphate In toluene at 97 - 100℃; for 3h; | 132 g |
With trichlorophosphate In toluene at 60 - 100℃; for 2h; Green chemistry; | 0.154 g |
2-n-butyl-4-chloro-5-hydroxymethylimidazole
A
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; N-chloro-succinimide; sodium hydrogencarbonate In water; toluene at 20℃; | A n/a B 85 % Chromat. |
2-n-butyl-4-chloro-5-hydroxymethylimidazole
A
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; N-Bromosuccinimide; sodium hydrogencarbonate In water; toluene at 20℃; | A n/a B 85 % Chromat. |
pentanonitrile
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: HCl / 12 h / 20 °C 1.2: aq. KOH / toluene / 5 °C 2.1: aq. KOH / toluene; methanol / 15 h / 40 °C 3.1: 132 g / POCl3 / toluene / 3 h / 97 - 100 °C View Scheme | |
Multi-step reaction with 4 steps 1: 190.8 g / HCl / dibutyl ether / 144 h / 4 °C 2: 95 percent / NaOH / methanol; toluene / 3 h / 20 °C 3: 44 percent / CH2Cl2 / 20 - 27 °C 4: 88 percent / POCl3 / 1.5 h / 100 °C View Scheme | |
Multi-step reaction with 5 steps 1: 190.8 g / HCl / dibutyl ether / 144 h / 4 °C 2: 95 percent / NaOH / methanol; toluene / 3 h / 20 °C 3: 31 percent / POCl3 / chlorobenzene / 2 h / 100 °C 4: Et3N / chlorobenzene / Heating 5: H2O / Acid hydrolysis View Scheme |
methyl pentanimidate
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aq. KOH / toluene; methanol / 15 h / 40 °C 2: 132 g / POCl3 / toluene / 3 h / 97 - 100 °C View Scheme | |
Multi-step reaction with 3 steps 1: 95 percent / NaOH / methanol; toluene / 3 h / 20 °C 2: 44 percent / CH2Cl2 / 20 - 27 °C 3: 88 percent / POCl3 / 1.5 h / 100 °C View Scheme | |
Multi-step reaction with 4 steps 1: 95 percent / NaOH / methanol; toluene / 3 h / 20 °C 2: 31 percent / POCl3 / chlorobenzene / 2 h / 100 °C 3: Et3N / chlorobenzene / Heating 4: H2O / Acid hydrolysis View Scheme |
pentanimidamide
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 2: 44 percent / CH2Cl2 / 20 - 27 °C 3: 88 percent / POCl3 / 1.5 h / 100 °C View Scheme | |
Multi-step reaction with 4 steps 2: 31 percent / POCl3 / chlorobenzene / 2 h / 100 °C 3: Et3N / chlorobenzene / Heating 4: H2O / Acid hydrolysis View Scheme | |
Multi-step reaction with 3 steps 2: 31 percent / POCl3 / chlorobenzene / 2 h / 100 °C 3: POCl3 / chlorobenzene / 4 h / 100 °C View Scheme |
ethyl valerimidate
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 40 percent / 24 h / -10 °C 2: 44 percent / CH2Cl2 / 20 - 27 °C 3: 88 percent / POCl3 / 1.5 h / 100 °C View Scheme | |
Multi-step reaction with 4 steps 1: 40 percent / 24 h / -10 °C 2: 31 percent / POCl3 / chlorobenzene / 2 h / 100 °C 3: Et3N / chlorobenzene / Heating 4: H2O / Acid hydrolysis View Scheme | |
Multi-step reaction with 3 steps 1: 40 percent / 24 h / -10 °C 2: 31 percent / POCl3 / chlorobenzene / 2 h / 100 °C 3: POCl3 / chlorobenzene / 4 h / 100 °C View Scheme |
2-butyl-2-imidazolin-5-one
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 44 percent / CH2Cl2 / 20 - 27 °C 2: 88 percent / POCl3 / 1.5 h / 100 °C View Scheme | |
Multi-step reaction with 3 steps 1: 31 percent / POCl3 / chlorobenzene / 2 h / 100 °C 2: Et3N / chlorobenzene / Heating 3: H2O / Acid hydrolysis View Scheme | |
Multi-step reaction with 2 steps 1: 31 percent / POCl3 / chlorobenzene / 2 h / 100 °C 2: POCl3 / chlorobenzene / 4 h / 100 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1.) POCl3 / 1.) toluene, 80 deg C, 2.) toluene, 100 deg C 2: H2O View Scheme |
2-butyl-5-chloro-1H-imidazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et3N / chlorobenzene / Heating 2: H2O / Acid hydrolysis View Scheme |
2-butyl-1H-imidazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: H2O 2: MnO2 / CH2Cl2 3: N-chlorosuccinimide View Scheme | |
Multi-step reaction with 5 steps 1: 56 percent / Br2 / CHCl3 / Ambient temperature 2: 85 percent / Na2SO3 / H2O; ethanol / 18 h / Heating 3: 78 percent / aq. NaOH / ethanol / Ambient temperature 4: 81 percent / MnO2 / CH2Cl2; dioxane / Heating 5: 87 percent / conc. aq. HCl / 24 h / Heating View Scheme |
2-butyl-5-hydroxymethyl-1H-imidazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: MnO2 / CH2Cl2 2: N-chlorosuccinimide View Scheme |
4(5)-bromo-2-butyl-1H-imidazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 78 percent / aq. NaOH / ethanol / Ambient temperature 2: 81 percent / MnO2 / CH2Cl2; dioxane / Heating 3: 87 percent / conc. aq. HCl / 24 h / Heating View Scheme |
4,5-dibromo-2-butyl-1H-imidazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 85 percent / Na2SO3 / H2O; ethanol / 18 h / Heating 2: 78 percent / aq. NaOH / ethanol / Ambient temperature 3: 81 percent / MnO2 / CH2Cl2; dioxane / Heating 4: 87 percent / conc. aq. HCl / 24 h / Heating View Scheme |
4(5)-bromo-2-butyl-1H-imidazole-5(4)-methanol
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 81 percent / MnO2 / CH2Cl2; dioxane / Heating 2: 87 percent / conc. aq. HCl / 24 h / Heating View Scheme |
water
2-n-butyl-4-chloro-5-hydroxymethylimidazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide In methanol | |
With hydrogenchloride; sodium hydroxide In methanol |
2-n-butyl-4-chloro-5-hydroxymethylimidazole
4-methyl-2-pentanone
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide In water |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With manganese dioxide; silica gel In methanol |
dichloromethane
Ethyl 4-(bromomethyl)benzoate
2-n-butyl-4-chloro-5-hydroxymethylimidazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With manganese dioxide In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide |
1H-imidazole
2-n-butyl-4-chloro-5-hydroxymethylimidazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With NH4Ca(NO3)3; sodium hydroxide In acetic acid | |
With NH4Ca(NO3)3; sodium hydroxide In acetic acid |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol
Conditions | Yield |
---|---|
Stage #1: 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde; N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole With potassium carbonate In N,N-dimethyl-formamide at 20 - 22℃; for 3h; Stage #2: With sodium tetrahydroborate In water; N,N-dimethyl-formamide at 48 - 52℃; for 3.08333h; | 99.2% |
With potassium carbonate In N,N-dimethyl acetamide | |
With potassium carbonate In N,N-dimethyl acetamide |
1H-benzimidazol-2-acetonitrile
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With L-proline In ethanol at 20℃; for 0.166667h; Knoevenagel Condensation; | 98% |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene In tetrahydrofuran; water; tert-butyl alcohol at 20℃; for 12h; | 95% |
Multi-step reaction with 2 steps 1.1: sodium cyanide; manganese(IV) oxide; acetic acid / 20 h / 60 °C 2.1: sodium hydroxide / ethanol; water / 2.5 h / Reflux 2.2: pH 3 - 4 View Scheme |
benzyl bromide
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
3-benzyl-2-butyl-5-chloro-3H-imidazole-4-carbaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 4h; | 92% |
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 1h; |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
1,3-chlorobromopropane
2-butyl-4-chloro-1-(3-chloropropyl)-1H-imidazole-5-carboxaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 2h; Reflux; | 92% |
With potassium carbonate In acetone at 60℃; for 2h; | 70% |
5-[4'-(bromomethyl)biphenyl-2-yl]-1-(p-methoxybenzyl)-1H-tetrazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
2-butyl-4-chloro-1-({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]-biphenyl-4-yl}-methyl)imidazole-5-carbaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl acetamide at -10 - 20℃; for 8h; | 92% |
5-[4'-(bromomethyl)biphenyl-2-yl]-1-(p-methoxybenzyl)-1H-tetrazole
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In ISOPROPYLAMIDE at -10 - 20℃; for 8h; Inert atmosphere; | 92% |
p-methyloxycarbonylbenzyl chloride
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
2-butyl-4-chloro-1-<(4-carbomethoxyphenyl)methyl>-1H-imidazole-5-carboxaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20 - 25℃; for 10h; Temperature; | 91.9% |
para-chloroacetophenone
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
1-(4-chlorophenyl)-3-(2-butyl-4-chloro-1H-imidazol-5-yl)-2-propen-1-one
Conditions | Yield |
---|---|
With potassium hydroxide In PEG-400 at 40℃; for 1h; Claisen-Schmidt condensation; | 91% |
With potassium hydroxide |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
2-n-butyl-4-chloro-5-hydroxymethylimidazole
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol at 20℃; for 2h; | 90% |
With hydrogen; magnesium In methanol at 20℃; under 258.574 - 413.718 Torr; for 0.583333h; |
1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 10h; | 90% |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
(3,4-methylenedioxy)-6-methylbenzyl chloride
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 10h; | 90% |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
1-bromomethyl-4-bromobenzene
2-n-Butyl-4-chloro-1-p-bromobenzyl-1H-imidazole-5-carboxaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl acetamide; water; toluene | 89.9% |
With potassium carbonate In N,N-dimethyl acetamide; water; toluene | 89.9% |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
methyl iodide
2-butyl-4-chloro-1-methyl-1H-imidazole-5-carbaldehyde
Conditions | Yield |
---|---|
Stage #1: 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde With sodium hydride In N,N-dimethyl-formamide at 0℃; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 4h; | 89.6% |
With potassium carbonate In N,N-dimethyl-formamide | 89.6% |
Methyl 4-(bromomethyl)benzoate
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
2-butyl-4-chloro-1-<(4-carbomethoxyphenyl)methyl>-1H-imidazole-5-carboxaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide | 89% |
Stage #1: 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde With potassium carbonate In N,N-dimethyl-formamide at 25 - 30℃; for 0.5h; Stage #2: Methyl 4-(bromomethyl)benzoate In N,N-dimethyl-formamide at 0 - 30℃; for 19.5 - 23.5h; | 82.12% |
With potassium carbonate In N,N-dimethyl-formamide Alkylation; | |
With caesium carbonate In N,N-dimethyl-formamide | |
With potassium carbonate In N,N-dimethyl-formamide at 25 - 70℃; for 12.5h; |
Methyl 4-(bromomethyl)benzoate
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
A
2-butyl-4-chloro-1-<(4-carbomethoxyphenyl)methyl>-1H-imidazole-5-carboxaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 1h; | A 89% B n/a |
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 1h; |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester
4’-(2-butyl-4-chloro-5-formylimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 89% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl acetamide at 20℃; for 2h; | 89% |
N,N-didesmethylvenlafaxine
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In methanol at 20℃; for 9h; | 89% |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
2-butyl-4-chloro-1H-imidazolyl-5-methaldoxime
Conditions | Yield |
---|---|
With sodium acetate; hydroxylamine sulfate In methanol Heating; | 88% |
With sodium acetate; hydroxylamine sulfate In methanol at 60℃; |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Stage #1: 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde; 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile With potassium carbonate In 1-methyl-pyrrolidin-2-one at 70 - 75℃; Stage #2: With sodium tetrahydroborate In 1-methyl-pyrrolidin-2-one at 30℃; Stage #3: With water In 1-methyl-pyrrolidin-2-one; isopropyl alcohol at 75 - 80℃; for 1.5h; | 88% |
With tetrabutylammomium bromide; sodium hydroxide In water; toluene at 20℃; | |
With tetrabutylammomium bromide; water; sodium hydroxide In toluene at 20℃; |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
edaravone
3-(2-butyl-4-chloro-1H-imidazol-5-yl-methylene)-4-methyl-1-phenyl-1H-pyrrol-2(3H)one
Conditions | Yield |
---|---|
With sodium acetate at 60 - 80℃; for 1.33333h; Green chemistry; | 88% |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With potassium carbonate | 88% |
2-chloro-1-(2,4-dihydroxyphenyl)ethanone
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 20℃; for 24h; | 86.3% |
With sodium hydroxide In ethanol at 20℃; for 24h; | 76.9% |
4-bromomethylphenylboronic acid
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
(4-((2-butyl-4-chloro-5-formyl-1H-imidazol-1-yl)methyl)phenyl)-boronic acid
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide for 3h; | 86% |
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