5-Methoxy-2-methyl-1H-indole supplier

Name
5-METHOXY-2-METHYLINDOLE
EINECS 214-066-5
CAS No. 1076-74-0
Article Data42
CAS DataBase
Density 1.134 g/cm³
Solubility
Melting Point 86-88 °C(lit.)
Formula C₁₀H₁₁NO
Boiling Point 308.501 °C at 760 mmHg
Molecular Weight 161.203
Flash Point 113.125 °C
Transport Information
Appearance white to light beige crystalline powder
Safety 37/39-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Indole,5-methoxy-2-methyl- (6CI,7CI,8CI);2-Methyl-5-methoxyindole;5-Methoxy-2-methyl-1H-indole;5-Methoxy-2-methylindole;5-Methoxy-2-methyllindole;NSC 63817;
PSA 25.02000
LogP 2.48490

Synthetic route

: methyl 5-methoxy-2-methyl-1H-indole-1-carboxylate

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With potassium hydroxide In methanol for 1h; Reflux;	100%
With potassium hydroxide In methanol for 1h; Reflux; Large scale;	98%

: 104894-18-0
bromure d'acetylamino-2 methoxy-5 benzyltriphenylphosphonium

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With potassium tert-butylate In toluene for 0.25h; Heating;	97%

: 98055-12-0
5-methoxy-2-methyl-3-(phenylthio)-1H-indole

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With thiosalicilyc acid In trifluoroacetic acid for 1.5h; Ambient temperature;	96%

: 938052-33-6
4-methoxy-2-(prop-1-yn-1-yl)aniline

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With Pd(II)-Y zeolites In toluene at 110℃; for 20h; Catalytic behavior;	96%
With palladium dichloride In acetonitrile at 85℃; Inert atmosphere;

: 104-94-9
4-methoxy-aniline

: 116-09-6
hydroxy-2-propanone

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With acetic acid for 8h; Reagent/catalyst; Reflux; Large scale;	94%

: 5-methoxy-2-methyl-1-tosyl-1H-indole

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With potassium hydroxide In tetrahydrofuran; ethanol for 6h; Reflux;	92%
With ethanol; potassium hydroxide In tetrahydrofuran Reflux;

: 153865-35-1
(3-Chloro-4-methoxy-phenyl)-isopropylidene-amine

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With sodium amide; sodium t-butanolate In tetrahydrofuran at 20℃; for 24h;	87%

: 104-94-9
4-methoxy-aniline

: 67-64-1
acetone

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With oxygen; palladium diacetate; acetic acid In dimethyl sulfoxide at 70℃; under 760.051 Torr; for 18h; Schlenk technique; Molecular sieve;	79%
With oxygen; palladium diacetate; acetic acid In dimethyl sulfoxide at 70℃; for 18h; Schlenk technique; Molecular sieve;	79%
With copper diacetate; palladium diacetate In dimethyl sulfoxide at 40℃; for 24h; Inert atmosphere;	55%

: 181651-13-8
N-(4-methoxyphenyl)-1-methylethenesulfinamide

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at -30℃; for 4h;	75%

: 50461-37-5
2-methyl-3-methylthio-5-methoxy-1H-indole

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
aluminum nickel	72%

: 20357-24-8
5-methoxy-2-nitro-benzaldehyde

: 56904-86-0
tert-butyl 2-(triphenylphosphoranylidene)propionate

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With triphenylphosphine In diphenylether at 260℃; for 1h;	48%

: 58901-12-5
N,N,N-tris(2-hydroxypropyl)amine hydrochloride

: 104-94-9
4-methoxy-aniline

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With tin(ll) chloride; dihydridotetrakis(triphenylphosphine)ruthenium In 1,4-dioxane; water at 180℃; for 20h;	37%

: 25981-89-9
1-(5-methoxy-2-nitrophenyl)propan-2-one

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With sodium dithionite In tetrahydrofuran; water at 20℃; Large scale reaction;	37%

: 32387-22-7
5-methoxy-2methyl-1H-indole-3-carboxylic acid

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With glycerol at 140℃;

: 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

: 1078-72-4
acetone(4-methoxyphenyl)hydrazone

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
at 110℃; im Vakuum;

: 1078-72-4
acetone(4-methoxyphenyl)hydrazone

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With zinc(II) chloride at 110℃;
With zinc(II) chloride at 140℃; Fisher indole cyclization;

: 34572-31-1
ethyl 5-methoxy-2-methyl-1H-indole-3-carboxylate

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With sodium hydroxide; ethanol; water

: 112-14-1
n-octyl acetate

: 117616-04-3
4-methoxy-2-trimethylsilylmethylbenzanilide

A: 1076-74-0
5-methoxy-2-methyl-1H-indole

B: 94-50-8
n-octyl benzoate

Conditions

Conditions	Yield
With 2,2,6,6-tetramethylpiperidinyl-lithium 1) -10 degC, THF, 2) 0 degC, 20 min; Yield given. Multistep reaction;

...Expand

: C10H10(3)HNO

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With water at 25℃; Rate constant;

: 122-20-3
triisopropanolamine

: 104-94-9
4-methoxy-aniline

A: 1076-74-0
5-methoxy-2-methyl-1H-indole

B: 21987-25-7
5-methoxy-3-methyl-1H-indole

Conditions

Conditions	Yield
With tin(ll) chloride; ruthenium trichloride; triphenylphosphine In 1,4-dioxane at 180℃; for 20h; Yield given. Yields of byproduct given;

...Expand

5-methoxy-2-methyl-indole-carboxylic acid-(3): 5-methoxy-2-methyl-indole-carboxylic acid-(3)

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 85 percent / 2-methyl-propan-2-ol / 0.5 h / Heating 2: 96 percent / thiosalicylic acid / trifluoroacetic acid / 1.5 h / Ambient temperature View Scheme

: 67567-46-8
2‐(bromomethyl)‐4‐methoxy‐1‐nitrobenzene

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: toluene / 1.) 6 h, RT; 2.) 3 h, 100 deg C 2: 74 percent / 48percent HBr, Zn / ethanol / 2 h / Heating 3: 92 percent / pyridine / CH2Cl2 / 1 h / Heating 4: 97 percent / t-BuOK / toluene / 0.25 h / Heating View Scheme

: 5367-32-8
5-methoxy-2-nitrotoluene

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: N-bromosuccinimide (NBS), azoisobutyronitrile (AIBN) / CCl4 / 3 h / Heating 2: toluene / 1.) 6 h, RT; 2.) 3 h, 100 deg C 3: 74 percent / 48percent HBr, Zn / ethanol / 2 h / Heating 4: 92 percent / pyridine / CH2Cl2 / 1 h / Heating 5: 97 percent / t-BuOK / toluene / 0.25 h / Heating View Scheme

: 104894-16-8
bromure d'amino-2 methoxy-5 benzyltriphenylphosphonium

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 92 percent / pyridine / CH2Cl2 / 1 h / Heating 2: 97 percent / t-BuOK / toluene / 0.25 h / Heating View Scheme

: 104894-14-6
bromure de nitro-2 methoxy-5 benzyltriphenylphosphonium

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 74 percent / 48percent HBr, Zn / ethanol / 2 h / Heating 2: 92 percent / pyridine / CH2Cl2 / 1 h / Heating 3: 97 percent / t-BuOK / toluene / 0.25 h / Heating View Scheme

: 13061-96-6
dihydroxy-methyl-borane

: 169383-96-4
2-bromo-5-methoxy-1H-indole

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane Suzuki coupling; Reflux;

: 1266659-05-5
ethyl 2-(5-fluoro-2-nitrophenyl)-3-oxobutanoate

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sulfuric acid; acetic acid / 30 - 70 °C / Large scale reaction 2: methanol / 30 - 35 °C / Large scale reaction 3: sodium dithionite / tetrahydrofuran; water / 20 °C / Large scale reaction View Scheme

: 1266659-06-6
1-(5-fluoro-2-nitrophenyl)propan-2-one

: 1076-74-0
5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 30 - 35 °C / Large scale reaction 2: sodium dithionite / tetrahydrofuran; water / 20 °C / Large scale reaction View Scheme

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 2-methyl-5-methoxy-3-iodo-1H-indole

Conditions

Conditions	Yield
Stage #1: 5-methoxy-2-methyl-1H-indole With potassium hydroxide In N,N-dimethyl-formamide for 0.333333h; Stage #2: With iodine In N,N-dimethyl-formamide for 1h;	100%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 194720-38-2
2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate

A: 98055-12-0
5-methoxy-2-methyl-3-(phenylthio)-1H-indole

B: 4-hydroxy-2,3,5,6-tetramethylphenyl 2-chloroacetate

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 0.166667h; Yields of byproduct given;	A 99% B n/a

...Expand

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 194720-38-2
2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate

: 98055-12-0
5-methoxy-2-methyl-3-(phenylthio)-1H-indole

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 0 - 20℃; for 0.166667h;	99%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 335642-28-9
1-(2,3,4,5,6-pentafluorophenylthio)-2,3,5,6-tetramethyl-4-oxocyclohexa-2,5-dienyl 2-chloroacetate

A: 4-hydroxy-2,3,5,6-tetramethylphenyl 2-chloroacetate

B: 3-(2,3,4,5,6-pentafluorophenylthio)-5-methoxy-2-methylindole

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In acetonitrile at -30 - 0℃; for 0.166667h;	A n/a B 99%

...Expand

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 883141-55-7
3-bromo-5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With N-Bromosuccinimide; silica gel In dichloromethane for 0.5h;	99%
With N-Bromosuccinimide; silica gel In dichloromethane at 20℃; for 0.5h;	99%
With N-Bromosuccinimide; silica gel In dichloromethane at 20℃; for 0.5h; Inert atmosphere;	93%
With bromine In N,N-dimethyl-formamide at 20℃; for 0.5h;
With N-Bromosuccinimide In dichloromethane at 20℃; for 1h; Inert atmosphere;

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 2-(2,5-dihydro-1H-pyrrol-1-yl)benzaldehyde

: 3-(2-(1H-pyrrol-1-yl)benzyl)-5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With diphenyl hydrogen phosphate In 1,2-dichloro-ethane at 20℃;	99%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 111-13-7
hexyl-methyl-ketone

: 1251532-65-6
5-methoxy-2-methyl-3-(1-methylheptyl)-1H-indole

Conditions

Conditions	Yield
With indium(III) tris[bis(trifluoromethanesulfonyl)amide]; methyldiphenylsilane In 1,4-dioxane at 50℃; for 24h; Inert atmosphere; Schlenk technique;	99%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: (-)-5-methoxy-2-methylindoline

Conditions

Conditions	Yield
With 1,1,1,3',3',3'-hexafluoro-propanol; RuBF4((S,S)-N-Me-Msdpen)(p-cymene); hydrogen at 10℃; under 37503.8 Torr; for 7h; Autoclave; enantioselective reaction;	99%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: (S)-2-methyl-5-methoxyindoline

Conditions

Conditions	Yield
With hydrogenchloride; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (S,R)-ZhaoPhos; hydrogen; acetic acid In dichloromethane at 25℃; under 30402 Torr; for 48h; Autoclave; enantioselective reaction;	99%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 74-88-4
methyl iodide

: 17591-06-9
5-methoxy-1,2-dimethyl-1H-indole

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide at 20℃; for 0.833333h;	98%
With sodium hydride In N,N-dimethyl-formamide at 60℃; for 1h;	80%
Stage #1: 5-methoxy-2-methyl-1H-indole With sodium hydride In N,N-dimethyl-formamide Inert atmosphere; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	80%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 13314-85-7
2-methyl-1H-indol-5-ol

Conditions

Conditions	Yield
With boron tribromide In dichloromethane at 0 - 20℃; for 2h;	98%
With boron tribromide In dichloromethane; water	93%
Stage #1: 5-methoxy-2-methyl-1H-indole With boron tribromide In dichloromethane at -78 - 20℃; for 0.5h; Inert atmosphere; Stage #2: With water; sodium hydrogencarbonate In dichloromethane Cooling with ice;	93%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 24424-99-5
di-tert-butyl dicarbonate

: tert-butyl 5-methoxy-2-methyl-1H-indole-1-carboxylate

Conditions

Conditions	Yield
With dmap In acetonitrile at 20℃; for 22h;	98%
With dmap In acetonitrile at 20℃;	0.92 g

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 1323902-49-3
tert-butyl ((ethylthio)(phenyl)methyl)carbamate

: 1612786-56-7
tert-butyl (5-methoxy-2-methyl-1H-indol-3-yl)(phenyl)methylcarbamate

Conditions

Conditions	Yield
With N-iodo-succinimide In dichloromethane at -78℃; for 0.0833333h; Friedel-Crafts Alkylation; Sealed tube; Inert atmosphere; chemoselective reaction;	98%

: 445262-62-4
3',5'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyde

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 1372797-84-6
3-(1,3-dimethoxy-9H-fluoren-9-yl)-5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
Stage #1: 5-methoxy-2-methyl-1H-indole With (S)-3,3’-bis(9-anthracenyl)-1,1’-binaphthyl-2,2’-diyl N-triflyl-phosphoramide In o-xylene at -15 - 20℃; for 0.166667h; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere; Stage #2: 3',5'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyde In o-xylene at -15℃; Friedel Crafts acylation; Molecular sieve; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	97%

Yield

Stage #1: 5-methoxy-2-methyl-1H-indole With (S)-3,3’-bis(9-anthracenyl)-1,1’-binaphthyl-2,2’-diyl N-triflyl-phosphoramide In o-xylene at -15 - 20℃; for 0.166667h; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere;
Stage #2: 3',5'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyde In o-xylene at -15℃; Friedel Crafts acylation; Molecular sieve; Inert atmosphere; optical yield given as %ee; enantioselective reaction;

97%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 1297914-66-9
Ethyl 3,3,3-trifluoro-2-hydroxy-2-(5-methoxy-2-methyl-indol-3-yl)propionate

Conditions

Conditions	Yield
With (SIr,RC)-[(η5-C5Me5)Ir{(R)-propane-1,2-diylbis(diphenylphosphane)}(H2O)][SbF6]2 In dichloromethane for 0.233333h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; Optical yield = 55 %ee;	97%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 2-(2,5-dihydro-1H-pyrrol-1-yl)-4-methylbenzaldehyde

: 5-methoxy-2-methyl-3-(4-methyl-2-(1H-pyrrol-1-yl)benzyl)-1H-indole

Conditions

Conditions	Yield
With diphenyl hydrogen phosphite In 1,2-dichloro-ethane at 20℃;	97%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 102-96-5
(2-nitroethenyl)benzene

: 1227380-56-4
5-methoxy-2-methyl-3-(2-nitro-1-phenylethyl)-1H-indole

Conditions

Conditions	Yield
In water at 150℃; for 0.1h; Michael addition; Microwave irradiation;	96%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 2,2,2-trifluoroethyl(2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate

: 5-methoxy-2-methyl-3-(2,2,2-trifluoroethyl)-1H-indole

Conditions

Conditions	Yield
With 2,6-di-tert-butyl-pyridine In dichloromethane at 25℃; for 0.666667h; regioselective reaction;	96%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 930-30-3
cyclopent-2-enone

: 1321804-40-3
3-(2-methyl-5-methoxy-1H-indol-3-yl)cyclopentanone

Conditions

Conditions	Yield
With aminosulfonic acid In acetonitrile at 80℃; for 8h; Michael condensation;	95%
With gluconic acid In water at 100℃; for 10h; Michael addition;	90%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 742100-39-6
5-bromo-2-(2,5-dihydro-1H-pyrrol-1-yl)benzaldehyde

: 3-(5-bromo-2-(1H-pyrrol-1-yl)benzyl)-5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With diphenyl hydrogen phosphite In 1,2-dichloro-ethane at 20℃;	95%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 941-55-9
4-toluenesulfonyl azide

: 201230-82-2
carbon monoxide

: 2-methyl-5-methoxy-N-p-toluenesulfonyl-1H-indole-3-carboxamide

Conditions

Conditions	Yield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer In acetonitrile at 80℃; for 12h;	95%
With chloro(1,5-cyclooctadiene)rhodium(I) dimer In acetonitrile at 80℃; under 760.051 Torr; for 12h; Schlenk technique;	95%

...Expand

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 2-(2,5-dihydro-1H-pyrrol-1-yl)-4-methoxybenzaldehyde

: 5-methoxy-3-(4-methoxy-2-(1H-pyrrol-1-yl)benzyl)-2-methyl-1H-indole

Conditions

Conditions	Yield
With diphenyl hydrogen phosphite In 1,2-dichloro-ethane at 20℃;	94%

: ammonium thiocyanate

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 5-methoxy-2-methyl-3-thiocyanato-1H-indole

Conditions

Conditions	Yield
With dipotassium peroxodisulfate In dichloromethane at 20℃; for 5h; regioselective reaction;	94%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 1374152-38-1
1-(1-azidovinyl)-4-fluorobenzene

: 3-(1-(4-fluorophenyl)vinyl)-5-methoxy-2-methyl-1H-indole

Conditions

Conditions	Yield
With indium(III) chloride In dichloromethane at 28 - 30℃; for 6h; Inert atmosphere;	94%

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 768-60-5
4-methoxyphenylacetylen

: 5-methoxy-3-(1-(4-methoxyphenyl)vinyl)-2-methyl-1H-indole

Conditions

Conditions	Yield
With bis[(trifluoromethanesulfonyl)imidate]-2-(dicyclohexyl(2’,6’-dimethoxybiphenyl))phosphine gold(I) In acetonitrile at 30℃; for 24h;	94%

5-Methoxy-2-methyl-1H-indole Chemical Properties

IUPAC Name: 5-methoxy-2-methyl-1H-indole
Synonyms of 1H-Indole,5-methoxy-2-methyl- (CAS NO.1076-74-0): EINECS 214-066-5 ; 5-Methoxy-2-methylindole
CAS NO: 1076-74-0
Molecular Formula: C₁₀H₁₁NO
Molecular Weight of 1H-Indole,5-methoxy-2-methyl- (CAS NO.1076-74-0): 161.2004
Molecular Structure:

H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 14.16 Å²
Index of Refraction: 1.621
Molar Refractivity: 50.03 cm³
Molar Volume: 142.1 cm³
Surface Tension: 43.4 dyne/cm
Density of 1H-Indole,5-methoxy-2-methyl- (CAS NO.1076-74-0): 1.134 g/cm³
Flash Point: 113.1 °C
Enthalpy of Vaporization: 52.73 kJ/mol
Boiling Point: 308.5 °C at 760 mmHg
Vapour Pressure: 0.00123 mmHg at 25°C
Melting point: 86-88 °C

5-Methoxy-2-methyl-1H-indole Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 37/39-26
S37/39: Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
HazardClass: IRRITANT

Product Name

5-METHOXY-2-METHYLINDOLE

Synthetic route

5-Methoxy-2-methyl-1H-indole Chemical Properties

5-Methoxy-2-methyl-1H-indole Safety Profile

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