Product Name

  • Name

    6-Aminonicotinic acid

  • EINECS 221-630-4
  • CAS No. 3167-49-5
  • Article Data22
  • CAS DataBase
  • Density 1.417 g/cm3
  • Solubility 1.0 g/L (20 °C) in water
  • Melting Point >300 °C(lit.)
  • Formula C6H6N2O2
  • Boiling Point 373.6 °C at 760 mmHg
  • Molecular Weight 138.126
  • Flash Point 179.8 °C
  • Transport Information
  • Appearance light yellow cryst
  • Safety 22-24/25-45-36/37/39-26
  • Risk Codes 36/37/38-23/24/25
  • Molecular Structure Molecular Structure of 3167-49-5 (6-Aminonicotinic acid)
  • Hazard Symbols IrritantXi,ToxicT
  • Synonyms 2-Amino-5-pyridinecarboxylic acid;2-Amino-5-carboxypyridine;6-Aminopyridine-3-carboxylic acid;
  • PSA 76.21000
  • LogP 0.94320

Synthetic route

2,2-dimethyl-3-(5-cyanopyrid-2-yl)-4-oxo-4H-1,3-benzoxazine
74405-04-2

2,2-dimethyl-3-(5-cyanopyrid-2-yl)-4-oxo-4H-1,3-benzoxazine

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
With hydrogenchloride for 6h; Heating;88%
5-chloro-2-pyridylamine
1072-98-6

5-chloro-2-pyridylamine

carbon dioxide
124-38-9

carbon dioxide

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 5℃; under 760 Torr; Electrochemical reaction;78%
6-(acetylamino)pyridine-3-carboxylic acid
21550-48-1

6-(acetylamino)pyridine-3-carboxylic acid

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
With water; sodium hydroxide for 6h; Reflux;46%
With sodium hydroxide
Multi-step reaction with 5 steps
1: methanol; HCl
2: acetic acid
3: concentrated aqueous NH3
4: concentrated aqueous NH3 / 130 °C
5: aqueous NaOH
View Scheme
ethyl-6-amino-nicotinate
39658-41-8

ethyl-6-amino-nicotinate

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
With water; sodium hydroxide In methanol at 20℃; for 18h;33%
6-aminonicotinonitrile
4214-73-7

6-aminonicotinonitrile

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
With hydrogenchloride at 160℃; im Rohr;
6-Chloro-3-pyridinecarboxylic acid
5326-23-8

6-Chloro-3-pyridinecarboxylic acid

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
With ammonia at 170℃;
6-aminonicotinic amide
329-89-5

6-aminonicotinic amide

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
With sodium hydroxide
6-methoxycarbonylamino-nicotinic acid methyl ester

6-methoxycarbonylamino-nicotinic acid methyl ester

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
With hydrogenchloride; acetic acid
1-(5-Carboxy-2-pyridyl)-2-pyridon-3-carbonsaeure
117638-64-9

1-(5-Carboxy-2-pyridyl)-2-pyridon-3-carbonsaeure

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
With base
With hydrogenchloride; sodium hydroxide 1.) heating; Multistep reaction;
nicotinyl 6-aminonicotinate

nicotinyl 6-aminonicotinate

A

3-hydroxymethylpyridin
100-55-0

3-hydroxymethylpyridin

B

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
With phosphate buffer In water at 65℃; Rate constant; Thermodynamic data; pH 5.17, ΔS, activation energy, other pH, solvent effect;
6-Chloro-3-pyridinecarboxylic acid
5326-23-8

6-Chloro-3-pyridinecarboxylic acid

ammonium hydroxide

ammonium hydroxide

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
at 170℃;
5-chloro-2-nitropyridine
52092-47-4

5-chloro-2-nitropyridine

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 82 percent / hydrogen; sulfuric acid / ethanol / 25 °C / Electrochemical reaction
2: 78 percent / Bu4NI / dimethylformamide / 5 °C / 760 Torr / Electrochemical reaction
View Scheme
nicotinic acid
59-67-6

nicotinic acid

phenyl-β-pyridyl ketone

phenyl-β-pyridyl ketone

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / 30percent H2O2 / acetic acid / 3 h / 90 °C
3: base
View Scheme
Nicotinic acid N-oxide
2398-81-4

Nicotinic acid N-oxide

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: base
View Scheme
Multi-step reaction with 2 steps
1: POCl3 / dimethylformamide
2: 1.) conc. NaOH solution, 2.) aq. HCl / 1.) heating
View Scheme
3-cyanopyridine N-oxide
14906-64-0

3-cyanopyridine N-oxide

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 23 percent / CHCl3 / 4 h / Heating
2: 88 percent / conc. HCl / 6 h / Heating
View Scheme
(5-methyl-pyridin-2-yl)amine
1603-41-4

(5-methyl-pyridin-2-yl)amine

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid
2: aqueous KMnO4
3: aqueous NaOH
View Scheme
Multi-step reaction with 7 steps
1: acetic acid
2: aqueous KMnO4
3: methanol; HCl
4: acetic acid
5: concentrated aqueous NH3
6: concentrated aqueous NH3 / 130 °C
7: aqueous NaOH
View Scheme
N-(5-methylpyridin-2-yl)acetamide
4931-47-9

N-(5-methylpyridin-2-yl)acetamide

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous KMnO4
2: aqueous NaOH
View Scheme
Multi-step reaction with 6 steps
1: aqueous KMnO4
2: methanol; HCl
3: acetic acid
4: concentrated aqueous NH3
5: concentrated aqueous NH3 / 130 °C
6: aqueous NaOH
View Scheme
methyl 6-aminonicotinoate
36052-24-1

methyl 6-aminonicotinoate

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid
2: concentrated aqueous NH3
3: concentrated aqueous NH3 / 130 °C
4: aqueous NaOH
View Scheme
6-acetamide-nicotinic acid methyl ester
98953-23-2

6-acetamide-nicotinic acid methyl ester

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: concentrated aqueous NH3
2: concentrated aqueous NH3 / 130 °C
3: aqueous NaOH
View Scheme
dimethyl 2,5-pyridine dicarboxylate
881-86-7

dimethyl 2,5-pyridine dicarboxylate

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: methanol; N2H4+H2O
2: aqueous HCl; aqueous NaNO2
3: methanol
4: acetic acid; concentrated aqueous HCl
View Scheme
6-hydrazinocarbonyl-nicotinic acid methyl ester
512782-63-7

6-hydrazinocarbonyl-nicotinic acid methyl ester

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aqueous HCl; aqueous NaNO2
2: methanol
3: acetic acid; concentrated aqueous HCl
View Scheme
6-azidocarbonyl-nicotinic acid methyl ester

6-azidocarbonyl-nicotinic acid methyl ester

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanol
2: acetic acid; concentrated aqueous HCl
View Scheme
6-acetylamino-nicotinic acid amide
77837-05-9

6-acetylamino-nicotinic acid amide

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: concentrated aqueous NH3 / 130 °C
2: aqueous NaOH
View Scheme
6-chloro-3-pyridinecarboxamide
6271-78-9

6-chloro-3-pyridinecarboxamide

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: concentrated aqueous NH3 / 170 °C
2: aqueous NaOH
View Scheme
6-hydroxy-3-pyridinecarboxylic acid
5006-66-6

6-hydroxy-3-pyridinecarboxylic acid

acetonitrile
75-05-8

acetonitrile

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
With potassium hydroxide; acetic anhydride; triethylamine
benzyl 6-aminopyridine-3-carboxylate
935687-49-3

benzyl 6-aminopyridine-3-carboxylate

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃;
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

potassium 2-chloro-3-ethoxy-3-oxoprop-1-en-1-olate

potassium 2-chloro-3-ethoxy-3-oxoprop-1-en-1-olate

imidazo[1,2-a]pyridine-3,6-dicarboxylic acid ethyl ester
936637-98-8

imidazo[1,2-a]pyridine-3,6-dicarboxylic acid ethyl ester

Conditions
ConditionsYield
With sulfuric acid In ethanol at 0℃; for 18h; Heating / reflux;100%
methanol
67-56-1

methanol

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

methyl 6-aminonicotinoate
36052-24-1

methyl 6-aminonicotinoate

Conditions
ConditionsYield
With hydrogenchloride for 18h; Reflux;98%
With thionyl chloride at 80℃; for 12h; Inert atmosphere;89%
With sulfuric acid at 0 - 80℃;81.5%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

ethanol
64-17-5

ethanol

ethyl-6-amino-nicotinate
39658-41-8

ethyl-6-amino-nicotinate

Conditions
ConditionsYield
Stage #1: 6-aminonicotinic acid; ethanol With thionyl chloride for 72h; Heating;
Stage #2: With sodium hydroxide In methanol for 1h;
97%
Stage #1: 6-aminonicotinic acid; ethanol With thionyl chloride at 60℃; for 18h; Heating / reflux;
Stage #2: With sodium hydrogencarbonate
95.8%
Stage #1: 6-aminonicotinic acid; ethanol With thionyl chloride at 0℃; Reflux;
Stage #2: With sodium carbonate In water pH=9;
94%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

1-amino-4-[(tert-butyloxycarbonyl)amino]butane
68076-36-8

1-amino-4-[(tert-butyloxycarbonyl)amino]butane

tert-butyl (4-(6-aminonicotinamido)butyl)carbamate

tert-butyl (4-(6-aminonicotinamido)butyl)carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;97%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

6-(1H-tetrazol-1-yl)nicotinic acid
299918-69-7

6-(1H-tetrazol-1-yl)nicotinic acid

Conditions
ConditionsYield
With sodium azide In neat (no solvent) at 90℃; for 0.7h; Reagent/catalyst; Green chemistry;95%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

acetic anhydride
108-24-7

acetic anhydride

6-(acetylamino)pyridine-3-carboxylic acid
21550-48-1

6-(acetylamino)pyridine-3-carboxylic acid

Conditions
ConditionsYield
In pyridine at 130℃; for 24h; Acetylation;92%
With pyridine at 130℃; for 16h;71%
With pyridine at 20 - 130℃;49%
With pyridine at 140℃; for 24h; Acidic aqueous solution;26%
With pyridine at 20 - 80℃; for 72h;22%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

ethyl-6-amino-nicotinate
39658-41-8

ethyl-6-amino-nicotinate

Conditions
ConditionsYield
In ethanol92%
In hydrogenchloride; ethanol; ethyl acetate
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

6-amino-N-methoxy-N-methylpyridine-3-carboxamide
1097210-47-3

6-amino-N-methoxy-N-methylpyridine-3-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;92%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃;
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h;0.61 g
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

N-(tert-butoxycarbonyl)-1,7-heptanediamine
99733-18-3

N-(tert-butoxycarbonyl)-1,7-heptanediamine

tert-butyl (7-(6-aminonicotinamido)heptyl)carbamate

tert-butyl (7-(6-aminonicotinamido)heptyl)carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;91%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

6-aminonicotinic acid monophosphate

6-aminonicotinic acid monophosphate

Conditions
ConditionsYield
With phosphoric acid In methanol at 20℃; for 0.333333h;90%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

2-amino-3,4,5,6-tetrahydropyridine-5-carboxylic acid hydrochloride

2-amino-3,4,5,6-tetrahydropyridine-5-carboxylic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; platinum(IV) oxide In ethanol under 1499.7 Torr; for 2h; Ambient temperature;89.7%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

(E)-diethyl 1-((4,8-dimethylnona-3,7-dienyl)(ethoxy)phosphoryl)vinylphosphonate
1240313-14-7

(E)-diethyl 1-((4,8-dimethylnona-3,7-dienyl)(ethoxy)phosphoryl)vinylphosphonate

C25H42N2O7P2
1240313-16-9

C25H42N2O7P2

Conditions
ConditionsYield
In toluene at 50℃; for 5h;85%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide
1246246-70-7

2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-methyl-N-[3-(methylamino)propyl]acetamide

6-amino-N-(3-[(([(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy)acetyl)(methyl)amino]propyl)-N-methylnicotinamide
1246246-89-8

6-amino-N-(3-[(([(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy)acetyl)(methyl)amino]propyl)-N-methylnicotinamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 20℃;85%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

6-amino-nicotinic acid ; nitrate

6-amino-nicotinic acid ; nitrate

Conditions
ConditionsYield
With nitric acid In methanol at 20℃; for 0.333333h;85%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

(6-aminopyridin-3-yl)(4-ethylpiperazin-1-yl)methanone

(6-aminopyridin-3-yl)(4-ethylpiperazin-1-yl)methanone

Conditions
ConditionsYield
Stage #1: 6-aminonicotinic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 70℃; for 1.16667h;
Stage #2: 4-ethylpiperazine In N,N-dimethyl-formamide at 20℃;
85%
Stage #1: 6-aminonicotinic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20 - 70℃; for 1.16667h;
Stage #2: 4-ethylpiperazine In N,N-dimethyl-formamide at 20℃;
85%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

N-Boc-1,3-diaminopropane
75178-96-0

N-Boc-1,3-diaminopropane

tert-butyl (3-(6-aminonicotinamido)propyl)carbamate

tert-butyl (3-(6-aminonicotinamido)propyl)carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;85%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

tert-butyl N-(6-aminohexyl)carbamate
51857-17-1

tert-butyl N-(6-aminohexyl)carbamate

tert-butyl (6-(6-aminonicotinamido)hexyl)carbamate

tert-butyl (6-(6-aminonicotinamido)hexyl)carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;85%
2-chloroethanal
107-20-0

2-chloroethanal

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

imidazo[1,2-a]pyridin-6-carboxylic acid hydrochloride salt
1314777-15-5

imidazo[1,2-a]pyridin-6-carboxylic acid hydrochloride salt

Conditions
ConditionsYield
In ethanol for 8h; Reflux;82%
In ethanol for 8h; Reflux;82%
In ethanol for 8h; Reflux;82%
In ethanol for 8h; Reflux;82%
2-chloroethanal
107-20-0

2-chloroethanal

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

imidazo[1,2-a]pyridine-6-carboxylic acid hydrochloride

imidazo[1,2-a]pyridine-6-carboxylic acid hydrochloride

Conditions
ConditionsYield
In ethanol for 8h; Reflux;82%
In ethanol for 8h; Reflux;82%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

1,3,5-triethyl-2,4,6-tris(aminomethyl)benzene
149525-65-5

1,3,5-triethyl-2,4,6-tris(aminomethyl)benzene

C33H39N9O3

C33H39N9O3

Conditions
ConditionsYield
Stage #1: 6-aminonicotinic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In N,N-dimethyl-formamide for 0.0833333h;
Stage #2: 1,3,5-triethyl-2,4,6-tris(aminomethyl)benzene With triethylamine In dichloromethane at 20℃; for 2h;
82%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

(1R,3S)-N1-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-yl)cyclohexane-1,3-diamine hydrochloride

(1R,3S)-N1-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-yl)cyclohexane-1,3-diamine hydrochloride

6-amino-N-((1S,3R)-3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)nicotinamide

6-amino-N-((1S,3R)-3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)nicotinamide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 24h;81%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

C6H6N2O2*BrH

C6H6N2O2*BrH

Conditions
ConditionsYield
With hydrogen bromide In methanol at 20℃; for 0.333333h;80%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

6,6-difluoro-5-methyl-5-hexenyl methanesulfonate
509101-25-1

6,6-difluoro-5-methyl-5-hexenyl methanesulfonate

6,6-difluoro-5-methyl-5-hexenyl 6-aminonicotinate

6,6-difluoro-5-methyl-5-hexenyl 6-aminonicotinate

Conditions
ConditionsYield
With sodium hydrogencarbonate In DMF (N,N-dimethyl-formamide) at 100℃; for 3h;78%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

6-[2-(2-benzyl-3-oxo-2,3-dihydro-1H-isoindol-1-ylsulfanyl)-acetylamino]-nicotinic acid

6-[2-(2-benzyl-3-oxo-2,3-dihydro-1H-isoindol-1-ylsulfanyl)-acetylamino]-nicotinic acid

Conditions
ConditionsYield
Stage #1: 3-(carboxymethylthio)-2,3-dihydro-2-(phenylmethyl)-1H-isoindol-1-one With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 0.5h;
Stage #2: 6-aminonicotinic acid With pyridine In tetrahydrofuran; dichloromethane at 20℃; for 4h;
77%
morpholine
110-91-8

morpholine

6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

(6-aminopyridin-3-yl)(morpholin-4-yl)methanone
827587-90-6

(6-aminopyridin-3-yl)(morpholin-4-yl)methanone

Conditions
ConditionsYield
Stage #1: 6-aminonicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 1.5h;
Stage #2: morpholine With pyridine In dichloromethane at 0 - 20℃;
Stage #3: With ethylenediamine In ethanol; dichloromethane for 0.5h; Reflux;
72.5%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;66%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In ethanol for 18h;30%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

1-methyl-2-(methylaminomethyl)-1H-indole
3514-15-6

1-methyl-2-(methylaminomethyl)-1H-indole

6-amino-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-nicotinamide

6-amino-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-nicotinamide

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In dichloromethane; N,N-dimethyl-formamide for 16h;72%
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

(6-amino-3-pyridinyl)methanol
113293-71-3

(6-amino-3-pyridinyl)methanol

Conditions
ConditionsYield
Stage #1: 6-aminonicotinic acid With ethanol; sulfuric acid for 16h; Heating / reflux;
Stage #2: With sodium carbonate In ethanol; water
Stage #3: With sodium hydroxide; lithium aluminium tetrahydride; water more than 3 stages;
72%
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃;
Stage #1: 6-aminonicotinic acid With borane-THF In tetrahydrofuran for 4h; Heating / reflux;
Stage #2: With hydrogenchloride; methanol; water In tetrahydrofuran at 80℃; for 1h;
Stage #3: With sodium hydroxide; water In tetrahydrofuran; methanol
6-aminonicotinic acid
3167-49-5

6-aminonicotinic acid

tert-butylamine
75-64-9

tert-butylamine

C10H15N3O

C10H15N3O

Conditions
ConditionsYield
Stage #1: 6-aminonicotinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: tert-butylamine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 4h;
71%

6-Aminonicotinic acid Chemical Properties

Molecular structure of 6-Aminonicotinic acid (CAS NO.3167-49-5) is:

Product Name: 6-Aminonicotinic acid
CAS Registry Number: 3167-49-5
IUPAC Name: 6-aminopyridine-3-carboxylic acid
Molecular Weight: 138.12404 [g/mol]
Molecular Formula: C6H6N2O2
XLogP3: 1.4
H-Bond Donor: 2
H-Bond Acceptor: 4 
EINECS: 221-630-4
Melting Point: >300 °C(lit.)
Surface Tension: 77.7 dyne/cm 
Water Solubility: ca 1.0 g/L (20 °C)
Density: 1.417 g/cm3
Flash Point: 179.8 °C
Enthalpy of Vaporization: 65.5 kJ/mol
Boiling Point: 373.6 °C at 760 mmHg
Vapour Pressure: 3.03E-06 mmHg at 25°C
Product Categories: Aminoacid;Amines;blocks;Carboxes;Pyridines;Pyridine;pyridine derivative;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Pyridine series;Carboxylic Acids;Organic acids;Chemical Amines;Heterocycles;Carboxylic Acids

6-Aminonicotinic acid Uses

 6-Aminonicotinic acid (CAS NO.3167-49-5)is used as an intermediate for feed additives,agrochemcials,pharmaceuticals and animal food enrichments. It is used for the prophylaxis. Their derivatives are used for these effects.It acts to reduce plasma cholesterol,as a vasodilator and to treat pellagra. 

6-Aminonicotinic acid Safety Profile

Hazard Codes: IrritantXi, ToxicT
Risk Statements: 36/37/38-23/24/25 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-24/25-45-36/37/39-26 
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
Hazard Note: Irritant
TSCA: T
HazardClass: IRRITANT

6-Aminonicotinic acid Specification

 6-Aminonicotinic acid , its cas register number is 3167-49-5. It also can be called 2-Amino-5-carboxypyridine ; 2-Amino-5-pyridinecarboxylic acid ; 6-Aminopyridine-3-carboxylic acid .It is a light yellow cryst.

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