Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure
potassium acesulfame
Conditions | Yield |
---|---|
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With sulfur trioxide In dichloromethane; water at 100℃; under 75007.5 Torr; for 2.77778E-06h; Stage #2: With potassium hydroxide In water at 50℃; for 0.1h; Pressure; Temperature; | 85% |
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With sulfur trioxide In dichloromethane at 1.5 - 4.5℃; Stage #2: With potassium hydroxide In water Temperature; | 56.7% |
Yield given. Multistep reaction; | |
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With sulfur trioxide In dichloromethane at -35 - -25℃; for 0.0833333h; Stage #2: With water In dichloromethane at -22 - 20℃; Stage #3: With potassium hydroxide In dichloromethane; water at 24 - 26℃; Time; Temperature; Reagent/catalyst; | |
With sulfur trioxide In dichloromethane at 11℃; |
4-methyleneoxetan-2-one
potassium acesulfame
Conditions | Yield |
---|---|
Stage #1: 4-methyleneoxetan-2-one With aminosulfonic acid; triethylamine In dichloromethane at 20 - 25℃; for 0.00833333h; Stage #2: With sulfur trioxide In dichloromethane at 20 - 40℃; under 0 - 7500.75 Torr; Stage #3: With potassium hydroxide In dichloromethane; water Temperature; | 85% |
acetoacetamido
potassium acesulfame
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
fluorosulfonyl fluoride
acetoacetamido
potassium acesulfame
Conditions | Yield |
---|---|
With triethylamine In acetonitrile |
Conditions | Yield |
---|---|
With triethylamine In acetonitrile |
acetosulfam
potassium acesulfame
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water at 35℃; Product distribution / selectivity; |
potassium acesulfame
Conditions | Yield |
---|---|
Stage #1: C4H5NO4S*4O3S With water In dichloromethane at -22 - -5℃; for 0.166667h; Stage #2: With potassium hydroxide In dichloromethane; water at 24 - 26℃; for 0.333333h; |
Conditions | Yield |
---|---|
With potassium hydroxide at 25℃; for 0.333333h; |
Conditions | Yield |
---|---|
In ethanol at 20℃; | 100% |
N,N-diethyl-N',N'-di-n-propyl-N''-n-hexyl-N''-n-octylguanidinium chloride
potassium acesulfame
N,N-diethyl-N',N'-di-n-propyl-N''-n-hexyl-N''-n-octylguanidinium acesulfamate
Conditions | Yield |
---|---|
In water at 60℃; | 99% |
Conditions | Yield |
---|---|
In acetonitrile at 50℃; for 4h; Sonication; | 99% |
potassium acesulfame
lidocaine hydrochloride
Conditions | Yield |
---|---|
In acetonitrile at 50℃; for 4h; Sonication; | 98% |
N,N-diethyl-N',N'-di-n-propyl-N''-n-hexyl-N''-n-decylguanidinium chloride
potassium acesulfame
N,N-diethyl-N',N'-di-n-propyl-N''-n-hexyl-N''-n-decylguanidinium acesulfamate
Conditions | Yield |
---|---|
In water at 60℃; | 97% |
Conditions | Yield |
---|---|
In acetonitrile at 50℃; for 4h; Sonication; | 97% |
Conditions | Yield |
---|---|
In ethanol at 65 - 75℃; for 6h; High pressure; | 92% |
potassium acesulfame
Conditions | Yield |
---|---|
In water at 20℃; for 2h; | 91.5% |
3-hydroxy-1-pentyloxymethylpyridinium chloride
potassium acesulfame
3-hydroxy-1-pentyloxymethylpyridinium acesulfamate
Conditions | Yield |
---|---|
In water for 26h; | 91% |
1-butoxymethyl-3-hydroxypyridinium chloride
potassium acesulfame
1-butoxymethyl-3-hydroxypyridinium acesulfamate
Conditions | Yield |
---|---|
In water for 26h; | 91% |
3-hydroxy-1-propoxymethylpyridinium chloride
potassium acesulfame
3-hydroxy-1-propoxymethylpyridinium acesulfamate
Conditions | Yield |
---|---|
In water for 26h; | 90% |
3-hydroxy-1-undecyloxymethylpyridinium chloride
potassium acesulfame
3-hydroxy-1-undecyloxymethylpyridinium acesulfamate
Conditions | Yield |
---|---|
In water for 26h; | 90% |
Conditions | Yield |
---|---|
In water Cooling with ice; | 90% |
potassium acesulfame
Conditions | Yield |
---|---|
In water soln. of Na2PdCl4 and the oxathiazine-dioxide in 3 ml H2O stirred (12 h, room temp.); ppt. sucked off, washed with H2O and EtOH, dried (vac.); elem. anal.; | 89% |
N,N-diethyl-N',N'-di-n-propyl-N'',N''-di-n-hexylguanidinium chloride
potassium acesulfame
N,N-diethyl-N',N'-di-n-propyl-N'',N''-di-n-hexyl-guanidinium acesulfamate
Conditions | Yield |
---|---|
In water at 60℃; | 88% |
potassium acesulfame
Conditions | Yield |
---|---|
In ethanol at 60℃; for 24h; | 88% |
potassium acesulfame
Conditions | Yield |
---|---|
In ethanol at 60℃; for 24h; | 88% |
potassium acesulfame
3'-nitro-2-bromoacetophenone
6-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 80℃; for 24h; Inert atmosphere; | 87% |
potassium acesulfame
Conditions | Yield |
---|---|
In methanol at 40℃; for 24h; | 87% |
potassium acesulfame
Conditions | Yield |
---|---|
In methanol at 40℃; for 24h; | 86% |
The Molecular Structure of Acesulfame-k (CAS NO.55589-62-3):
Empirical Formula: C4H5KNO4S
Molecular Weight: 202.2496
Nominal Mass: 202 Da
Melting Point: 229-232 ºC (dec.)
Storage temp: 0-6°C
Average Mass: 202.2496 Da
Monoisotopic Mass: 201.957086 Da
Product Categories: Food & Feed ADDITIVES;K (Potassium) Compounds (excluding simple potassium salts);Classes of Metal Compounds;Typical Metal Compounds;Sweeteners;Food & Flavor Additives
IUPAC Name: potassium 3-methyl-5,5-dioxo-4-oxa-5$l^{6}-thia-6-azanidacyclohex-2-en-1-one
InChI
InChI=1/C4H5NO4S.K/c1-3-2-4(6)5-10(7,8)9-3;/h2H,1H3,(H,5,6);/q;+1/p-1
Smiles
S1(N=C(C=C(O1)C)[O-])(=O)=O.[K+]
Synonyms: 1,2,3-Oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide, potassium salt ; Acesulfam-K ; Acesulfame K ; Acesulfame potassium ; Acesulfame-potassium ; CCRIS 1032 ; EINECS 259-715-3 ; H733293 ; Hoe 095 ; Potassium 6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide ; UNII-23OV73Q5G9 ; 6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide, potassium
salt
Acesulfame-k (CAS NO.55589-62-3) is 180-200 times sweeter than SUCROSE (table sugar), as sweet as ASPARTAME , about half as sweet as saccharin, and one-quarter as sweet as Sucralose . It has a slightly bitter aftertaste, especially at high concentrations. Like saccharin.Acesulfame K is often blended with other sweeteners (usually Sucralose or ASPARTAME ). These blends are reputed to give a more sugar-like taste whereby each sweetener masks the other's aftertaste, and exhibits a synergistic effect by which the blend is sweeter than its components.
Acesulfame-k (CAS NO.55589-62-3) is stable under HEAT, even under moderately acidic or basic conditions, so it is used in baking, or in products that require a long shelf life. In carbonated drinks, it is almost always used in conjunction with another sweetener, such as ASPARTAME or Sucralose . It is also used as a sweetener in pharmaceutical products,especially chewable and liquid medications, where it can make the active ingredients more palatable.
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
WGK Germany: 1
RTECS: RP4489165
As with aspartame,sucralose,saccharin, and other sweeteners that are sweeter than common sugars, there is concern over the safety of acesulfame potassium. Although studies of these sweeteners show varying and controversial degrees of dietary safety,USFDA (the United States Food and Drug Administration) has approved these for use as general-purpose sweetening agents. Critics of the use of acesulfame potassium say the chemical has not been studied adequately and may be carcinogenic, although these claims have been dismissed by the USFDA and by equivalent authorities in the European Union.
Based largely on animal studies,Several potential problems associated with the use of acesulfame have been raised:
1. been shown to stimulate insulin secretion in rats in a dose dependent fashion thereby possibly aggravating reactive hypoglycemia ("low blood sugar attacks").
2. no increased incidence of tumors in response to administration of acesulfame K.
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