Acetamide,N,N'-1,2-ethanediylbis- supplier

Name
N,N'-DIACETYLETHYLENEDIAMINE
EINECS 212-811-9
CAS No. 871-78-3
Article Data57
CAS DataBase
Density 1.033 g/cm³
Solubility 6.83E+05 mg/L at 25 °C
Melting Point 170-172°C
Formula C₆H₁₂N₂O₂
Boiling Point 438.7 °C at 760 mmHg
Molecular Weight 144.173
Flash Point 214.8 °C
Transport Information
Appearance
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms Acetamide,N,N'-ethylenebis- (7CI,8CI);1,2-Diacetamidoethane;1,2-Ethanediamine,N,N'-diacetyl-;Diacetylethylenediamine;N,N'-Diacetylethylenediamine;N,N'-Ethylenebisacetamide;N-[2-(Acetylamino)ethylene]acetamide;NSC 603;
PSA 58.20000
LogP 0.04040

Synthetic route

: 108-24-7
acetic anhydride

: 107-15-3
ethylenediamine

: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
yttria-stabilized zirconia In acetonitrile for 2.5h; Heating;	99%
With silica gel for 0.05h; Microwave irradiation; neat (no solvent);	98%
With polydopamine sulfamic acid-functionalized silica gel nanocatalyst In neat (no solvent) at 20℃; for 0.2h;	96%

: 13483-16-4
2,4,6-triacetyloxy-1,3,5-triazine

: 107-15-3
ethylenediamine

: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
at 25℃; for 0.0833333h; neat (no solvent);	99%

: 918-00-3
1,1,1-trichloroacetone

: 107-15-3
ethylenediamine

: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
In hexane at 25℃;	97%

: 64-19-7
acetic acid

: 107-15-3
ethylenediamine

: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
at 80 - 160℃;	93%
In water at 240 - 250℃; for 0.666667h;
With lithium chloride supported solid acid catalyst at 110 - 120℃; for 2h; Temperature; Large scale;

: 137465-85-1
1,8-bis(acetylamino)-3,6-diaza-4,5-dimethyl-3,5-octadiene

A: 871-78-3
N,N'-diacetylethylenediamine

B: 137465-87-3
1-isocyano-2-(N-acetylamino)-ethane

Conditions

Conditions	Yield
With oxygen; rose bengal In acetonitrile at 13℃; for 11h; Irradiation;	A 87% B 87%

: 107-15-3
ethylenediamine

microgel-supported-CH3CO: microgel-supported-CH3CO

A: 1001-53-2
monoacetylaminoethylamine

B: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
In tetrahydrofuran at 25℃; for 14h; Inert atmosphere;	A 83.5% B 9.9%

...Expand

: 141-78-6
ethyl acetate

: 107-15-3
ethylenediamine

A: 1001-53-2
monoacetylaminoethylamine

B: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
at 100℃; for 36h;	A 81% B n/a
at 20℃; for 6h;	A 70% B n/a
at 20℃;
at 100℃;

...Expand

: 64-19-7
acetic acid

: 107-15-3
ethylenediamine

A: 534-26-9
lysidine

B: 1001-53-2
monoacetylaminoethylamine

C: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
With copper In benzene at 80℃; for 5h;	A 74% B n/a C n/a

...Expand

: 321746-35-4
C4H9ClN2O

: 1001-53-2
monoacetylaminoethylamine

A: 1021441-10-0
1,2-bis(2-acetamidoethyl)-3-(acetamidomethyl)diaziridine

B: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
With potassium carbonate In chloroform at 15℃; under 3750380 Torr; for 48h;	A 57% B n/a

...Expand

: 107-15-3
ethylenediamine

: 603-69-0
ethyl 2-acetylacetoacetate

A: 871-78-3
N,N'-diacetylethylenediamine

B: 23652-55-3
ethyl (2Z)-3-[(2-{[(1Z)-3-ethoxy-1-methyl-3-oxoprop-1-enyl]amino}ethyl)amino]but-2-enoate

Conditions

Conditions	Yield
In diethyl ether at 20℃;	A 48% B n/a

...Expand

: 124-38-9
carbon dioxide

: 107-15-3
ethylenediamine

: 75-05-8
acetonitrile

A: 120-93-4
imidazolidone

B: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
With ZnO-KF loaded on γ-Al2O3 at 180℃; under 7500.75 Torr; for 4h;	A 27% B n/a

...Expand

: 44398-42-7
(N-chloromethyl)acetamide

: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
With copper; benzene

: 6780-13-8
1,2-ethanediamine monohydrate

: 108-24-7
acetic anhydride

: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
Erhitzen bis der Siedepunkt auf 170grad bis 175grad gestiegen ist;

: 141-78-6
ethyl acetate

: 107-15-3
ethylenediamine

: 871-78-3
N,N'-diacetylethylenediamine

: 79-16-3
N-methyl-acetamide

: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
With di-tert-butyl peroxide

: 60-35-5
acetamide

: 107-15-3
ethylenediamine

: 871-78-3
N,N'-diacetylethylenediamine

: 79-16-3
N-methyl-acetamide

A: 871-78-3
N,N'-diacetylethylenediamine

B: 16873-50-0
N,N'-dimethylsuccinamide

C: 33233-69-1
N-acetyl-β-alanine N'-methylamide

Conditions

Conditions	Yield
In solid at -196.1℃; Product distribution; Mechanism; Irradiation; also in aqueous solution;

...Expand

: 137706-80-0
N,Ν,Ν'-triacetylenediamine

A: 79-21-0
peracetic acid

B: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
With 1,2-ethanediylbistetraphosphonic acid; dihydrogen peroxide at 25℃; Kinetics; Thermodynamic data; various pH values (carbonate buffer), other temperatures; ΔH(excit.), ΔS(excit.);

: 137706-80-0
N,Ν,Ν'-triacetylenediamine

A: 871-78-3
N,N'-diacetylethylenediamine

B: 64-19-7
acetic acid

Conditions

Conditions	Yield
With water at 25℃; Rate constant; pH 9.60 and 10.47 (carbonate buffer);

: 108-24-7
acetic anhydride

: 107-15-3
ethylenediamine

A: 534-26-9
lysidine

B: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
	A 11 g B 80 g

...Expand

: 64-19-7
acetic acid

: 107-15-3
ethylenediamine

A: 288-32-4
1H-imidazole

B: 534-26-9
lysidine

C: 693-98-1
2-methylimidazole

D: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
5% platinum on alumina at 280 - 400℃;
5% platinum on alumina at 280 - 400℃; Product distribution; var. catalysts, temp. and contact time;

...Expand

: 64-19-7
acetic acid

: 107-15-3
ethylenediamine

A: 534-26-9
lysidine

B: 1739-84-0
1,2-dimethyl-1H-imidazole

C: 693-98-1
2-methylimidazole

D: 871-78-3
N,N'-diacetylethylenediamine

E: 4814-93-1
1-ethyl-2-methyl-4,5-dihydro-1H-imidazole

Conditions

Conditions	Yield
With hydrogen; Pt/Al AP-64K catalyst at 280℃; Product distribution; var. temp. and molar ratio of ragents;

...Expand

: 64-19-7
acetic acid

: 107-15-3
ethylenediamine

A: 534-26-9
lysidine

B: 21202-52-8
1-ethyl-2-methylimidazole

C: 693-98-1
2-methylimidazole

D: 1001-53-2
monoacetylaminoethylamine

E: 871-78-3
N,N'-diacetylethylenediamine

F: 4814-93-1
1-ethyl-2-methyl-4,5-dihydro-1H-imidazole

Conditions

Conditions	Yield
Pt/Al2O3 at 300 - 400℃; Product distribution; other ratios of reactants;

...Expand

: 64-19-7
acetic acid

: 107-15-3
ethylenediamine

A: 534-26-9
lysidine

B: 693-98-1
2-methylimidazole

C: 1001-53-2
monoacetylaminoethylamine

D: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
γ-Al2O3 at 330℃; for 0.4h; Product distribution; var. temp. and contact time;

...Expand

: 10543-57-4
N,N,N',N'-tetraacetylethylenediamine

A: 871-78-3
N,N'-diacetylethylenediamine

B: 137706-80-0
N,Ν,Ν'-triacetylenediamine

Conditions

Conditions	Yield
With iron(III) perchlorate In water at 20℃; for 480h; pH=2.9 - 5.5; Kinetics; Hydrolysis;

: 108-22-5
Isopropenyl acetate

: 107-15-3
ethylenediamine

A: 871-78-3
N,N'-diacetylethylenediamine

B N-acetyl-ethylenediamine: N-acetyl-ethylenediamine

Conditions

Conditions	Yield
With water

...Expand

: 137706-80-0
N,Ν,Ν'-triacetylenediamine

: 64-19-7
acetic acid

A: 871-78-3
N,N'-diacetylethylenediamine

B: 108-24-7
acetic anhydride

Conditions

Conditions	Yield
at 140℃; Kinetics; Temperature;

...Expand

: tetra-acetylenediamine

A: 79-21-0
peracetic acid

B: 871-78-3
N,N'-diacetylethylenediamine

Conditions

Conditions	Yield
With water; dihydrogen peroxide at 20℃;

: 871-78-3
N,N'-diacetylethylenediamine

: 108-24-7
acetic anhydride

: 137706-80-0
N,Ν,Ν'-triacetylenediamine

Conditions

Conditions	Yield
at 125℃; for 3h; Temperature;	99.62%

: 871-78-3
N,N'-diacetylethylenediamine

: tetra-acetylethylenediamine

Conditions

Conditions	Yield
With acetic anhydride	98%
With acetic anhydride
With acetic anhydride
With acetic anhydride

: 871-78-3
N,N'-diacetylethylenediamine

: 108-24-7
acetic anhydride

: 117659-76-4
ethylenediamine tetraacetic acid

Conditions

Conditions	Yield
With lithium chloride supported solid acid catalyst at 130 - 140℃; for 3h; Temperature; Large scale;	93.41%

: 131543-46-9
Glyoxal

: 871-78-3
N,N'-diacetylethylenediamine

: 960507-67-9
1,4-diacetylpiperazine-2,3-diol

Conditions

Conditions	Yield
With sodium carbonate In water at 20℃; pH=8 - 9;	90%

: cobalt(II) bromide hydrate

: 871-78-3
N,N'-diacetylethylenediamine

: Co(2+)*2CH3CONH(CH2)2NHCOCH3*2Br(1-)*2H2O=[Co(CH3CONH(CH2)2NHCOCH3)2(H2O)2]Br2

Conditions

Conditions	Yield
With 2,2-dimethoxypropane In acetonitrile 2 equiv. of ligand, 10 vol % dimethoxypropane in MeCN; slow concn.; elem. anal.;	83%

: 871-78-3
N,N'-diacetylethylenediamine

: 108-24-7
acetic anhydride

: 10543-57-4
N,N,N',N'-tetraacetylethylenediamine

Conditions

Conditions	Yield
With solid acid SO4(2-)/Al2O3 at 110 - 160℃; for 4.5h; Reagent/catalyst; Temperature;	81.9%

: manganese(II) bromide tetrahydrate

: 871-78-3
N,N'-diacetylethylenediamine

: Mn(2+)*3CH3CONH(CH2)2NHCOCH3*2Br(1-)*H2O=Mn(CH3CONH(CH2)2NHCOCH3)3Br2*H2O

Conditions

Conditions	Yield
With 2,2-dimethoxypropane In acetonitrile 2 equiv. of ligand, 10 vol % dimethoxypropane in MeCN; slow concn.; elem. anal.;	79%

: nickel(II) nitrate hydrate

: 871-78-3
N,N'-diacetylethylenediamine

: Ni(2+)*2CH3CONH(CH2)2NHCOCH3*2NO3(1-)*3H2O=Ni(CH3CONH(CH2)2NHCOCH3)2(NO3)2*3H2O

Conditions

Conditions	Yield
In methanol; acetonitrile mixing hot solns. of metal nitrate (in MeOH) with 2 equiv. ligand (in MeCN); sepn. of oil; trituration with Et2O; elem. anal.;	79%

: cobalt(II) nitrate hexahydrate

: 871-78-3
N,N'-diacetylethylenediamine

: Co(2+)*2CH3CONH(CH2)2NHCOCH3*2NO3(1-)*2H2O=Co(CH3CONH(CH2)2NHCOCH3)2(NO3)2*2H2O

Conditions

Conditions	Yield
In methanol; acetonitrile mixing hot solns. of metal nitrate (in MeOH) with 2 equiv. ligand (in MeCN); sepn. of oil; trituration with Et2O; elem. anal.;	76%

: 871-78-3
N,N'-diacetylethylenediamine

: nickel dibromide

: Ni(2+)*2CH3CONH(CH2)2NHCOCH3*2Br(1-)*2H2O=Ni(CH3CONH(CH2)2NHCOCH3)2Br2*2H2O

Conditions

Conditions	Yield
With 2,2-dimethoxypropane In acetonitrile 2 equiv. of ligand, 10 vol % dimethoxypropane in MeCN; slow concn.; elem. anal.;	66%

: 787-07-5
diethyl 1,4-cyclohexanedione-2,5-dicarboxylate

: 871-78-3
N,N'-diacetylethylenediamine

: 102314-88-5
2,5-bis-(2-acetylamino-ethylamino)-terephthalic acid diethyl ester

Conditions

Conditions	Yield
anschliessend Behandeln mit Jod in Aethanol;

: 871-78-3
N,N'-diacetylethylenediamine

: 534-26-9
lysidine

Conditions

Conditions	Yield
With magnesium
With calcium oxide at 220 - 265℃; for 2h; Yield given;
With calcium oxide at 210 - 220℃; for 2h;

: 871-78-3
N,N'-diacetylethylenediamine

: 111-74-0
N,N'-diethylethylenediamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

: 871-78-3
N,N'-diacetylethylenediamine

: 73314-67-7
but-3-ene-1,2-diamine

Conditions

Conditions	Yield
bei der Destillation, teilweise;

: 871-78-3
N,N'-diacetylethylenediamine

: N',N'''-diphenyl-N,N''-ethanediyl-bis-acetamidine

Conditions

Conditions	Yield
With phosphorus pentachloride; benzene beim Erwaermen anschliessend mit Anilin;

: 871-78-3
N,N'-diacetylethylenediamine

: N',N'''-bis-(4-ethoxy-phenyl)-N,N''-ethanediyl-bis-acetamidine

Conditions

Conditions	Yield
aufeinanderfolgenden Umsetzen mit PCl5 und mit p-Phenetidin;

Acetamide,N,N'-1,2-ethanediylbis- Specification

This chemical is called Acetamide, N,N'-1,2-ethanediylbis-, and its systematic name is N,N'-Ethane-1,2-diyldiacetamide. With the molecular formula of C₆H₁₂N₂O₂, its molecular weight is 144.17. The CAS registry number of this chemical is 871-78-3.

Other characteristics of the Acetamide, N,N'-1,2-ethanediylbis- can be summarised as followings: (1)ACD/LogP: -2.01; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.01; (4)ACD/LogD (pH 7.4): -2.01; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.92; (8)ACD/KOC (pH 7.4): 1.92; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 40.62 Å²; (13)Index of Refraction: 1.444; (14)Molar Refractivity: 37.09 cm³; (15)Molar Volume: 139.4 cm³; (16)Polarizability: 14.7×10^-24cm³; (17)Surface Tension: 34 dyne/cm; (18)Density: 1.033 g/cm³; (19)Flash Point: 214.8 °C; (20)Enthalpy of Vaporization: 69.56 kJ/mol; (21)Boiling Point: 438.7 °C at 760 mmHg; (22)Vapour Pressure: 6.74E-08 mmHg at 25°C.

Production method of this chemical: The Acetamide, N,N'-1,2-ethanediylbis- could be obtained by the reactants of acetic acid anhydride and ethane-1,2-diamine. This reaction needs the catalyst of yttria-zirconia Lewis acidcatalyst, and the solvent of acetonitrile. The yield is 99 %. In addition, this reaction should be taken for 2.5 hours. The other condition is heating.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin, so you should wear suitable protective clothing when you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: O=C(NCCNC(=O)C)C
2.InChI: InChI=1/C6H12N2O2/c1-5(9)7-3-4-8-6(2)10/h3-4H2,1-2H3,(H,7,9)(H,8,10)
3.InChIKey: WNYIBZHOMJZDKN-UHFFFAOYAT

Product Name

N,N'-DIACETYLETHYLENEDIAMINE

Synthetic route

Acetamide,N,N'-1,2-ethanediylbis- Specification

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