Acetyl chloride,2-(2,4-dichlorophenoxy)- supplier

Name
2-(2,6-DICHLOROPHENOXY)ACETYL CHLORIDE
EINECS 212-268-8
CAS No. 774-74-3
Article Data68
CAS DataBase
Density 1.475 g/cm³
Solubility
Melting Point
Formula C₈H₅Cl₃O₂
Boiling Point 296.4 °C at 760 mmHg
Molecular Weight 239.485
Flash Point 126.3 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Acetylchloride, (2,4-dichlorophenoxy)- (6CI,7CI,8CI,9CI);(2,4-Dichlorophenoxy)acetylchloride;2-(2,4-Dichlorophenyloxy)acetyl chloride;
PSA 26.30000
LogP 3.13760

Synthetic route

: 94-75-7
2,4-Dichlorophenoxyacetic acid

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

Conditions

Conditions	Yield
With thionyl chloride at 100℃; for 5h; Substitution;	100%
With thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride In chloroform for 4h; Chlorination; Heating;	85%
With thionyl chloride at 75℃; for 2h;	80%

: 120-83-2
2,4-dichlorophenol

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 77 percent / NaOH / H2O / 3 h / 110 - 120 °C 2: SOCl2 View Scheme
Multi-step reaction with 2 steps 1: 33percent aq. NaOH / 1 h / Heating 2: SOCl2 / CHCl3 / 6 h / Heating View Scheme
Multi-step reaction with 2 steps 1: aq. NaOH / 0.5 h / Heating 2: SOCl2 / benzene; ethyl acetate / 6 h / Heating View Scheme

: 120-83-2
2,4-dichlorophenol

sodium-salt of/the/ 3-formyl-benzenesulfonic acid: sodium-salt of/the/ 3-formyl-benzenesulfonic acid

A: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

B silver-salt of/the/ <2,4-dichloro-phenoxy>-acetic acid: silver-salt of/the/ <2,4-dichloro-phenoxy>-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: K2CO3; KI; PEG-600 / toluene / 1.5 h / 100 °C 1.2: 94 percent / HCl / H2O / 60 °C 2.1: 85 percent / SOCl2; benzyltriethylammonium chloride / CHCl3 / 4 h / Heating View Scheme

...Expand

: 3757-76-4
sodium 2,4-dichlorophenolate

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethyl acetate 2: thionyl chloride / 8 h / Heating View Scheme

: 120-83-2
2,4-dichlorophenol

(+-)-3,4-dihydro-2H-pyran-2-carboxylic acid ethyl ester: (+-)-3,4-dihydro-2H-pyran-2-carboxylic acid ethyl ester

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaOH / H2O / Heating 2: SOCl2 / ethyl acetate; methanol / 7 h / Heating View Scheme

: 5-[2-chloro-4-(trifluoromethyl)phenoxy]benzoyl chloride

A: 77207-06-8
2-hydroxyethyl 5-(2-chloro-4-trifluoromethyl phenoxy)-2-nitrobenzoate

B: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

Conditions

Conditions	Yield
With triethylamine In dichloromethane; ethylene glycol

: 533-23-3
ethyl 2,4-dichlorophenoxyacetate

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide 2: thionyl chloride / Reflux View Scheme

: 1928-38-7
methyl 2,4-dichlorophenoxyacetate

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: lithium hydroxide / methanol; water / 12 h / 50 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C View Scheme

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 92-87-5
p,p'-diaminobiphenyl

: 2-(2,4-dichloro-phenoxy)-N-{4'-[2-(2,4-dichloro-phenoxy)-acetylamino]-biphenyl-4-yl}-acetamide

Conditions

Conditions	Yield
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation;	99%

: 119-93-7
o-tolidin

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 2-(2,4-dichloro-phenoxy)-N-{4'-[2-(2,4-dichloro-phenoxy)-acetylamino]-3,3'-dimethyl-biphenyl-4-yl}-acetamide

Conditions

Conditions	Yield
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation;	98%

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 106-50-3
1,4-phenylenediamine

: 2-(2,4-dichloro-phenoxy)-N-{4-[2-(2,4-dichloro-phenoxy)-acetylamino]-phenyl}-acetamide

Conditions

Conditions	Yield
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation;	98%

: 95-54-5
1,2-diamino-benzene

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 2-(2,4-dichloro-phenoxy)-N-{2-[2-(2,4-dichloro-phenoxy)-acetylamino]-phenyl}-acetamide

Conditions

Conditions	Yield
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation;	96%

: 10184-66-4
dimethyl (1-hydroxyethyl)phosphonate

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 215655-76-8
O,O-dimethyl α-(2,4-dichlorophenoxyacetoxy)ethylphosphonate

Conditions

Conditions	Yield
With dmap; triethylamine In chloroform; toluene at -40 - -30℃; for 4h; Temperature; Solvent; Reagent/catalyst; Autoclave; Large scale;	95.8%
With organic base In chloroform at 20 - 40℃; for 5h;	90.7%
With pyridine In chloroform at 10 - 42℃;	89%

: 3272-96-6
(Z)-2-chloro-N'-hydroxyethanimidamide

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 31912-19-3
O-(2,4-dichlorophenoxy)acetylchloroacetamidoxime

Conditions

Conditions	Yield
With triethylamine In toluene	95.1%

: 6-hydroxy-4'-methylaurone

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 6-(2,4-dichlorophenoxyacetoxy)-4'-methylaurone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.5h;	94.6%

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 64046-52-2
(2,4-dichloro-phenoxy)-acetic acid-(2-dimethylamino-ethyl ester); hydrochloride

Conditions

Conditions	Yield
In chloroform	94%
With chloroform
With benzene

: 123-31-9
hydroquinone

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: (2,4-Dichloro-phenoxy)-acetic acid 4-[2-(2,4-dichloro-phenoxy)-acetoxy]-phenyl ester

Conditions

Conditions	Yield
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation;	93%

: 656243-32-2
6-amino-4-methyl-2-(4-morpholinyl)quinoline

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 2-(2,4-dichloro-phenoxy)-N-(4-methyl-2-morpholin-4-yl-quinolin-6-yl)-acetamide

Conditions

Conditions	Yield
In dichloromethane for 3h;	93%

: 124-09-4
1,6-Hexanediamine

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 2-(2,4-dichloro-phenoxy)-N-{6-[2-(2,4-dichloro-phenoxy)-acetylamino]-hexyl}-acetamide

Conditions

Conditions	Yield
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation;	92%

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 28236-62-6
2,4-dichlorophenoxyacetylhydrazine

: 2-(2,4-dichlorophenoxy)-N'-(2-(2,4-dichlorophenoxy)acetyl)acetohydrazide

Conditions

Conditions	Yield
In tetrahydrofuran for 0.166667h; Time; Reagent/catalyst; Temperature; Microwave irradiation;	92%

: 142531-17-7
3-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)propenone

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 4'-(2,4-dichlorophenoxyacetoxy)-2,4-dichlorochalcone

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 12h;	91.5%

: 20727-61-1
6-hydroxy-4'-methoxylaurone

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 6-(2,4-dichlorophenoxyacetoxy)-4'-methoxylaurone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.5h;	91.2%

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 3-methyl-2,4-decadienyl alcohol

: 3-methyl-2ξ,4E-decadienyl (2,4-dichlorophenoxy)acetate

Conditions

Conditions	Yield
In benzene for 0.5h;	91%

: 98335-90-1
dimethyl α-hydroxy-α-(2-thienyl)methanephosphonate

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: O,O-dimethyl (2,4-dichlorophenoxyacetoxy)(thien-2-yl)methylphosphonate

Conditions

Conditions	Yield
In chloroform	91%
With organic base In chloroform at 20 - 40℃; for 5h;	86.2%
With pyridine In dichloromethane at 5℃; for 4h;
With pyridine In dichloromethane at 5℃; for 4h;

: 121-32-4
4-hydroxy-3-ethoxybenzaldehyde

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 933675-45-7
C17H14Cl2O5

Conditions

Conditions	Yield
With pyridine In benzene at 20 - 23℃;	91%

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 105-53-3
diethyl malonate

: diethyl-2',4'-dichloro-phenoxy-acetyl-malonate

Conditions

Conditions	Yield
With hydrogenchloride; magnesium chloride; triethylamine In acetonitrile	91%

: 637753-80-1
6-hydroxy-4'-dimethylaminoaurone

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 6-(2,4-dichlorophenoxyacetoxy)-4'-dimethylaminoaurone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.5h;	90.8%

: 4940-56-1
2-benzylidene-6-hydroxybenzofuran-3(2H)-one

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 6-(2,4-dichlorophenoxyacetoxy)aurone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.5h;	90.1%

: 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 128998-08-3
(2,4-Dichloro-phenoxy)-acetic acid 6-hydroxymethyl-4-oxo-4H-pyran-3-yl ester

Conditions

Conditions	Yield
With sodium hydroxide In water; acetone for 2h; Ambient temperature;	90%

: 37939-80-3
1,7,7-trimethyl-bicyclo[2.2.1]heptane-2-one-oxime

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: C18H21NCl2O3

Conditions

Conditions	Yield
With pyridine In benzene at 20 - 23℃;	90%

: C10H22N2O

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: N-(2-dimethylaminoethyl)-N-(trans-2-hydroxycyclohexyl)-2,4-dichlorophenoxyacetamide

Conditions

Conditions	Yield
With sodium hydroxide In water; benzene	90%

: 32396-83-1
2-(3,4-dimethoxybenzylidene)-6-hydroxybenzofuran-3(2H)-one

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 6-(2,4-dichlorophenoxyacetoxy)-3',4'-dimethoxyaurone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.5h;	89.4%

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 77052-40-5
5-Phenoxymethyl-3H-[1,3,4]oxadiazol-2-one

: 3-[2-(2,4-Dichloro-phenoxy)-acetyl]-5-phenoxymethyl-3H-[1,3,4]oxadiazol-2-one

Conditions

Conditions	Yield
for 0.5h;	89%

: 30343-16-9
Diethyl-α-hydroxyethylphosphinoxid

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: C14H19Cl2O4P

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 6h;	89%

: 3-(furan-2-yl)-1-pyrimidin-1H-pyrazol-5-amine

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 2-(2,4-dichlorophenoxy)-N-(3-(furan-2-yl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl)acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	88.96%

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: O,O-dimethyl-1-hydroxy-1-(pyridin-2-yl)methylphosphonate

: 845899-06-1
O,O-dimethyl 1-[(2,4-dichlorophenoxy)acetoxy]-1-(pyridin-2-yl)methylphosphonate

Conditions

Conditions	Yield
With triethylamine In chloroform at 0 - 40℃;	88%
With organic base In chloroform at 20 - 40℃; for 5h;	82.5%

: 1883-27-8
dimethyl(furan-2-yl(hydroxy)methyl)phosphonate

: 774-74-3
2-(2,4-dichlorophenoxy)acetyl chloride

: 263722-89-0
O,O-dimethyl (2,4-dichlorophenoxyacetoxy)(furan-2-yl)methylphosphonate

Conditions

Conditions	Yield
In chloroform	87%
With organic base In chloroform at 20 - 40℃; for 5h;	81.4%

Acetyl chloride,2-(2,4-dichlorophenoxy)- Specification

The Acetyl chloride,2-(2,4-dichlorophenoxy)- is an organic compound with the formula C₈H₅Cl₃O₂. The IUPAC name of this chemical is 2-(2,4-dichlorophenoxy)acetyl chloride. With the CAS registry number 774-74-3, it is also named as 2,4-Dichlorophenoxyacetyl chloride.

Physical properties about Acetyl chloride,2-(2,4-dichlorophenoxy)- are: (1)ACD/LogP: 3.32; (2)ACD/LogD (pH 5.5): 3.32; (3)ACD/LogD (pH 7.4): 3.32; (4)ACD/BCF (pH 5.5): 195.7; (5)ACD/BCF (pH 7.4): 195.7; (6)ACD/KOC (pH 5.5): 1520.29; (7)ACD/KOC (pH 7.4): 1520.29; (8)#H bond acceptors: 2; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 26.3 Å²; (11)Index of Refraction: 1.556; (12)Molar Refractivity: 52.23 cm³; (13)Molar Volume: 162.3 cm³; (14)Polarizability: 20.7×10^-24cm³; (15)Surface Tension: 44.3 dyne/cm; (16)Density: 1.475 g/cm³; (17)Flash Point: 126.3 °C; (18)Enthalpy of Vaporization: 53.62 kJ/mol; (19)Boiling Point: 296.4 °C at 760 mmHg; (20)Vapour Pressure: 0.00144 mmHg at 25°C.

Preparation: this chemical can be prepared by (2,4-dichloro-phenoxy)-acetic acid. This reaction will need reagent SOCl₂.

Uses of Acetyl chloride,2-(2,4-dichlorophenoxy)-: it can be used to produce N-(2-vinyloxyethyl)-2,4-dichlorophenoxyacetamide at temperature of 40 - 45 °C. It will need reagent Et₃N and solvent benzene with reaction time of 30 min. The yield is about 62%.

You can still convert the following datas into molecular structure:
(1)SMILES: Clc1cc(Cl)ccc1OCC(Cl)=O
(2)InChI: InChI=1/C8H5Cl3O2/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2
(3)InChIKey: FUJSJWRORKKPAI-UHFFFAOYAT
(4)Std. InChI: InChI=1S/C8H5Cl3O2/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2
(5)Std. InChIKey: FUJSJWRORKKPAI-UHFFFAOYSA-N

Product Name

2-(2,6-DICHLOROPHENOXY)ACETYL CHLORIDE

Synthetic route

Acetyl chloride,2-(2,4-dichlorophenoxy)- Specification

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