Alloxan monohydrate supplier

Name
ALLOXAN MONOHYDRATE
EINECS 251-501-8
CAS No. 2244-11-3
Article Data1
CAS DataBase
Density 1.681g/cm3
Solubility Soluble in water, ethanol, acetone, glacial acetic acid and methanol. Slightly soluble in chloroform, petroleum ether, toluene, ethyl acetate and acetic anhydride. Insoluble in ether.
Melting Point 240 °C
Formula C₄H₂N₂O₄^.H₂O
Boiling Point 374.1 °C at 760 mmHg
Molecular Weight 160.086
Flash Point 180 °C
Transport Information
Appearance Off-white to beige-yellowish crystalline powder
Safety 36/37
Risk Codes 20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms 2,4,5,6(1H,3H)-Pyrimidinetetrone,monohydrate (9CI);
PSA 115.73000
LogP -2.30910

Synthetic route

: 116138-07-9
N-(2-Ethyl-phenyl)-benzene-1,2-diamine

: 2244-11-3
alloxan monohydrate

: 116138-09-1
10-(2-Ethyl-phenyl)-10H-benzo[g]pteridine-2,4-dione

Conditions

Conditions	Yield
With boric acid In acetic acid at 60℃; for 0.5h;	83.3%

: 13021-18-6
1-(4'-methoxy-biphenyl-4-yl)-ethanone

: 2244-11-3
alloxan monohydrate

: 1416355-06-0
C19H16N2O6

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h; Reflux;	82%

: 2244-11-3
alloxan monohydrate

: 83085-94-3
4-acetyl-4'-(methylthio)<1,1'-biphenyl>

: 1416355-08-2
C19H16N2O5S

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h; Reflux;	80%

: N-(4-acetylphenyl)-4-methoxybenzenesulfonamide

: 2244-11-3
alloxan monohydrate

: N-(4-(2-(5-hydroxy-2,4,6-trioxohexahydropyrimidin-5-yl)acetyl)phenyl)-4-methoxybenzenesulfonamide

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h;	76%

: C14H12N2O5S

: 2244-11-3
alloxan monohydrate

: N-(4-(2-(5-hydroxy-2,4,6-trioxohexahydropyrimidin-5-yl)acetyl)phenyl)-3-nitrobenzenesulfonamide

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h;	74%

: 1088162-86-0
C15H12F3NO3S

: 2244-11-3
alloxan monohydrate

: N-(4-(2-(5-hydroxy-2,4,6-trioxohexahydropyrimidin-5-yl)acetyl)phenyl)-4-(trifluoromethyl) benzenesulfonamide

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h;	73%

: 347320-93-8
N-(4-acetylphenyl)-4-fluorobenzenesulfonamide

: 2244-11-3
alloxan monohydrate

: 4-fluoro-N-(4-(2-(5-hydroxy-2,4,6-trioxohexahydropyrimidin-5 yl)acetyl)phenyl)benzenesulfonamide

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h;	72%

: 5317-94-2
4-(p-toluenesulfonylamino)acetophenone

: 2244-11-3
alloxan monohydrate

: N-(4-(2-(5-hydroxy-2,4,6-trioxohexahydropyrimidin-5-yl)acetyl)phenyl)-4-methyl benzenesulfonamide

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h;	71%

: 5748-38-9
4-acetyl-4'-methylbiphenyl

: 2244-11-3
alloxan monohydrate

: 1416355-03-7
C19H16N2O5

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h; Reflux;	69%

: 282095-74-3
1-[4-(trifluoromethoxy)[1,1'-biphenyl]-4-yl-]-1-ethanone

: 2244-11-3
alloxan monohydrate

: 1416355-07-1
C19H13F3N2O6

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h; Reflux;	69%

: N-(4-acetylphenyl)-3-methylbenzenesulfonamide

: 2244-11-3
alloxan monohydrate

: N-(4-(2-(5-Hydroxy-2,4,6-trioxohexahydropyrimidin-5-yl)acetyl)phenyl)-3-methylbenzenesulfonamide

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h;	68%

: 76883-69-7
N-(4-acetylphenyl)benzenesulfonamide

: 2244-11-3
alloxan monohydrate

: N-(4-(2-(5-hydroxy-2,4,6-trioxohexahydropyrimidin-5-yl)acetyl)phenyl)benzenesulfonamide

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h;	67%

: 5433-86-3
N-(4-acetylphenyl)-4-nitrobenzenesulfonamide

: 2244-11-3
alloxan monohydrate

: N-(4-(2-(5-hydroxy-2,4,6-trioxohexahydropyrimidin-5-yl)acetyl)phenyl)-4-nitrobenzenesulfonamide

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h;	67%

: 16734-96-6
4-Acetyl-4'-methylsulfonyl-biphenyl

: 2244-11-3
alloxan monohydrate

: 1416355-09-3
C19H16N2O7S

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h; Reflux;	65%

: 5002-11-9
1-(3'-nitrobiphenyl-4-yl)ethanone

: 2244-11-3
alloxan monohydrate

: 1416355-02-6
C18H13N3O7

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h; Reflux;	64%

: 690961-82-1
N-(4-acetylphenyl)-3-fluorobenzenesulfonamide

: 2244-11-3
alloxan monohydrate

: 3-fluoro-N-(4-(2-(5-hydroxy-2,4,6-trioxohexahydropyrimidin-5-yl)acetyl)phenyl)benzenesulfonamide

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h;	63%

: 5814-40-4
methyl 2-((2-aminophenyl)amino)benzoate

: 2244-11-3
alloxan monohydrate

: 116138-10-4
2-(2,4-Dioxo-3,4-dihydro-2H-benzo[g]pteridin-10-yl)-benzoic acid methyl ester

Conditions

Conditions	Yield
With boric acid In acetic acid at 60℃; for 0.5h;	62.5%

: 2244-11-3
alloxan monohydrate

: 405520-68-5
4-(N,N-dimethylaminocarbonyl)phenylboronic acid

: 1416355-12-8
C21H19N3O6

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h; Reflux;	62%

: 2244-11-3
alloxan monohydrate

: 1-(4'-(hydroxymethyl)-[1,1'-biphenyl]-4-yl)ethan-1-one

: 1416355-05-9
C19H16N2O6

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h; Reflux;	62%

: C15H12F3NO3S

: 2244-11-3
alloxan monohydrate

: N-(4-(2-(5-hydroxy-2,4,6-trioxohexahydropyrimidin-5-yl)acetyl)phenyl)-2-(trifluoromethyl) benzenesulfonamide

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h;	62%

: 5002-07-3
4'-(4-chlorophenyl)acetophenone

: 2244-11-3
alloxan monohydrate

: 1416355-04-8
C18H13ClN2O5

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h; Reflux;	60%

: 2244-11-3
alloxan monohydrate

: 137-07-5
2-amino-benzenethiol

: 106609-62-5
spiro

Conditions

Conditions	Yield
In acetonitrile for 5h; Heating;	57%

: 787-69-9
4,4'-diacetylbiphenyl

: 2244-11-3
alloxan monohydrate

: 1416355-10-6
C20H16N2O6

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h; Reflux;	55%

: 101908-73-0
N1-(biphenyl-2-yl) benzene-1,2-diamine

: 2244-11-3
alloxan monohydrate

: 116138-08-0
10-Biphenyl-2-yl-10H-benzo[g]pteridine-2,4-dione

Conditions

Conditions	Yield
With boric acid In acetic acid at 60℃; for 0.5h;	54.5%

: 92642-29-0
3-(methylamino)-4-aminoacetophenone

: 2244-11-3
alloxan monohydrate

: 79127-38-1
8-acetyl-10-methylisoalloxazine

Conditions

Conditions	Yield
In hydrogenchloride; ethanol for 0.333333h; Heating;	51%

: 2244-11-3
alloxan monohydrate

: 172035-84-6
1-(4-(thiophen-3-yl)phenyl)ethan-1-one

: 1416355-13-9
C16H12N2O5S

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h; Reflux;	49%

: 5333-01-7
1-(4-biphenylyl)-2-propanone

: 2244-11-3
alloxan monohydrate

A: 1416355-14-0
C19H16N2O5

B: 1416355-15-1
C19H16N2O5

Conditions

Conditions	Yield
With acetic acid at 115℃; for 3h; Reflux;	A 27% B 48%

...Expand

: 64241-76-5
N-1-dodecyl ortho-phenylenediamine

: 2244-11-3
alloxan monohydrate

: 79828-16-3
10-dodecyl-10H-benzo[g]pteridine-2,4-dione

Conditions

Conditions	Yield
With boric acid In methanol at 60℃; for 1h; Yield given;

: 1035802-16-4
N-(2-Benzhydrylsulfanyl-ethyl)-benzene-1,2-diamine

: 2244-11-3
alloxan monohydrate

: 116385-06-9
10-(2-diphenylmethylthio)ethylisoalloxazine

Conditions

Conditions	Yield
With hydrogenchloride; ethanol 110-115 degC, 30 min. then r.t., 24 h; Yield given;

: 2244-11-3
alloxan monohydrate

: 1-(2-Amino-3-methylamino-phenyl)-ethanone

: 92642-15-4
6-acetyl-10-methylisoalloxazine

Conditions

Conditions	Yield
In hydrogenchloride; ethanol 1.) 50-60 deg C, 70 min; 2.) reflux, 15 min;	498 mg

Alloxan monohydrate Chemical Properties

Product Name: Mesoxalylurea monohydrate (CAS NO.2244-11-3)

Molecular Formula: C₄H₄N₂O₅
Molecular Weight: 160.08g/mol
Mol File: 2244-11-3.mol
Einecs: 251-501-8
Appearance: Off-white to beige-yellowish crystalline powder
Melting Point: 255 °C (dec.)(lit.)
Boiling point: 374.1 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 180 °C
Water Solubility: H₂O: may be hazy yellow
Sensitive: Air Sensitive
Enthalpy of Vaporization: 69.46 kJ/mol
Vapour Pressure: 8.59E-07 mmHg at 25°C
H-Bond Donor: 3
H-Bond Acceptor: 5
Product Categories: Pyridines, Pyrimidines, Purines and Pteredines; Active Pharmaceutical Ingredients

Alloxan monohydrate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
hamster	LD50	intravenous	65400ug/kg (65.4mg/kg)	GASTROINTESTINAL: OTHER CHANGES	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 382, 1946.
mouse	LDLo	intravenous	100mg/kg (100mg/kg)		Diabetes. Vol. 12, Pg. 66, 1963.
pig	LDLo	intravenous	200mg/kg (200mg/kg)	ENDOCRINE: DIABETES MELLITIS ENDOCRINE: HYPERGLYCEMIA	Metabolism, Clinical and Experimental. Vol. 29, Pg. 40, 1980.

Alloxan monohydrate Safety Profile

Poison by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Safety Information of Mesoxalylurea monohydrate (CAS NO.2244-11-3):
Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements: 36-26-36/37
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves

Alloxan monohydrate Specification

Mesoxalylurea monohydrate ,its CAS NO. is 2244-11-3,the synonyms is 2,4,5,6(1H,3h)-pyrimidinetetronehydrate ; 2,4,5,6-Tetraoxohexahydropyrimidinehydrate ; Mesoxalylcarbamidemonohydrate ; Labotest-bb lt00138148 ; Mesoxalylurea ; Mesoxalylurea, monohydrate ; 2,4,5,6-Tetraoxypyrimidine ; 2,4,5,6-Tetraoxypyrimidine monohydrate .

Product Name

ALLOXAN MONOHYDRATE

Synthetic route

Alloxan monohydrate Chemical Properties

Alloxan monohydrate Toxicity Data With Reference

Alloxan monohydrate Safety Profile

Alloxan monohydrate Specification

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