• Name

  Alverine citrate

• EINECS 226-929-3
• CAS No. 5560-59-8
• Article Data3
• CAS DataBase
• Density
• Solubility
• Melting Point 100-102°
• Formula C₂₀H₂₇N^.C₆H₈O₇
• Boiling Point 358.8 °C at 760 mmHg
• Molecular Weight 473.566
• Flash Point 174.4 °C
• Transport Information
• Appearance COA
• Safety 24/25
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Alverine citrate [USAN];Alverine citrate(USAN);Dipropylamine, N-ethyl-3,3-diphenyl-, citrate (1:1) (8CI);N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine;Dipropylamine, N-ethyl-3,3-diphenyl-;N-Ethyl-3, 3-diphenyldipropylamine citrate (1:1);Prestwick_912;Benzenepropanamine,N-ethyl-N-(3-phenylpropyl)-,2-hydroxy-1,2,3-propanetricarboxylate (1:1);Dipropylamine, N-ethyl-3,3-diphenyl-, citrate (1:1);Alverine dihydrogen citrate;Benzenepropanamine, N-ethyl-N- (3-phenylpropyl)-, 2-hydroxy-1,2, 3-propanetricarboxylate (1:1);150-59-4;Antispasmin;Dipropylamine, N-ethyl-3, 3-diphenyl-, citrate;N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine; 2-hydroxypropane-1,2,3-tricarboxylic acid;Alverine citrate salt;N-Ethyl-3,3-diphenyldipropylamine;Benzenepropanamine, N-ethyl-N-(3-phenylpropyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (9CI);Spacolin;Gamatran citrate;N-Ethyl-bis(3-phenylpropyl)amin-dihydrogencitrat;N-Ethyl-3,3-diphenyldipropylamine citrate (1:1);Dipropylamine, N-ethyl-3,3-diphenyl-, citrate;NCI 85x;
• PSA 135.37000
• LogP 3.32540

Synthetic route

150-59-4

alverine

77-92-9

citric acid

5560-59-8

alverine citrate

Conditions

Conditions	Yield
In ethyl acetate; isopropyl alcohol at 45 - 50℃; Solvent; Temperature;	92%
In ethanol at 20℃;	66.9%

637-59-2

1-Bromo-3-phenylpropane

5560-59-8

alverine citrate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrabutylammomium bromide; sodium hydroxide / 85 - 90 °C 2: ethanol / 20 °C View Scheme

122-97-4

3-Phenyl-1-propanol

5560-59-8

alverine citrate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0 - 30 °C 2: sodium bromide / N,N-dimethyl-formamide / 25 - 30 °C 3: N-benzyl-N,N,N-triethylammonium chloride; triethylamine / N,N-dimethyl-formamide; water / 10 - 40 °C 4: ethyl acetate; isopropyl alcohol / 45 - 50 °C View Scheme
Multi-step reaction with 2 steps 1.1: sulfuric acid; sodium bromide / water / 20 °C / Reflux 2.1: tetrabutylammomium bromide; sodium hydroxide / 85 - 90 °C 2.2: 6 h / 15 °C View Scheme

69804-99-5

3-phenylpropanol methanesulfonate

5560-59-8

alverine citrate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium bromide / N,N-dimethyl-formamide / 25 - 30 °C 2: N-benzyl-N,N,N-triethylammonium chloride; triethylamine / N,N-dimethyl-formamide; water / 10 - 40 °C 3: ethyl acetate; isopropyl alcohol / 45 - 50 °C View Scheme

637-59-2

1-Bromo-3-phenylpropane

557-66-4

ethanamine hydrochloride

77-92-9

citric acid

5560-59-8

alverine citrate

Conditions

Conditions	Yield
Stage #1: 1-Bromo-3-phenylpropane; ethanamine hydrochloride With tetrabutylammomium bromide; sodium hydroxide at 85 - 90℃; Stage #2: citric acid In ethanol at 15℃; for 6h; Temperature;	10.48 g

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Alverine citrate Chemical Properties

Alverine citrate Specification