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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality S)-(-)-N -Methyl-3-Hydroxy-3-(2-Thienyl)Propanamine supplier in China

Cas:116539-55-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

3-Methylamino-1-(2-thienyl)-1-propanol manufacturer/supplier

Cas:116539-55-0

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:cool dry place Package:25kg/drum Application:pharmaceutical intermediate Transpor

Manufacturer high quality 3-Methylamino-1-(2-thienyl)-1-propanol Cas 116539-55-0 with good price

Cas:116539-55-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (1S)-3-(methylamino)-1-(2-thienyl)propan-1-ol

Cas:116539-55-0

Min.Order:1

Negotiable

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specifica

3-Methylamino-1-(2-thienyl)-1-propanol

Cas:116539-55-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(S)-N-Methyl-3-hydroxy-3-(2-thienyl)-1-propanamine

Cas:116539-55-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

3-Methylamino-1-(2-thienyl)-1-propanol

Cas:116539-55-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

3-Methylamino-1-(2-thienyl)-1-propanol CAS 116539-55-0

Cas:116539-55-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 116539-55-0 with competitive price

Cas:116539-55-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

(S)-(-)-N-Methyl-3-hydroxy-3-(2-thienytl)propanamine Chemical name:(S)-(-)-N-Methyl-3-hydroxy-3-(2-thienytl)propanamine Molecular formula:C8H13NOS Molecular weight:171.26 CAS:116539-55-0

3-Methylamino-1-(2-thienyl)-1-propanol CAS:116539-55-0

Cas:116539-55-0

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

3-Methylamino-1-(2-thienyl)-1-propanolCAS116539-55-0

Cas:116539-55-0

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Thiophenemethanol, a-[2-(methylamino)ethyl]-, (aS)- 116539-55-0

Cas:116539-55-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 3-Methylamino-1-(2-thienyl)-1-propanol CAS: 116539-55-0 MF: C8H13NOS MW: 171.26 EINECS: 601-437-5 Mol File: 116539-55-0.mol 3-Methylamino-1-(2-thienyl)-1-propanol Structure 3-Methylamino-1-(2-thienyl)-1-propanol Chem

3-Methylamino-1-(2-thienyl)-1-propanol

Cas:116539-55-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

(S)-3-(MethylaMino)-1-(2-thienyl)-1-propanol CAS:116539-55-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in

(S)-3-(MethylaMino)-1-(2-thienyl)-1-propanol CAS:116539-55-0

Cas:116539-55-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Thiophenemethanol, a-[2-(methylamino)ethyl]-, (aS)-

Cas:116539-55-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Thiophenemethanol, a-[2-(methylamino)ethyl]-, (aS)-

Cas:116539-55-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

S)-(-)-N -Methyl-3-Hydroxy-3-(2-Thienyl)Propanamine

Cas:116539-55-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

3-Methylamino-1-(2-thienyl)-1-propanol

Cas:116539-55-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS116539-55-0 3-Methylamino-1-(2-thienyl)-1-propanol

Cas:116539-55-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-Methylamino-1-(2-thienyl)-1-propanol

Cas:116539-55-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(S)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Cas:116539-55-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

(S)-3-(METHYLAMINO)-1-(2-THIENYL)1-PROPANOL

Cas:116539-55-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zhejiang Huili Pharmaceutical Co., Ltd

ProName: High quality S)-(-)-N -Methyl-3-Hydrox... CasNo: 116539-55-0 Molecular Formula: C8H13NOS Appearance: white-off powder or granule ( referto ... Application: Duloxetine.HCL DeliveryTime: IN STOCK . PackAge: 25kgs/fiber drum or 200kgs/U

N-1; Duloxetine

Cas:116539-55-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products (S)-N-methyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:116539-55-0

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

3-Methylamino-1-(2-thienyl)-1-propanol CAS 116539-55-0

Cas:116539-55-0

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(1S)-3-(methylamino)-1-thiophen-2-ylpropan-1-ol

Cas:116539-55-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

3-Methylamino-1-(2-thienyl)-1-propanolAppearance:Pls see the Details Storage:Keep away of light, hot, water, Store in dry, dark and ventilated place Package:according to customers' requirements Application:Steroids, Cosmetics Ingredients, APIs, Inter

3-Methylamino-1-(2-thienyl)-1-propanol

Cas:116539-55-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:A Duloxetine intermediate. Transportation:as per yo

3-Methylamino-1-(2-thienyl)-1-propanol

Cas:116539-55-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationship

116539-55-0 3-Methylamino-1-(2-thienyl)-1-propanol supplier

Cas:116539-55-0

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (S)-3-(Methylamino)-1-(2-thienyl)-1-propanol CAS No.: 116539-55-0 Molecule Formula:C8H13NOS Molecule Weight:171.26 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

Lower Price (S)-3-(Methylamino)-1-(2-thienyl)-1-propanol on stock

Cas:116539-55-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

C8H13NO2S
1035456-55-3

C8H13NO2S

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
Stage #1: C8H13NO2S With acetic acid; zinc In water at 50℃; for 1.5h;
Stage #2: With sodium hydroxide In water
100%
(S)-3-hydroxy-N-methyl-3-(thiophen-2-yl)propanamide
603959-56-4

(S)-3-hydroxy-N-methyl-3-(thiophen-2-yl)propanamide

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 20℃; for 4h; Reagent/catalyst;98%
Stage #1: (S)-3-hydroxy-N-methyl-3-(thiophen-2-yl)propanamide With sodium tetrahydroborate; iodine In tetrahydrofuran at 20℃; for 4.33333h; Heating / reflux;
Stage #2: With sodium hydroxide; water In tetrahydrofuran; water; butanone at 64℃; for 0.333333h;
91%
With lithium aluminium tetrahydride In tetrahydrofuran Heating / reflux;80%
methylamine
74-89-5

methylamine

(S)-3-hydroxy-3-(2-thienyl)propyl methanesulfonate
556801-68-4

(S)-3-hydroxy-3-(2-thienyl)propyl methanesulfonate

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
In tetrahydrofuran; water at 65℃; for 3h;94%
N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride

N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With Rh[((S,S)-BenzP*)(cod)]SbF6; hydrogen; caesium carbonate; zinc(II) chloride In methanol at 20℃; under 19001.3 Torr; for 20h; Reagent/catalyst; Solvent; Autoclave; enantioselective reaction;94%
With hydrogen; potassium carbonate; [Rh{(SC,RP)-duanphos}(norbornadiene)]SbF6 In methanol at 20℃; under 7500.6 Torr; for 12h;93%
With [Rh((S,S)-QuinoxP*)(cod)]SbF6; potassium tert-butylate; hydrogen; zinc(II) iodide In tetrahydrofuran at 25℃; under 15001.5 Torr; for 12h; Reagent/catalyst; enantioselective reaction;83%
(S)-3-(N-trifluoroacetyl-N-methyl)amino-1-(2-thienyl)propan-1-ol
1204210-39-8

(S)-3-(N-trifluoroacetyl-N-methyl)amino-1-(2-thienyl)propan-1-ol

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With water; sodium carbonate In methanol at 20℃; for 4h;94%
(S)-[3-methoxy(methyl)amino]-1-(2-thienyl)propan-1-ol
1146978-94-0

(S)-[3-methoxy(methyl)amino]-1-(2-thienyl)propan-1-ol

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With hydrogen; Raney-nickel In methanol at 50℃; for 12h; Autoclave;90.8%
Raney-nickel In methanol at 50℃; for 12h; Autoclave;
((S)-3-Hydroxy-3-thiophen-2-yl-propyl)-carbamic acid ethyl ester
597581-29-8

((S)-3-Hydroxy-3-thiophen-2-yl-propyl)-carbamic acid ethyl ester

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 1.5h; Heating;88%
salt of (S)-(-)-3-N-methylamino-1-(2-thienyl)-1-propanol and (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid

salt of (S)-(-)-3-N-methylamino-1-(2-thienyl)-1-propanol and (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane; water for 0.25h; Product distribution / selectivity;87%
(S)-3-chloro-1-(thiophen-2-yl)propan-1-ol
164071-56-1

(S)-3-chloro-1-(thiophen-2-yl)propan-1-ol

methylamine
74-89-5

methylamine

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With chloro-trimethyl-silane In methanol; water at 80℃; for 8h; Reagent/catalyst;85%
(S)-3-methyl-6-(2-thienyl)-1,3-oxazinan-2-one
654062-24-5

(S)-3-methyl-6-(2-thienyl)-1,3-oxazinan-2-one

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With water; lithium hydroxide In methanol for 8h; Reflux;84%
C12H17NO5S

C12H17NO5S

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With methanol; potassium hydroxide at 75℃; for 4h;83%
phenyl (S)-N-[3-acetoxy-3-(thien-2-yl)propyl]-N-methylcarbamate
625853-22-7

phenyl (S)-N-[3-acetoxy-3-(thien-2-yl)propyl]-N-methylcarbamate

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With methanol; potassium hydroxide at 75℃; for 4h;83%
S-(-)-3-iodo-1-(2-thienyl)-1-propanol
164071-58-3

S-(-)-3-iodo-1-(2-thienyl)-1-propanol

methylamine
74-89-5

methylamine

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
In tetrahydrofuran; water at 25℃; for 12h; Inert atmosphere;80%
In tetrahydrofuran; water for 6h; Ambient temperature;71.5%
In tetrahydrofuran; water at 20℃; for 18h;71%
In tetrahydrofuran
In tetrahydrofuran; water at 20℃; for 18h;
3-(N-methyl-N-benzylamino)-1-(2-thienyl)-2-propen-1-one
1337865-86-7

3-(N-methyl-N-benzylamino)-1-(2-thienyl)-2-propen-1-one

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With potassium tert-butylate; hydrogen; [(R)-Binap RuCl2 (R)-DAIPEN] In isopropyl alcohol at 80℃; under 7500.75 Torr; for 16h; Inert atmosphere;80%
(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

isobutyl chloroformate
543-27-1

isobutyl chloroformate

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
Stage #1: (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol; isobutyl chloroformate With triethylamine In toluene at 20 - 30℃; for 6h;
Stage #2: With potassium hydroxide In methanol at 75℃; for 3.5h; Heating / reflux;
79.6%
3-methylamino-1-thiophen-2-yl-propenone
39145-15-8

3-methylamino-1-thiophen-2-yl-propenone

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With hydrogen; potassium carbonate; ruthenium(II) chloride In isopropyl alcohol at 30℃; under 18751.9 Torr; for 18h;79.2%
methylamine
74-89-5

methylamine

(S)-1-hydroxy-3-(thiophen-2-yl)propanenitrile
591727-36-5

(S)-1-hydroxy-3-(thiophen-2-yl)propanenitrile

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With hydrogen; nickel In methanol; water at 65℃; under 37503.8 Torr; for 24h; Product distribution / selectivity;79%
With hydrogen; 5%-palladium/activated carbon In methanol; water at 60℃; under 75007.5 Torr; for 24h; Product distribution / selectivity;74%
(S)-3-(N-ethoxycarbonyl-N-methyl)amino-1-ethoxycarbonyloxy-(2-thienyl)propane

(S)-3-(N-ethoxycarbonyl-N-methyl)amino-1-ethoxycarbonyloxy-(2-thienyl)propane

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 82℃; for 3h;74.6%
N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride

N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride

A

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

B

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride Product distribution / selectivity;A 74%
B n/a
With hydrogen; sodium methylate; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine) In methanol at 30 - 50℃; under 22502.3 Torr; for 24h; Product distribution / selectivity;A 12.7 - 20.4 %Chromat.
B n/a
With hydrogen; sodium methylate; ethyl acetoacetate; [(12aS)-6,7-dihudrodibenzo[e,g][1,4]dioxocin-1,12-diyl]bis[diphenylphosphine]; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate In methanol at 50℃; under 22502.3 Torr; for 24h; Product distribution / selectivity;A 6.2 %Chromat.
B n/a
With hydrogen; [(12aS)-6,7-dihudrodibenzo[e,g][1,4]dioxocin-1,12-diyl]bis[diphenylphosphine]; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In methanol at 50℃; under 22502.3 Torr; for 24h; Product distribution / selectivity;A 11.6 %Chromat.
B n/a
With hydrogen; [(12aS)-6,7-dihudrodibenzo[e,g][1,4]dioxocin-1,12-diyl]bis[diphenylphosphine]; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate In methanol at 50℃; under 22502.3 Torr; for 24h; Product distribution / selectivity;A 4 %Chromat.
B n/a
(S)-3-N-methylammonio-1-(2-thienyl)-1-propanol 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonate

(S)-3-N-methylammonio-1-(2-thienyl)-1-propanol 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonate

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With potassium hydroxide In water70%
With sodium carbonate In water for 0.25h;61%
With sodium hydroxide In water
(S)-N-(3-hydroxy-3-(thiophen-2-yl)propyl)-N-methylacetamide
625853-14-7

(S)-N-(3-hydroxy-3-(thiophen-2-yl)propyl)-N-methylacetamide

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With potassium hydroxide In methanol at 70℃; for 2h;68%
(S)-MMAA (S)-mandelic acid monohydrate

(S)-MMAA (S)-mandelic acid monohydrate

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With sodium hydroxide In water; iso-butanol66%
C9H13NO2S

C9H13NO2S

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With bis-[(trifluoroacetoxy)iodo]benzene In water; acetonitrile for 4h; Reflux;54%
3-N-methylamino-1-(2-thienyl)-1-propanone methanesulphonate

3-N-methylamino-1-(2-thienyl)-1-propanone methanesulphonate

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With formic acid; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; triethylamine; N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide In methanol at 40 - 45℃; for 2h; Time; Reagent/catalyst;48%
N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride

N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride

A

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

B

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
With sodium hydroxide; (p-cymene)-ruthenium(II) chloride dimer In isopropyl alcohol at 20 - 85℃; for 5h;A 39%
B n/a
3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-56-1

3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

A

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

B

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
With (S)-Mandelic acid In water at 29 - 50℃;A 27%
B n/a
With diethylamine In ethanol; n-heptane Resolution of racemate;
(2S,6S)-2-[(S)-1-triisopropylsilyloxyethyl]-3-methyl-6-(thiophen-2-yl)-1,3-oxazinane
919530-17-9

(2S,6S)-2-[(S)-1-triisopropylsilyloxyethyl]-3-methyl-6-(thiophen-2-yl)-1,3-oxazinane

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 4h;
(2S,6S)-2-[(S)-1-triisopropylsilyloxyethyl]-6-(thiophen-2-yl)-[1,3]oxazinan-4-one
919530-12-4

(2S,6S)-2-[(S)-1-triisopropylsilyloxyethyl]-6-(thiophen-2-yl)-[1,3]oxazinan-4-one

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: LiHMDS / tetrahydrofuran / 0 - 20 °C
2: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C
3: HCl / H2O; tetrahydrofuran / 4 h / 20 °C
View Scheme
(2S,6S)-N-methyl-2-[(S)-1-triisopropylsilyloxyethyl]-6-(thiophen-2-yl)-[1,3]oxazinan-4-one
919530-14-6

(2S,6S)-N-methyl-2-[(S)-1-triisopropylsilyloxyethyl]-6-(thiophen-2-yl)-[1,3]oxazinan-4-one

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C
2: HCl / H2O; tetrahydrofuran / 4 h / 20 °C
View Scheme
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

polymer-bound-N-(3-(4-bromophenyl)-3-oxopropanamide)

polymer-bound-N-(3-(4-bromophenyl)-3-oxopropanamide)

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 36 percent / BF3*Et2O / CH2Cl2 / -78 - 20 °C
2: aluminum amalgam / propan-2-ol
3: LiHMDS / tetrahydrofuran / 0 - 20 °C
4: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C
5: HCl / H2O; tetrahydrofuran / 4 h / 20 °C
View Scheme
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

duloxetine hydrochloride
136434-34-9

duloxetine hydrochloride

Conditions
ConditionsYield
Stage #1: 1-Fluoronaphthalene; (S)-3-methylamino-1-(2-thienyl)-1-propanol With sodium hydride In paraffin oil (nujol); dimethyl sulfoxide at 20 - 50℃;
Stage #2: With hydrogenchloride; acetic acid In Isopropyl acetate at 0 - 15℃; for 5h;
93%
Stage #1: (S)-3-methylamino-1-(2-thienyl)-1-propanol With sodium hydride In dimethyl sulfoxide at 20 - 35℃;
Stage #2: 1-Fluoronaphthalene In dimethyl sulfoxide at 45 - 50℃; for 30h;
Stage #3: With hydrogenchloride In water; dimethyl sulfoxide; toluene pH=4 - 5; Solvent;
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
With potassium tert-butylate In dimethyl sulfoxide at 60℃; for 8h;90%
With potassium tert-butylate In dimethyl sulfoxide at 60℃; for 8h;90%
With sodium hydride In dimethyl sulfoxide for 8h;81%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

N-[3S-hydroxy-3-(thiophen-2-yl)propyl]-N-methylbenzenesulfonamide

N-[3S-hydroxy-3-(thiophen-2-yl)propyl]-N-methylbenzenesulfonamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 14h;90%
3-fluorobromobenzene
1073-06-9

3-fluorobromobenzene

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

(S)-3-(3-bromophenoxy)-N-methyl-3-(thiophen-2-yl)propan-1-amine

(S)-3-(3-bromophenoxy)-N-methyl-3-(thiophen-2-yl)propan-1-amine

Conditions
ConditionsYield
Stage #1: (S)-3-methylamino-1-(2-thienyl)-1-propanol With sodium hydride In N,N-dimethyl acetamide; mineral oil at 20℃; for 0.5h;
Stage #2: 3-fluorobromobenzene In N,N-dimethyl acetamide; mineral oil at 90℃; for 3h;
90%
Stage #1: (S)-3-methylamino-1-(2-thienyl)-1-propanol With sodium hydride In N,N-dimethyl acetamide; mineral oil at 20℃; for 0.5h;
Stage #2: 3-fluorobromobenzene In N,N-dimethyl acetamide; mineral oil at 90℃; for 3h;
(1S)-10-camphorsulfonic acid
3144-16-9

(1S)-10-camphorsulfonic acid

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

(S)-3-methylamino-1-thiophen-2-yl-propan-1-ol 1-(S)-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)-methanesulfonate

(S)-3-methylamino-1-thiophen-2-yl-propan-1-ol 1-(S)-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)-methanesulfonate

Conditions
ConditionsYield
In ethanol; ethyl acetate at 30 - 50℃; for 0.916667h; Product distribution / selectivity;89%
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

(S)-(-)-3-N-methylamino-1-(2-thienyl)-1-propanol p-toluenesulfonate

(S)-(-)-3-N-methylamino-1-(2-thienyl)-1-propanol p-toluenesulfonate

Conditions
ConditionsYield
In methanol; dichloromethane at 25℃; for 1h; Product distribution / selectivity;60%
4-[2-(tert-butyldimethylsilyloxy)ethyl]phenol
96013-76-2

4-[2-(tert-butyldimethylsilyloxy)ethyl]phenol

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

(R)-3-[4-[2-(tert-butyldimethylsilyloxy)ethyl]phenoxy]-N-methyl-3-(thiophen-2-yl)propan-1-amine
1615654-56-2

(R)-3-[4-[2-(tert-butyldimethylsilyloxy)ethyl]phenoxy]-N-methyl-3-(thiophen-2-yl)propan-1-amine

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In ethyl acetate; toluene52%
With triphenylphosphine; diethylazodicarboxylate In toluene at 20℃; for 18h;52%

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