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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(1R)-3-(Methylamino)-1-(2-thienyl)-1-propanol Manufacturer/High quality/Best price/In stock

Cas:116539-57-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-3-(Methylamino)-1-(thiophen-2-yl)-propan-1-ol

Cas:116539-57-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

(R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL Basic information Product Name: (R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL Synonyms: (R)-(+)-3-(N-METHYLA

(R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL 116539-57-2

Cas:116539-57-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 116539-57-2 with competitive price

Cas:116539-57-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

Qingdao Beluga Import and Export Co., LTD

(R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL CAS:116539-57-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializ

(R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL CAS:116539-57-2

Cas:116539-57-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol

Cas:116539-57-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(1R)-3-(Methylamino)-1-(2-thienyl)-1-propanol

Cas:116539-57-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Trading Company

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec (R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol 1g

Cas:116539-57-2

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

(R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Fandachem Co.,Ltd

(1R)-3-(Methylamino)-1-(2-thienyl)-1-propanol cas 116539-57-2Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

(1R)-3-(Methylamino)-1-(2-thienyl)-1-propanol cas 116539-57-2

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Other

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

(R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Other

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Shanghai Terui OP New Material Technology Co., Ltd.

The factory supplies Application:manufacturing supplies

(R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

116539-57-2

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Trading Company

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LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

(R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Trading Company

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Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

(R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol

Cas:116539-57-2

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

(R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL 116539-57-2 CAS NO.116539-57-2

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Trading Company

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Watson International Ltd

Watson International Ltd' has a very strong R&D and technical capacity supported by FCAD's platform. The subsidiaries under FCAD Group have accumulated much know-how of different fine chemical branches. For example, Apnoke Scientific L

(1R)-3-(Methylamino)-1-(2-thienyl)-1-propanol

Cas:116539-57-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Forever Synthesis Co.,Ltd.

As a professional chemical R&D and synthesis supplier, Shanghai Forever Synthesis Co.,Ltd. is specialized R&D and synthesizing APIs and Impurities. Besides, we value more special service, that is, to customize chemical synthesis according t

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Cas:116539-57-2

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Chemical Technology Co.,LTD

1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi

(R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Other

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Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

(R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Simson Pharma Limited

The system can just identify the products information in first sheet, it is not be permitted to add or edit new sheet by userself.Our products are required in MG to Gram only. · Pharmaceutical Reference Standards· Traceable workin

(R)-3-Methylamino-1-(2-thienyl)-1-propanol

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Nanjing Raymon Biotech Co., Ltd.

(R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol Storage:keep in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/pharma intermediate Transportation:By Sea,by Air,By courier like DHL or Fedx. Port:Sha

(R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol

Cas:116539-57-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride

N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
With hydrogen; potassium carbonate; [Rh{(RC,SP)-duanphos}(norbornadiene)]SbF6 In methanol at 20℃; under 7500.6 Torr; for 12h;93%
(R)-(3-hydroxy-3-thiophen-2-yl-propyl)carbamic acid ethyl ester
597581-30-1

(R)-(3-hydroxy-3-thiophen-2-yl-propyl)carbamic acid ethyl ester

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 1.5h; Heating;88%
With lithium aluminium tetrahydride In tetrahydrofuran for 14h; Reflux;87%
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating;
N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride

N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride

A

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

B

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride Product distribution / selectivity;A 74%
B n/a
With hydrogen; sodium methylate; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine) In methanol at 30 - 50℃; under 22502.3 Torr; for 24h; Product distribution / selectivity;A 12.7 - 20.4 %Chromat.
B n/a
With hydrogen; sodium methylate; ethyl acetoacetate; [(12aS)-6,7-dihudrodibenzo[e,g][1,4]dioxocin-1,12-diyl]bis[diphenylphosphine]; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate In methanol at 50℃; under 22502.3 Torr; for 24h; Product distribution / selectivity;A 6.2 %Chromat.
B n/a
With hydrogen; [(12aS)-6,7-dihudrodibenzo[e,g][1,4]dioxocin-1,12-diyl]bis[diphenylphosphine]; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In methanol at 50℃; under 22502.3 Torr; for 24h; Product distribution / selectivity;A 11.6 %Chromat.
B n/a
With hydrogen; [(12aS)-6,7-dihudrodibenzo[e,g][1,4]dioxocin-1,12-diyl]bis[diphenylphosphine]; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate In methanol at 50℃; under 22502.3 Torr; for 24h; Product distribution / selectivity;A 4 %Chromat.
B n/a
(R)-3-chloro-1-thiophenyl-2-yl-propan-1-ol
164071-55-0

(R)-3-chloro-1-thiophenyl-2-yl-propan-1-ol

methylamine
74-89-5

methylamine

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
In ethanol at 90℃; Sealed tube;62%
In ethanol; water at 130℃; for 1h; Sealed tube;55%
In ethanol at 90℃; Sealed tube;41%
In ethanol at 90℃; Sealed tube;41%
N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride

N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride

A

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

B

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
With sodium hydroxide; (p-cymene)-ruthenium(II) chloride dimer In isopropyl alcohol at 20 - 85℃; for 5h;A 39%
B n/a
3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-56-1

3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

A

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

B

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
With (S)-Mandelic acid In water at 29 - 50℃;A 27%
B n/a
With diethylamine In ethanol; n-heptane Resolution of racemate;
(2R,6R)-2-[(S)-1-triisopropylsilyloxyethyl]-3-methyl-6-(thiophen-2-yl)-1,3-oxazinane
919530-16-8

(2R,6R)-2-[(S)-1-triisopropylsilyloxyethyl]-3-methyl-6-(thiophen-2-yl)-1,3-oxazinane

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 4h;
(2R,6R)-2-[(S)-1-triisopropylsilyloxyethyl]-6-(thiophen-2-yl)-[1,3]oxazinan-4-one
919530-11-3

(2R,6R)-2-[(S)-1-triisopropylsilyloxyethyl]-6-(thiophen-2-yl)-[1,3]oxazinan-4-one

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: LiHMDS / tetrahydrofuran / 0 - 20 °C
2: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C
3: HCl / H2O; tetrahydrofuran / 4 h / 20 °C
View Scheme
(2R,6R)-N-methyl-2-[(S)-1-triisopropylsilyloxyethyl]-6-(thiophen-2-yl)-[1,3]oxazinan-4-one
919530-13-5

(2R,6R)-N-methyl-2-[(S)-1-triisopropylsilyloxyethyl]-6-(thiophen-2-yl)-[1,3]oxazinan-4-one

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C
2: HCl / H2O; tetrahydrofuran / 4 h / 20 °C
View Scheme
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

polymer-bound-N-(3-(4-bromophenyl)-3-oxopropanamide)

polymer-bound-N-(3-(4-bromophenyl)-3-oxopropanamide)

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 54 percent / BF3*Et2O / CH2Cl2 / -78 - 20 °C
2: aluminum amalgam / propan-2-ol
3: LiHMDS / tetrahydrofuran / 0 - 20 °C
4: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C
5: HCl / H2O; tetrahydrofuran / 4 h / 20 °C
View Scheme
(2R,5R,6R)-2-[(S)-1-triisopropylsilyloxyethyl]-6-(thiophen-2-yl)-5-phenylthio-[1,3]oxazinan-4-one
919530-02-2

(2R,5R,6R)-2-[(S)-1-triisopropylsilyloxyethyl]-6-(thiophen-2-yl)-5-phenylthio-[1,3]oxazinan-4-one

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aluminum amalgam / propan-2-ol
2: LiHMDS / tetrahydrofuran / 0 - 20 °C
3: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C
4: HCl / H2O; tetrahydrofuran / 4 h / 20 °C
View Scheme
2-Acetylthiophene
88-15-3

2-Acetylthiophene

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCl / ethanol / 110 °C
2: 93 percent / hydrogen; K2CO3 / [Rh{(RC,SP)-duanphos}(norbornadiene)]SbF6 / methanol / 12 h / 20 °C / 7500.6 Torr
View Scheme
2-Thenoylacetonitrile
33898-90-7

2-Thenoylacetonitrile

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: borane-dimethylsulfide complex; polymer-supported chiral sulfonamide / tetrahydrofuran / Heating
2: sodium hydrogen carbonate / CH2Cl2; H2O / 2 h / 20 °C
3: lithium aluminum hydride / tetrahydrofuran / 2 h / Heating
View Scheme
(R)-3-amino-1-(thiophen-2-yl)propan-1-ol
858130-53-7

(R)-3-amino-1-(thiophen-2-yl)propan-1-ol

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydrogen carbonate / CH2Cl2; H2O / 2 h / 20 °C
2: lithium aluminum hydride / tetrahydrofuran / 2 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C
2: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / dichloromethane; water / 1 h
2: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / Reflux
View Scheme
2-chloro-1-(thiophen-2-yl)ethanone
29683-77-0

2-chloro-1-(thiophen-2-yl)ethanone

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 90 percent / NaBH4 / methanol / 0.5 h / 20 °C
2: 77 percent / methanol; H2O / 4 h / 20 °C
3: 43 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2
4: BH3*Me2S / tetrahydrofuran / 2 h / Heating
5: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C
6: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating
View Scheme
2-(1-hydroxy-2-chloroethyl)-thiophene
49703-01-7

2-(1-hydroxy-2-chloroethyl)-thiophene

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 77 percent / methanol; H2O / 4 h / 20 °C
2: 43 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2
3: BH3*Me2S / tetrahydrofuran / 2 h / Heating
4: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C
5: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating
View Scheme
(±)-3-hydroxy-3-(thiophen-2-yl)propanenitrile
235085-83-3

(±)-3-hydroxy-3-(thiophen-2-yl)propanenitrile

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 43 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2
2: BH3*Me2S / tetrahydrofuran / 2 h / Heating
3: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C
4: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: Candida antarctica lipase B-W104A; sodium carbonate / toluene / 24 h / 50 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
2: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 80 °C
3: sodium hydrogencarbonate / dichloromethane; water / 1 h
4: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: Candida antarctica lipase B; dicarbonyl(chloro)(η5-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate / tetrahydrofuran; toluene / 25 h / 50 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
2: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 80 °C
3: sodium hydrogencarbonate / dichloromethane; water / 1 h
4: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: Candida antarctica lipase B; sodium carbonate / toluene / 4 h / 80 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
2: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 80 °C
3: sodium hydrogencarbonate / dichloromethane; water / 1 h
4: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / Reflux
View Scheme
(R)-1-hydroxy-3-(thiophen-2-yl)propanenitrile
524047-48-1

(R)-1-hydroxy-3-(thiophen-2-yl)propanenitrile

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: BH3*Me2S / tetrahydrofuran / 2 h / Heating
2: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C
3: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating
View Scheme
acetic acid 2-cyano-1-thiophen-2-yl-ethyl ester

acetic acid 2-cyano-1-thiophen-2-yl-ethyl ester

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 41 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / acetone / 14 h / pH 7.2
2: BH3*Me2S / tetrahydrofuran / 2 h / Heating
3: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C
4: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating
View Scheme
(R)-2-cyano-1-(thiophen-2-yl)ethyl acetate
597581-26-5

(R)-2-cyano-1-(thiophen-2-yl)ethyl acetate

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: BH3*Me2S / tetrahydrofuran / 2 h / Heating
2: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C
3: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 80 °C
2: sodium hydrogencarbonate / dichloromethane; water / 1 h
3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / Reflux
View Scheme
methylamine
74-89-5

methylamine

A

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

B

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Stage #1: 3-chloro-1-(2-thienyl)propan-1-one With sodium hydroxide; D-glucose; 2,3,4,5,6-pentahydroxy-hexanal In water at 30℃; for 2 - 8h; pH=6.0;
Stage #2: methylamine In water at 60℃; for 6h; pH=6.0;
A n/a
B n/a
C8H13NO2S
1035456-56-4

C8H13NO2S

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Stage #1: C8H13NO2S With acetic acid; zinc In water at 50℃; for 1.5h;
Stage #2: With sodium hydroxide In water
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: 18 h / -78 °C / Inert atmosphere
2.1: Candida antarctica lipase B-W104A; sodium carbonate / toluene / 24 h / 50 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
3.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 80 °C
4.1: sodium hydrogencarbonate / dichloromethane; water / 1 h
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: 18 h / -78 °C / Inert atmosphere
2.1: Candida antarctica lipase B; sodium carbonate / toluene / 4 h / 80 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
3.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 80 °C
4.1: sodium hydrogencarbonate / dichloromethane; water / 1 h
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: 18 h / -78 °C / Inert atmosphere
2.1: Candida antarctica lipase B; dicarbonyl(chloro)(η5-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate / tetrahydrofuran; toluene / 25 h / 50 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
3.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 80 °C
4.1: sodium hydrogencarbonate / dichloromethane; water / 1 h
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / Reflux
View Scheme
(S)-1-hydroxy-3-(thiophen-2-yl)propanenitrile
591727-36-5

(S)-1-hydroxy-3-(thiophen-2-yl)propanenitrile

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: dicarbonyl(chloro)(η5-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate / tetrahydrofuran; toluene / 0.08 h / 80 °C / Inert atmosphere
2: Candida antarctica lipase B-W104A; sodium carbonate / toluene / 24 h / 50 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
3: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 80 °C
4: sodium hydrogencarbonate / dichloromethane; water / 1 h
5: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1: dicarbonyl(chloro)(η5-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate / tetrahydrofuran; toluene / 0.08 h / 80 °C / Inert atmosphere
2: Candida antarctica lipase B; sodium carbonate / toluene / 4 h / 80 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
3: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 80 °C
4: sodium hydrogencarbonate / dichloromethane; water / 1 h
5: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1: dicarbonyl(chloro)(η5-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate / tetrahydrofuran; toluene / 0.08 h / 80 °C / Inert atmosphere
2: Candida antarctica lipase B; dicarbonyl(chloro)(η5-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate / tetrahydrofuran; toluene / 25 h / 50 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
3: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 80 °C
4: sodium hydrogencarbonate / dichloromethane; water / 1 h
5: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / Reflux
View Scheme
(Z)-3-(methylamino)-1-(thiophen-2-yl)prop-2-en-1-one
663603-70-1

(Z)-3-(methylamino)-1-(thiophen-2-yl)prop-2-en-1-one

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
With ruthenium(II) dichloro{(S)-(-)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2S)-(+)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]; potassium tert-butylate; hydrogen In isopropyl alcohol at 20℃; under 750.075 Torr; for 24h; Autoclave; optical yield given as %ee; enantioselective reaction;> 99 %Spectr.
N-methyl-(3S)-3-hydroxy-3-(thien-2-yl)propanamide

N-methyl-(3S)-3-hydroxy-3-(thien-2-yl)propanamide

A

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

B

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
With dimethylsulfide borane complex In tetrahydrofuran at 20℃; for 4h; Overall yield = 98 %; Optical yield = 89 %ee;
3-chloro-1-(2-thienyl)propan-1-one
40570-64-7

3-chloro-1-(2-thienyl)propan-1-one

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / toluene / 1 h / 0 °C
2: water; ethanol / 1 h / 130 °C / Sealed tube
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

(3-hydroxy-3-thiophen-2-yl-propyl)-methyl-carbamic acid tert-butyl ester
597581-31-2

(3-hydroxy-3-thiophen-2-yl-propyl)-methyl-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h;88%
3-fluorobromobenzene
1073-06-9

3-fluorobromobenzene

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

(R)-3-(3-bromophenoxy)-N-methyl-3-(thiophen-2-yl)propan-1-amine

(R)-3-(3-bromophenoxy)-N-methyl-3-(thiophen-2-yl)propan-1-amine

Conditions
ConditionsYield
Stage #1: (R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol With sodium hydride In N,N-dimethyl acetamide; mineral oil at 20℃; for 0.5h;
Stage #2: 3-fluorobromobenzene In N,N-dimethyl acetamide; mineral oil at 90℃; for 3h;
83%
With sodium hydride In N,N-dimethyl acetamide at 90℃; for 3h;
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

(R)-Duloxetine
116539-60-7

(R)-Duloxetine

Conditions
ConditionsYield
With sodium hydride In dimethyl sulfoxide for 8h;81%
Stage #1: (R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 0.5h;
Stage #2: 1-Fluoronaphthalene In dimethyl sulfoxide; mineral oil at 50℃; for 1h;
80%
With sodium hydride In dimethyl sulfoxide at 45 - 50℃; for 1h;
o-fluorobromobenzene
1072-85-1

o-fluorobromobenzene

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

(R)-3-(2-bromophenoxy)-N-methyl-3-(thiophen-2-yl)propan-1-amine

(R)-3-(2-bromophenoxy)-N-methyl-3-(thiophen-2-yl)propan-1-amine

Conditions
ConditionsYield
With potassium tert-butylate In dimethyl sulfoxide at 60℃; for 8h; Inert atmosphere;78%
With potassium tert-butylate In dimethyl sulfoxide at 60℃; for 8h; Inert atmosphere;78%
6-fluoroquinoline
396-30-5

6-fluoroquinoline

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

(R)-N-methyl-3-(quinolin-6-yloxy)-3-(thiophen-2-yl)propan-1-amine

(R)-N-methyl-3-(quinolin-6-yloxy)-3-(thiophen-2-yl)propan-1-amine

Conditions
ConditionsYield
Stage #1: (R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol With sodium hydride In N,N-dimethyl acetamide; mineral oil at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 6-fluoroquinoline In N,N-dimethyl acetamide; mineral oil at 50℃; for 1.5h; Inert atmosphere;
59%
5-fluoro phthalazine
103119-77-3

5-fluoro phthalazine

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

(R)-N-methyl-3-(phthalazin-5-yloxy)-3-(thiophen-2-yl)propan-1-amine

(R)-N-methyl-3-(phthalazin-5-yloxy)-3-(thiophen-2-yl)propan-1-amine

Conditions
ConditionsYield
Stage #1: (R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol With sodium hydride In dimethyl amine; mineral oil at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 5-fluoro phthalazine In dimethyl amine; mineral oil at 50℃; for 1.5h;
49%
(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / triethyl amine / CH2Cl2 / 2 h / 20 °C
2: 51 percent / PPh3; DIAD / tetrahydrofuran / 24 h
3: 70 percent / TFA / CHCl3
View Scheme
(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

(S)-N-BOC-duloxetine
597581-32-3

(S)-N-BOC-duloxetine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88 percent / triethyl amine / CH2Cl2 / 2 h / 20 °C
2: 51 percent / PPh3; DIAD / tetrahydrofuran / 24 h
View Scheme
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

oxalic acid
144-62-7

oxalic acid

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
116539-57-2

(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol

(-)-duloxetine oxalate
116817-78-8

(-)-duloxetine oxalate

Conditions
ConditionsYield
Stage #1: (R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol With sodium hydride; potassium hexanoate In tetrahydrofuran; dimethyl sulfoxide at 20℃; for 1h;
Stage #2: 1-Fluoronaphthalene In tetrahydrofuran; dimethyl sulfoxide at 60℃; for 6h;
Stage #3: oxalic acid In isopropyl alcohol Product distribution / selectivity;
n/a

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