Androst-4-ene-3,6,17-trione supplier

Name
Androst-4-ene-3,6,17-trione
EINECS 200-589-5
CAS No. 2243-06-3
Article Data50
CAS DataBase
Density 1.188 g/cm³
Solubility
Melting Point 223-224 °C
Formula C₁₉H₂₄O₃
Boiling Point 460.044 °C at 760 mmHg
Molecular Weight 300.398
Flash Point 198.465 °C
Transport Information
Appearance Yellow solid
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 4-Androstenetriol;
PSA 51.21000
LogP 3.26640

Synthetic route

: 103232-92-4
4α-ethylthio-5α-androstane-3,6,17-trione

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In ethyl acetate for 9h; Ambient temperature;	90%

: 53-43-0
dehydroepiandrosterone

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With Montmorillonite K10; pyridinium chlorochromate In 1,4-dioxane for 0.75h; Irradiation;	89%
With chromium(VI) oxide; sulfuric acid In acetone at 0℃; modified Jones oxidation;	85%
With Jones reagent	83%

: 74395-56-5
5α-hydroxyandrostane-3,6,17-trione

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With sulfuric acid; water In ethanol for 3.5h; Reflux;	89%
	80%
With hydrogenchloride; chloroform

: C19H26O4

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With sulfuric acid In ethanol for 5h; Concentration; Reflux;	87%

: 19637-35-5
3-tetrahydropyran-2-yloxy-androst-5-en-17-one

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With 3 A molecular sieve; pyridinium chlorochromate In benzene for 5h; Heating;	86%

: 24704-84-5
6α-hydroxy-androst-4-ene-3,17-dione

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With potassium hydroxide; tetrazolium blue In ethanol Heating;	85%
With potassium hydroxide; tetrazolium blue In ethanol at 25 - 50℃; Rate constant; rate constants for enolisation and oxidation;

: 63-05-8
Androstenedione

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; Rh2(cap)4 In 1,2-dichloro-ethane at 40℃; for 16h; Product distribution / selectivity; Allylic oxidation;	80%
With tert.-butylhydroperoxide; [Rh2(cap)4*2CH3CN] In water; 1,2-dichloro-ethane at 40℃; for 40h;	80%
With tert.-butylhydroperoxide; Rh2(cap)4 In water at 40℃; for 16h; Product distribution / selectivity; Allylic oxidation;	62%

: 103232-93-5
6-methoxy-4,6-androstadiene-3,17-dione

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With hydrogenchloride In dichloromethane for 72h; Ambient temperature;	73%

: 63-05-8
Androstenedione

A: 6-hydroperoxyandrost-4-ene-3,17-dione

B: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With N-hydroxyphthalimide; 2,2’-azobis(4-methoxy-2,4-dimethyl)valeronitrile; oxygen In acetonitrile at 30℃; under 760 Torr; for 48h;	A 56% B 12%

: 25375-38-6
3-hydroxy-5-androsten-17-one

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With pyridinium chlorochromate In dichloromethane for 96h;	53%

: 63-00-3
6β-hydroxy-4-androstene-3,17-dione

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With potassium hydroxide; tetrazolium blue In ethanol Heating;	32%
With potassium hydroxide; tetrazolium blue at 25 - 50℃; Rate constant; rate constants for enolisation and oxidation;

: 58-22-0
testosterone

A: 63-05-8
Androstenedione

B: 570-94-5
17β-hydroxy-4-androstene-3,6-dione

C: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; Rh2(cap)4 In 1,2-dichloro-ethane at 40℃; for 16h; Product distribution / selectivity; Allylic oxidation;	A n/a B 28% C n/a
With tert.-butylhydroperoxide; Rh2(cap)4 In water at 40℃; for 16h; Product distribution / selectivity; Allylic oxidation;	A n/a B 23% C n/a
With tert.-butylhydroperoxide; [Rh2(cap)4*2CH3CN] In water; 1,2-dichloro-ethane at 40℃; for 16h;	A n/a B 23% C n/a

...Expand

: 53-43-0
dehydroepiandrosterone

A: 2243-06-3
androst-4-ene-3,6,17-trione

B: 63-00-3
6β-hydroxy-4-androstene-3,17-dione

Conditions

Conditions	Yield
With jones reagent In diethyl ether for 0.25h; Heating;	A 24% B 8%

: 63-05-8
Androstenedione

A: 2243-06-3
androst-4-ene-3,6,17-trione

B: 89617-12-9
4-hydroxy-androsta-4,6-diene-3,17-dione

Conditions

Conditions	Yield
With potassium tert-butylate In tert-butyl alcohol for 20h;	A n/a B 15%

: 897-06-3
Androsta-1,4-diene-3,17-dione

A: 2243-06-3
androst-4-ene-3,6,17-trione

B: 95192-09-9
4-hydroxy-1,4,6-androstatriene-3,17-dione

Conditions

Conditions	Yield
With potassium tert-butylate In tert-butyl alcohol for 20h;	A n/a B 6%

: 53-43-0
dehydroepiandrosterone

A: 2243-06-3
androst-4-ene-3,6,17-trione

B: 74395-56-5
5α-hydroxyandrostane-3,6,17-trione

Conditions

Conditions	Yield
With chromium(VI) oxide; water; acetic acid

: 62-99-7, 2944-87-8, 34096-63-4, 34442-08-5, 145772-79-8
6β-hydroxytestosterone

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With sodium dichromate

: 548-97-0
6β,17α,21-trihydroxypregn-4-ene-3,20-dione

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With chromium(VI) oxide

: 60268-49-7
3β,6β-dihydroxyandrost-4-en-17-one

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With manganese(IV) oxide

: 571-36-8
5-androstenedione

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide In dichloromethane at 25℃; ultrasonic irradiation; Yield given;

: 94535-03-2
6α-nitro-androst-4-ene-3,17-dione

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With aluminum oxide

: 57144-06-6
3-methoxyandrosta-3,5-dien-17-one

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With (tBuO)2CrO2 In tetrachloromethane

: 102600-95-3
6β-Methoxy-7α-hydroxy-androsten-(4)-dion-(3,17)

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid

: 71418-25-2
6-Chloro-3-ethoxyandrosta-3,5-dien-17-on

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid

: 218625-22-0
17-β-hydroxyandrosta-4,6-diene

A: 2243-06-3
androst-4-ene-3,6,17-trione

B: 184435-18-5
androst-5-ene-4,7,17-trione

Conditions

Conditions	Yield
With chromium(VI) oxide In acetone for 0.166667h; Ambient temperature;	A 60 mg B 500 mg

: 1912-63-6
androsta-3,5-dien-17-one

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With chromic acid In acetone at 0 - 20℃; Oxidation;	190 mg

: 53-43-0
dehydroepiandrosterone

: 64-19-7
acetic acid

CrO3: CrO3

A: 2243-06-3
androst-4-ene-3,6,17-trione

B: 74395-56-5
5α-hydroxyandrostane-3,6,17-trione

...Expand

: 7647-01-0
hydrogenchloride

: 67-66-3
chloroform

: 74395-56-5
5α-hydroxyandrostane-3,6,17-trione

: 2243-06-3
androst-4-ene-3,6,17-trione

...Expand

: 1229-09-0
3-chloroandrosta-3,5-dien-17-one

: 2243-06-3
androst-4-ene-3,6,17-trione

Conditions

Conditions	Yield
With chromium(VI) oxide; sulfuric acid In acetone at 0 - 20℃;

: 2243-06-3
androst-4-ene-3,6,17-trione

: 1614218-94-8
androst-4-ene-3β,6α,17β-triol

Conditions

Conditions	Yield
With sodium tetrahydroborate; cerium(III) chloride	95%

: 2243-06-3
androst-4-ene-3,6,17-trione

: 540-63-6
ethane-1,2-dithiol

: 103232-86-6
3α,4α-ethylenedithio-3β-hydroxy-5α-androstane-6,17-dione

Conditions

Conditions	Yield
In methanol for 48h; Ambient temperature;	88%

: 2243-06-3
androst-4-ene-3,6,17-trione

: 540-63-6
ethane-1,2-dithiol

A: 103232-84-4
3,3:6,6-bis(ethylenedithio)-4-androsten-17-one

B: 3,3:6,6:17,17-tris(ethylenedithio)-androst-4-ene

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In methanol for 24h; Ambient temperature;	A 84% B 6%

...Expand

: 2243-06-3
androst-4-ene-3,6,17-trione

: 2243-05-2
5α-androst-3,6,17-trione

Conditions

Conditions	Yield
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In methanol at 20℃; for 1h; Concentration;	81%
Stage #1: androst-4-ene-3,6,17-trione With sodium tetrahydroborate; nickel(II) Stage #2: With pyridinium chlorochromate	78%
With acetic acid; zinc

: 2243-06-3
androst-4-ene-3,6,17-trione

: 100-53-8
phenylmethanethiol

: 4α-benzylthio-5α-androstane-3,6,17-trione

Conditions

Conditions	Yield
In methanol for 28h; Ambient temperature;	80%

: 2243-06-3
androst-4-ene-3,6,17-trione

: 75-08-1
ethanethiol

: 103232-92-4
4α-ethylthio-5α-androstane-3,6,17-trione

Conditions

Conditions	Yield
With methanol; sodium hydrogencarbonate for 10h; Ambient temperature;	80%

: 2243-06-3
androst-4-ene-3,6,17-trione

: 19316-60-0
5α-androst-3β,6β,17β-triol

Conditions

Conditions	Yield
With sodium tetrahydroborate; nickel dichloride	73%

: 2243-06-3
androst-4-ene-3,6,17-trione

: 546-67-8
lead(IV) tetraacetate

: 153711-29-6
7α-acetoxyandrost-4-ene-3,6,17-trione

Conditions

Conditions	Yield
In acetic anhydride; acetic acid for 72h; Ambient temperature;	72%

: 2243-06-3
androst-4-ene-3,6,17-trione

: 540-63-6
ethane-1,2-dithiol

A: 103232-83-3
3,3-ethylenedithio-4-androstene-6,17-dione

B: 103232-84-4
3,3:6,6-bis(ethylenedithio)-4-androsten-17-one

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In methanol for 7h; Ambient temperature;	A 60% B 4%

...Expand

: 5573-62-6
(ethylthio)trimethylsilane

: 2243-06-3
androst-4-ene-3,6,17-trione

A: 2243-05-2
5α-androst-3,6,17-trione

B: 103232-89-9
3,3-diethylthio-5α-androstane-6,17-dione

Conditions

Conditions	Yield
With zinc(II) iodide In chloroform for 48h; Ambient temperature;	A 30% B 46%

...Expand

: 2243-06-3
androst-4-ene-3,6,17-trione

A: 2243-05-2
5α-androst-3,6,17-trione

B: 103232-89-9
3,3-diethylthio-5α-androstane-6,17-dione

Conditions

Conditions	Yield
With (ethylthio)trimethylsilane; zinc(II) iodide In chloroform for 48h; Ambient temperature;	A 30% B 46%

: 2243-06-3
androst-4-ene-3,6,17-trione

: 75-08-1
ethanethiol

A: 103232-88-8
3-ethylthio-2,4-androstadiene-6,17-dione

B: 103232-87-7
3,3-diethylthio-4-androstene-6,17-dione

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 6h; Heating;	A 35% B 2%

...Expand

: 2243-06-3
androst-4-ene-3,6,17-trione

: 75-08-1
ethanethiol

A: 103232-93-5
6-methoxy-4,6-androstadiene-3,17-dione

B: 103232-87-7
3,3-diethylthio-4-androstene-6,17-dione

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol for 8h; Ambient temperature;	A 10% B 26%

...Expand

: 67-56-1
methanol

: 2243-06-3
androst-4-ene-3,6,17-trione

A: 2243-05-2
5α-androst-3,6,17-trione

B: 103232-93-5
6-methoxy-4,6-androstadiene-3,17-dione

C: 103232-92-4
4α-ethylthio-5α-androstane-3,6,17-trione

D: 103232-87-7
3,3-diethylthio-4-androstene-6,17-dione

Conditions

Conditions	Yield
With ethanethiol In methanol for 24h; Ambient temperature;	A 4% B 10% C 20% D 2%

...Expand

: 616-91-1
N-acetylcystein

: 2243-06-3
androst-4-ene-3,6,17-trione

A: 2243-05-2
5α-androst-3,6,17-trione

B: sodium N-acetyl-S-(3,6,17-trioxo-5α-androstan-4α-yl)-L-cysteinate

Conditions

Conditions	Yield
With methanol for 96h; Ambient temperature;	A 2% B 20%

...Expand

: 52-90-4
L-Cysteine

: 2243-06-3
androst-4-ene-3,6,17-trione

A: 2243-05-2
5α-androst-3,6,17-trione

B: sodium S-(3,6,17-trioxo-5α-androstan-4α-yl)-L-cysteinate

Conditions

Conditions	Yield
In methanol for 96h; Ambient temperature;	A 8% B n/a

...Expand

Androst-4-ene-3,6,17-trione Specification

The Androst-4-ene-3,6,17-trione with the cas number 2243-06-3 is also called (8R,9S,10R,13S,14S)-10,13-dimethyl-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,6,17-trione. Its molecular formula is C₁₉H₂₄O₃. This chemical belongs to the following product categories: (1)Steroids & Hormones - 13C & 2H; (2)Steroids. It is an aromatase inhibitor.

You can still convert the following datas into molecular structure:
(1)SMILES: C1(CC[C@@]2([C@H]3CC[C@@]4(C(CC[C@@H]4[C@@H]3CC(C2=C1)=O)=O)C)C)=O
(2)InChI: InChI=1/C19H24O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14H,3-8,10H2,1-2H3/t12-,13-,14-,18+,19-/m0/s1

Product Name

Androst-4-ene-3,6,17-trione

Synthetic route

Androst-4-ene-3,6,17-trione Specification

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