BIS(2,6-DIISOPROPYLPHENYL)CARBODIIMIDE supplier

Name
Bis(2,6-diisopropylphenyl)carbodiimide
EINECS 218-487-5
CAS No. 2162-74-5
Article Data14
CAS DataBase
Density 0.953 g/cm³
Solubility 50μg/L at 20℃
Melting Point 51 °C
Formula C₂₅H₃₄N₂
Boiling Point 477.699 °C at 760 mmHg
Molecular Weight 362.558
Flash Point 235.604 °C
Transport Information
Appearance White to off-white crystalline powder
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms Carbodiimide,bis(2,6-diisopropylphenyl)- (7CI,8CI);Additin RC 8500;Bis(2,6-diisopropylphenyl)carbodiimide;Bis(o,o'-diisopropylphenyl)carbodiimide;Carbo D;EN 160;N,N'-(2,2',6,6'-Tetraisopropyldiphenyl)carbodiimide;N,N'-Bis(2,6-diisopropylphenyl)carbodiimide;Raschig 7000;Stabaxol 1;StabaxolI;Stabaxol I-LF;Stabaxol P 1;Stabilizer 7000;Stabilizer 7000F;
PSA 24.72000
LogP 8.31730

Synthetic route

: 25348-97-4
N,N'-bis(2,6-diisopropylphenyl)thiourea

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

Conditions

Conditions	Yield
With bis(trichloromethyl) carbonate; sodium hydrogencarbonate In ethyl acetate at 20℃; for 0.25h;	95%
With dmap; iodine In tetrahydrofuran at 0 - 20℃; Reagent/catalyst;	90%
With magnesium sulfate; mercury(II) oxide In toluene for 12h; Reflux;	87%

: 201230-82-2
carbon monoxide

: C21H44CoNP3

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

Conditions

Conditions	Yield
In toluene at 20℃; under 760.051 Torr; for 0.166667h; Mechanism;	86%

: 28178-42-9
2,6-diisopropylphenyl isocyanate

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

Conditions

Conditions	Yield
With 3,4-dimethyl-1-phenyl-3-phospholene 1-oxide In xylene for 12h; Heating;	78%
at 150℃;
With methylphospholene oxide at 160 - 170℃;

: 7564-51-4
2,5-dihydro-3-methyl-1-phenyl-1H-phosphole 1-oxide

: 28178-42-9
2,6-diisopropylphenyl isocyanate

A bis(2,6diisopropylphenyl)carbodimide: bis(2,6diisopropylphenyl)carbodimide

B: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

Conditions

Conditions	Yield
	A 1.43 g (79%) B n/a

...Expand

: 24544-04-5
2,6-diisopropylbenzenamine

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / water 2: tetrachloromethane; triphenylphosphine; triethylamine / dichloromethane View Scheme
Multi-step reaction with 2 steps 1: triethylamine / water / Inert atmosphere; Schlenk technique 2: triethylamine; triphenylphosphine / tetrachloromethane; dichloromethane / Inert atmosphere; Schlenk technique View Scheme

: [Cu((methylcarbodiimide)-2,6-diisopropylphenylimidazolium)2]+[BPh4-]

A: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

B: C10H16CuN4(1+)*C24H20B(1-)

Conditions

Conditions	Yield
In chlorobenzene at 90℃; for 2h; Inert atmosphere; Schlenk technique;

: 136551-45-6
2,6-diisopropyl-1-azidobenzene

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diethyl ether / 0.5 h / 20 °C 2: toluene / 0.17 h / 20 °C / 760.05 Torr View Scheme

: 109-99-9
tetrahydrofuran

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 591-51-5
phenyllithium

: 1512828-35-1
[PhC(NC6H4iPr2-2,6)2]Li(THF)

Conditions

Conditions	Yield
In dibutyl ether at 20℃; for 2h;	100%

...Expand

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 75-24-1
trimethylaluminum

: (MeC(N-(2,6-diisopropylphenyl))2)AlMe2

Conditions

Conditions	Yield
In hexane at 20℃; Schlenk technique; Inert atmosphere;	99%
In hexane N2-atmosphere; addn. of soln. of AlMe3 (slight excess) to soln. of carbodiimide, stirring at room temp. for 18 h; evapn.; NMR spectroscopy;	74%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 536-74-3
phenylacetylene

: (E)-N,N'-bis(2,6-diisopropylphenyl)-3-phenylpropiolamidine

Conditions

Conditions	Yield
Stage #1: phenylacetylene With (tri(3,5-dimethylpyrazolyl)borate)CpGd(CH2Ph)(THF) In toluene for 0.5h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In toluene at 110℃; for 22h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Time; Concentration; Inert atmosphere; Glovebox; Schlenk technique;	99%

: 705-31-7
4-trifluoromethylphenylacetylene

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: (E)-N,N'-bis(2,6-diisopropylphenyl)-3-(4-(trifluoromethyl)phenyl)propiolamidine

Conditions

Conditions	Yield
Stage #1: 4-trifluoromethylphenylacetylene With (tri(3,5-dimethylpyrazolyl)borate)CpGd(CH2Ph)(THF) In toluene for 0.5h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In toluene at 110℃; for 22h; Inert atmosphere; Glovebox; Schlenk technique;	99%

: 123-75-1
pyrrolidine

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: (Z)-N,N'-bis(2,6-diisopropylphenyl)pyrrolidine-1-carboximidamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 2h;	99%

: 110-89-4
piperidine

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: (Z)-N,N'-bis(2,6-diisopropylphenyl)piperidine-1-carboximidamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 2h;	99%

: 110-91-8
morpholine

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: (Z)-N,N'-bis(2,6-diisopropylphenyl)morpholine-4-carboximidamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 2h;	99%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: C31H47BN2O2

Conditions

Conditions	Yield
With C37H59AlN2 In neat (no solvent) at 60℃; for 12h; Inert atmosphere;	99%
With C41H57N3Th In benzene-d6 at 70℃; for 6h; Reagent/catalyst; regioselective reaction;	96 %Spectr.
With 9-borabicyclo[3.3.1]nonane dimer In benzene-d6 at 60℃; for 2.5h; Inert atmosphere; Glovebox; Schlenk technique;

: 766-98-3
1-ethynyl-4-fluorobenzene

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: (E)-N,N'-bis(2,6-diisopropylphenyl)-3-(4-fluorophenyl)propiolamidine

Conditions

Conditions	Yield
Stage #1: 1-ethynyl-4-fluorobenzene With (tri(3,5-dimethylpyrazolyl)borate)CpGd(CH2Ph)(THF) In toluene for 0.5h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In toluene at 110℃; for 22h; Inert atmosphere; Glovebox; Schlenk technique;	98%

: 4298-52-6
2-ethynyl-thiophene

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: (E)-N,N'-bis(2,6-diisopropylphenyl)-3-(2-thiophenyl)propiolamidine

Conditions

Conditions	Yield
Stage #1: 2-ethynyl-thiophene With (tri(3,5-dimethylpyrazolyl)borate)CpGd(CH2Ph)(THF) In toluene for 0.5h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In toluene at 110℃; for 22h; Inert atmosphere; Glovebox; Schlenk technique;	98%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 693-02-7
hex-1-yne

: (E)-N,N'-bis(2,6-diisopropylphenyl)-3-n-butylpropiolamidine

Conditions

Conditions	Yield
Stage #1: hex-1-yne With (tri(3,5-dimethylpyrazolyl)borate)CpGd(CH2Ph)(THF) In toluene for 0.5h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In toluene at 110℃; for 22h; Inert atmosphere; Glovebox; Schlenk technique;	98%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: (tri(3,5-dimethylpyrazolyl)borate)CpGdC≡CPh(THF)

: C53H66BGdN8

Conditions

Conditions	Yield
In tetrahydrofuran at 55℃; for 12h; Inert atmosphere; Glovebox;	97%

: 766-96-1
4-bromo-1-ethynylbenzene

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: (E)-3-(4-bromophenyl)-N,N'-bis(2,6-diisopropylphenyl)propiolamidine

Conditions

Conditions	Yield
Stage #1: 4-bromo-1-ethynylbenzene With (tri(3,5-dimethylpyrazolyl)borate)CpGd(CH2Ph)(THF) In toluene for 0.5h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In toluene at 110℃; for 22h; Inert atmosphere; Glovebox; Schlenk technique;	97%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 2213-43-6
1-Aminopiperidine

: 1255649-91-2
(2,6-iPr2C6H3)NC(Npip)N(2,6-iPr2C6H3)

Conditions

Conditions	Yield
With [Al(NMe2)3]2 In toluene at 120℃; for 4h; Inert atmosphere;	95%

: 931-48-6
2-cyclohexylacetylene

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: (E)-3-cyclohexyl-N,N'-bis(2,6-diisopropylphenyl)propiolamidine

Conditions

Conditions	Yield
Stage #1: 2-cyclohexylacetylene With (tri(3,5-dimethylpyrazolyl)borate)CpGd(CH2Ph)(THF) In toluene for 0.5h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In toluene at 110℃; for 22h; Inert atmosphere; Glovebox; Schlenk technique;	95%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 4333-62-4
1,3-dimethylimidazolim iodide

: (methylcarbodiimide)-2,6-diisopropylphenylimidazolium

Conditions

Conditions	Yield
Stage #1: 1,3-dimethylimidazolim iodide With potassium tert-butylate In tetrahydrofuran at -78 - 20℃; for 0.166667h; Inert atmosphere; Schlenk technique; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In tetrahydrofuran at 20℃; Inert atmosphere; Schlenk technique;	95%

: 79-37-8
oxalyl dichloride

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: C27H34Cl2N2O2

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 4h; Inert atmosphere; Schlenk technique;	95%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 64-19-7
acetic acid

A: 16637-13-1
N-(2,6-diisopropylphenyl) acetamide

B: 28178-42-9
2,6-diisopropylphenyl isocyanate

Conditions

Conditions	Yield
In benzene for 3h; Heating;	A 94% B n/a

...Expand

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 768-60-5
4-methoxyphenylacetylen

: (E)-N,N'-bis(2,6-diisopropylphenyl)-3-(4-methoxyphenyl)propiolamidine

Conditions

Conditions	Yield
Stage #1: 4-methoxyphenylacetylen With (tri(3,5-dimethylpyrazolyl)borate)CpGd(CH2Ph)(THF) In toluene for 0.5h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In toluene at 110℃; for 22h; Inert atmosphere; Glovebox; Schlenk technique;	94%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 766-97-2
4-n-methylphenylacetylene

: (E)-N,N'-bis(2,6-diisopropylphenyl)-3-(p-tolyl)propiolamidine

Conditions

Conditions	Yield
Stage #1: 4-n-methylphenylacetylene With (tri(3,5-dimethylpyrazolyl)borate)CpGd(CH2Ph)(THF) In toluene for 0.5h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In toluene at 110℃; for 22h; Inert atmosphere; Glovebox; Schlenk technique;	94%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 55853-40-2
tin(II) dimethylamide

: C54H80N6Sn

Conditions

Conditions	Yield
In tetrahydrofuran at -78 - 20℃; for 2h; Inert atmosphere; Schlenk technique;	94%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 107-92-6
butyric acid

A: 28178-42-9
2,6-diisopropylphenyl isocyanate

B: 113416-63-0
N-(2,6-diisopropylphenyl)butanamide

Conditions

Conditions	Yield
In benzene for 3h; Heating;	A n/a B 92%

...Expand

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 536-74-3
phenylacetylene

: N,N′-bis(2,6-di-isopropylphenyl)-2-phenylethynylamidine

Conditions

Conditions	Yield
Stage #1: phenylacetylene With [2-(tBuN=CH)C8H5N]Sm[N(SiMe3)2]2 In tetrahydrofuran for 0.5h; Inert atmosphere; Schlenk technique; Glovebox; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In toluene at 110℃; for 40h; Concentration; Inert atmosphere; Glovebox;	92%
With [(tetrahydrofuran)2Sr{N(SiMe3)2}2] In tetrahydrofuran-d8; benzene-d6 at 100℃; for 48h; Catalytic behavior; Temperature;	71%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 3585-33-9
lithium dimethylamide

: 1805-37-4
2,3-bis(2,6-diisopropylphenyl)-1,1-dimethylguanidine

Conditions

Conditions	Yield
In tetrahydrofuran at -78 - 20℃; for 2h; Inert atmosphere;	92%

: 1785-61-1
1,3-diethynylbenzene

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: (1E,1'E)-3,3'-(1,3-phenylene)bis(N,N'-bis(2,6-diisopropylphenyl)propiolamidine)

Conditions

Conditions	Yield
Stage #1: 1,3-diethynylbenzene With (tri(3,5-dimethylpyrazolyl)borate)CpGd(CH2Ph)(THF) In toluene for 0.5h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In toluene at 110℃; for 36h; Inert atmosphere; Glovebox; Schlenk technique;	91%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 108-18-9
diisopropylamine

: 1119723-22-6, 910608-83-2
PrisoH

Conditions

Conditions	Yield
Stage #1: diisopropylamine With n-butyllithium In tetrahydrofuran; hexanes at 20℃; Inert atmosphere; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In tetrahydrofuran; hexanes Reflux; Inert atmosphere;	90%

: (tri(3,5-dimethylpyrazolyl)borate)Y(benzyl)2(tetrahydrofuran)

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: C54H70BN8Y

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 12h; Inert atmosphere;	90%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 1,3-bis(cyclohexyl)imidazolium tetrafluoroborate

: (cyclohexanecarbodiimide)-2,6-diisopropylphenylimidazolium

Conditions

Conditions	Yield
Stage #1: 1,3-bis(cyclohexyl)imidazolium tetrafluoroborate With potassium tert-butylate In tetrahydrofuran at -78 - 20℃; Inert atmosphere; Schlenk technique; Stage #2: N,N'-bis(2,6-diisopropylphenyl)carbodiimide In tetrahydrofuran Inert atmosphere; Schlenk technique;	90%

: 2162-74-5
N,N'-bis(2,6-diisopropylphenyl)carbodiimide

: 542-63-2
diethylberyllium

: 109-66-0
pentane

: [EtC(N(2,6-i-Pr2-C6H3))2]2Be*pentane

Conditions

Conditions	Yield
at -78 - 25℃; Inert atmosphere;	90%

...Expand

BIS(2,6-DIISOPROPYLPHENYL)CARBODIIMIDE Chemical Properties

Product Name:Bis-(2,6-diisopropylphenyl)carbodiimide(2162-74-5)
CAS No:2162-74-5
Molecular Formula : C₂₅H₃₄N₂Molecular Formula:362.55
CBNumber : CB1347186
Formula Weight : 362.55
MP : 51 °C
Synonyms of Bis-(2,6-diisopropylphenyl)carbodiimide(2162-74-5):BIS(2,6-DIISOPROPYLPHENYL)CARBODIIMIDE;(2,6-diisopropylphenyl)carbodiimide;2,2’,6,6’-Tetraisopropyldiphenylcarbodiimide;bis(2,6-diisopropylphenyl)-carbodiimid;carbod;n,n’-methanetetraylbis(2,6-bis(1-methylethyl)-benzenamin;n,n’-methanetetraylbis(2,6-bis(1-methylethyl)benzenamine);n,n’-methanetetraylbis[2,6-bis(1-methylethyl)-benzenamin
Molecular Structure of Bis-(2,6-diisopropylphenyl)carbodiimide(2162-74-5):

BIS(2,6-DIISOPROPYLPHENYL)CARBODIIMIDE Toxicity Data With Reference

1.	orl-rat LD50:200 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0545280 .
2.	ihl-rat LCLo:100 mg/m3/6H	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0545280 .
3.	ipr-rat LD50:200 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0545280 .
4.	ihl-mus LCLo:1 g/m3/1H	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0545280 .
5.	ihl-rbt LCLo:100 mg/m3/6H	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0545280 .
6.	ihl-gpg LCLo:100 mg/m3/6H	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0545280 .

BIS(2,6-DIISOPROPYLPHENYL)CARBODIIMIDE Safety Profile

A poison by ingestion, intraperitoneal, and inhalation. When Bis-(2,6-diisopropylphenyl)carbodiimide was heated to decomposition, it emits toxic vapors of NO_x.
Risk Statements 36/37/38
Safety Statements 26-36/37/39
RTECS CY0887250

Product Name

Bis(2,6-diisopropylphenyl)carbodiimide

Synthetic route

BIS(2,6-DIISOPROPYLPHENYL)CARBODIIMIDE Chemical Properties

BIS(2,6-DIISOPROPYLPHENYL)CARBODIIMIDE Toxicity Data With Reference

BIS(2,6-DIISOPROPYLPHENYL)CARBODIIMIDE Safety Profile

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