Benazepril supplier | CasNO.86541-75-5

Name
Benazepril
EINECS
CAS No. 86541-75-5
Article Data4
CAS DataBase
Density 1.26 g/cm³
Solubility
Melting Point 133-135°C(lit.)
Formula C₂₄H₂₈N₂O₅
Boiling Point 691.2 °C at 760 mmHg
Molecular Weight 424.497
Flash Point 371.8 °C
Transport Information
Appearance
Safety 22-24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1H-1-Benzazepine-1-aceticacid, 3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-,[S-(R*,R*)]-;Benapril;Briem;Cibacen;Cibacen WS;Cibacene;[(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid;1H-1-benzazepine-1-acetic acid, 3-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3S)-;acide [(3S)-3-{[(1S)-1-(éthoxycarbonyl)-3-phénylpropyl]amino}-2-oxo-2,3,4,5-tétrahydro-1H-1-benzazépin-1-yl]acétique;
PSA 95.94000
LogP 3.02900

Benazepril History

According to a 2006 article in the New England Journal of Medicine, patients with advanced renal insufficiency taking benazepril showed "substantial" kidney benefits.
This study marks the first indication that benazepril, and perhaps other ACE inhibitors, may actually be beneficial in the treatment of hypertension in patients with kidney disease.

Benazepril Specification

The Benazepril, with the CAS registry number 86541-75-5, has the systematic name of 2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid. It belongs to the product categories of Active Pharmaceutical Ingredients and Antihypertensive. The molecular formula of this chemical is C₂₄H₂₈N₂O₅. What's more, it is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. In addition, while dealing with this chemical, you should not breathe dust and then try to avoid contacting with skin and eyes.

The physical properties of Benazepril are as following: (1)ACD/LogP: 3.86; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.75; (4)ACD/LogD (pH 7.4): 0.31; (5)ACD/BCF (pH 5.5): 3.95; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 23.39; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 7; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 10; (12)Polar Surface Area: 76.15 Å²; (13)Index of Refraction: 1.607; (14)Molar Refractivity: 116.09 cm³; (15)Molar Volume: 335.8 cm³; (16)Polarizability: 46.02×10^-24cm³; (17)Surface Tension: 58.9 dyne/cm; (18)Density: 1.26 g/cm³; (19)Flash Point: 371.8 °C; (20)Enthalpy of Vaporization: 106.37 kJ/mol; (21)Boiling Point: 691.2 °C at 760 mmHg; (22)Vapour Pressure: 4.69E-20 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(OCC)[C@@H](N[C@@H]2C(=O)N(c1ccccc1CC2)CC(=O)O)CCc3ccccc3
(2)InChI: InChI=1/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1
(3)InChIKey: XPCFTKFZXHTYIP-PMACEKPBBT

Product Name

Benazepril

Benazepril History

Benazepril Specification

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