-
Name
Bipariden
- EINECS 208-184-6
- CAS No. 514-65-8
- Article Data3
- CAS DataBase
- Density 1.105 g/cm3
- Solubility water: 25.1 mg/L
- Melting Point 114 °C
- Formula C21H29NO
- Boiling Point 462.1 °C at 760 mmHg
- Molecular Weight 311.467
- Flash Point 224.5 °C
- Transport Information
- Appearance
- Safety
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms 1-Piperidinepropanol,a-5-norbornen-2-yl-a-phenyl- (6CI,7CI,8CI);Akineton;KL 373;a-(Bicyclo[2.2.1]hept-5-en-2-yl)-a-phenyl-1-piperidinopropanol;a-5-Norbornen-2-yl-a-phenyl-1-piperidinepropanol;
- PSA 23.47000
- LogP 3.90030
Bipariden Chemical Properties
IUPAC Name: 1-(6-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol
Synonyms: 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol ;1-Bicycloheptenyl-1-phenyl-3-piperidinopropanol ;1-Piperidinepropanol, alpha.-bicyclo[2.2.1]hept-5-en-2-yl-.alpha.-phenyl- ; 1-Piperidinepropanol, a-bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl- ; 1-Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl- ; 3-Piperidino-1-phenyl-(D5-bicyclo[2.2.1]hepten-2-yl)-1-propanol ; A-5-Norbornen-2-yl-a-phenyl-1-piperidinepropanol ; A-Bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-1-piperidinepropanol
Molecular Structure of Biperiden (CAS NO. 514-65-8) : 
Molecular Formula of Biperiden (CAS NO. 514-65-8) : C21H29NO
Molecular Weight of Biperiden (CAS NO. 514-65-8) : 311.46
CAS NO: 514-65-8
EINECS: 208-184-6
Mol File: 514-65-8.mol
Melting point 114 ºC
Water solubility 25.1 mg/L
Index of Refraction: 1.582
Surface Tension: 46.9 dyne/cm
Density: 1.105 g/cm3
Flash Point: 224.5 °C
Enthalpy of Vaporization: 76.19 kJ/mol
Boiling Point: 462.1 °C at 760 mmHg
Vapour Pressure: 2.45E-09 mmHg at 25°C
Appearance: crystal.
Solubility: easily soluble in water, slightly soluble in ethanol, soluble in methanol
Bipariden Uses
Biperiden (CAS NO. 514-65-8) is used for the anti-Parkinson drugs and antispasmodic drugs.
Bipariden Production
With cyclopentadiene as raw materials, first the synthesis with chlorethylene to get Chloro-bicyclo heptene, and then reaction with Magnesium and Ether, producing Magnesium chloride of bicyclo heptene, the last condensation with β-piperidine phenyl acetone,then Biperiden (CAS NO. 514-65-8) is derived.
Bipariden Toxicity Data With Reference
| 1. | orl-rat LD50:750 mg/kg | NIIRDN Drugs in Japan. Ethical Drugs, 6th Edition 1982. 6 (1982),636. | ||
| 2. | orl-mus LD50:530 mg/kg | NIIRDN Drugs in Japan. Ethical Drugs, 6th Edition 1982. 6 (1982),636. | ||
| 3. | ipr-mus LD50:161 mg/kg | NIIRDN Drugs in Japan. Ethical Drugs, 6th Edition 1982. 6 (1982),636. | ||
| 4. | orl-dog LD50:340 mg/kg | NIIRDN Drugs in Japan. Ethical Drugs, 6th Edition 1982. 6 (1982),636. | ||
| 5. | scu-mus LD50:195 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 128 (1960),204. | ||
| 6. | ivn-mus LD50:56 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 128 (1960),204. |
Bipariden Safety Profile
Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition, it emits toxic fumes of NOx.
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