Bis(tributyltin) oxide supplier

Name
Bis(tributyltin) oxide
EINECS 200-268-0
CAS No. 56-35-9
Article Data71
CAS DataBase
Density 1.17g/mLat 25°C(lit.)
Solubility insoluble in water
Melting Point -45 °C
Formula C₂₄H₅₄OSn₂
Boiling Point 474.847 °C at 760 mmHg
Molecular Weight 596.112
Flash Point 240.979 °C
Transport Information UN 2788
Appearance Clear colorless liquid
Safety 35-36/37/39-45-60-61
Risk Codes 21-25-36/38-48/23/25-50/53
Molecular Structure
Hazard Symbols T,N
Synonyms Bis(tributyltin)oxide (6CI);Distannoxane, hexabutyl- (8CI,9CI);6-Oxa-5,7-distannaundecane,5,5,7,7-tetrabutyl-;Aceto TBTO;BioMeT 66;BioMeT SRM;BioMeT TBTO;Bis(tributylstannic oxide);Bis(tributylstannyl) ether;Bis(tributylstannyl)oxide;Butinox;Di-tributyl tin oxide;Distannoxane,1,1,1,3,3,3-hexabutyl-;Hexabutyldistannoxane;Hexabutylditin oxide;Intercide 340A;Lastanox F;Lastanox Q;Lastanox Q1;Lastanox Super;Lastanox T;Lastanox T 20;MT 1E;Mykolastanox F;NSC 22332;NSC 28132;Oxybis(tributylstannane);Oxybis[tributyltin];Stannicide A;Stannicide O;TBTO;TnBTO;Tri-n-butyltin oxide;Tributyltin oxide;Vikol AF25;Vikol LO 25;
PSA 9.23000
LogP 9.69460

Synthetic route

: 5035-69-8
bis(tributyltin) carbonate

A: 124-38-9
carbon dioxide

B: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In not given tin compd. was heated at 65°C under vac.;	A n/a B 100%

: (C4H9)3SnOCH(N(C2H5)2)CHCHC6H5

A: C6H5CH(N(C2H5)2)CHCHN(C2H5)2

B: 104-55-2
3-phenyl-propenal

C: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
decompn. at 25°C within 8 h;	A 75.3% B n/a C n/a
decompn. at 25°C within 8 h;	A 75.3% B n/a C n/a

...Expand

: 73622-44-3
β-(cyclohexylthio)ethyl tri-n-butyltin sulfide

A: 10160-81-3
β-(cyclohexylthio)ethyl mercaptan

B: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
With silica gel In dichloromethane; pentane	A 64% B 27%

: 994-89-8
tributylethynyltin

: 88016-29-9
μ-oxobis[(trifluoromethanesulfonato)(phenyl)iodine]

A: 125803-61-4
ethynylphenyl-iodonium-1,1,1-trifluoromethanesulfonate

B: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In dichloromethane at 0℃; for 0.5h;	A 56% B n/a

...Expand

: 1-Diaethylamino-1-tributylstannyloxy-cyclopentan

A: 34969-48-7
1-(N,N-diethylamino)cyclopentene

B: 17851-95-5
(CH3CH2CH2CH2)3SnOC5H7

C: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
byproducts: H2O, NH(C2H5)2; decompn. at 100°C for 6 h;	A 56% B 5% C n/a
byproducts: H2O, NH(C2H5)2; decompn. at 100°C for 6 h;	A 56% B 5% C n/a

...Expand

: 109-72-8, 29786-93-4
n-butyllithium

: (hydroxy)-di-n-butyltin(IV)methanesulfonate

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether under N2, Schlenk setup, 1:1 mixt., n-BuLi soln. in THF added to soln. of tin compd. in Et2O (1:1), stirred for 10 h at room temp.; water added, org. layer septd., dried (Na2SO4), evapd., elem. anal.;	55%

: 28483-60-5
Acetonyltributylstananne

: 38900-20-8
(C4H9)3SnN(C2H5)Sn(C4H9)3

A: 61385-73-7
(C4H9)3SnCH2C(CH3)N(C2H5)

B: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
	A 40% B n/a
	A 40% B n/a

...Expand

: 7732-18-5
water

: 813-19-4
bis(tri-n-butyltin)

: phenyleuropium iodide

A: 960-16-7
tributylphenylstannane

B: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In tetrahydrofuran under Ar; addn. of freshly prepd. THF soln. of PhEuI to mixt. of THF and Bu3SnSnBu3, mixing at 25°C for 3 h, decompn. of react. mixt. with water acidified with HCl; thin layer chromy.;	A 25% B 23%

...Expand

: 688-73-3
tri-n-butyl-tin hydride

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
CpFe(CO)2(Ph3P)Me In not given heating for 48 h at 90°C;	5%
dicarbonyl(cyclopentadienyl)methyliron(II) In not given Irradiation (UV/VIS); for 12 h at ambient temp.;	1%
methyl-tricarbonyl(η-cyclopentadienyl)molybdenum In not given Irradiation (UV/VIS); for 12 h at ambient temp.;	1%

: 1461-22-9
tributyltin chloride

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
With sodium hydroxide
Multi-step reaction with 2 steps 1: tetrahydrofuran 2: air View Scheme
Multi-step reaction with 2 steps 1: hexane View Scheme

: 3524-73-0
5-methyl-1-hexene

: 765-03-7
1-dodecyne

: 1461-22-9
tributyltin chloride

: 280-64-8
9-bora-bicyclo[3.3.1]nonane

A: 35354-39-3
(Z)-2-Methyl-7-octadecen

B: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 1613-37-2
Quinoline N-oxide

: 688-73-3
tri-n-butyl-tin hydride

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In not given byproducts: H2O;

: 4053-40-1
4-methylquinoline 1-oxide

: 688-73-3
tri-n-butyl-tin hydride

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In not given byproducts: H2O;

: 1461-22-9
tributyltin chloride

: 7732-18-5
water

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In water (CH3(CH2)3)3SnCl hydrolyzed; recrystd. from benzene;

: 85938-52-9
Na(1+)*OSn(C4H9)3(1-)=NaOSn(C4H9)3

: 1461-22-9
tributyltin chloride

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In methanol; toluene byproducts: NaCl; (Ar); Schlenk tube technique; Bu3SnCl in toluene was added dropwise to NaOSn(C4H9)3 in methanol; mixt. was refluxed for 6 h; NaCl was centrifuged; solvent was removed in vac.; residue was distd. under reduced pressure; elem. anal.;

: 694-59-7
pyridine N-oxide

: 688-73-3
tri-n-butyl-tin hydride

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In not given byproducts: H2O;

: tetrabutoxytitanium

: 102-71-6
triethanolamine

: 56-36-0
tributyltin acetate

A: {(C4H9)3SnOTi(OCH2CH2)3N}*{N(CH2CH2O)3TiOTi(OCH2CH2)3N}

B: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In toluene equimolar amts.;
In toluene equimolar amts.;

...Expand

: 1067-97-6
tributyltin hydroxide

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
byproducts: H2O;
byproducts: H2O; on melting;

: 5764-62-5
tributyl-trichloromethyl-stannane

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In not given byproducts: CHCl3; hydrolysis;;
In not given byproducts: CHCl3; hydrolysis;;

: 23897-61-2
tributyl-tribromomethyl-stannane

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In not given byproducts: CHBr3; hydrolysis;;
In not given byproducts: CHBr3; hydrolysis;;

: 31126-39-3
Phenylsulfonylmethyl-tri-n-butylzinn

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
With air
With air
With air

: 64307-51-3
(C4H9)3SnONC(NH2)CH3

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
distn. at 180°C / 0.1 Torr;
distn. at 180°C / 0.1 Torr;

: 21001-95-6
Ethyl-(tributyl-stannyl)-sulfit

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
With water byproducts: C2H5OH, SO2;

: 64307-52-4
(C4H9)3SnONC(NH2)C2H5

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
distn. at 180°C / 0.1 Torr;
distn. at 180°C / 0.1 Torr;

: 681-95-8
4-Methyl-2--pent-2-en

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
With H2O byproducts: CH3COCH2CH(CH3)2; rapid hydrolysis;

: 64307-53-5
(C4H9)3SnONC(NH2)C3H7

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
distn. at 180°C / 0.1 Torr;
distn. at 180°C / 0.1 Torr;

: 1,3-Diphenyl-1-(tri-n-butylstannyloxy)-propen

A: 1083-30-3
dihydrochalcone

B: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
With water hydrolysis;
With H2O hydrolysis;

: 1801-43-0
Tributylzinnester des Acetylglycins

: 100-46-9
benzylamine

A: 3262-56-4
(C6H5CH2NH3)(1+)*(CH3CONHCH2COO)(1-)

B: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In 1,4-dioxane; water dioxane:water=6:1, room temp., 4 h;	A >99 B n/a
In 1,4-dioxane; water dioxane:water=6:1, room temp., 4 h;	A >99 B n/a

...Expand

: 122-60-1
Phenyl glycidyl ether

: 93574-88-0
tributyl(1-chloro-3-phenoxy-2-propanyloxy)stannane

: 56-35-9
bis(tri-n-butyltin)oxide

Conditions

Conditions	Yield
In N,N-dimethyl acetamide const. temp. (+/-1°C) in range 363-393 K in air or nitrogen atmosphere; monitoring by concn. accumulation of chloride ion (potentiometric anal.);

: 96-81-1, 3067-19-4, 7295-89-8, 17916-88-0, 67079-28-1, 98392-56-4
N-acetyl-D,L-valine

: 56-35-9
bis(tri-n-butyltin)oxide

: 1801-45-2
N-acetyl-DL-CH3CH(CH3)CHNHCOO-tri-n-butyltin

Conditions

Conditions	Yield
byproducts: H2O;	100%
byproducts: H2O;	100%
In toluene byproducts: H2O; azeotropic dehydration with toluene; recrystn. (benzene) or sublimation;

: 56-35-9
bis(tri-n-butyltin)oxide

: 4064-06-6
1,2:3,4-di-O-isopropylidene-α-D-galactopyranose

: 58931-11-6
(C4H9)3SnOCH2C7H5O5(CH3)4

Conditions

Conditions	Yield
byproducts: H2O; dehydration of 1:2 mixt. of Bu3SnOSnBu3 and alc.; separation of water by distn. or azeotropic distn. in benzene or toluene;	100%
byproducts: H2O; dehydration of 1:2 mixt. of Bu3SnOSnBu3 and alc.; separation of water by distn. or azeotropic distn. in benzene or toluene;	100%

: 115-17-3
bromal

: 56-35-9
bis(tri-n-butyltin)oxide

: 23897-61-2
tributyl-tribromomethyl-stannane

Conditions

Conditions	Yield
In tetrachloromethane byproducts: (C4H9)3SnOCHO; 23 h;;	100%
In tetrachloromethane byproducts: (C4H9)3SnOCHO; 23 h;;	100%

: 79-10-7
acrylic acid

: 56-35-9
bis(tri-n-butyltin)oxide

: 13331-52-7
tributyltin acrylate

Conditions

Conditions	Yield
In benzene	100%
In benzene	100%
	92%

: 56-35-9
bis(tri-n-butyltin)oxide

: 471-25-0
Propiolic acid

: 7316-46-3
Propiolsaeure-tri-n-butylstannylester

Conditions

Conditions	Yield
In benzene byproducts: H2O, dicarboxylate; mole ratio of (C4H9)3SnOSn(C4H9)3 and carboxylic acid 1:2; at 20°C or at reflux temp. to remove of water formed by azeotropic distn.;	100%

: 56-35-9
bis(tri-n-butyltin)oxide

: 127-06-0
acetone oxime

: 10218-32-3
Isopropylidenaminooxy-tributyl-stannan

Conditions

Conditions	Yield
In toluene 1:2; azeotropic dehydration; 2 h;	100%
In benzene 1:2; azeotropic dehydration; 2 h;	100%
In benzene 1:2; azeotropic dehydration; 2 h;	100%

: 375-22-4
heptafluorobutyric Acid

: 56-35-9
bis(tri-n-butyltin)oxide

: 23716-72-5
Tributyl-heptafluorbutyroxy-zinn

Conditions

Conditions	Yield
byproducts: H2O;	100%
byproducts: H2O;	100%

: 335-67-1
Perfluorooctanoic acid

: 56-35-9
bis(tri-n-butyltin)oxide

: 23716-75-8
Tributyl-perfluoroctanoyloxy-zinn

Conditions

Conditions	Yield
byproducts: H2O;	100%
byproducts: H2O;	100%

: 312-73-2
2-Trifluoromethylbenzimidazole

: 56-35-9
bis(tri-n-butyltin)oxide

: 139591-01-8
1-(tri-n-butylstannyl)-2-trifluoromethylbenzimidazole

Conditions

Conditions	Yield
In benzene to a soln. of imidazole-compd. was added a soln. of Sn-compd., refluxed for 3.5 h; cooled to room temp., evapn., elem. anal.;	100%

: 6270-74-2
3-oxo-1,4-benzothiazin-2-ylacetic acid

: 56-35-9
bis(tri-n-butyltin)oxide

: 24291-36-9
Tributylzinn-dihydro-oxo-benzothiazin-acetat

Conditions

Conditions	Yield
byproducts: H2O;	100%

: 56-35-9
bis(tri-n-butyltin)oxide

: 175689-87-9
N,N'-di(4-hydroxybenzyl)isopthalamide

: 175689-90-4
C6H4(CONHCH2C6H4OSn(C4H9)3)2

Conditions

Conditions	Yield
In toluene byproducts: H2O; stoichiometric ratio, refluxing (20 h); cooling, evapn., drying (vac., 2 h);	100%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 56-35-9
bis(tri-n-butyltin)oxide

: 84839-04-3
(C4H9)3SnONC4H4O2

Conditions

Conditions	Yield
In neat (no solvent) byproducts: H2O; heating in 2/1 ratio and gradually evacuating (50-1 mm) for 30-40 min; IR; elem.anal.;	99.7%
In neat (no solvent) byproducts: H2O; heating; elem. anal.;	99.7%
heating;	>99
heating;	>99

: 11113-50-1
boric acid

: 56-35-9
bis(tri-n-butyltin)oxide

: 57754-92-4
(C4H9)3SnOB(OH)2

Conditions

Conditions	Yield
byproducts: H2O; B(OH)3 excess; 160°C;	99%
byproducts: H2O; B(OH)3 excess; 160°C;	99%

: 56-35-9
bis(tri-n-butyltin)oxide

: 79428-56-1
1,2,3-tris(tributyltinoxy) propane

Conditions

Conditions	Yield
With glycerol In neat (no solvent) glycerol to bis(tributyltin) oxide ratio 2:3; mixed, heated at 100-150°C for 1 h at P=50 mm; evacuated to P=1 mm for 0.5 h, heated at 190-220°C; distd., IR, elem. anal.;	99%

: 108-98-5
thiophenol

: 56-35-9
bis(tri-n-butyltin)oxide

: 17314-33-9
tributyltin phenyl sulfide

Conditions

Conditions	Yield
In toluene byproducts: H2O; mixt. of (Bu3Sn)2O and PhSH (1:2 molar ratio) refluxed (12 h) in toluenewith removal of H2O (Dean-Stark apparatus); toluene removed (vac.); residue distd. (vac.);	99%
In toluene byproducts: H2O; refluxing for 2 h, removing H2O with a water separator;	80%

: 613-92-3
N-hydroxybenzenecarboximidamide

: 56-35-9
bis(tri-n-butyltin)oxide

: 64307-54-6
(C4H9)3SnONC(NH2)C6H5

Conditions

Conditions	Yield
In benzene 1:2; azeotropic dehydration; 2 h;	99%
In benzene 1:2; azeotropic dehydration; 2 h;	99%

: 110-91-8
morpholine

: 541-59-3
maleiimide

: 56-35-9
bis(tri-n-butyltin)oxide

: 79430-48-1
(C4H9)3Sn(C8H11N2O3)

Conditions

Conditions	Yield
In methanol amine and maleimide added to soln. of trialkyltin oxide in CH3OH (molar ratio 10:2:1), refluxed for half h; evapn.;	99%

...Expand

: 1122-10-7
2,3-dibromomaleimide

: 56-35-9
bis(tri-n-butyltin)oxide

: 79430-51-6
N-tributylstannyl-2,3-dibromomaleimide

Conditions

Conditions	Yield
In not given byproducts: H2O; solvent toluene or heptane; azeotropic removal water and solvent, recrystn.; elem. anal.;	99%
In water; benzene to a soln. of (Bu3Sn)2O in benzene was added imide in water (molar ratio oxide/imide = 1/2); shaking at room temp. for 15-20 min, org. layer was separated, water layer washed with benzene; org. layers were combined; drying over MgSO4, evapn.;	96%

: N-(5-bromine-2-hydroxysalicylidene)-(D,L)-β-phenylalanine

: 56-35-9
bis(tri-n-butyltin)oxide

: C28H40BrNO4Sn

Conditions

Conditions	Yield
In methanol at 25℃; for 24h;	99%

: 178978-97-7
5-(3,5-dichlorophenylthio)-4-isopropyl-1-methyl-2-hydroxymethyl-1H-imidazole

: 624-83-9
methyl isocyanate

: 56-35-9
bis(tri-n-butyltin)oxide

: 5-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-2-(N-methylcarbamoyl)oxymethyl-1H-imidazole

Conditions

Conditions	Yield
In tetrahydrofuran	98%

...Expand

: 56-35-9
bis(tri-n-butyltin)oxide

: 56-36-0
tributyltin acetate

Conditions

Conditions	Yield
With acetic acid byproducts: H2O; heating;	98%
With CH3COOH byproducts: H2O; heating;	98%
With acetic acid In benzene byproducts: H2O;

: 10221-56-4
bis(pinacolato)diborane

: 56-35-9
bis(tri-n-butyltin)oxide

: 40276-78-6
(C4H9)3SnOBO2C2(CH3)4

Conditions

Conditions	Yield
1:1; 130°C; distn.;	98%
1:1; 130°C; distn.;	98%

: 56-35-9
bis(tri-n-butyltin)oxide

: 24978-39-0
2,2'-bis-(1,2-dihydro-4-oxo-3,1-benzoxazine)

: {(C4H9)3Sn(OOCC6H4NCH)}2

Conditions

Conditions	Yield
In benzene byproducts: H2O; in refluxing benzene; H2O was removed as azeotrope of benzene; elem. anal.;	98%

: 84839-05-4
(β-carboxyethyl)diallylisocyanurate

: 56-35-9
bis(tri-n-butyltin)oxide

: 84838-98-2
diallyl 2-[(tributylstannyloxy)carbonyl]ethyl isocyanurate

Conditions

Conditions	Yield
In neat (no solvent) byproducts: H2O; heating in 2/1 ratio and gradually evacuating (50-1 mm) for 30-40 min; IR; elem.anal.;	98%
In neat (no solvent) byproducts: H2O; heating; elem. anal.;	98%

: HOOCC6I4COOCH2CH(C6H13)C8H17

: 56-35-9
bis(tri-n-butyltin)oxide

: 31434-88-5
(C4H9)3SnOOCC6I4COOCH2CH(C6H13)C8H17-2

Conditions

Conditions	Yield
In benzene byproducts: H2O; 1:2 mole ratio; azeotropic removal of water;	98%
In toluene byproducts: H2O; 1:2 mole ratio; azeotropic removal of water;	98%
In toluene byproducts: H2O; 1:2 mole ratio; azeotropic removal of water;	98%
In benzene byproducts: H2O; 1:2 mole ratio; azeotropic removal of water;	98%

trimethylacetaldoximoyl chloride: trimethylacetaldoximoyl chloride

: 105-37-3
Ethyl propionate

: 56-35-9
bis(tri-n-butyltin)oxide

: 2207-46-7
3-tert-butyl-isoxazole-5-carboxylic acid ethyl ester

Conditions

Conditions	Yield
In toluene	97%
In toluene	97%

...Expand

: 762-04-9
phosphonic acid diethyl ester

: 56-35-9
bis(tri-n-butyltin)oxide

: 108890-21-7
O-ethyl-O'-tri-n-butylstannyl phosphonate

Conditions

Conditions	Yield
In neat (no solvent) byproducts: diethylether; (Ar); addn. of TBTO to phosphonate with stirring, heating to 10°C (4 h); concn. in vac. at 40-80°C; elem. anal.;	97%
In not given (Ar); excess of diethylphosphonate; (31)P-NMR spectroscopic monitoring;

: 102-09-0
bis(phenyl) carbonate

: 56-35-9
bis(tri-n-butyltin)oxide

: 3587-18-6
tributyltin phenoxide

Conditions

Conditions	Yield
by heating at 140°C for 1 h;	97%
by heating at 90-100°C for 1.25 h;	97%
by heating at 140°C for 1 h;	97%
by heating at 90-100°C for 1.25 h;	97%

: 4656-04-6
bis(trimethylsilyl)mercury

: 56-35-9
bis(tri-n-butyltin)oxide

A: 813-19-4
bis(tri-n-butyltin)

B: 17908-18-8
Bu3SnOSiMe3

Conditions

Conditions	Yield
In hexane byproducts: Hg; 2:1; 25°C; 0.2 h;	A n/a B 97%
In benzene byproducts: Hg; 2:1; 25°C; 0.2 h;	A n/a B 97%
In benzene byproducts: Hg; 2:1; 25°C; 0.2 h;	A n/a B 97%
In hexane byproducts: Hg; 2:1; 25°C; 0.2 h;	A n/a B 97%

...Expand

Bis(tributyltin) oxide Consensus Reports

BIS(TRIBUTYL TIN)OXIDE is reported in EPA TSCA Inventory.

Bis(tributyltin) oxide Standards and Recommendations

OSHA PEL: TWA 0.1 mg(Sn)/m³ (skin)
ACGIH TLV: TWA 0.1 mg(Sn)/m³; STEL 0.2 mg(Sn)/m³ (skin).
DFG MAK: 0.0021 ppm (0.05 mg/m³)
NIOSH REL: (Organotin Compounds) TWA 0.1 mg(Sn)/m³

Bis(tributyltin) oxide Analytical Methods

For occupational chemical analysis use NIOSH: Organotin Compounds 5504.

Bis(tributyltin) oxide Specification

1. Introduction of Bis(tributyltin) oxide
The Tributyltin oxide, with the CAS registry number 56-35-9, is also known as Bis(tri-n-butyltin)oxide. It belongs to the product categories of Industrial/Fine Chemicals; Organometallics. Its IUPAC name is called tributyl(tributylstannyloxy)stannane. This chemical's classification codes are Agricultural Chemical; Anti-Infective Agents; Disinfectants; Fungicide, bactericide, wood preservative; Fungicides, industrial; Immunologic Factors; Immunosuppressive agents; Molluscicide; Mutation data; Organometallic; Pesticides; Reproductive Effect; Skin / Eye Irritant; Tumor data.

2. Properties of Bis(tributyltin) oxide
(1)ACD/LogP: 3.84; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 5; (4)ACD/LogD (pH 7.4): 5; (5)ACD/BCF (pH 5.5): 3840; (6)ACD/BCF (pH 7.4): 3840; (7)ACD/KOC (pH 5.5): 12801; (8)ACD/KOC (pH 7.4): 12801; (9)#H bond acceptors: 1; (10)#Freely Rotating Bonds: 20; (11)Flash Point: 240.979 °C; (12)Enthalpy of Vaporization: 71.007 kJ/mol; (13)Boiling Point: 474.847 °C at 760 mmHg; (14)Vapour Pressure: 0 mmHg at 25°C.

3. Structure Descriptors of Bis(tributyltin) oxide
(1)Canonical SMILES: CCCC[Sn](CCCC)(CCCC)O[Sn](CCCC)(CCCC)CCCC
(2)InChI: InChI=1S/6C4H9.O.2Sn/c6*1-3-4-2;;;/h6*1,3-4H2,2H3
(3)InChIKey: APQHKWPGGHMYKJ-UHFFFAOYSA-N

4. Toxicity of Bis(tributyltin) oxide

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LCLo	inhalation	200mg/m³ (200mg/m³)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: AGGRESSION LUNGS, THORAX, OR RESPIRATION: DYSPNEA	European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 339, 1976.
mouse	LD50	intraperitoneal	12500ug/kg (12.5mg/kg)		Russian Pharmacology and Toxicology Vol. 42, Pg. 73, 1979.
mouse	LD50	intravenous	6mg/kg (6mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 31, 1976.
mouse	LD50	oral	55mg/kg (55mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 41(5), Pg. 10, 1976.
mouse	LD50	skin	163mg/kg (163mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.
rabbit	LD50	skin	900mg/kg (900mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 31, 1976.
rabbit	LDLo	oral	50mg/kg (50mg/kg)		Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 15, Pg. 3, 1973.
rat	LC50	inhalation	64uL/m³/4H (0.064mL/m³)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	National Technical Information Service. Vol. OTS0572027,
rat	LD50	intraperitoneal	5mg/kg (5mg/kg)	BEHAVIORAL: COMA GASTROINTESTINAL: ALTERATION IN GASTRIC SECRETION	National Technical Information Service. Vol. OTS0571270,
rat	LD50	oral	87mg/kg (87mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1255, 1986.
rat	LD50	skin	> 300mg/kg (300mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	National Technical Information Service. Vol. OTS0571915,

5. Safety Information of Bis(tributyltin) oxide
Hazard Symbols: Toxic T; Dangerous N
Risk Codes:
R21:Harmful in contact with skin.
R25 :Toxic if swallowed.
R36/38:Irritating to eyes and skin.
R23/25:Toxic by inhalation and if swallowed.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description:
S35:This material and its container must be disposed of in a safe way.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.

6. Preparation of Bis(tributyltin) oxide
Bis(tributyltin) oxide can be prepared by anhydrous tin tetrachloride and butyl bromide. This reaction will need reagent KOH.

Sn+2Cl₂ → SnCl₄
C₄H₉OH+HCl → C₄H₉Cl+H₂O
3Mg+3C₄H₉Cl+SnCl₄ → (C₄H₉)₃SnCl+MgCl₂
2(C₄H₉)₃SnCl+2NaOH → C₂₄H₅₄OSn₂+NaCl+H₂O

7. Use of Bis(tributyltin) oxide
Bis(tributyltin) oxide, is an organotin compound chiefly used as a biocide (fungicide and molluscicide), especially a wood preservative. Tributyltin compounds had been used as marine anti-biofouling agents. Concerns over toxicity of these compounds have led to a worldwide ban by the International Maritime Organization. It is now considered a severe marine pollutant.

8. Other details of Bis(tributyltin) oxide
When you are using bis(tributyltin) oxide, please be cautious about it as the following:
Bis(tributyltin) oxide that at low level can cause damage to health. It may present an immediate or delayed danger to one or more components of the environment. In addition, it is irritating to eyes and skin. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

Product Name

Bis(tributyltin) oxide

Synthetic route

Bis(tributyltin) oxide Consensus Reports

Bis(tributyltin) oxide Standards and Recommendations

Bis(tributyltin) oxide Analytical Methods

Bis(tributyltin) oxide Specification

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