Conditions | Yield |
---|---|
With mercury dichloride In ethanol Ambient temperature; | 95% |
With sodium methylate In tetrahydrofuran at 20℃; for 18h; Elimination; | 72% |
With potassium dihydrogenphosphate In ethanol at 40℃; Rate constant; Kinetics; Thermodynamic data; var. buffers, pH, temp., ionic strengh, spironolactone and buffer conc.; energy of activation; |
canrenone
Conditions | Yield |
---|---|
With NH2SO4 In methanol for 0.0833333h; Heating; | 92% |
With hydrogenchloride In chloroform for 8h; Heating; | 86% |
With acetic acid for 0.5h; Heating; |
canrenone
Conditions | Yield |
---|---|
With chloranil In methanol; water; 1,2-dichloro-ethane at 20℃; for 1h; | 84% |
canrenone
Conditions | Yield |
---|---|
Stage #1: 17β-hydroxy-3-ethoxy-17α-pregn-3,5-diene-21-carboxylic acid-γ-lactone With chloranil In methanol; dichloromethane; water at 20℃; for 1h; Stage #2: With sodium thiosulfate In methanol; water at 20℃; for 1h; | 83% |
Conditions | Yield |
---|---|
With chloranil In tert-butyl alcohol Heating; | 70% |
With chloranil; toluene-4-sulfonic acid; xylene |
Conditions | Yield |
---|---|
With mercury dichloride In ethanol for 2h; Heating; | A 38% B 54% |
C22H32O3
canrenone
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 98 percent / trimethyl orthoformate, p-toluenesulfonic acid / methanol / 3 h / 50 °C 2: H2, triphenylphosphine, rhodium acetate dimer / ethyl acetate / 20 h / 80 °C / 9000.7 Torr 3: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h 4: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h 5: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating View Scheme |
17α-ethynyl-17β-hydroxy-5-androsten-3-one ethylene ketal
canrenone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: H2, triphenylphosphine, rhodium acetate dimer / ethyl acetate / 20 h / 80 °C / 9000.7 Torr 2: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h 3: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h 4: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating View Scheme |
5'-hydroxyspiro-5-en-3-one
canrenone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h 2: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h 3: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating View Scheme |
C24H34O4
canrenone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h 2: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating View Scheme |
3-(3-oxo-7α-thio-17β-hydroxy-4-androsten-17α-yl)propionic acid γ-lactone
methyl iodide
A
canrenone
B
7-Thiomethylspirolactone
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 20℃; for 2h; |
3-(3-oxo-7α-thio-17β-hydroxy-4-androsten-17α-yl)propionic acid γ-lactone
canrenone
Conditions | Yield |
---|---|
With sodium methylate; methyl iodide In methanol at 20℃; for 1h; |
SPIRONOLACTONE
A
3-(3-oxo-7α-thio-17β-hydroxy-4-androsten-17α-yl)propionic acid γ-lactone
B
canrenone
Conditions | Yield |
---|---|
With sodium hypochlorite; octabromotetrakis(2,6-dichlorophenyl)porphyrin Fe(III)Cl In water; acetonitrile at 80℃; for 0.833333h; Microwave irradiation; | |
With curvularia lunata Microbiological reaction; |
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium hydroxide / tetrahydrofuran / 6.5 h / 15 - 20 °C / Inert atmosphere 2: 5%-palladium/activated carbon; hydrogen / ethanol / 5 h / 20 - 30 °C / Inert atmosphere 3: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; tetrabutyl-ammonium chloride / dichloromethane / 6 h / 10 - 15 °C 4: pyridine; sodium acetate; acetic acid; N-Bromosuccinimide / acetone; water / 2 h / -2 - 2 °C 5: lithium carbonate; lithium bromide / N,N-dimethyl-formamide / 3 h / 100 - 105 °C View Scheme |
canrenone
Conditions | Yield |
---|---|
With lithium carbonate; lithium bromide In N,N-dimethyl-formamide at 100 - 105℃; for 3h; | 7.8 g |
17,23-dihydroxy-21,24-dinor-17βH-chol-4-en-20-yn-3-one
canrenone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 5%-palladium/activated carbon; hydrogen / ethanol / 5 h / 20 - 30 °C / Inert atmosphere 2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; tetrabutyl-ammonium chloride / dichloromethane / 6 h / 10 - 15 °C 3: pyridine; sodium acetate; acetic acid; N-Bromosuccinimide / acetone; water / 2 h / -2 - 2 °C 4: lithium carbonate; lithium bromide / N,N-dimethyl-formamide / 3 h / 100 - 105 °C View Scheme |
17α-(3-hydroxypropyl)-17β-hydroxy-4-androsten-3-one
canrenone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; tetrabutyl-ammonium chloride / dichloromethane / 6 h / 10 - 15 °C 2: pyridine; sodium acetate; acetic acid; N-Bromosuccinimide / acetone; water / 2 h / -2 - 2 °C 3: lithium carbonate; lithium bromide / N,N-dimethyl-formamide / 3 h / 100 - 105 °C View Scheme |
SPIRONOLACTONE
A
3-(17β-hydroxy-3-oxo-1,4,6-androstadien-17α-yl)propionic acid γ-lactone
B
canrenone
Conditions | Yield |
---|---|
With gibberella fujikuroi for 240h; Microbiological reaction; |
SPIRONOLACTONE
A
15α-hydroxycanrenone
E
3-(3-oxo-7α-thio-17β-hydroxy-4-androsten-17α-yl)propionic acid γ-lactone
F
3-(17β-hydroxy-3-oxo-1,4,6-androstadien-17α-yl)propionic acid γ-lactone
G
canrenone
Conditions | Yield |
---|---|
With aspergillus alliaceus Microbiological reaction; |
SPIRONOLACTONE
A
15α-hydroxycanrenone
E
3-(17β-hydroxy-3-oxo-1,4,6-androstadien-17α-yl)propionic acid γ-lactone
F
canrenone
Conditions | Yield |
---|---|
With fusarium lini Microbiological reaction; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium bromide; C30H31Cl3N3(1+)*BF4(1-); triethylamine / 1,2-dichloro-ethane / 5 h / 20 °C / Inert atmosphere; Sealed tube 2: chloranil / 1,2-dichloro-ethane; methanol; water / 1 h / 20 °C View Scheme |
canrenone
Conditions | Yield |
---|---|
With acetic acid In water; toluene at 0 - 100℃; for 24h; pH=7.1; Temperature; pH-value; Autoclave; Inert atmosphere; | 33.1 g |
canrenone
Conditions | Yield |
---|---|
With methanesulfonyl chloride; triethylamine In dichloromethane at 0℃; for 4h; Temperature; Reagent/catalyst; Solvent; Inert atmosphere; | 8.6 g |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: iodine; mercury dichloride; magnesium / diethyl ether / 0.5 h / 40 °C 1.2: 2.5 h / 0 - 20 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C 2.2: 2 h / 0 - 20 °C 2.3: 1 h / 0 - 20 °C 3.1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C 4.1: chloranil / tert-butyl alcohol / 3 h / 80 °C View Scheme |
21,24-dinor-3β,17β-dihydroxy-chol-5-en-22-yne
canrenone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C 1.2: 2 h / 0 - 20 °C 1.3: 1 h / 0 - 20 °C 2.1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C 3.1: chloranil / tert-butyl alcohol / 3 h / 80 °C View Scheme |
3β,17β-Dihydroxy-5-androsten-17α-propanoic Acid γ-Lactone
canrenone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C 2: chloranil / tert-butyl alcohol / 3 h / 80 °C View Scheme |
canrenone
Conditions | Yield |
---|---|
With chloranil In tert-butyl alcohol at 80℃; for 3h; | 7.9 mg |
formic acid
canrenone
A
C22H27ClO3
B
7α-Chlor-6β-(formyloxy)-17β-hydroxy-3-oxo-4,6-pregnadien-21-carbonsaeure-γ-lacton
Conditions | Yield |
---|---|
With tert-butylhypochlorite for 1h; Ambient temperature; Title compound not separated from byproducts; | A n/a B 91% |
canrenone
4-(t-butyldimethylsilyloxy)-benzyl mercaptan
3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone
Conditions | Yield |
---|---|
With sodium at 45℃; for 0.75h; Addition; | 91% |
canrenone
11α-hydroxyl canrenone
Conditions | Yield |
---|---|
With D-glucose; peptone In water | 90% |
With D-glucose In water for 72h; | 80% |
With D-glucose In water for 72h; | 80% |
N,N-dimethyl(methylene)ammonium chloride
canrenone
Conditions | Yield |
---|---|
In acetonitrile for 24h; Ambient temperature; | 86% |
canrenone
[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanethiol
Conditions | Yield |
---|---|
With sodium at 45℃; for 1h; Addition; | 82% |
canrenone
Conditions | Yield |
---|---|
With Nocardia farcinica NCAIM (P)-B 001342 9α-hydroxylase; 13-ethyl-10,11α-dihydroxy-4-gonene-3,17-dione In methanol; water; N,N-dimethyl-formamide at 30℃; for 16h; Enzymatic reaction; | 82% |
With dipotassium hydrogenphosphate; D-glucose; sodium chloride In methanol; water at 26℃; for 5 - 48h; Conversion of starting material; | |
With dipotassium hydrogenphosphate; D-glucose; sodium chloride In methanol; water at 26℃; for 5 - 48h; Conversion of starting material; |
Conditions | Yield |
---|---|
Stage #1: tiolacetic acid With trifluoromethylsulfonic anhydride In tetrahydrofuran Stage #2: canrenone In tetrahydrofuran at 20℃; for 1h; | 76% |
With trimethylsilyl trifluoromethanesulfonate In tetrahydrofuran at 20℃; for 3h; | 60% |
In water at 20℃; for 2h; Michael addition; |
Conditions | Yield |
---|---|
With sodium at 60℃; for 24h; Addition; | 74% |
Conditions | Yield |
---|---|
titanium tetrachloride In dichloromethane at -70℃; | A 73% B 15% |
Conditions | Yield |
---|---|
With sodium at 60℃; for 24h; Addition; | 72% |
Conditions | Yield |
---|---|
With pyridine for 24h; Heating; | 70% |
Conditions | Yield |
---|---|
With ethanol; boron trifluoride diethyl etherate In nitromethane at -19℃; for 17h; | A 69.5% B 19.8% |
canrenone
Conditions | Yield |
---|---|
With pyridinium hydrobromide perbromide In acetic acid for 1.5h; Ambient temperature; | 69% |
Conditions | Yield |
---|---|
With piperidine at 10℃; | 69% |
With piperidine In methanol at 20℃; for 20h; |
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate In tetrahydrofuran for 1h; Ambient temperature; Yields of byproduct given; | A n/a B 64% |
With trimethylsilyl trifluoromethanesulfonate In tetrahydrofuran for 1h; Ambient temperature; Yield given; | A n/a B 64% |
Conditions | Yield |
---|---|
With sodium at 60℃; for 24h; Addition; | 62% |
Conditions | Yield |
---|---|
With sodium at 60℃; for 24h; Addition; | 59% |
Conditions | Yield |
---|---|
With sodium at 60℃; for 24h; Addition; | 59% |
1-hexene
canrenone
A
(+)-7α-hexyl-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone
B
(+)-7β-hexyl-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone
Conditions | Yield |
---|---|
Stage #1: 1-hexene With Schwartz's reagent In dichloromethane at 20℃; for 0.666667h; Inert atmosphere; Schlenk technique; Stage #2: canrenone With chloro-trimethyl-silane; copper(I) trifluoromethanesulfonate benzene In diethyl ether; dichloromethane at 20℃; for 15h; Inert atmosphere; Schlenk technique; diastereoselective reaction; | A 59% B 21% |
Stage #1: 1-hexene With Schwartz's reagent In dichloromethane at 20℃; for 0.666667h; Inert atmosphere; Stage #2: With C36H30CuNO2P(1+)*CF3O3S(1-) In diethyl ether; dichloromethane at 20℃; for 0.166667h; Inert atmosphere; Stage #3: canrenone With chloro-trimethyl-silane In diethyl ether; dichloromethane at 20℃; for 15h; Inert atmosphere; | A 59% B 21% |
canrenone
γ-lactone of 17α-pregna-4,6-diene-3β,17β-diol-20-carboxylic acid
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol | 56% |
canrenone
Conditions | Yield |
---|---|
With 2,6-di-tert-butyl-4-methyl-phenol; 3-chloro-benzenecarboperoxoic acid In chloroform for 1.66667h; Heating; | 53% |
The CAS registry number of Canrenone is 976-71-6. The IUPAC name is (8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione. Its EINECS registry number is 213-554-5. In addition, the molecular formula is C22H28O3 and the molecular weight is 340.46. It is a kind of pale yellow to pale green solid and belongs to the classes of Spironolacrone; Intermediates & Fine Chemicals; Pharmaceuticals; Steroids. And it is a synthetic pregnadiene compound with anti-aldosterone activity.
Physical properties about this chemical are: (1)ACD/LogP: 2.99; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.99; (4)ACD/LogD (pH 7.4): 2.99; (5)ACD/BCF (pH 5.5): 110.05; (6)ACD/BCF (pH 7.4): 110.05; (7)ACD/KOC (pH 5.5): 1006.86; (8)ACD/KOC (pH 7.4): 1006.86; (9)#H bond acceptors: 3; (10)Polar Surface Area: 43.37 Å2; (11)Index of Refraction: 1.581; (12)Molar Refractivity: 95.22 cm3; (13)Molar Volume: 285.5 cm3; (14)Polarizability: 37.75 ×10-24cm3; (15)Surface Tension: 47.2 dyne/cm; (16)Density: 1.19 g/cm3; (17)Flash Point: 237.6 °C; (18)Enthalpy of Vaporization: 81.89 kJ/mol; (19)Boiling Point: 541.1 °C at 760 mmHg; (20)Vapour Pressure: 8.95E-12 mmHg at 25°C.
Preparation of Canrenone: it can be prepared by potassium canrenoate. This reaction will need reagent NH2SO4 and solvent methanol. The reaction time is 5 minutes by heating. The yield is about 92%.
Uses of Canrenone: it can be used to get 6a,7a-Epoxycanrenone. This reaction will need reagents m-chloroperbenzoic acid and 2,6-di-t-butyl-4-methylphenol and solvent CHCl3. The reaction time is 100 minutes by heating. The yield is about 53%.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C5\C=C4\C=C/[C@@H]1[C@H](CC[C@]3([C@H]1CC[C@]32OC(=O)CC2)C)[C@@]4(C)CC5
(2)InChI: InChI=1/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1
(3)InChIKey: UJVLDDZCTMKXJK-WNHSNXHDBD
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 36, 1990. |
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