Carbobenzyloxy-beta-alanine supplier

Name
Carbobenzyloxy-beta-alanine
EINECS 218-967-4
CAS No. 2304-94-1
Article Data43
CAS DataBase
Density 1.249 g/cm³
Solubility
Melting Point 100-105 °C
Formula C₁₁H₁₃NO₄
Boiling Point 435.9 °C at 760 mmHg
Molecular Weight 223.229
Flash Point 217.4 °C
Transport Information
Appearance White powder
Safety 26-39
Risk Codes 22-41
Molecular Structure
Hazard Symbols Xn
Synonyms b-Alanine, N-carboxy-, N-benzylester (6CI,7CI,8CI);3-(Benzyloxycarbonylamino)propanoic acid;3-[N-(Benzyloxycarbonyl)amino]propionic acid;Carbobenzoxy-b-alanine;N-(Benzyloxycarbonyl)-b-alanine;N-CBZ-b-alanine;N-Carbobenzoxy-b-alanine;N-Carbobenzyloxy-b-alanine;N-[(Phenylmethoxy)carbonyl]-b-alanine;NSC 17161;NSC 28943;NSC 657842;Z-β-Ala-OH;Z-b-Ala-OH;
PSA 75.63000
LogP 1.77840

Synthetic route

: 501-53-1
benzyl chloroformate

: 107-95-9
3-amino propanoic acid

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 0 - 20℃;	99%
With sodium carbonate In 1,4-dioxane; water at 20℃;	96%
With sodium carbonate In 1,4-dioxane; water at 0 - 20℃;	92%

: 34637-22-4
3-[(N-benzyloxycarbonyl)amino]propanol

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
With NADH oxidase; horse liver alcohol dehydrogenase Enzymatic reaction;	10%

: C18H20N4O4*H(1+)

A: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

B: C7H9N3O*H(1+)

Conditions

Conditions	Yield
With L-Phenylalanine amide; sodium chloride; calcium chloride In N,N-dimethyl-formamide at 25℃; for 3h; pH=8; aq. buffer;	A 7.4% B n/a

: 54755-77-0
3-(benzyloxycarbonylamino)-propionic acid methyl ester

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 108-30-5
succinic acid anhydride

: 100-51-6
benzyl alcohol

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
(i) tBu3SnN3, dioxane, (ii) /BRN= 878307/, (iii) aq. NaOH; Multistep reaction;
(i) nBu3SnN3, THF, (ii) /BRN= 878307/; Multistep reaction;

: 3642-91-9
N-carbobenzoxy-β-alanine-p-nitrophenyl ester

A: 100-02-7
4-nitro-phenol

B: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
With 1H-imidazole; water In ethanol at 25℃; Mechanism; Kinetics; phosphate buffer (pH=8.05);

: 4515-23-5
N-benzyloxycarbonyl-L-aspartic acid anhydride

A: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

B: 1142-20-7
N-Cbz-Ala

Conditions

Conditions	Yield
With hydrogenchloride; bis(1,5-cyclooctadiene)nickel (0); N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran for 8h; Product distribution; Heating; Further complex ligands.;
With hydrogenchloride; [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0) 1.) THF, reflux, 8h.; Yield given. Multistep reaction. Yields of byproduct given;
With hydrogenchloride; bis(1,5-cyclooctadiene)nickel (0); N,N,N,N,-tetramethylethylenediamine 1.) THF, reflux, 8h.; Yield given. Multistep reaction. Yields of byproduct given;

: 18605-26-0
3-(((benzyloxy)carbonyl)amino)propionic tert-butyl ester

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
With trifluoroacetic acid for 0.5h;

: 67865-70-7
1-diazo-3-(N-benzyloxycarbonyl)amino-2-propanone

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
silver trifluoroacetate In 1,4-dioxane; water for 0.5h; Wolff rearrangement; sonication;
With silver benzoate In 1,4-dioxane; water at 110℃; under 3102.97 Torr; for 0.0166667h; Wolff rearrangement; Microwave irradiation; Closed vessel;

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: ClCOOEt; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C 1.2: tetrahydrofuran; CH2Cl2 / -15 - 20 °C 2.1: CF3COOAg / dioxane; H2O / 0.5 h / sonication View Scheme

: 501-53-1
benzyl chloroformate

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Et3N / 0.17 h / 20 °C 2: CF3CO2H / 0.5 h View Scheme

: 100-51-6
benzyl alcohol

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine 2: aq.-ethanolic NaOH View Scheme

H-Sta-β-Ala-His-NH2: H-Sta-β-Ala-His-NH2

: 501-53-1
benzyl chloroformate

: 107-95-9
3-amino propanoic acid

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
With hydrogenchloride In sodium hydroxide; toluene

...Expand

: 1093125-18-8
N-(benzyloxycarbonyl)-β-alanine (9-methoxy-3-oxo-3H-benzo[f]benzopyran-1-yl)methyl ester

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
In methanol for 8.55h; Kinetics; Wavelength; Time; UV-irradiation; aq. HEPES buffer;

: 1333386-44-9
N-(benzyloxycarbonyl)-L-β-alanine (6-methoxy-2-oxo-2H-benzo[h]benzopyran-4-yl)methyl ester

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
In methanol for 7.3h; Kinetics; Wavelength; Time; UV-irradiation; aq. HEPES buffer;

: 1254122-51-4
C19H18N2O5

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
With methanol for 0.0566667h; pH=7.2; Kinetics; Wavelength; Time; UV-irradiation; aq. HEPES buffer;

: 1254122-53-6
C23H20N2O5

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
With methanol for 0.08h; pH=7.2; Kinetics; Wavelength; Time; UV-irradiation; aq. HEPES buffer;

: 1254122-55-8
C23H20N2O7

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
With methanol for 0.463333h; pH=7.2; Kinetics; Wavelength; Time; UV-irradiation; aq. HEPES buffer;

: 1254122-57-0
C23H20N2O7

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
With methanol for 0.46h; pH=7.2; Kinetics; Wavelength; Time; UV-irradiation; aq. HEPES buffer;

: 63613-10-5
3-benzyloxycarbonylaminopropionic acid benzyl ester

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In methanol for 1h;

: N-(benzyloxycarbonyl)-β-alanine [11-oxo-2,3,5,6,7,11-hexahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-9-yl]methyl ester

A: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

B: 9-(hydroxymethyl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one

Conditions

Conditions	Yield
In methanol for 0.0666667h; pH=7.2; Quantum yield; Kinetics; Solvent; Time; Wavelength; Irradiation;

: 34637-22-4
3-[(N-benzyloxycarbonyl)amino]propanol

A: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

B: 65564-05-8
3-[(benzyloxycarbonyl)amino]propanal

C: benzyl (3-hydroperoxy-3-hydroxypropyl)carbamate

D: dibenzyl (peroxybis(3-hydroxypropane-3,1-diyl))dicarbamate

Conditions

Conditions	Yield
With chloroperoxidase from C. fumago; dihydrogen peroxide In aq. acetate buffer for 24h; pH=5.0; Kinetics; Time; Enzymatic reaction;	A 1.5 μmol B 11.5 μmol C n/a D 4.0 mg

...Expand

: 34637-22-4
3-[(N-benzyloxycarbonyl)amino]propanol

A: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

B: dibenzyl (peroxybis(3-hydroxypropane-3,1-diyl))dicarbamate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dihydrogen peroxide; chloroperoxidase from C. fumago / aq. acetate buffer / 24 h / pH 5.0 / Enzymatic reaction 2: dihydrogen peroxide; chloroperoxidase from C. fumago / aq. acetate buffer / 19 h / pH 5.0 / Enzymatic reaction View Scheme

: 75-91-2
tert.-butylhydroperoxide

: 34637-22-4
3-[(N-benzyloxycarbonyl)amino]propanol

A: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

B: 65564-05-8
3-[(benzyloxycarbonyl)amino]propanal

C: benzyl (3-(tert-butylperoxy)-3-hydroxypropyl)carbamate

Conditions

Conditions	Yield
With chloroperoxidase from C. fumago In aq. acetate buffer for 7h; pH=5.0; Kinetics; Time; Enzymatic reaction;	A 2.6 μmol B 16.1 μmol C n/a

...Expand

: 65564-05-8
3-[(benzyloxycarbonyl)amino]propanal

A: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

B: dibenzyl (peroxybis(3-hydroxypropane-3,1-diyl))dicarbamate

Conditions

Conditions	Yield
With chloroperoxidase from C. fumago; dihydrogen peroxide In aq. acetate buffer for 19h; pH=5.0; Kinetics; Enzymatic reaction;

: 75-91-2
tert.-butylhydroperoxide

: 65564-05-8
3-[(benzyloxycarbonyl)amino]propanal

A: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

B: benzyl (3-(tert-butylperoxy)-3-hydroxypropyl)carbamate

Conditions

Conditions	Yield
With chloroperoxidase from C. fumago In aq. acetate buffer for 19h; pH=5.0; Kinetics; Enzymatic reaction;

...Expand

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 512178-52-8
3-Benzyloxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h; Inert atmosphere;	100%
With dmap; dicyclohexyl-carbodiimide In dichloromethane

: 2033-24-1
cycl-isopropylidene malonate

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 1246303-67-2
[3-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-3-oxo-propyl]-carbamic acid benzyl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 20h; Inert atmosphere;	100%
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane for 4.08333h; Inert atmosphere;

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 51513-97-4
N-[(phenylmethoxy)carbonyl]-β-alanine chloride

Conditions

Conditions	Yield
With oxalyl dichloride In dichloromethane at 25℃; for 4h;	99%
With oxalyl dichloride In dichloromethane at 20 - 25℃; for 4h;	99%
With oxalyl dichloride In dichloromethane at 20℃; for 6h;	98%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 2-(tert-butoxy)-2-oxoethyl 3-(((benzyloxy)carbonyl)amino)propanoate

Conditions

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 16h; Product distribution / selectivity;	99%
With potassium carbonate In acetone at 60℃; for 16h; Product distribution / selectivity;	99%
With potassium carbonate In [(2)H6]acetone at 20 - 60℃; for 16h; Reflux;	99%
With potassium carbonate In acetone Reflux;	99%
With potassium carbonate In acetone for 18h; Heating;

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 6112-83-0
benzyl (R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

: (R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-(3-Benzyloxycarbonylamino-propionyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid benzyl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 16h;	99%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 1086-00-6
1-chloromethylpyrene

: N-(benzyloxycarbonyl)-L-β-alanine (pyren-1-yl)methyl ester

Conditions

Conditions	Yield
With potassium fluoride In N,N-dimethyl-formamide at 20℃;	99%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 1190769-03-9
C34H47N5O5

: 1412423-25-6
C45H58N6O8

Conditions

Conditions	Yield
Stage #1: 3-(benzyloxycarbonylamino)propanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.25h; Stage #2: C34H47N5O5 In dichloromethane at 20℃;	99%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 64-04-0
phenethylamine

: benzyl 3-oxo-3-(phenethylamino)propylcarbamate

Conditions

Conditions	Yield
With diethyl cyanophosphonate; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	99%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 53733-97-4
N-benzyloxycarbonyl-3-aminopropionic acid succinimide ester

Conditions

Conditions	Yield
With polymer supported ethyl dimethylaminopropylcarbodiimide In chloroform; N,N-dimethyl-formamide for 14h;	98%
With dicyclohexyl-carbodiimide In 1,4-dioxane stirred overnight;
With dicyclohexyl-carbodiimide In acetonitrile for 2h; Ambient temperature;
With diisopropyl-carbodiimide In 1,4-dioxane for 2h;

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 1254122-49-0
8-(chloromethyl)-2-methyl-6-oxo-6H-benzopyrano[6,7-d]oxazole

: 1254122-57-0
C23H20N2O7

Conditions

Conditions	Yield
With potassium fluoride In N,N-dimethyl-formamide at 20℃; for 24h;	98%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 136586-99-7
4-amino-4-(2-tert-butoxycarbonylethyl)heptanedioic acid di-tertbutyl ester

: 4-(3-benzyloxycarbonylaminopropionylamino)-4-(2-tert-butoxycarbonylethyl)heptanedioic acid di-tert-butyl ester

Conditions

Conditions	Yield
With HATU In N,N-dimethyl-formamide at 20℃; for 16h;	98%
With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h;	98%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 2,2'-dimethyl-[1,1'-biphenyl]iodonium trifluoromethanesulfonate salt

: C25H24INO4

Conditions

Conditions	Yield
With copper diacetate; sodium carbonate; (3aR,3a'R,8aS,8a'S)-2,2'-(propane-2,2-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole) In dichloromethane; water at 30℃; for 12h; enantioselective reaction;	97%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 148930-30-7
2’-carboxybenzoylpaclitaxel

: 264254-84-4
2’-carboxybenzoyl-7-(N-carboxybenzoyl-β-alanyl)paclitaxel

Conditions

Conditions	Yield
With dmap In dichloromethane at 20℃; for 20h;	96%
With dmap; dicyclohexyl-carbodiimide at 23℃; for 18h; Inert atmosphere;	95%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;	90.5%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 124-40-3
dimethyl amine

: 23159-09-3
N',N'-dimethyl-N-carbobenzoxy-β-alaninamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 24h;	95%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 72h;	90%
(i) ClCO2Et, Et3N, CHCl3, (ii) /BRN= 605257/; Multistep reaction;
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In 1,4-dioxane at 0℃; for 1.5h;

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 138516-82-2
Z-β-alanine pentafluorophenyl ester

Conditions

Conditions	Yield
With polymer supported ethyl dimethylaminopropylcarbodiimide In chloroform; N,N-dimethyl-formamide for 14h;	95%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In ethyl acetate	87%
With dicyclohexyl-carbodiimide In ethyl acetate; N,N-dimethyl-formamide at 0 - 5℃;

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 100-53-8
phenylmethanethiol

: 3-Benzyloxycarbonylamino-thiopropionic acid S-benzyl ester

Conditions

Conditions	Yield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In chloroform for 16h;	95%

: 67-56-1
methanol

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 54755-77-0
3-(benzyloxycarbonylamino)-propionic acid methyl ester

Conditions

Conditions	Yield
With thionyl chloride at 0 - 20℃; for 12h;	95%
With hydrogenchloride for 0.333333h; Heating;	22.7 g

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 106-95-6
allyl bromide

: 1062263-64-2
2-propen-1-yl 3-(phenylmethoxycarbonylamino)propanoate

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;	95%
With potassium carbonate In acetone Reflux;	95%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 1254122-48-9
2-(bromomethyl)-8-methyl-6-oxo-6H-benzopyrano[6,7-d]oxazole

: 1254122-55-8
C23H20N2O7

Conditions

Conditions	Yield
With potassium fluoride In N,N-dimethyl-formamide at 20℃; for 5h;	95%

: 40052-13-9
mono-tert-butyl malonate

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: tert-butyl 5-(((benzyloxy)carbonyl)amino)-3-oxopentanoate

Conditions

Conditions	Yield
Stage #1: 3-(benzyloxycarbonylamino)propanoic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 25℃; for 18h; Stage #2: mono-tert-butyl malonate With isopropylmagnesium chloride In tetrahydrofuran at 0 - 40℃; for 5.5h;	95%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 1236069-47-8
[2-(2-carbamoyl-1-methyl-vinylamino)-ethyl]-carbamic acid tert-butyl ester

: [5-(2-tert-butoxycarbonylamino-ethylamino)-4-carbamoyl-3-oxo-hex-4-enyl]carbamic acid benzyl ester

Conditions

Conditions	Yield
Stage #1: 3-(benzyloxycarbonylamino)propanoic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In dichloromethane at 0℃; for 0.0833333h; Stage #2: [2-(2-carbamoyl-1-methyl-vinylamino)-ethyl]-carbamic acid tert-butyl ester With dmap In dichloromethane at 0 - 20℃; for 1h;	95%

: 924-73-2
3-amino-propionic acid ethyl ester

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 71710-18-4
N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine ethyl ester

Conditions

Conditions	Yield
With 1-ethyl-piperidine; dicyclohexyl-carbodiimide In dichloromethane 1) -5 deg C; 2) 0 deg C, 2 h; 3) 12h, room temp.;	93%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 760178-19-6
1-O-allyl-2,3-di-O-benzyl-6-O-tosyl-β-D-glucose

: 760178-20-9
1-O-allyl-2,3-di-O-benzyl-4-O-(carbobenzoxy-β-alanyl)-6-O-tosyl-β-D-glucopyranoside

Conditions

Conditions	Yield
With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 18h;	93%
With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	89%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 35088-96-1
(S)-2-amino-N1,N5-didodecylpentanediamide

: 111682-03-2
N',N"-didodecyl-Nα-[(3-(N'''-benzyloxycarbonyl)amino)propanoyl]-L-glutamide

Conditions

Conditions	Yield
With diethyl cyanophosphonate; triethylamine In tetrahydrofuran at 20℃; for 24h;	93%

: C52H95N13O18

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 651354-69-7
C63H106N14O21

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃;	93%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyloleanate acid

: 1434557-30-8
N-Cbz-3-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl olean-12-en-28-oate-3-yl)oxy-3-oxopropylamine

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 12h;	93%

: 33941-15-0
1-aza-18-crown-6

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 139346-62-6
N-<3-propanoyl>-1-aza-18-crown-6

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane Ambient temperature;	92%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 112160-37-9
NG-2,2,5,7,8-pentamethylchroman-6-sulfonyl-L-arginine

: 221665-11-8
N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine

Conditions

Conditions	Yield
With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 12h; Condensation;	92%
With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide 1.) DMF, room temperature, overnight, 2.) room temperature, overnight; Yield given; Multistep reaction;

: C42H42N4O4

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: C45H47N5O5

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;	92%

Carbobenzyloxy-beta-alanine Chemical Properties

Product Name: Carbobenzyloxy-beta-alanine
Synonyms: BENZYLOXYCARBONYL-BETA-ALANINE;carbobenzyloxy-beta-alanine;CBZ-BETA-ALANINE;CBZ-BETA-ALA-OH;Z-BETA-ALA-OH;Z-BETA-ALANINE;Z-NH-(CH2)2-COOH;Z-GLY(C*CH2)-OH ;
The Molecular formula of Z-BETA-ALA-OH（2304-94-1）: C₁₁H₁₃NO₄
The Molecular Weight of Z-BETA-ALA-OH（2304-94-1）:223.23
Molecular Structure :

EINECS: 218-967-4
Melting point: 100-105^°C
storage temp.: 2-8^°C

Carbobenzyloxy-beta-alanine Safety Profile

The Hazard Codes of Z-BETA-ALA-OH（2304-94-1）:

Xn
The Risk Statements information of Z-BETA-ALA-OH（2304-94-1）：
22: Harmful if swallowed
41: Risk of serious damage to eyes
The Safety Statements information of Z-BETA-ALA-OH（2304-94-1）：
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
39: Wear eye/face protection
WGK Germany: 2

Product Name

Carbobenzyloxy-beta-alanine

Synthetic route

Carbobenzyloxy-beta-alanine Chemical Properties

Carbobenzyloxy-beta-alanine Safety Profile

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