Carboxyethylgermanium sesquioxide supplier

Name
Carboxyethylgermanium sesquioxide
EINECS 235-800-0
CAS No. 12758-40-6
Density
Solubility Slightly soluble in water.
Melting Point 320 °C
Formula C₆H₁₀Ge₂O₇
Boiling Point
Molecular Weight 339.321
Flash Point
Transport Information
Appearance white powder
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms 2-(Carboxyethyl)germaniumsesquioxide;Arlamol GEO;Ge 132;NSC 267004;Proxigermanium;Rapagermanium;SK 818;Serocion;Dipropanoic acid germanium sequioxide;Bis-beta-carboxyethylgermanium sesquioxide;3,3'-(Germanoic anhydride) dipropanoic acid;
PSA 117.97000
LogP 0.01480

Synthetic route

: sodium [99Tc]pertechnetate

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: (99m)Tc-labeled bis-carboxyethylgermanium sesquioxide

Conditions

Conditions	Yield
With hydrogenchloride; sodium chloride; tin(ll) chloride In water at 20℃; for 0.5h; pH=4;	99%

: samarium(III) oxide

: 66-71-7
1,10-Phenanthroline

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: [Sm8(1,10-phenanthroline)2Ge12(μ3-O)24(CH2CH2COO-)12(H2O)16]*2(1,10-phenanthroline)*16H2O

Conditions

Conditions	Yield
With hydrogenchloride at 150℃; for 168h; pH=2; Autoclave;	86%

...Expand

: 66-71-7
1,10-Phenanthroline

: europium(III) oxide

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: [Eu8(1,10-phenanthroline)2Ge12(μ3-O)24(CH2CH2COO-)12(H2O)16]*2(1,10-phenanthroline)*16H2O

Conditions

Conditions	Yield
With hydrogenchloride at 150℃; for 168h; pH=2; Autoclave;	83%

...Expand

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: cadmium(II) oxide

: Cd1.5(CH2CH2CO2)3Ge3O5

Conditions

Conditions	Yield
With HNO3 In water High Pressure; mixt. of Ge-compound, CdO, HNO3 and H2O stirred for 2 h pH 3, heated at 150°C for 5 d; filtered; elem. anal.;	65%

: neodymium(III) oxide

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: Nd8Ge12C36H48O48*30H2O

Conditions

Conditions	Yield
at 140℃; for 170h; pH=3 - 7; Autoclave;	58%

...Expand

: 98-97-5
2-pyrazylcarboxylic acid

: neodymium(III) oxide

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: {[Nd(2-pyrazinecarboxylato)2(H2O)][Nd8Ge12(μ3-O)24(-CH2CH2COO-)12(2-pyrazinecarboxylato)(H2O)12]}·3H2O

Conditions

Conditions	Yield
Stage #1: neodymium(III) oxide; water; bis(2-carboxyethylgermanium(IV) sesquioxide) for 0.5h; Stage #2: 2-pyrazylcarboxylic acid With perchloric acid for 0.5h; pH=2; Stage #3: at 170℃; for 168h; Sealed tube;	57%

...Expand

: erbium(III) oxide

: 66-71-7
1,10-Phenanthroline

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: [Er8(1,10-phenanthroline)2Ge12(μ3-O)24(CH2CH2COO-)12(H2O)16]*2H2O

Conditions

Conditions	Yield
With hydrogenchloride at 150℃; for 168h; pH=2; Autoclave;	57%

...Expand

: 98-97-5
2-pyrazylcarboxylic acid

: neodymium(III) oxide

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: {([Nd(2-pyrazinecarboxylate)2(H2O)2]2[Nd8Ge12(CH2CH2COO)12(μ3-O)24(H2O)12])([Nd(2-pyrazinecarboxylate)2]2[Nd8Ge12(CH2CH2COO)12-(2-pyrazinecarboxylic acid)2(μ3-O)24(H2O)10])}*4OH*14H2O

Conditions

Conditions	Yield
at 170℃; for 168.5h; pH=2 - 5; Autoclave;	56%

...Expand

: praseodymium oxide

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: Pr8Ge12C36H48O48*30H2O

Conditions

Conditions	Yield
at 140℃; for 170h; pH=3 - 7; Autoclave;	55%

...Expand

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: lead (II) hydroxide

: Pb(CH2CH2CO2)2Ge2O3

Conditions

Conditions	Yield
With HNO3 In water High Pressure; mixt. of Ge-compound, Pb(OH)2, HNO3 and H2O stirred for 2 h pH 3, heatedat 150°C for 5 d; filtered; elem. anal.;	53%

: samarium(III) oxide

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: Sm8Ge12C36H48O48*30H2O

Conditions

Conditions	Yield
at 140℃; for 170h; pH=3 - 7; Autoclave;	52%

...Expand

: 98-98-6
2-Picolinic acid

: terbium(III, IV) oxide

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: {[Tb(2-picolinato)2(H2O)]3[Tb8Ge12(μ3-O)24(-CH2CH2COO-)12(H2O)4]}·(OH)3·10H2O

Conditions

Conditions	Yield
Stage #1: terbium(III, IV) oxide; water; bis(2-carboxyethylgermanium(IV) sesquioxide) With 1,2-diaminopropan for 0.0833333h; Stage #2: 2-Picolinic acid With perchloric acid for 0.5h; pH=2; Stage #3: at 170℃; for 168h; Sealed tube;	52%

...Expand

: europium(III) oxide

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: Eu8Ge12C36H48O48*30H2O

Conditions

Conditions	Yield
at 140℃; for 170h; pH=3 - 7; Autoclave;	45%

...Expand

: dysprosium((III) oxide

: 66-71-7
1,10-Phenanthroline

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: [Dy8(1,10-phenanthroline)2Ge12(μ3-O)24(CH2CH2COO-)12(H2O)16]*2H2O

Conditions

Conditions	Yield
With hydrogenchloride at 150℃; for 168h; pH=2; Autoclave;	45%

...Expand

: 98-97-5
2-pyrazylcarboxylic acid

: dysprosium((III) oxide

: 7732-18-5
water

: 51437-68-4, 100462-49-5, 104959-61-7
sodium formate dihydrate

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: {[Dy(2-pyrazinecarboxylato)2(H2O)][Dy(2-pyrazinecarboxylato)2(H2O)2][Dy(2-pyrazinecarboxylato)3(H2O)][Dy8Ge12(μ3-O)24(-CH2CH2COO-)12(2-pyrazinecarboxylato)(HCOO)(H2O)6]}·5H2O

Conditions

Conditions	Yield
Stage #1: 2-pyrazylcarboxylic acid; dysprosium((III) oxide; water; sodium formate dihydrate; bis(2-carboxyethylgermanium(IV) sesquioxide) for 0.5h; pH=3; Stage #2: at 170℃; for 168h; Sealed tube;	43%

...Expand

: gadolinium(III) oxide

: 66-71-7
1,10-Phenanthroline

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: [Gd8(1,10-phenanthroline)2Ge12(μ3-O)24(CH2CH2COO-)2(H2O)16]*2(1,10-phenanthroline)*16H2O

Conditions

Conditions	Yield
With hydrogenchloride at 150℃; for 168h; pH=2; Autoclave;	43%

...Expand

: 98-98-6
2-Picolinic acid

: 499-83-2
Pyridine-2,6-dicarboxylic acid

: neodymium(III) oxide

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: {[Nd8Ge12(CH2CH2COO)12(μ3-O)24(H2O)10][Nd(2-picolinate)(2,6-pyridinedicarboxylate)(H2O)]2}*12H2O

Conditions

Conditions	Yield
With perchloric acid at 170℃; for 168.5h; pH=2 - 5; Autoclave;	42%

...Expand

: 98-97-5
2-pyrazylcarboxylic acid

: terbium(III) nitrate hexahydrate

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: {[TbGe(-CH2CH2COO-)(HO)2O(2-pyrazinecarboxylato)(H2O)]2[Tb8Ge12(μ3-O)24(-CH2CH2COO-)12(H2O)6]}·18H2O

Conditions

Conditions	Yield
Stage #1: terbium(III) nitrate hexahydrate; water; bis(2-carboxyethylgermanium(IV) sesquioxide) With 1,2-diaminopropan for 0.5h; pH=6; Stage #2: 2-pyrazylcarboxylic acid for 0.5h; Stage #3: at 170℃; for 168h; Sealed tube;	41%

...Expand

: 98-97-5
2-pyrazylcarboxylic acid

: 499-83-2
Pyridine-2,6-dicarboxylic acid

: neodymium(III) oxide

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: {[Nd8Ge12(CH2CH2COO)12(μ3-O)24(H2O)10][Nd(2-pyrazinecarboxylate)(2,6-pyridinedicarboxylate)(H2O)]2}*12H2O

Conditions

Conditions	Yield
With perchloric acid at 170℃; for 168.5h; pH=2 - 5; Autoclave;	40%

...Expand

: neodymium(III) oxide

: 141-82-2
malonic acid

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: 2Nd2GeC3H6O5(4+)*Nd8Ge12C36H48O48*2CO3(2-)*4C2H3O2(1-)*18H2O

Conditions

Conditions	Yield
at 140℃; for 170h; pH=2 - 7; Autoclave;	37%

...Expand

: 98-98-6
2-Picolinic acid

: terbium(III, IV) oxide

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: [TbGe(CH2CH2COO)(HO)2O(H2O)(2-picolinate)]2[Tb8Ge12(CH2CH2COO)12-(μ3-O)24(H2O)8]*10H2O

Conditions

Conditions	Yield
With perchloric acid at 170℃; for 168.5h; pH=2 - 5; Autoclave;	35%

...Expand

: gadolinium(III) oxide

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: Gd8Ge12C36H48O48*30H2O

Conditions

Conditions	Yield
at 140℃; for 170h; pH=3 - 7; Autoclave;	32%

...Expand

: 7732-18-5
water

: 15280-55-4, 85077-87-8
dysprosium acetate tetrahydrate

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: 497-19-8
sodium carbonate

: {[Dy(CH3COO)(CO3)(H2O)]2[Dy8Ge12(μ3-O)24(-CH2CH2COO-)12(H2O)12]}·11H2O

Conditions

Conditions	Yield
Stage #1: water; dysprosium acetate tetrahydrate; bis(2-carboxyethylgermanium(IV) sesquioxide); sodium carbonate for 0.5h; pH=6; Stage #2: at 170℃; for 144h; Sealed tube;	32%

...Expand

: holmium(III) oxide

: 66-71-7
1,10-Phenanthroline

: 7732-18-5
water

: 12758-40-6
bis(2-carboxyethylgermanium(IV) sesquioxide)

: [Ho8(1,10-phenanthroline)2Ge12(μ3-O)24(CH2CH2COO-)12(H2O)14]*2(1,10-phenanthroline)*13H2O

Conditions

Conditions	Yield
at 120℃; for 168h; pH=6; Autoclave;	32%

...Expand

Carboxyethylgermanium sesquioxide Consensus Reports

Reported in EPA TSCA Inventory.

Carboxyethylgermanium sesquioxide Specification

The Carboxyethylgermanium sesquioxide, with the CAS registry number 12758-40-6, is also known as Bis-beta-carboxyethylgermanium sesquioxide. It belongs to the product categories of Ge (Germanium) Compounds; Classes of Metal Compounds; Semimetal Compounds; Nutritional Supplements. Its EINECS number is 235-800-0. This chemical's molecular formula is C₆H₁₀Ge₂O₇ and molecular weight is 339.42. What's more, its systematic name is 3,3'-(1,3-Dioxo-1,3-digermoxanediyl)dipropanoic acid. Its classification codes are: (1)Antineoplastic agents; (2)Drug / Therapeutic Agent; (3)Immunologic Factors; (4)Interferon inducers; (5)Mutation data; (6)Reproductive Effect. This chemical is stable at common pressure and temperature, and it should be sealed and stored in a cool, ventilated and dry place. Moreover, it should be protected from oxides, acids and bases. This chemical is an organometallic compound of germanium that is sold as a complementary medicine.

Physical properties of Carboxyethylgermanium sesquioxide are: (1)#H bond acceptors: 7; (2)#H bond donors: 2; (3)#Freely Rotating Bonds: 8; (4)Polar Surface Area: 117.97 Å²; (5)Rotatable Bond Count: 8; (6)Exact Mass: 339.885907; (7)MonoIsotopic Mass: 341.885009; (8)Topological Polar Surface Area: 118; (9)Heavy Atom Count: 15; (10)Formal Charge: 0; (11)Complexity: 259.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: O=[Ge](O[Ge](=O)CCC(=O)O)CCC(=O)O
(2)Std. InChI: InChI=1S/C6H10Ge2O7/c9-5(10)1-3-7(13)15-8(14)4-2-6(11)12/h1-4H2,(H,9,10)(H,11,12)
(3)Std. InChIKey: XEABSBMNTNXEJM-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD	oral	> 4gm/kg (4000mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 19, 1990.
mouse	LD50	intraperitoneal	1250mg/kg (1250mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
mouse	LD50	intravenous	> 200mg/kg (200mg/kg)		Drugs in Japan Vol. -, Pg. 1195, 1995.
mouse	LD50	oral	5600mg/kg (5600mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
mouse	LD50	subcutaneous	> 4gm/kg (4000mg/kg)		Drugs in Japan Vol. -, Pg. 1195, 1995.
rat	LD50	intraperitoneal	1670mg/kg (1670mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
rat	LD50	intravenous	> 200mg/kg (200mg/kg)		Drugs in Japan Vol. -, Pg. 1195, 1995.
rat	LD50	oral	7050mg/kg (7050mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
rat	LD50	subcutaneous	> 4gm/kg (4000mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.

Product Name

Carboxyethylgermanium sesquioxide

Synthetic route

Carboxyethylgermanium sesquioxide Consensus Reports

Carboxyethylgermanium sesquioxide Specification

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