• Name

  Cefoperazone sodium

• EINECS 263-751-5
• CAS No. 62893-20-3
• Article Data5
• CAS DataBase
• Density
• Solubility Soluble in water. Slightly soluble in alcohol.
• Melting Point 200-202 °C
• Formula C₂₅H₂₇N₉O₈S₂. Na
• Boiling Point
• Molecular Weight 667.659
• Flash Point
• Transport Information
• Appearance Faint beige powder
• Safety 22-36/37
• Risk Codes 42/43
• Molecular Structure
• Hazard Symbols Xn
• Synonyms 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2R)-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt, [6R-[6a,7b(R*)]]-;Bioperazone;CP 52640-2;Cefobis;Cefogram;Cefomycin;Cefoneg;Cefoperazone sodium;Cefoperazone sodium salt;Cefosint;Dardum;Farecef;Kefazon;Myticef;Novobiocyl;Pathozone;Peracef;Sodium cefoperazone;
• PSA 273.69000
• LogP -1.85120

Synthetic route

62893-19-0, 68779-10-2

cefoperazone

62893-20-3

Cefobis

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetone at 15 - 25℃; for 0.666667h; pH=6.5 - 6.6;	98.1%
With sodium isooctanoate; pyrographite In acetone at 25℃; pH=6.6; Reagent/catalyst; pH-value;	71.8%
With sodium carbonate In water; ethyl acetate at 25℃; pH=6.2; Temperature; Solvent; pH-value;	102.61 g
With sodium hydrogencarbonate In ethanol; water at 30℃; pH=6; Reagent/catalyst; Solvent; Temperature; pH-value;	453g

957-68-6

7-Aminocephalosporanic acid

62893-20-3

Cefobis

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridine; titanium tetrachloride; tetrabutoxytitanium / acetonitrile / 3 h / 5 - 30 °C 2: chloro-trimethyl-silane / N,N-dimethyl-formamide / 4 h / -25 - -20 °C 3: sodium isooctanoate; pyrographite / acetone / 25 °C / pH 6.6 View Scheme

iron(II) chloride tetrahydrate

62893-20-3

Cefobis

1448807-93-9

C25H26N9O8S2(1-)*Fe(2+)*Cl(1-)

Conditions

Conditions	Yield
In methanol at 20℃; for 5h; Inert atmosphere;

iron(III) chloride hexahydrate

62893-20-3

Cefobis

C25H26N9O8S2(1-)*Fe(3+)*2Cl(1-)*3H2O

Conditions

Conditions	Yield
In methanol at 20℃; for 5h; Inert atmosphere;

cobalt(II) chloride hexahydrate

62893-20-3

Cefobis

C25H26N9O8S2(1-)*Co(2+)*Cl(1-)*H2O

Conditions

Conditions	Yield
In methanol at 20℃; for 5h; Inert atmosphere;

nickel(II) chloride hexahydrate

62893-20-3

Cefobis

C25H26N9O8S2(1-)*Ni(1+)*Cl(1-)

Conditions

Conditions	Yield
In methanol at 20℃; for 5h; Inert atmosphere;

copper(II) choride dihydrate

62893-20-3

Cefobis

C25H26N9O8S2(1-)*Cu(2+)*Cl(1-)*H2O

Conditions

Conditions	Yield
In methanol at 20℃; for 5h; Inert atmosphere;

62893-20-3

Cefobis

10108-64-2

cadmium(II) chloride

1448808-06-7

C25H26N9O8S2(1-)*Cd(2+)*Cl(1-)

Conditions

Conditions	Yield
In methanol at 20℃; for 5h; Inert atmosphere;

62893-20-3

Cefobis

cefoperazone sodium hemihydrate

Conditions

Conditions	Yield
With water; pyrographite at 30℃; for 0.5h; Temperature;	48.5 g

Cefoperazone Sodium Specification