Cefpodoxime supplier | CasNO.80210-62-4

Name
Cefpodoxime
EINECS
CAS No. 80210-62-4
Article Data10
CAS DataBase
Density 1.785 g/cm³
Solubility
Melting Point 200-202 °C
Formula C₁₅H₁₇N₅O₆S₂
Boiling Point
Molecular Weight 427.462
Flash Point
Transport Information
Appearance off-white solid
Safety 22-36/37-45
Risk Codes 42/43
Molecular Structure
Hazard Symbols Xn
Synonyms 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-,[6R-[6a,7b(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-,(6R,7R)- (9CI);Cefpodoxime acid;R 3763;
PSA 209.98000
LogP 0.37080

Synthetic route

: 80756-85-0
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate

: 24701-69-7
(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 80210-62-4
cefpodoxime

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at -5 - 5℃; for 2h;	82.86%
With triethylamine In tetrahydrofuran at 0 - 5℃; for 2h;	82.86%
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; (6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid With triethylamine In methanol at 8 - 12℃; Stage #2: With sulfuric acid In methanol; water at 0 - 20℃; pH=2.4 - 2.5; Product distribution / selectivity;
With triethylamine In methanol; water at 15 - 20℃;	81 mg

: 124-41-4
sodium methylate

: 75994-59-1
2-(2-amino-4-thiazolyl)-2-(Z)-methoxyiminoacetyl chloride

: 7-amino-3-chloromethyl-3-cephem-4-carboxylic acid

: 80210-62-4
cefpodoxime

Conditions

Conditions	Yield
Stage #1: sodium methylate; 7-amino-3-chloromethyl-3-cephem-4-carboxylic acid With benzyltrihexylammonium chloride; potassium iodide In dimethyl sulfoxide at 15℃; for 8h; Stage #2: 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyiminoacetyl chloride In dimethyl sulfoxide at 10℃; for 4h; Temperature; Solvent; Reagent/catalyst;	82.2%

...Expand

: 82618-98-2
(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester

A: 126747-46-4
(2R,6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid

B: 80210-62-4
cefpodoxime

C: 126617-55-8
(2R,6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester

Conditions

Conditions	Yield
With water In N,N-dimethyl-formamide at 37℃; Rate constant; phosphate buffer, var. pH, add of bovin serum albumin (as protein);

...Expand

: 957-68-6
7-Aminocephalosporanic acid

: 80210-62-4
cefpodoxime

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanesulfonic acid / 5 - 12 °C 2: triethylamine / water; methanol / 15 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: methyl bisulfate / N,N-dimethyl-formamide; methanol / 5 h / 0 - 20 °C 2: triethylamine / tetrahydrofuran / 2 h / 0 - 5 °C View Scheme

: 15690-38-7
(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 80210-62-4
cefpodoxime

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanesulfonic acid / acetonitrile / 5 - 40 °C 2: triethylamine / methanol; water / 15 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: methanesulfonic acid / 5 - 40 °C 2: triethylamine / methanol; water / 15 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: methanesulfonic acid / 5 - 40 °C 2: triethylamine / methanol; water / 15 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: methanesulfonic acid / 5 - 40 °C 2: triethylamine / methanol; water / 15 - 20 °C View Scheme
Multi-step reaction with 2 steps 1.1: boron trifluoride diethyl etherate / acetonitrile / 0.92 h / -20 - 25 °C 1.2: 25 °C 2.1: triethylamine / dichloromethane / 5 - 25 °C / pH 8 - 9 View Scheme

: (benzothiazol-2-yl)-2-(2-aminothiazol-4-yl)-Z-2-methoxyimino-thioacetate

: 24701-69-7
(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 80210-62-4
cefpodoxime

Conditions

Conditions	Yield
Stage #1: (benzothiazol-2-yl)-2-(2-aminothiazol-4-yl)-Z-2-methoxyimino-thioacetate; (6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid With triethylamine In methanol; water at 15 - 20℃; Stage #2: With sulfuric acid In methanol; water

: 94088-75-2
2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one

: 24701-69-7
(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 80210-62-4
cefpodoxime

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 5 - 25℃; pH=8 - 9; Temperature;

: 65872-41-5
cefotaxime

: 80210-62-4
cefpodoxime

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: N,N-dimethyl acetamide / 0.08 h 1.2: 1.5 h / -11 - 15 °C 2.1: triethylamine / methanol / 0.5 h / -30 - 0 °C View Scheme

: C13H13N3O5S2

: 24701-69-7
(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 80210-62-4
cefpodoxime

Conditions

Conditions	Yield
With triethylamine In methanol at -30 - 0℃; for 0.5h; Solvent;

: 80756-85-0
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate

: 15690-38-7
(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 149-73-5
trimethyl orthoformate

: 80210-62-4
cefpodoxime

Conditions

Conditions	Yield
Stage #1: trimethyl orthoformate With boron trifluoride diethyl etherate In acetonitrile at -30℃; for 1.58333h; Stage #2: (6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid In acetonitrile at 25℃; for 0.25h; Stage #3: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate With triethylamine In dichloromethane at 0℃; pH=8 - 9;

Yield

Stage #1: trimethyl orthoformate With boron trifluoride diethyl etherate In acetonitrile at -30℃; for 1.58333h;
Stage #2: (6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid In acetonitrile at 25℃; for 0.25h;
Stage #3: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate With triethylamine In dichloromethane at 0℃; pH=8 - 9;

...Expand

: 84089-73-6, 91508-00-8
1-iodoethyl isopropyl carbonate

: 80210-62-4
cefpodoxime

: 87239-81-4
cefpodoxime proxetil

Conditions

Conditions	Yield
Stage #1: cefpodoxime With 1-butyl-3-methylimidazolium hydroxide; potassium carbonate In N,N-dimethyl-formamide at -18 - -15℃; for 0.333333h; Inert atmosphere; Stage #2: 1-iodoethyl isopropyl carbonate In N,N-dimethyl-formamide for 0.5h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;	94.5%
Stage #1: cefpodoxime With sodium acetate In water; N,N-dimethyl-formamide at 25℃; for 0.5h; Stage #2: 1-iodoethyl isopropyl carbonate In water; N,N-dimethyl-formamide at 3℃; for 2h;	73%
Stage #1: cefpodoxime With N,N,N',N'-tetramethylguanidine In ISOPROPYLAMIDE at -12 - -4℃; for 1h; Stage #2: 1-iodoethyl isopropyl carbonate In ISOPROPYLAMIDE at -15 - -8℃; for 0.5 - 1.5h; Product distribution / selectivity;

: 84089-73-6, 91508-00-8
1-iodoethyl isopropyl carbonate

: 80210-62-4
cefpodoxime

A: 87239-81-4
cefpodoxime proxetil

B: 1-(isopropoxycabonyloxy) ethyl (6R, 7R) [7-[2-(2-AMINOTHIAZOL-4-YL)-2-METHOXYIMINO-] [ACETAMIDO]-3-(METHOXYMETHYL) 3-CEPHEM-4-CARBOXYLATE]

Conditions

Conditions	Yield
With disodium hydrogenphosphate; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene In ISOPROPYLAMIDE at -10 - -5℃; for 2.16667h;	A 80.5% B 0.5%

...Expand

: 84089-73-6, 91508-00-8
1-iodoethyl isopropyl carbonate

: 80210-62-4
cefpodoxime

A: 112345-70-7
(R)-1-(isopropoxycarbonyloxy)ethyl-(+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-((Z)-methoxyimino)acetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-en-2-carboxylate

B: 1-isopropoxycarbonyloxyethyl(6R,7R)-7-[2-(2-aminothiazol-4-yl)-2(Z)-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate

Conditions

Conditions	Yield
Stage #1: 1-iodoethyl isopropyl carbonate; cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In ISOPROPYLAMIDE; water at -15 - -6℃; for 0.5 - 0.75h; Stage #2: With hydrogenchloride Product distribution / selectivity;

...Expand

: 84089-73-6, 91508-00-8
1-iodoethyl isopropyl carbonate

: 80210-62-4
cefpodoxime

Reaxys ID: 12045429: Reaxys ID: 12045429

Conditions

Conditions	Yield
Stage #1: cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In ISOPROPYLAMIDE at -10 - -6℃; Stage #2: 1-iodoethyl isopropyl carbonate In ISOPROPYLAMIDE at -10 - -6℃; for 0.5 - 0.75h;

: 75-75-2
methanesulfonic acid

: 84089-73-6, 91508-00-8
1-iodoethyl isopropyl carbonate

: 80210-62-4
cefpodoxime

A: 112345-70-7
(R)-1-(isopropoxycarbonyloxy)ethyl-(+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-((Z)-methoxyimino)acetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-en-2-carboxylate

B: 1-isopropoxycarbonyloxyethyl(6R,7R)-7-[2-(2-aminothiazol-4-yl)-2(Z)-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate

Conditions

Conditions	Yield
Stage #1: 1-iodoethyl isopropyl carbonate; cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In ISOPROPYLAMIDE at -15 - 6℃; for 0.666667h; Stage #2: With hydrogenchloride Stage #3: methanesulfonic acid With sodium hydrogencarbonate Product distribution / selectivity; more than 3 stages;

...Expand

: 1-iodoethyl methyl carbonate

: 80210-62-4
cefpodoxime

: 1-(methoxycarbonyloxy)ethyl (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate

Conditions

Conditions	Yield
Stage #1: cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 20℃; for 0.5h; Stage #2: 1-iodoethyl methyl carbonate In N,N-dimethyl acetamide; toluene at -20 - -15℃; for 2.5h;	20.5 g

: 1-iodopropyl isopropyl carbonate

: 80210-62-4
cefpodoxime

: 1-(isopropoxycarbonyloxy)propyl (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate

Conditions

Conditions	Yield
Stage #1: cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 20℃; for 0.5h; Stage #2: 1-iodopropyl isopropyl carbonate In N,N-dimethyl acetamide; toluene at -20 - -15℃; for 2.5h;	52 g

: 91507-81-2
1-iodoethyl propyl carbonate

: 80210-62-4
cefpodoxime

: 1-(propoxycarbonyloxy)ethyl (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate

Conditions

Conditions	Yield
Stage #1: cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 20℃; for 0.5h; Stage #2: 1-iodoethyl propyl carbonate In N,N-dimethyl acetamide; toluene at -20 - -15℃; for 2.5h;	20.5 g

: 80210-62-4
cefpodoxime

: 80196-04-9
ethyl 1-iodoethylcarbonate

: 1-(ethoxycarbonyloxy)ethyl (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate

Conditions

Conditions	Yield
Stage #1: cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 20℃; for 0.5h; Stage #2: ethyl 1-iodoethylcarbonate In N,N-dimethyl acetamide; toluene at -20 - -15℃; for 2.5h;	20 g

Cefpodoxime Specification

The Cefpodoxime, with the CAS registry number 80210-62-4, is also known as 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-,(6R,7R)-. It belongs to the product categories of Various Metabolites and Impurities; Intermediates & Fine Chemicals; Metabolites & Impurities; Pharmaceuticals; Heterocycles; Sulfur & Selenium Compounds. This chemical's molecular formula is C₁₅H₁₇N₅O₆S₂ and molecular weight is 427.46. What's more, its systematic name is (6R,7R)-7-{[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. Cefpodoxime is an oral third generation cephalosporin antibiotic. It is marketed as the prodrug cefpodoxime proxetil by Pharmacia & Upjohn under the trade name Vantin. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. This chemical also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.

Physical properties of Cefpodoxime are: (1)ACD/LogP: 0.938; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -1.80; (4)ACD/LogD (pH 7.4): -2.81; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 11; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 7; (12)Index of Refraction: 1.78; (13)Molar Refractivity: 100.498 cm³; (14)Molar Volume: 239.526 cm³ ; (15)Polarizability: 39.84 10-24cm³; (16)Surface Tension: 79.25 dyne/cm; (17)Density: 1.785 g/cm³

You can still convert the following datas into molecular structure:
(1)SMILES: O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)COC)C(=O)O
(2)Std. InChI: InChI=1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1
(3)Std. InChIKey: WYUSVOMTXWRGEK-HBWVYFAYSA-N

Product Name

Cefpodoxime

Synthetic route

Cefpodoxime Specification

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